Hart2Heart with Dr. Mike Hart
by Dr. Mike Hart
Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff.Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you understand what actually works so you can make better decisions for your health.The show also looks at the bigger picture, including how public health policy and politics influence personal well-being, and what you can do to take back control.If you want clear, actionable, no-BS conversations about living healthier, performing better, and thinking for yourself, this podcast is for you.
Episodes
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#245 Dr. Scott Eilers on Negative Thoughts, Stoicism, Sleep, and Lifestyle Tools for Depression
Dr. Mike Hart sits down with psychologist Dr. Scott Eilers to explore why negative thoughts can feel so convincing, how past experiences shape our beliefs, and why emotional suppression can make it harder to experience happiness. They discuss the balance between logic and emotion, the hidden…
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#244 Dr. Amanda Kahn on Peptides, Skincare, Hair Growth, GLP-1 Microdosing, and Preventive Screening
Dr. Amanda Kahn joins Dr. Mike Hart to explore the role of peptides, regenerative medicine, and emerging longevity treatments in improving health and recovery. She discusses her clinical experience with BPC-157 for soft tissue injuries, pain, and inflammation, while addressing its limitations,...
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#243 Dr. Jess on Blood Sugar, Cortisol, Gut-Histamine Issues, Mold, and Environmental Toxins
Dr. Mike Hart sits down with Dr. Jessica Peatross to explore the overlooked factors that may contribute to unexplained health symptoms, from blood sugar fluctuations that resemble anxiety to disrupted cortisol rhythms that affect sleep and energy. They discuss how meal timing, fasting, and…
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#242 Hair Loss Treatments: Minoxidil, Topical Dutasteride, Microneedling, and PRP/Placental Exosomes
In this solo Hart2Heart Podcast episode (focused on male androgenetic alopecia), Dr. Mike Hart reviews hair-loss treatments, emphasizing that regrowth is harder if follicles are gone after 12–18 months. He highlights minoxidil (topical or oral), noting similar efficacy between 2.5 mg and 5 mg…
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#241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price
Dr. Mike Hart and Dr. Ira Price explore how medicine is adapting as patients gain greater access to emerging treatments, health information, and tools once limited to physicians. They discuss unapproved peptides and GLP-1 drugs, the growing shift toward personalized and patient-centered care, and...
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#240 Dr. Spencer Nadolsky on Repatha, ApoB Targets, and What Actually Matters in Lipidology
Dr. Mike Hart sits down with lipidologist Dr. Spencer Nadolsky for a practical discussion on cardiovascular prevention, cholesterol management, and metabolic health. They break down how to interpret ApoB, LDL, HDL, triglycerides, and Lp(a), when cholesterol-lowering medications may make sense…
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#239 Oral Peptides: How They Work Without Entering the Bloodstream
Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1...
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#238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati
In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and...
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#237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening
Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing,...
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#236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims
In this episode, Dr. Mike Hart sits down with Lee Whitley and physician Dr. Ira Price for a wide-ranging discussion about Lee's proprietary cannabis formulation and the extraordinary cancer-treatment claims surrounding it. Lee shares his own experience with stage IV squamous cell throat cancer,...
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#235 Dr. Leigh Erin Connealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors
In this episode, Dr. Mike Hart sits down with Dr. Leigh Erin Connealy for a wide-ranging conversation on cancer prevention and the factors she believes influence long-term health. Dr. Connealy shares her perspective on why cancer should be approached as a whole-body problem, exploring the roles…
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#234 Navigating Weight Loss: Breaking Down Barriers with Dan Go
After a five-year hiatus, Dan Go returns to break down a sustainable approach to fat loss for busy people who do not have hours to spend in the gym. He explains why identifying the main physiological or psychological bottleneck—such as late-night eating, stress, grazing, or weekend overeating—can...
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#233 Understanding NAD+: Insights with Dr. Charles Brenner
Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other...
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#233 Understanding NAD+: Insights with Dr. Charles Brenner
Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other...
