PODCAST · health
Depresh Mode with John Moe
by John Moe, Maximum Fun
Join host John Moe (The Hilarious World of Depression) for honest, relatable, and, yes, sometimes funny conversations about mental health. Hear from comedians, musicians, authors, actors, and other top names in entertainment and the arts about living with depression, anxiety, and many other common disorders. Find out what they’ve done to address it, what worked, and what didn’t. Depresh Mode also features useful insights on mental health issues with experts in the field. It’s honest talk from people who have been there and know their stuff. No shame, no stigma, and more laughs than you might expect.
Episodes
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E (from Eels) Talks Art, Persistence in the Face of Tragedy, and Cookie Monster
“Me no cry because cookie is finished,” Cookie Monster once said. “Me smile because cookie happened.” Eels has been a band for 35 years and just dropped their 16th studio album, with the Cookie Monster-inspired title Cookie Happened. In that time, Mark Oliver Everett (aka E) has been the only...
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Showbiz! For Murray Hill, it’s an Industry, Memoir, and Mantra
Audiences know Murray Hill as the hilarious pencil-mustachioed guy who looks like a Catskills comedian. Much of that identity was deliberately formed after an abusive childhood where he was raised as a girl and sure didn’t feel like one. He grew up, broke hard with the past, named himself for the...
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Andy Frasco Is Figuring Out Who He IS When He’s NOT a Good Time Rock & Roll Frontman
Andy Frasco has been hard at work since the age of 13. As an adolescent that meant booking shows, helping out at record labels, running a flag football business. When he was 19, he took his carefully saved Bar Mitzvah money, bought a van, skipped college, and went on tour with his band. Now 38,...
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Gabrielle Moss On Midlife Plot Twists and Just Not Talking To Your Mom Anymore
Midlife doesn’t need to be a point of crisis, says author Gabrielle Moss. You don’t need to make dangerous choices, blow things up, take a spiritual trek through Nepal, or buy a red convertible. Her new book, Mid-Life Plot Twist, co-written with Lindsay Goldwert, explores how to set boundaries,...
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Mental Illness Before and After Pregnancy with Dr. Kara Zivin, Who Has Been There
There has been a great deal of press coverage of the Lindsay Clancy case lately. What the world needs more of is first-hand experiences of severe mental health problems both before and after a baby is born. Dr. Kara Zivin is a researcher and professor of psychiatry at the University of Michigan....
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Singer Nicole Atkins Doesn’t Recommend Insomnia, Alcoholism, Falling Down Sinkholes
The acclaimed singer and songwriter Nicole Atkins is pretty adept at reading clues that something is wrong. After she’d fall asleep on a Saturday and wake up on Monday, she knew it was time to get more aggressive about addressing her insomnia. Years before, a fall down an actual sinkhole made her...
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AI Chatbots Destroyed His Reality. Dr. Jeremy Heffner Explains Why He Believed Them.
Dr. Jeremy Heffner was a highly educated, high achieving surgeon. Not the kind of person one would expect to slide down an AI chatbot-generated rabbit hole, lose touch with reality, and give credence to the bot’s suggestion that he was one of the three smartest humans ever. But that’s what...
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Best of Depresh Mode: Cameron Esposito on Comedy, Rehab, and Bipolar Disorder
Cameron Esposito has many titles: hugely successful standup comedian, actor in television and film, writer, podcast host. After a recent rehab stay led to a mental health diagnosis, she has realized that she’s also a person with bipolar disorder, type II. Cameron has a new special, Four Pills,...
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Cat Grief is Real. So is Human Grief. We’re Underestimating and Misunderstanding Both.
Bay Area journalist s.e. smith thinks the high school goths were right: we should be talking about death all the time. It’s underdiscussed for something that will literally affect us all. And in that silence, they say, things get worse: the topic becomes less approachable, inevitable periods of...
