EPISODE · Jul 26, 2026 · 37 MIN
用進廢退，是需要被重新檢驗的常識｜Scholar Rock 與復健醫學的下一個典範
from MDBros｜Paradigm Shifts in Healthcare · host MDBros
一位 63 歲的女性八個月瘦了 14 公斤，指數全部漂亮，卻從馬桶上站不起來。同一段時間，一支叫 apitegromab 的抗體讓 188 位脊髓性肌肉萎縮症的孩子在運動功能上多跨了一步。兩件事背後是同一個分子。Scholar Rock 押注肌肉流失不是老化的自然結果，而是一個可以被關掉的開關；它的第三期試驗達標了，第二期的減重試驗也保住了 1.9 公斤淨體重，但手持式肌力計與坐到站測試沒有測出差別。這一集談的是一個典範能不能翻過來，以及翻過來之前，我們還缺哪一份證據。 -- Hosting provided by SoundOn
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用進廢退，是需要被重新檢驗的常識｜Scholar Rock 與復健醫學的下一個典範
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