TWiV 1126: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID.

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Links for this episode

• CDC ACIP for RSV (CDC)
• This respiratory virus season everyone age 75 and older receive the RSV vaccine (CDC Newsroom)
• Revised RSV vaccine recommendations (CIDRAP)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Local and systemic response dynamics to SARS-CoV-2 infection (Nature)
• Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience)
• Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN)
• Do older versions of the COVID-19 vaccine still provide any protection (JAMA Internal Medicine)
• Where to get pemgarda (Pemgarda)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Adjuvant statin therapy reduces SARS-CoV-2 mortality (American Journal of Medicine)
• Nirmatrelvir and ritonavir beyond 5 days of symptom onset improved the multiple organ dysfunction in severe COVID-19 patient (BMC Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Faecal microbtiota transplantation cures sleep disturbance in post-acute COVID-19 syndrome (Clinical Gastroenterology and Hepatology)
• Long COVID defined by patient phenotype (CIDRAP)
• Three distinct symptom-based post-COVID condition phenotypes (JID)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1126
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]