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#232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition
This episode explores the opportunities and risks of testosterone optimization, beginning with the US military's decision to screen men over 30 for low testosterone. Dr. Mike Hart and Dr. Jonathan Schoeff discuss why symptoms such as fatigue, low libido, and difficulty changing body composition...
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#231 Dr. Kyle Gillett on Nootropics, Peptides, GLP-1 Side Effects, Hair Loss, and Microplastics
Dr. Kyle Gillett joins Dr. Mike Hart to discuss safer, more practical approaches to biohacking, performance, and longevity. They cover indoor microplastic exposure, bromantane, low-dose nicotine, healing peptides, BPC-157 safety, tesamorelin, growth hormone, GLP-1 digestive side effects, NAD...
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#230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K
Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment…
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#229 Supplements, Methylation, and Genetics: Why "Healthy" Stacks Can Trigger Anxiety
Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed,...
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#228 Minoxidil for Hair Loss: Topical vs Oral, Tretinoin, and Microneedling
The episode explains how to use minoxidil for hair loss, emphasizing that it supports follicles and prolongs the anagen phase but does not block DHT (with topical dutasteride mentioned as a scalp-focused DHT option). It reviews evidence that 5% topical minoxidil is optimal (better than 2% and...
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#227 Diet Update: High-Protein, High-Fiber Meal Plan Built for Training and Consistency
The speaker shares a structured, consistent diet designed to support hard training (three strength sessions, Norwegian 4x4, Zone 2 cardio, and one MMA session weekly), reduce "food noise," and stay full with high protein and fiber. He explains cooling/freezing rice to increase resistant starch…
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#226 Viewpoint Diversity, Physician-Assisted Suicide, AI, and Human Dignity in Medicine
Dr. Kristin Collier joins Dr. Mike Hart to discuss the ethical, cultural, and technological forces reshaping modern medicine. Reflecting on the 2022 white coat speech walkout, she explores viewpoint diversity, self-censorship, moral courage, and the importance of cultivating wisdom alongside...
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#225 GLP-1 Masterclass: Dosing, Optimal Use, Lifestyle Changes, and Benefits Beyond Weight Loss
This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food noise, appetite suppression, and the risks of...
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#224 Dr. Alex Tatum on Peptides, FDA Crackdowns, TRT Nuance, and Safe Penis Enhancement
Dr. Mike Hart interviews board-certified urologist Dr. Alex Tatum about peptide access, compounding, and men's health. Tatum argues many peptides are naturally occurring and lacked FDA commercialization incentives, says the FDA's 2023 move banning 19 compounds from Category 1 was contested due to...
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#223 How I Increased My VO2 Max at 41 With the Norwegian 4x4 Protocol
The host explains how he raised his estimated VO2 max in 2026 in his 40s, emphasizing that the biggest driver was structured hard training with progressive overload, not "hacks" like peptides, supplements, sauna, red light, or ketones. After years of mostly zone 2 cardio (under ~124 bpm) plus...
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#222 Peptides, Hormones, and Longevity: Safety, Skin Aging, NAD+, GLP-1s, and Mitochondrial Health with Dr. Ksenia
Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, while exploring topics like NAD+, glutathione,...
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#221 Acute vs. Chronic Inflammation: Causes, Biomarkers, and How to Lower It
The episode explains that inflammation is a necessary survival mechanism, with acute inflammation supporting healing, while chronic inflammation drives chronic disease. It outlines major contributors to chronic inflammation including visceral fat (with fasting insulin as a proxy for insulin...
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#220 Wnt vs DHT: Understanding Androgenic Alopecia and the Top Treatments to Slow Hair Loss
In this solo episode on androgenic alopecia, the host explains that hair loss is slow and progressive, driven largely by genetics and DHT-mediated miniaturization of follicles across the anagen, catagen, and telogen cycle, and stresses early detection using periodic photos of the temples,...
