⏱️🩸 Timing is Brain: Early DOACs in Atrial Fibrillation

🧠💉 When should you start anticoagulation after an ischaemic stroke in atrial fibrillation? The CATALYST meta-analysis may have the answer!   📊 5,441 patients from 4 RCTs ⏱️ Early DOAC (≤4 days) reduced recurrent stroke risk at 30 days ⚖️ No increased bleeding, even in moderate stroke severity 🚫 But patients with PH2 or very severe strokes were excluded Individual Participant Data Meta-Analysis allowed detailed subgroup analysis and minimized bias 💡 Clinical Takeaway: In most mild-to-moderate strokes, don't delay—start DOACs early! 📄 #Stroke #AtrialFibrillation #CATALYST #DOAC #Neurology #Cardiology #MetaAnalysis #IPDMA #ClinicalTrials #PrecisionMedicine #StrokePrevention