TWiV 751: Sputnik spat and furin in ferrets

TWiV examines the claim by Brazil's ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls Brazil rejects Gamaleya vaccine (Sci Transl Med) Russian vaccine behavior (Sci Transl Med) Is Gamaleya vaccine safe? (Science) Furin cleavage site in replication and transmission (Nat Micro) Furin site loss attenuates pathogenesis (Nature) Timestamps by Jolene. Thanks! Weekly Picks Rich – The diversity and function of sourdough starter microbiomes; Dunn Lab Wild Sourdough Project Kathy – ISS, Crew Dragon, and the sun  Doubly warped world of binary black holes Vincent – Mr. Labman Listener Picks Joy – Abandoned America: Matthew Christopher's Autopsy of the American Dream Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]