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#219 Dr. Allen Frances on AI Chatbots, Mental Health Risks, Privacy, and the Overdiagnosis of Autism
Dr. Allen Frances discusses how AI chatbots can provide effective support for everyday stress and mild symptoms, with tens of millions using them, but warns they can be dangerous for vulnerable groups—especially the very young, the very old, the socially isolated, and people with severe mental...
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#218 Lab-Grown Meat, Grocery Prices, and the Real Drivers of Food Inflation in Canada (with the Food Professor)
In a wide-ranging interview, Dr. Sylvain Charlebois ("The Food Professor") discusses whether lab-grown (cellular) meat is overhyped, citing consumer acceptance, cost, and labeling as key barriers, though he found lab-grown chicken indistinguishable in taste and notes potential for nutrient...
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#217 Dr. Russell Kennedy on Anxiety as a Body Alarm: Childhood Patterns, Worry, Somatic Healing
Dr. Mike Hart interviews Dr. Russell Kennedy about chronic anxiety as a childhood safety adaptation that never turns off, driven more by a body-based "alarm" than by thinking. Kennedy explains why understanding anxiety and talk-based cognitive approaches often have limited effect because...
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#216 VO2 Max, Zone 2 Training, HRV Wearables, Sauna, and Evidence-Based Performance Supplements with Brady Holmer
Dr. Mike Hart interviews elite runner Brady Holmer about endurance training, VO2 max physiology, and common misconceptions. Holmer explains that zone 2 builds the aerobic base and enables high training volume with less fatigue, notes heart-rate zones are ideally defined by lactate thresholds, and...
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#215 Brain Health From Morning to Night: Sleep, Exercise, Supplements, Screens, and ADHD Meds
Dr. Tommy Wood discusses evidence that stimulants can help people with ADHD but may worsen complex cognitive performance in non-ADHD users despite feeling more focused. He outlines an ideal brain-health day centered on consistent sleep opportunity, morning caffeine timed to protect sleep,...
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#214 Optimal Nutrition: Fiber's Impact on Glucose and Cholesterol
The script explains why fiber is critical for gut and metabolic health, focusing on how soluble fiber is fermented in the colon to produce short-chain fatty acids (butyrate, propionate, acetate). It contrasts soluble fiber (forms a gel, lowers LDL by binding bile acids, slows glucose absorption,...
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#213 Emotions, Mind Control, and Mental Health Labels: A Conversation with Dr. Roger McFillin
Dr. Roger McFillin argues that Western allopathic medicine and psychiatry have medicalized normal human suffering by reducing emotions to biological or chemical reactions, turning symptom checklists into fixed identities, and sustaining a drug-driven "sick care" system that creates lifelong...
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#212 Cialis as a Potential Longevity Drug: Vascular, Heart, Metabolic, and Brain Benefits
This episode explores tadalafil (Cialis) as a potential longevity drug, though no randomized human trials prove it extends lifespan. Cialis works by blocking PDE5, enhancing nitric oxide signaling, and improving blood flow through vasodilation. Originally approved for pulmonary hypertension, it's...
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#211 Understanding the Anti-Aging Benefits of Telmisartan
In this podcast episode, an in-depth discussion is provided on the drug Telmisartan, commonly used for lowering blood pressure. The host elaborates on how it belongs to a class of medications known as angiotensin receptor blockers (ARBs) and stands out due to its 24-hour half-life and partial...
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#210 A Personal Journey: My Decision to Quit THC
In this podcast episode, the speaker shares his personal journey of quitting THC, explaining his reasons, the gradual process over several years, and the impacts on his life. He recounts his history with THC, from early recreational use to daily dependence for sleep aid during medical school and...
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#209 Advanced Healing and Prevention Techniques with Stem Cells and Peptides
Most people think they go into your body and make all new tissue… but in actuality, they are a delivery mechanism of growth factors. I call them the ultimate traffic cop. In this episode, the host converses with Dr. Jesse Morse, a physician specializing in regenerative and anti-aging medicine.…
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#208 The Real Science Behind Detoxification: Liver, Kidneys, and Gut Health Explained
Most "detox" advice focuses on cleanses and quick fixes — but real detoxification is a constant, biological process your body runs every day. In this solo episode, the host breaks down how detoxification actually works, starting with what counts as a "toxin" (including hormones and environmental...