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Oh, It’s Autism, Mary H.K. Choi Learned at 43. Okay, She Thought, That Explains a Lot.
Mary H.K. Choi compares living with her brain to just not understanding the operating system on a computer. She didn’t know if this was a result of trauma and neglect in her childhood, the experience of being parentified as a child, grief after the death of her father, or what. So she spent…
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Margaret Glaspy Ends Her Instagram Addiction and Sings From Her Original Thought
Margaret Glaspy compares the experience she was having on Instagram to being lightly punched in the gut, over and over, for a very long time. Like it’s not like being hit hard, just a little tap of something negative with each update you read, each comparison made, each distancing away from…
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Depression, Loneliness, and Memory Problems Are Worse In Middle Age, But Only in America
For most of the world, the advent of middle age does not make depression, loneliness, and memory issues more of a problem than earlier in life. In some countries, things actually get better. The only nation on earth where it all gets worse is right here in the USA. Arizona State University...
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Codependency and Covid on a Tiny Boat in the Middle of the Ocean, with Angela Harger-Thompson
Angela Harger-Thompson had moved to Hollywood to make it big in showbiz but soon fell victim to a devastating assault. There to comfort her was her intermittent boyfriend. She really liked him and thought his offer of a four-week, 4000 mile sailing voyage on the Pacific Ocean, accompanies by a...
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Maybe It IS Time to Panic Over AI Chatbots and Mental Health with Maggie Harrison Dupré
This week, we take a look at a couple of acronyms that are soaring in popularity and ask what their widespread adoption means for mental health. Maggie Harrison Dupré of Futurism has been following the AI space closely and has an update on lawsuits related to chatbots’ culpability in numerous…
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Jo Dee Messina on Hard Times, Jesus, and Her First Album in 12 Years
Jo Dee Messina has a long career in the music industry: number one hits, platinum and gold records, many awards. She’s a country music icon. Jo Dee just released Bridges, her first new album in 12 years and those were 12 years filled with some tough times. Her marriage ended, leaving her as a...
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Best of Depresh Mode: Hanif Abdurraqib on Cultivating a Support System, Depression, Anxiety, and Basketball
Hanif Abdurraqib is a MacArthur Fellow, accomplished poet, and critically lauded author of numerous books, including There’s Always This Year: On Basketball and Ascension, which is now out in paperback. He’s also a person who deals with major depressive disorder and numerous anxiety disorders. In…
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We Should Praise Addiction, Not Condemn It, Says Anthropologist Elizabeth Roberts
The title of Elizabeth Roberts’ new book, In Praise of Addiction, is likely to catch your attention, maybe even set off some cognitive dissonance in your mind. But the University of Michigan’s Elizabeth Roberts doesn’t want you to be unhealthy or take up new habits that can hurt you and others…
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Cartoonist Gemma Correll Saw a Therapist with a Clown-Festooned Office. Once.
British-born, LA-based author and illustrator Gemma Correll had a couple of reasons to choose the motif of an amusement park for her new anxiety book, Anxietyland. One, she loves amusement parks and wanted to be able to write off a Disneyland trip as a research expedition. And also, there are so...
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RFK Jr. Wants To Take Your SSRIs Away. So What Are Democrats Doing About It?
Secretary of Health & Human Services Robert F. Kennedy, Jr. is, to put it mildly, a skeptic of selective serotonin reuptake inhibitor (SSRI) medication, a form of meds that millions of Americans use regularly with tremendous benefit. He was once on SSRIs, went off them, then became addicted to...
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Robyn Hitchcock is Fundamentally Delusional, Welcomes Birds
If you’ve ever listened to Robyn Hitchcock’s music, you know that it can get pretty surrealistic. Some might say divinely bizarre and eclectic. Others might just say weird. All of that’s fine with the London-born, Nashville-based artist, who has been putting out music on his own and with The Soft...
