Too Much Sitting, "Spiky" Cholesterol, and Heart Disease

Biomechanist Katy Bowman and biologist Dr. Jeannette Loram unpack emerging research on heart disease, inflammation, cholesterol, and arterial plaque. Inspired by a recent Scientific American article, they explore what plaque is, how and why it forms, and how blood flow patterns influence where plaque accumulates in the arteries. They discuss recent evidence that places inflammation as a foundational piece of heart disease and how the ‘spiky’ shape and structure of cholesterol in plaque has a direct role in the inflammatory pathways and immune system overreactions that occur in heart disease. Katy and Jeannette offer practical insights into how regular activity, varied positioning, and lifestyle choices can help support healthy arteries. They also discuss the importance of scientific curiosity, prevention over treatment, and why understanding the body's processes can inspire better self-care.Enhanced Show Notes and Full Transcript0:00 — Introduction:  the Scientific American article on heart inflammation3:43 — Dynamic Collective9.15 — Main takeaway: inflammation, cholesterol and heart disease9:47 — What is plaque? 15:33 — Why plaque forms in specific locations within arteries: wounding and blood flow 23:12 — How cholesterol enters arterial walls  40:00 — Why understanding the body can deepen appreciation and motivation for self-care44:16 — Listener question: sciatic pain (sponsored by Venn Design).Books, Links and Resources:Science and Poetry by Mary Midgely Connect, Move & Learn:Join Our Newsletter: Movement Colored GlassesFollow Katy on SubstackTry Katy's Virtual Studio Free for 7 days!Made Possible By Our Wonderful Sponsors:Venn Design: Beautifully upholstered ball-shaped Air Chairs and floor cushions that encourage dynamic sittingMy Happy Feet: Toe-spacing socks that gently realign toes for comfortable shoe recovery—take 20% off with code MYDNAEarth Runners:  makers of minimalist earthing sandals designed for natural foot movement and connection to the ground— use code DNA10 for 10% off.Ikaria Design: The Soul Seat® offers height-adjustable, multi-position sitting—get 10% off new chairs and desks with code DNA10Movemate: Active standing boards with smoothly articulating wooden slats. Designed to keep you moving without interrupting your focus.ScreenFit™: a complete online vision training program —take $200 off with code NUTRITIOUSMOVEMENTFreet Barefoot: creators of comfortable barefoot shoes built for natural movement, flexibility, and durability— use code DNA10 for 10% off.Thoughts/questions email us at [email protected] Voice on the Podcast: Read The Credits  October Retreats 2026