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#207 Mastering Hydration: The Essential Guide to Water, Electrolytes, and Optimal Performance
What if your "healthy" water intake is still quietly hurting your performance? In this solo episode, Dr. Mike breaks down hydration from a performance-first perspective — how dehydration affects cognition and physical output, why "8 glasses a day" is an oversimplified myth, and how to personalize...
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#206 How to Fix High Blood Pressure (Without Guessing)
In this solo episode, Dr. Mike breaks down everything you need to know about blood pressure, why it's so commonly misunderstood, how to measure it correctly, and what optimal numbers really look like. He explains why 120/80 isn't ideal for everyone, why blood pressure variability can be more...
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#205 Stop Nighttime Peeing
In this solo episode, Dr. Mike discusses the common issue of nocturia, where individuals frequently wake up at night to urinate, which disrupts sleep. The episode covers the root causes including sleep apnea, enlarged prostate, and overactive bladder, and dives into the roles of antidiuretic...
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#204 Resetting Dopamine for Monogamy
In this solo episode, Dr. Mike delves into the complex relationship between dopamine, romantic relationships, and the Coolidge Effect. The discussion highlights why men often feel the need for a new partner due to a desensitization of dopamine and how our overstimulated lifestyles contribute to...
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#203 Rethinking 10k Steps
In this episode, Dr. Mike Hart delves into the origins and contemporary relevance of the 10,000 steps rule. He discusses the latest research outcomes from a massive meta-analysis comparing daily step counts from 2,000 to 12,000 steps and their associated health benefits. Listeners will learn…
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#202 Better Alternatives To Metformin
In this solo episode, the host discusses the effects of metformin, berberine, and dihydroberberine on exercise adaptation and longevity. While metformin is known for its longevity benefits and is popular in the biohacking community, it has been shown to significantly reduce exercise adaptations…
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#201 Building True Mental Toughness with Tony Ricci
In this episode of the Heart to Heart podcast, Dr. Mike Hart chats with Tony Ricci, an athletic performance and mental health coach for athletes. Tony shares his fascinating journey from studying exercise physiology to working with elite athletes like MMA fighter Chris Weidman. They discuss the...
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#200 Rethinking LDL and Longevity with Greg Mushen
In this episode of the Heart to Heart Podcast, Dr. Mike Hart sits down with Greg Mushen, a former tech professional turned health advocate, to discuss his incredible journey of transforming his body and lifestyle. Greg shares insights from his background growing up in a medical family and how…
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#199 How to Train Like a Pro Fighter with Dr. Corey Peacock
In this episode of the Heart to Heart podcast, Dr. Mike Hart interviews Dr. Corey Peacock, an exercise physiologist and department chair at Nova Southeastern University. Dr. Peacock discusses his diverse background, from establishing the Fight Science Laboratory to working with elite MMA fighters...
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#198 How to Reverse Insulin Resistance
In this solo podcast episode, Dr. Mike Hart delves into the intricacies of insulin resistance, a prevalent yet misunderstood condition. The episode covers the fundamental role of insulin, what happens during insulin resistance, and its linkage to various diseases like diabetes and heart disease.…
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#197 Why Your Brain Needs Friends with Dr. Ben Rein
In this episode, host Dr. Mike Hart welcomes neuroscientist and author Dr. Ben Rein to discuss his new book, 'Why Brains Need Friends: The Neuroscience of Social Connection.' Dr. Rein shares his journey in neuroscience, his research on autism and MDMA, and his pivot towards science communication....
About this show
Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff.Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you understand what actually works so you can make better decisions for your health.The show also looks at the bigger picture, including how public health policy and politics influence personal well-being, and what you can do to take back control.If you want clear, actionable, no-BS conversations about living healthier, performing better, and thinking for yourself, this podcast is for you.
Hosted by
Dr. Mike Hart