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Blake Mycoskie Helped the World, Got Rich, Retired to a Life of Ease, Then Fell Apart
There is no Tom behind TOMS Shoes. It’s short for “Tomorrow’s.” There is a Blake, however. Blake Mycoskie founded the company in 2006 under the model that for every pair sold, a second pair would be donated to children in the developing world. TOMS took off, which meant years of constant work for...
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An Episode About the Grind, Singer Zayna Youssef of Sweet Pill, and YOU
Yes, the episode is about a rock singer but it’s also about any of us who grind away for the benefit of our work and the detriment of ourselves. The sudden cancellation of the band Sweet Pill’s extensive tour promoting their sophomore album Still There’s a Glow came as a shock to fans and the...
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Terrifying Times for Immigrants in America and Cristina Jimínez is Incredibly Hopeful
This episode of the show is about America, ultimately. We’re joined by Cristina Jimínez, author of the memoir Dreaming of Home: How We Turn Fear into Pride, Power, and Real Change and MacArthur genius grant recipient for a discussion of mental health in the immigrant and undocumented immigrant...
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Claude Steele on Churn, the Awkward Social Distress That Divides Us All
I’m pretty sure you’ve been in this situation: you’re in a group setting of consequence and importance. Maybe it’s at work, maybe in school, but something is on the line. In that place are people different from you. They’re of a different race, ethnicity, gender, sexual orientation, and you begin...
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Connecting Childhood Events To Your Stress Issues Today with Benjamin Wagner
The things that happened when you were young, especially the really painful things, can easily and often carry into adulthood. For documentarian, former high-powered executive, and actual Mister Rogers neighbor Benjamin Wagner, an adult life of terrible stress and substance use issues wasn’t…
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Sampler Episode Depresh Meals
You have to eat. We know this. But when depression is flaring, it’s really hard to even get to the kitchen, let alone make something tasty and good for you. Don’t worry. Our Depresh Meals episode has expert ideas for just that situation from Food & Wine’s Kat Kinsman and The Sporkful podcast host...
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Bonus mini-sode: Checking In with Bill Corbett
You have to call your friends once in a while and see how they’re doing, especially if they’re undergoing big changes and their city has been rocked with upheaval. Twin Cities-based actor and writer Bill Corbett will always be associated with Crow T. Robot, the wisecracking robotic commentator on...
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Bonus Mini-Sode: A Dramatic Reading by Helen Hong and Interview with Playwright Sunny Kase
Hi, everyone, John Moe here. “Can I read you what Sunny just posted on Facebook?” asked my wife, Jill. I figured it was something about Tom Petty or her dogs but it was, in fact, a very funny and skillful micro-essay on why she listens to Depresh Mode and why, after years of listening, she became…
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Casters on Casters: John Moe and Brenda Snell
It's MaxFunDrive. And here, for the first time, we give you an exclusive look (well, listen) at the craft of podcasting: presenting Casters on Casters. In this episode, John Moe (Sleeping with Celebrities & Depresh Mode with John Moe) talks about his double life, as a person who speaks in a…
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Andy Richter on Divorce, Dating, Depression, and Dancing with the Stars
When our host, John Moe, started doing podcasts about mental health ten years ago, one of his first guests was his friend Andy Richter. Andy, who you know from various Conan shows and tons of other TV shows and movies, talked about having his depression pretty well managed at the time. Since…
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Bonus mini-sode: Checking In with Felicia Day
We’re delighted to welcome the actor, writer, web celebrity (celwebrity?) Felicia Day back to the program as part of our ongoing effort to reach out to friends and just ask how they’re doing. You might know her from The Guild, the web series she created, or from Buffy the Vampire Slayer or…
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BONUS CONTENT PREVIEW: All-Star Sad Songs That Make You Feel Better with Neko Case, Gavin Rossdale, and more
There is actual science that says listening to sad songs - about heartache, heartbreak, grief, worry, whatever it is - can make you feel better. The brain seeks that kind of stuff out and you feel less alone, more understood. It’s a paradox but there it is. We asked some friends of the show what...
