What is PRP and does it work?

Dr. Zach Guiser dives into the polarizing world of Platelet-Rich Plasma (PRP), a treatment that rose to fame after Super Bowl heroics but remains largely uncovered by insurance By breaking down the specific growth factors, which he likens to a construction crew, Zach explores why some studies show "miracle" results while others find no benefit. The key, according to 2025 research, lies in the dosage and preparation, specifically reaching a threshold of 10 billion platelets. Guiser ultimately grades PRP as "Promising," suggesting it as a viable second-line defense for athletes who haven't found relief through high-quality physical therapy.Timestamps00:00 – The Hines Ward Miracle: PRP’s Mainstream Debut01:34 – Blood Breakdown: Erythrocytes, Leukocytes, and Thrombocytes02:11 – The "Vampire" Process: Centrifuges and Activation02:46 – The Construction Crew: 5 Key Growth Factors04:55 – Study 1: PRP for Chronic Back Pain07:40 – Study 2: Spine Gaps and the Corticosteroid Comparison09:15 – Study 3: The Patellar Tendinopathy Disappointment11:18 – Study 4: The 10 Billion Platelet "Magic Number" (2025)13:43 – Leukocyte-Poor vs. Leukocyte-Rich: Choosing the Right Mix15:03 – Final Takeaways: Zach’s Dosing Stance and Attia Grade