PODCAST · business
In the Know with Amol Sarva
by Amol Sarva
Amol Sarva's series with changemakers and innovators in longevity, tech, and ideas
Episodes
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PJ Parson, Northzone and Spotify
🎙️ Episode Guide — PJ Parson (Northzone) Welcome to my series on OG NY Tech Celebrating 30 years of the New York tech ecosystem, from 1995 to now. PJ Parson is a partner at Northzone, best known for backing Spotify when it expanded to New York in 2012. But his path to venture capital wasn’t...
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Kevin Ryan, Alleycorp + MongoDB ++ Doubleclick, Dilbert
>updated with vibier sound!< Welcome to my series on OG NY Tech Celebrating 30 years of the New York tech ecosystem, from 1995 to now. Kevin Ryan joined DoubleClick in 1996, just months after it was founded—and helped turn it into the most important New York technology company of the internet…
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Howard Morgan, First Round and BCap
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Howard Morgan started as an engineer and professor in the early computing days, and ended up building three (four? five?) huge and import investment groups. Renaissance... Idealab... and listen for...
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*Fred Wilson, Union Square Ventures
>updated with vibier sound!< Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Fred Wilson's USV is kind of a 'nuff said, to borrow NYC comic book language. Hear the very early days and listen past through into the epilogue to hear Fred on music...
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Alan Patricof, APAX, Greycroft and Primetime
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Alan Patricof's been at it since he graduated from Columbia Business School just a couple years apart from Warren Buffett. And you might as well think of him in that same legend league, in Alan's…
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Ben Lerer, Thrillist and Lerer Hippeau
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Ben Lerer tells us what ideas led to the creation of a whole new type of media company in the 2000s -- Thrillist -- and the age of newsletters and bloggers in New York, and how the powerhouse...
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Dennis Crowley, Foursquare and Dodgeball
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Dennis Crowley tells us how he got to New York and the early internet culture in the media/Wall Street world: and how it all led to Foursquare -- the art of the game 🎙️ Episode Chapters — Dennis...
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Albert Wenger, Union Square Ventures
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Albert Wenger tells me about his 20 years at USV, and how NY went from apps-mostly to deep and infra. 🎙️ In the Know — OG NY Tech Guest: Albert Wenger (Union Square Ventures) Theme: 30 years of New...
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Owen Davis, Contour and NYC Seed
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Owen Davis tells us how advertising powered early NYC tech and the big transition post-dot-com-crash to both consumer and enterprise tech superstars from New York.
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John Borthwick, Betaworks
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. John Borthwick tells us the roots story of media and art and agencies at the heart of the early NY tech ecosystem and some of the players, and takes it through predictions for what to expect today.
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Pablos Holman from Deep Future VC on “invention” vs. just innovation
Pablos built one of the first decentralized money networks, the first experimental Blue Origin rockets, one of the first handheld computers, invented 1000s of new patents with Nathan Myhrvold, and most recently launched a deeptech venture firm called Deep Future. And now, on July 12, expect his...
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AI x Bio x NY: highlights from our conference
So you missed the all-day all-science+technology collection of superstars gathered by LifeX and Bits in Bio at Fenwick in New York? Wondering what the frontiers of foundation models in bio, longevity, startups and more are pushing? Now you can use the cheat code and just listen to this synopsis…
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What’s super-investor Jim Mellon thinking about?
Jim, founder of Juvenescence, old China and Russia hand, and investor in our fund LifeX sends me an email every morning with lots of attachments that he read that morning. Here's what he's been thinking about the last month.
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De-growth, de-acceleration from the Slow Down manifesto by Shohei Saito, by Amolbot
Read the post here: https://amol.sarva.co/%f0%9f%90%8c-kohei-saitos-slow-down-de-acc-manifesto/
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Cyborgs! Our AI and Bio Future, by Amolbot
I gave a talk in Stockholm last year, that I asked these robots to discuss. Hope you enjoy it. This doesn't look LIKE me but it does sort of resemble what I could possibly look like. It was the first draft. Some better prompting got us to the final image.
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What’s Om Malik interested in these days?
The legendary tech beat reporter is back with a team effort newsletter covering some of the most interesting people in tech. Listen in to hear what he's been thinking about over the last 10 issues.
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10 x Trends for AI x Health + Bio in 2025 from LifeX dealflow analysis, courtesy of Amolbot
We analyzed the 1,000s of companies we're watching and investing in at LifeX. We looked at every update email from every CEO and every conversation notes from every team member. And we made hits outlook for the year ahead, automagically. (Excuse robo-typos.) Enjoy!
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20 Trends for 2025 in Health and Biopharma from Wall Street, synthesized by Amolbot
We synthesized the dozens of outlook reports from Wall Street analysts on health, biopharma, and related trends. Listen in to Amolbot (an automated Amol) and co-hosts.
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Techbio 2025 predictions from Amol’s inbox full of reports, via Amolbot
We synthesized the dozens of outlook reports from Silicon Valley observers of techbio for AI x Health startups and trends. Listen in to Amolbot (an automated Amol) and co-hosts.
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Soluble and insoluble fiber, food and gut health and their role in overall health with Dr. Will Bulsiewicz from Zoe
Dr. B is an expert on gut health and shouting its power from the rooftops, both in his practice and writings but also through the company Zoe where he is US medical director. Some interesting news about coffee in this one. Metabolic Health is the biggest medical breakthrough of the moment. Dive in!
