Why Don't Antiseizure Medications Work for Everyone? - Graeme Sills, PhD

Why do around 30% of people with epilepsy still have uncontrolled seizures despite decades of new antiseizure medications? Graeme Sills, PhD, explains the leading theories behind drug resistance - and how a better understanding of the brain could transform future epilepsy treatments.Chapters 📖00:00 Trailer & intro00:45 Meet Graeme Sills01:29 Introduction to pharmacology and epilepsy02:17 Challenges in epilepsy reatment06:30 Why the drugs don’t work: the drug-transporter hypothesis08:38 Why the drugs don’t work: the network hypothesis09:31 Why the drugs don’t work: the severity and genetic hypothesis10:06 Future directions in epilepsy research13:08 Innovative approaches to research and treatment?17:58 Closing thoughts & thanks🔗 Episode page and transcript epilepsysparks.com/epilepsy-sparks-insights/pharmacology-past-present-future🌐 More about Graeme epilepsysparks.com/guests/graeme-sills🌐 More Epilepsy Sparks Insights epilepsysparks.com/epilepsy-sparks-insights🎥 Watch on YouTube youtube.com/@EpilepsySparksInsights🔤 Don’t understand terms used? Check out the Epilepsy Sparks Glossary epilepsysparks.com/glossary📲 Join us on social media!〰️ LinkedIn epilepsy-sparks〰️ Instagram epilepsysparks〰️ Facebook epilepsysparks〰️ TikTok epilepsysparks〰️ Bluesky epilepsysparks​