Building Lifelong Athletes

Welcome back to the trenches! In our final breakdown of the 2026 ACC/AHA lipid guidelines, we are unpacking the pharmacology toolbox. From statins and ezetimibe to PCSK9 inhibitors and the nuances of side effects like SAMS, I want to give you the practical, evidence-informed strategies we need for our patients. We are all just trying to navigate this together. Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life. ➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf CHAPTERS:00:00 - Intro00:01:00 - Statin Mechanism of Action00:01:34 - Types of Statins and Intensities00:03:04 - Hydrophobic vs Hydrophilic Statins00:05:15 - Statins and Glycemic Control00:06:14 - Pleiotropic Effects of Statins00:07:12 - Statin Side Effects Overview00:08:36 - Ezetimibe as First-Line Add-On00:09:54 - Bempedoic Acid00:11:18 - PCSK9 Inhibitors00:13:16 - Inclisiran and siRNA Therapy00:14:26 - Bile Acid Sequestrants00:15:47 - The Rule of 6 and Combination Therapy00:17:16 - Statin-Associated Muscle Symptoms00:19:04 - CoQ10 Supplementation00:20:07 - Special Populations: Older Adults and Pregnancy00:21:20 - Liver Safety and Drug Interactions00:23:15 - Statins, Dementia, and Brain Fog00:24:23 - Statins and Diabetes Risk00:25:21 - Managing High Triglycerides00:27:06 - Conclusion and Summer Sabbatical SELECTED REFERENCES: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423 *Disclaimer*This podcast is for entertainment, education, and informational purposes only.The topics discussed should not solely be used to diagnose, treat , or prevent any condition.The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

In this episode, I'm breaking down sections 4.2.3 through 4.2.10 of the dense ACC/AHA dyslipidemia guidelines so you don't have to. We'll cut through the noise on the new PREVENT equations, risk enhancers, imaging, and algorithms for primary and secondary prevention. Let's get you equipped to handle these complex lipid management decisions in the clinic.Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life.➡️ Download Here: https://www.jrennickemd.com/necessaryninepdfCHAPTERS:00:00 - Intro00:25 - Individualized Risk-Benefit Discussions02:24 - The New PREVENT ASCVD Equations Explained04:29 - Understanding New Risk Thresholds05:32 - The Math Behind the 3% Treatment Threshold09:28 - Risk Enhancers and Personalizing Risk11:21 - Reproductive Age Risk Markers12:15 - Polygenic Risk Scores13:12 - Selective Imaging: CAC and Coronary CT15:16 - Treating Incidental Plaque15:58 - The Core Primary Prevention Algorithm19:26 - Severe Hypercholesterolemia (LDL > 190)21:58 - Diabetes and Lipid Management23:15 - Residual Risk and Omega-3s23:37 - Secondary Prevention Targets26:46 - Special Populations: Children and Young Adults28:04 - Older Adults and Deprescribing28:54 - Pregnancy and Lactation29:55 - HIV, CKD, and Inflammatory Diseases31:14 - Heart Failure and Cancer Survivors32:05 - Managing Hypertriglyceridemia 34:18 - Lipoprotein(a) as a Risk EnhancerSELECTED REFERENCES:https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423*Disclaimer*This podcast is for entertainment, education, and informational purposes only.The topics discussed should not solely be used to diagnose, treat , or prevent any condition.The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

In this video, we break down the 2026 guidelines for lipid-lowering lifestyle treatments. From the minimalist vs. optimizer diet approach to exercise dosing and managing supplements, let's equip you with actionable tools for the primary care trenches. Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life. ➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf CHAPTERS:00:00 - Intro01:36 - The Strategy of Primordial Prevention02:45 - The Dietary Shift: Minimalist vs. Optimizer04:56 - Titrating for Elevated Triglycerides06:23 - Weight Loss and Sick Fat07:31 - Physical Activity as the 5th Vital Sign08:27 - The Truth About Dietary Supplements10:15 - When to Consult a Registered Dietitian10:48 - The Comprehensive Impact & Takeaways SELECTED REFERENCES:https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423 *Disclaimer*This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

In this video we'll talk about the Evaluation and Diagnosis Section from the 2026 ACC/AHA Lipid Guidelines.  Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life. ➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf CHAPTERS:00:00 - Intro00:32 - The Shift in ACC/AHA Guidelines01:44 - Universal Pediatric Screening05:47 - Why Non-Fasting Lipid Panels Are Now Standard07:42 - Changing the LDL Equation09:48 - Why Advanced Lipid Testing (NMR) is Not Recommended12:05 - The Rise of ApoB: Counting the Trucks13:14 - CKM Syndrome and High Discordance17:28 - Lipoprotein(a): The Once-In-A-Lifetime Test21:29 - New Monitoring & Follow-Up Goals23:07 - Rapid Fire Summary SELECTED REFERENCES:https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423 DisclaimerThis podcast is for entertainment, education, and informational purposes only.The topics discussed should not solely be used to diagnose, treat , or prevent any condition.The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.