Toddler Time Bombs (Poison Center Triage)

Ryan and Toxo cover some topics off the "one pill can kill" list, try breaking down the toxic mechanism of opioid induced respiratory depression in a simplistic way (but maybe fail), and walk through the triage and management of poison center case where a child was "potentially" exposed to a lethal toxin at home. Case ReportPediatric ingestion case study discussed at the beginning of the episode: https://pediatrics.aappublications.org/content/130/6/e1700"One Pill Can Kill" ResourcesMissouri Poison Center resource guide:http://missouripoisoncenter.org/wp-content/uploads/2015/02/2011-One-Pill-Can-Kill.pdfPediatric poison prevention article:https://pubmed.ncbi.nlm.nih.gov/16419734/HealthyChildren.org guide on medication safety:https://www.healthychildren.org/English/safety-prevention/at-home/medication-safety/Pages/Poison-Prevention-One-Pill-Can-Kill.aspxRespiratory Centers and Drug EffectsDetailed overview of the impact of drugs on respiratory centers:https://www.ncbi.nlm.nih.gov/books/NBK482414Buprenorphine StudiesEpidemiologyAAPCC Annual Report on poisoning trends:https://pubmed.ncbi.nlm.nih.gov/31752545/Trends in pediatric opioid exposures:https://pubmed.ncbi.nlm.nih.gov/32178937/Trends in ED visits for unsupervised medication exposures:https://pubmed.ncbi.nlm.nih.gov/26347435/Exposure StudiesU.S. Poison Center data on buprenorphine: https://pubmed.ncbi.nlm.nih.gov/29941678/Harvard Emergency Medicine group analysis: https://pubmed.ncbi.nlm.nih.gov/27756148/Maryland Poison Center/RADARS data:https://pubmed.ncbi.nlm.nih.gov/18381506/ICU exposures in children:https://pubmed.ncbi.nlm.nih.gov/20921918/Triage Considerations for Pediatric ExposuresSymptoms: What are the current symptoms and their severity?Causative Agent & Exposure Characteristics: What substance was ingested, and in what quantity? What’s the context of the exposure?History: Includes past medical history, patient weight, and the time elapsed since exposure.Onset: When are symptoms expected to appear?Labs: Perform toxin-specific assessments where applicable.Aggravating/Remitting Factors: What interventions have already been performed, and how have they affected the patient?If you have questions about these studies or poisoning scenarios, consult your local poison center or toxicologist. Thank you for tuning in!A Morel DilemmaSupport the showReview the show where ever your listeningGet Messages from Toxo (Join the Newsletter!)Join as a supporting memberAd free episodesBonus content and early accessDiscounts and give aways on GOTA PICCEM Mushroom card gameThe GOTTA PICCEM Poisonous Mushroom Game!The Poisonus Fungus Amongus Children's Book!Full book reading (6 minutes!)Tox trinkets (Rep the show at home!)Reach the showEmail: [email protected] Show ResourcesRyan's Medical Games and ResourcesShow Website