TWiV 1128: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the fourth US case of H5N1 human infection and reminds the audience of the definition of "pasteurization" before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, how an EEG can be used to look for signatures of cognitive decline after SARS-CoV-2 infection and what we observed 2 years following SARS-CoV-2 infection for tissue-resident T cell and viral RNA persistence.

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Links for this episode

• Fourth case human infection associated with an ongoing multistate outbreak of A(H5N1) (CDC)
• Human H5N1 in Colorado and thedefinition of pasteurization (CIDRAP)
• Is "raw" milk more risky than pasteurized (Annenberg Public Policy Center)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Winter, spring, summer and fall COVID-19 surges? (CDC)
• Where to get pemgarda (Pemgarda)
• Unable to access Pemgarda, gotta call Daniel (microbeTV)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Molunpiravir works: reduces hospitalizations and deaths due to COVID-19 and all-cause mortality (CID)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Benefits of dexamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell)
• Anticoagulation guidelines (hematology.org)
• EEG signatures for cognitive decline after SARS-CoV-2 infection (BMC Medicine)
• Tissue resident T-cells and viral RNA 2 years after SARS-CoV-2 infection (Science Translational Medicine)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1128
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]