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How food becomes energy and the view from sports nutrition on metabolism with Professor Derek Huffman of Einstein
The journey from food through digestion to your liver to energy stores and metabolizing work is the obsession of sports science - and hugely relevant to metabolic health overall. Let's get this perspective from research professor Derek Huffman at Einstein Medicine in New York. Dive into metabolic...
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Food as medicine with physician and founder Jeff Alfonsi
The different foods we eat and how they interact make a huge difference in disease progression, weight, and everything else. Dr. Jeff Alfonsi is a practicing physician for years, and chief medical officer of RxFoods which is designed to identify what you are eating and how to get better results....
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Pro biotics, pre biotics, and what your digestive system knows with Maya Kaelberer, Ph.D.
Let's understand an overlooked dimension of the weight loss revolution underway -- the microbes in the digestive system themselves, potentially where GLP-1s come from in the first place. Duke's gut biome expert Maya Kaelberer gives us a guide. Metabolic Health is the biggest medical breakthrough…
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Metformin, Rapamycin, the cellular mechanisms at the cutting edge of weight loss and longevity with Matt Kaeberlein, Ph.D.
Metabolic Health is the biggest medical breakthrough of the moment Let's understand the cellular mechanisms and some of the most promising and widely used drugs in the world with one of the foremost researchers in the field, Matt Kaeberlein, formerly of University of Washington and now founder of...
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Bariatric surgery, the gut biome, and the interactions that create weight loss with surgery and nutrition professor Randy Seeley, Ph.D. at Michigan
Metabolic Health is the biggest medical breakthrough of the moment Mapping all the ways the GLP-1 drugs like Ozempic do and might work means we need to understand the biome and the efficacy of surgical interventions. We talk to Professor Randy Seeley who directs University of Michigan's Nutrition...
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Understanding blood sugar and insulin with world leader on diabetes Dr. John Buse of UNC
Metabolic Health is the biggest medical breakthrough of the moment Dr. John Buse has been at the forefront of diabetes research and endocrinology since before the first GLP-1 results started to become known. He studies the body's systems that seem to be at the core of how Ozempic and diabetes...
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How weight loss works with Yale’s Dr. Waj Mehal
Metabolic Health is the biggest medical breakthrough of the moment We have one of the world's experts on the liver - the place your body stores lots of energy from food, and distributes it onward to other systems, Dr. Waj Mehal of the Yale School of Medicine. We lay out a map of the systems in...
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How Ozempic works and what else could revolutionize metabolic health with James Peyer, Ph.D. of Cambrian Bio
Metabolic Health is the biggest medical breakthrough of the moment Get up to speed on the cellular biology with a fantastic overview from PhD scientist and founder of breakthrough pharma platform Cambrian Bio
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Matt Kaeberlein on which longevity supplements might really work, and which don’t
Professor Matt Kaeberlein is an outspoken proponent of rapamycin, and pretty skeptical about virtually all the other interventions people talk most about. Here he lays out a pretty complete and persuasive model for why and how aging happens at all, and why some approaches are most likely to work.
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Nir Barzilai on the genes of centenarians and some nuance on metformin
A rare MD at the cutting edge of the longevity field, Dr. Barzilai heads the Institute for Longevity Research at Einstein. We cover his unique contributions, especially the currently buzzy topic of metformin, as well as his work on the genetic luck of centenarians.
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Jean Herbert on regenerating the brain in the lab
One of the more incredible research programs in longevity is regeneration: rebuilding and replacing failing organs with lab-grown cells. Jean Herbert at Einstein is working on regenerating your brain.
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James Peyer from Cambrian Biosciences and Apollo Health Ventures tells us how to play longevity to win
This founder has been part of so many of the exciting longevity startups, investments, and discussions that you simply must understand the world the way he sees it before taking a view about life extension. In this episode, you will.
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Aubrey de Grey, the longevity OG, gives us a peek into the early days of the cult of living forever
Longevity superstar alert. A deep dive with one of the most recognized and longest-serving visionaries of longevity world. After recording this episode, friends pointed out that I didn't cover big important parts of personal history that are covered here: https://en.wikipedia.org/wiki/Aubrey_de_Grey
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Vincere Bio’s computer model for solving Parkinson’s with the cofounders Spring Behrouz and Andy Lee
The easy way to attack Parkinson's? A neuron-by-neuron model of the brain.
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Altos Labs’ Morgan Levine on how to measure biological age and why she left Yale
Cellular rejuvenation is in the house on this episode, and fundamental research on the processes far beneath the surface of your typical aging research. And a little peek into the billionaire-backed mega-project happening at Altos.
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Muneeb Ali, CEO of Blockstack, talks to us about the future network protocol and blockchain
Started a long way off in Pakistan, made it to Princeton among the great inventors of the Internet, and now building the New Internet.
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ABOUT THIS SHOW
Amol Sarva's series with changemakers and innovators in longevity, tech, and ideas
HOSTED BY
Amol Sarva
CATEGORIES
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Frequently Asked Questions
How many episodes does In the Know with Amol Sarva have?
In the Know with Amol Sarva currently has 94 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is In the Know with Amol Sarva about?
Amol Sarva's series with changemakers and innovators in longevity, tech, and ideas
How often does In the Know with Amol Sarva release new episodes?
In the Know with Amol Sarva has 94 episodes. Check the episode list to see recent publication dates and frequency.
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You can listen to In the Know with Amol Sarva on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts In the Know with Amol Sarva?
In the Know with Amol Sarva is created and hosted by Amol Sarva.
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