Zevahim 107: How Holy Is the Holy City (without a Temple)?

After we've established how we know that slaughtering outside of the Temple violates a prohibition and likewise offering outside of the Temple, there's an investigating of the offerings that are meant to be burnt and offered in various places. Also, a focus on Rabbi Yishmael's and Rabbi Akiva's views regarding sprinkling the blood outside the Temple, and moving into discussion of offerings that were to be brought inside, and then incomplete and finished outside of the Temple. Plus, the sources they respectively derive their opinions regarding these issues from. Also, what about making such an offering outside of the Temple courtyard - in the era of "now" - when there is no Temple? Was the sanctification of the Temple and Jerusalem forever, or just for the time that the Temple stood?