⏰ Timing the Tumor: Circadian Clocks in Cancer Progression

  ⏰🧬 Timing matters in cancer. A superb JCI Review, Rhythms of risk: the intersection of clocks, cancer, and chronotherapy, shows how circadian clocks regulate cell cycle, DNA repair, metabolism, immunity, hypoxia, and even metastasis—and how circadian disruption (e.g., night-shift work) can reshape cancer risk and treatment response. ⚖️💊 The takeaway: clock biology is context-specific, and aligning therapy with circadian phase may enhance efficacy while reducing toxicity—an underused lever in precision oncology. 🎯 Worth a careful read for clinicians, scientists, and trialists thinking about the fourth dimension of cancer: time. ⏱️