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Jimmy Pardo on Being Funny, Depression, Anxiety, Trauma, Alcoholism, Contentment, and Being Funny Some More
When Jimmy Pardo joined us for a hilarious and revealing interview, he had just conducted a Never Not Funny anniversary show that exceeded nine hours in length. Not all that shocking if you’ve been listening to the show, which routinely exceeds two hours of jokes, interviews, and rapid-fire...
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Joshua Roman on Long Covid, Cello, Charging Hard, and Brick Walls
Covid hit everybody, either personally or as members of society, and our mental health was damaged. It was trauma and it largely hasn’t been processed. When Joshua Roman became the principal cellist at the prestigious Seattle Symphony at age 22, it wasn’t really a surprise. As he explains, he had...
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Featuring Proxy with Yowei Shaw: Is it time to break up the band?
Today, I want to share an episode from a podcast I think you’ll enjoy called Proxy. It’s hosted by Yowei Shaw, who you might know from the NPR show Invisibilia. After getting laid off in 2023, she found herself stuck with a question she couldn’t shake: why did she feel so ashamed… like it was her...
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Annabelle Gurwitch: Author, Actor, Unexpectedly Still Alive
Covid was already rough for the very funny and personable Annabelle Gurwitch, as it was for everyone, and that was before her car broke down on an LA freeway just as she was getting a call with a terminal cancer diagnosis. Stage four. Annabelle has dealt with anxiety and depression for a long…
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Taking Small Steps That Form Great Strides with Eric Zimmer
At age 24, Eric Zimmer was in rough shape. He was addicted to heroin, weighed maybe a hundred pounds, and was facing the prospect of a lengthy prison sentence. So he gave rehab another try and he had some success and started getting his life back together, diving into just about any book or...
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Bonus Episode from In This Family: Ka Vang on War in Southeast Asia, ICE in Minnesota, and Mental Health Echoes
We are proud to present a very special episode of In This Family as a bonus for Depresh Mode with John Moe listeners. In This Family is produced by John Moe in conjunction with Nexus Family Healing and it’s about the connection between family and mental health. It’s a fascinating and moving look…
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Bubbles of Love: Your Burnout Treatment, with Emily Nagoski
When Emily’s twin, Amelia, ended up in the hospital twice, she knew that stress wasn’t something to be dismissed as “all in your head”. First of all, the head is connected to the body (by the neck), so stress is a physical issue that you can feel and be hurt by in all sorts of ways. Too much...
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Group Therapy Royalty and First-Time Movie Star Elliot Zeisel From GROUP
The patients in the therapy sessions in the new film GROUP: The Schopenhauer Effect are actors, but it’s not a scripted film. The actors were given characters and circumstances and then they improvised dialogue with each other and with the group leader, who is also acting. Kind of. Dr. Elliott...
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Jonathan Edward Durham Was In Horrible Mental Shape But Didn’t Realize It
Although he has a huge following on social media now, Jonathan Edward Durham’s life as a writer used to be a lot more low tech. It involved locking himself in a room in Los Angeles, pounding away on screenplays that almost no one ever read, sucking back smokes and liquor, barely sleeping, and...
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Huge Scientific Breakthroughs Are Changing How You’ll Think About Eating Disorders
You might remember Alexandra Paul as one of the stars of Baywatch or the Tom Hanks-Dan Aykroyd Dragnet film. You may not have realized that as a child and on to her long trip through the worlds of modeling and Hollywood, she was bingeing and purging and dealing with severe eating disorders. She...
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Are Dating Apps a Mental Health Grenade? And, How Are Kids Doing in ICE-Era Minnesota?
Dating apps and websites are booming right now as people look for ways to leverage to find love or even just companionship. Liesel Sharabi of Arizona State University compiled a meta-analysis of a huge number of studies about the connection between online dating and mental health and the results?...
