Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: a systematic review and meta-analysis

Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: asystematic review and meta-analysis DOI https://doi.org/10.1186/s13098-025-01616-9 Abstract Background The significant burden of cardiovascular diseases underscores the necessity for identifying novel predictive markers that can forecast both cardiovascular diseases and mortality. In recent years, Triglycerideglucose -obesity-related parameters have gained special attention in thisregard. This study aimed to assess the association between Triglyceride glucose -waist circumference (TyG-WC) and cardiovascular diseases and mortality. Methods A comprehensive search was performed in databases including PubMed, Scopus, and Web of Science from their inception until October 6, 2024. The key outcomes of interest included all-cause mortality, cardiovascular mortality, cardiovascular diseases, myocardialinfarction, stroke, coronary artery diseases, peripheral artery diseases, and heart failure. The pooled risk ratio (RR) with corresponding 95% confidence intervals (CI) was calculated. Meta-analysis was carried out using StataMP 14.0. Results A total of 17 studies were included in the analysis. The number of participants ranged between 2,224 and 95,342. The meta-analysis revealed that Triglyceride glucose -waist circumference is significantly associated with an increased risk of all-cause mortality, cardiovascular mortality, cardiovascular diseases, myocardial infarction,stroke, coronary artery diseases, and peripheral artery diseases. However, only one study addressed the relationship between Triglyceride glucose -waist circumference and heart failure with a positive correlation. Conclusion This study indicates that Triglyceride glucose -waist circumference could serve as a promising predictor ofcardiovascular diseases, along with cardiovascular and all-cause mortality. Given its accessibility, Triglyceride glucose -waist circumference may be a practical tool for screening purposes. Disclaimer: Lupin makes no representation or warranty of any kind, expressed or implied, regarding the accuracy, adequacy, validity, reliability, availability, or completeness of any scientific information shared by the HCP on the ­­­STARUPDATE podcast. You should not allow the contents of this to substitute for your own medical judgment, which you should exercise in evaluating the information on this website.