TWiV 932: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID.

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Links for this episode

• Vaccine effectiveness against Influenza illness in children (CID)
• Clinical manifestations of infection with Polio (JAMA)
• Characteristics of deaths among fully vaccinated persons with Coronavirus (CID)
• Spike protein attenuation of Omicron Variant in lab mice (Cell Reports)
• Concordance of SARS-CoV-2 results in nasal swabs self-collected vs healthcare collected (JAMA)
• Probable animal-to-human transmission of Sars-Cov-2 (CID)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• COVID-19–associated hospitalizations among adults during BA.2 variant (CDC)
• Sars-Cov-2 specific T-cells and antibodies (CID)
• Nirmatrelvir use and outcomes during the Omicron surge (NEJM)
• Effectiveness of early Molnupiravir or Nirmatrelvir–Ritonavir in hospitalized patients (The Lancet)
• Distinguishing features of long COVID (medRxiv)
• Unexplained post-acute infection syndromes (Nature Med)
• Contribute to Floating Doctors fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 932
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]