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Niko Stratis on Dad Rock, Glasswork, Depression, Addiction, and Becoming Herself
Niko Stratis knew a couple of things growing up in the Yukon in Canada: that she was, in truth, a woman, despite being regarded by the world as male, and that being trans or different in any way was absolutely not okay. It wasn’t just a matter of identity, it was a matter of safety too, as she...
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SPECIAL EPISODE: Mental Health and ICE in Minnesota
The ICE surge in Minnesota has meant a huge number of arrests, protests, confrontations, deportations, children and adults sent to detention facilities, and deaths. It’s also meant massive anxiety, fear, and trauma around the state. Marcus Schmit of NAMI Minnesota says this is being felt acutely...
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Amanda Knox on Facing Her Prosecutor, Her Past, Her Trauma, and Her Future
In 2007, Amanda Knox, an American studying abroad in Italy, was arrested, tried, and convicted of the murder of her roommate, Meredith Kercher. After years in an Italian jail, she was ultimately freed, reconvicted, and finally exonerated in 2015. Since then, she has married, become a mother, and...
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Intentionally Blunt and Very Useful Talk About Suicide with Clancy Martin
Suicide is a problem. It’s perpetually a top cause of death around the world but society shames it, stigmatizes it, and is reluctant to discuss it even when talking about it would save lives. Well guess what, we’re talking about it. We’re offering insight, sympathy, and practical ideas to help...
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Stephanie Foo on Complex PTSD, Finding Recovery, and This American Life
It was several years into her talk therapy sessions that Stephanie Foo was offered a diagnosis: complex post-traumatic stress disorder, or C-PTSD. Regular PTSD stems from a single traumatic event like a car crash or a mugging. C-PTSD comes from a long series of traumas from which there seems like...
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A.J. Daulerio on Bipolar, Substances, Depression, Suicide, and the Psychic Weight of Hulk Hogan
A.J. Daulerio exists as a caricature to a lot of people because he was the guy who published a clip from a Hulk Hogan sex tape on Gawker, got sued by Hogan, and he and Gawker lost to the tune of a $140 million payout. The enmity and shame of that was a lot to carry around, as was a lifelong…
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Two Truths To Make 2026 a Better Mental Health Year
We live in complicated times and, for a whole lot of us, we do so with complicated minds. A billion people worldwide are living with some form of mental illness and 20% of the U.S. population has experienced a mental health crisis in the past year. Circumstances in our shared world are surely...
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ABOUT THIS SHOW
Join host John Moe (The Hilarious World of Depression) for honest, relatable, and, yes, sometimes funny conversations about mental health. Hear from comedians, musicians, authors, actors, and other top names in entertainment and the arts about living with depression, anxiety, and many other common disorders. Find out what they’ve done to address it, what worked, and what didn’t. Depresh Mode also features useful insights on mental health issues with experts in the field. It’s honest talk from people who have been there and know their stuff. No shame, no stigma, and more laughs than you might expect.
HOSTED BY
John Moe, Maximum Fun
CATEGORIES
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Frequently Asked Questions
How many episodes does Depresh Mode with John Moe have?
Depresh Mode with John Moe currently has 312 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Depresh Mode with John Moe about?
Join host John Moe (The Hilarious World of Depression) for honest, relatable, and, yes, sometimes funny conversations about mental health. Hear from comedians, musicians, authors, actors, and other top names in entertainment and the arts about living with depression, anxiety, and many other common...
How often does Depresh Mode with John Moe release new episodes?
Depresh Mode with John Moe publishes regularly with 312 episodes available. Check the episode list for the typical release schedule.
Where can I listen to Depresh Mode with John Moe?
You can listen to Depresh Mode with John Moe on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Depresh Mode with John Moe?
Depresh Mode with John Moe is created and hosted by John Moe, Maximum Fun.
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