🔌 Unplugging Pulmonary Hypertension: Can Denervation Change Heart Failure?

🫀 Cut the Signal, Cut the Risk? Could pulmonary-artery denervation change the trajectory of heart failure–related pulmonary hypertension? In PADN-HF-PH, 264 symptomatic patients were randomized to denervation + guideline-directed medical therapy or medical therapy alone. Clinical worsening at 2 years: 25.7% vs 51.5% (HR 0.49; P=0.006). ⚡ A provocative concept: pulmonary sympathetic overactivity may be a modifiable therapeutic target. 🎯 But no sham control, China-only enrollment, and mortality benefit remains unproven