TWiV 953: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19,  protection against Omicron from vaccination and previous infection in a prison system, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system, imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution, can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review, and retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.

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Links for this episode

• High demand for Amoxicillin causing shortages amid RSV surge (Washington Post)
• Epidemiologic and clinical features of children & adolescents with monkeypox (CDC)
• Low risk of SARS-Cov2 transmission by fomites (IDSA)
• Nucleocapsid Antigenemia Is a marker of acute SARS-CoV-2 Infection (JID)
• Impact of community masking on COVID-19 (Science)
• Remdesivir fact sheet for providers (Veklury) 
• Protection against Omicron from vaccination & previous infection in prison system (NEJM)
• Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv)
• Bebtelovimab for high-risk outpatients with COVID-19 (OFID)
• Imprinted SARS-CoV-2 immunity induces convergent Omicron evolution (bioRxiv)
• PAXLOVID patient eligibility screening checklist (FDA)
• Can SARS-CoV-2 trigger new onset of autoimmune disease in adults? (Cell)
• Bebtelovimab fact sheet for providers (FDA)
• Modeling the effects of global vaccine sharing on the COVID-19 pandemic (Nature)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 953
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]