TWiV 1152: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition.

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Links for this episode

• Waning vaccine protection against mpox…..isn't this the way the humoral immune response works? (CIDRAP) 1:46
• Uncontrollable mpox outbreak in Africa  (Reuters) 4:10
• Antibodies elicited by the Jynneos vaccine against mpox contract after 6-9 months….can you believe? (medrxiv) 4:45
• Mpox vaccine for adolescents approved (Pharmaceutical Technology) 14:05
• Clade 1b mpox visiting India (CIDRAP) 15:05
• Mpox clade 1b in Kerala (ANI South Asia's Leading Multimedia News Agency) 15:13
• US government orders $63M worth of small pox/mpox vaccine (Reuters) 15:34
• Mpox donations boosting global supply (US Department of Health and Human Services)
• 1 million mpox vaccine doses for Africa….with love from US government (CIDRAP) 15:55
• Speed doses of mpox vaccine (CIDRAP)
• Mpox vaccine donations (UNICEF) 17:35
• Bavarian Nordic mpox vaccine (Yahoo finances)
• Early epicenter of COVID-19 pandemic Huanan seafood market (Science) 23:07
• Wildlife trade likely source of SARS-CoV-2 (Science) 23:16
• Zoonotic origins of SARS-CoV-2 (Science) 23:20
• Surveillance at the Huanan Seafood market (Europe PMC) 25:03
• TWiV shout outs…..all for the SARS-CoV-2 spill over from nature 25:31
  • TWiV 1019: Eddie Holmes on SARS-CoV-2 origins
  • TWiV 1017: From Nature, not a lab
  • TWiV 995: Viral origin stories
  • TWiV 940: Eddie Holmes in on viral origins
  • TWiV 876: Spillover market with Michael Worobey
  • TWiV 762: SARS-CoV-2 origins with Robert Garry
  • TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
  • TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
• Genetic tracing of market wildlife and viruses at Huanan Market (Cell) 18:56
• Combatting scientific misinformation (microbeTV: TWiV) 34:14
• COVID-19 deaths (CDC) 35:20
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Suggestion for the use of a new preventive COVID-19 agent (IDSA)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)
• Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Lower mortality risk associated with remdesivir + dexamethasone versus dexamethasone for hospitalized COVID-19 patients (CID) 39:17
• Changes in memory and cognition during the SARS-CoV-2 human challenge study (eClinical Medicine) 42:25
• Letters read on TWiV 1152 48:18
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]