All Episodes
In the Know with Amol Sarva — 94 episodes
PJ Parson, Northzone and Spotify
Kevin Ryan, Alleycorp + MongoDB ++ Doubleclick, Dilbert
Howard Morgan, First Round and BCap
*Fred Wilson, Union Square Ventures
Alan Patricof, APAX, Greycroft and Primetime
Ben Lerer, Thrillist and Lerer Hippeau
Dennis Crowley, Foursquare and Dodgeball
Albert Wenger, Union Square Ventures
Owen Davis, Contour and NYC Seed
John Borthwick, Betaworks
Pablos Holman from Deep Future VC on “invention” vs. just innovation
AI x Bio x NY: highlights from our conference
What’s super-investor Jim Mellon thinking about?
De-growth, de-acceleration from the Slow Down manifesto by Shohei Saito, by Amolbot
Cyborgs! Our AI and Bio Future, by Amolbot
What’s Om Malik interested in these days?
10 x Trends for AI x Health + Bio in 2025 from LifeX dealflow analysis, courtesy of Amolbot
20 Trends for 2025 in Health and Biopharma from Wall Street, synthesized by Amolbot
Techbio 2025 predictions from Amol’s inbox full of reports, via Amolbot
Soluble and insoluble fiber, food and gut health and their role in overall health with Dr. Will Bulsiewicz from Zoe
How food becomes energy and the view from sports nutrition on metabolism with Professor Derek Huffman of Einstein
Food as medicine with physician and founder Jeff Alfonsi
Pro biotics, pre biotics, and what your digestive system knows with Maya Kaelberer, Ph.D.
Metformin, Rapamycin, the cellular mechanisms at the cutting edge of weight loss and longevity with Matt Kaeberlein, Ph.D.
Bariatric surgery, the gut biome, and the interactions that create weight loss with surgery and nutrition professor Randy Seeley, Ph.D. at Michigan
Understanding blood sugar and insulin with world leader on diabetes Dr. John Buse of UNC
How weight loss works with Yale’s Dr. Waj Mehal
How Ozempic works and what else could revolutionize metabolic health with James Peyer, Ph.D. of Cambrian Bio
Alex Zhavoronokov from In Silico, the AI longevity drug discovery giant, on the revolution now and tomorrow
Kristen Fortney from a16z-backed BioAge Labs on how they’re reversing the molecular mechanisms of aging
Noah Davidson of Rejuvenate.bio on their gene therapy to reverse aging across the entire system
Joe Betts-Lacroix from Retro.bio on the power of AI to shorten the path to transformative longevity
Matt Kaeberlein on which longevity supplements might really work, and which don’t
Nir Barzilai on the genes of centenarians and some nuance on metformin
Jean Herbert on regenerating the brain in the lab
James Peyer from Cambrian Biosciences and Apollo Health Ventures tells us how to play longevity to win
Aubrey de Grey, the longevity OG, gives us a peek into the early days of the cult of living forever
Vincere Bio’s computer model for solving Parkinson’s with the cofounders Spring Behrouz and Andy Lee
Altos Labs’ Morgan Levine on how to measure biological age and why she left Yale
Bjoern Schumacher’s research on cellular damage, and that incredible longevity-busting work on worms
Professor Richard Miller’s experiments on all the life extending elixirs
Reason of Repair Biotechnologies on reversing cellular aging
Longevity VC Sergey Young on living forever and his book “Growing Young”
John Katzman on making digital education work and post-virus universities
Henrik Werdelin on the innovation factory that created BarkBox and his new book The Acorn Method
Saeju Jeong of Noom on helping people be healthier through an app
Anil Dash on the invention of social media and the responsibilities to society
Abdur Chowdhury, former Chief Scientist of Twitter and now founder of Aura Frames on the promise and dangers of social
Muneeb Ali, CEO of Blockstack, talks to us about the future network protocol and blockchain
Jared Hecht on creating the serendipity behind GroupMe and Fundera
Snowflake CEO Frank Slootman on selling lightning in a bottle
Stacy Schiff on women in history: Cleopatra, the Witches of Salem, and Mrs. Nabokov
Bari Williams on diversity in Silicon Valley culture
ARUP, which designs whole cities, lends us their Deputy Chair Tristram Carfrae on the ways a huge creative organization stays great
Blue Apron founder Matt Salzberg on the ride from idea to IPO
Andrew McAfee, MIT author of The Second Machine Age and prophet of abundance previews his new book on doing more with less and his way of finding powerful new ideas
Robbie Carp of the early days of Microsoft, the invention of Product Management, and the once and once again Most Valuable Company in the World
Sheila Hood of the Difficult Conversations mega-bestseller, of the Harvard Negotiation Project, on the toughest stuff we do between people and in teams, plus how they figured it out
The inventor of Agile: Jeff Sutherland, on the way to do everything twice as fast
Josh Abramson, creator of CollegeHumor and BustedTees on hunting the biggest startup game
George Church, the synthetic biology superstar on reading, writing, and re-writing life and the way science does innovation
Innovation guru and IDEO’s biographer Jonathan Littman on the ways new things get invented
Legendary Geoffrey Moore on the canonical ideas: Crossing the Chasm, Th Bowling Alley, Inside the Tornado, and the theory of the evangelistic sale
DoubleClick founder Kevin O’Connor on building the biggest ad company in the world, and then all of it in reverse
My hero and guru Ronald Heifetz, Harvard Kennedy School professor and counselor to presidents, protestors and revolutionaries on: the hardest problems of leadership
Evangelist Guy Kawasaki of Garage Ventures, Apple, Canva and the true Silicon Valley religion
Philip Tetlock, the guru of Superforecasting, seeing the future, and the foxes and hedgehogs of decisionmaking
John Nesheim, the guru of Silicon Valley art and science, National Semiconductor, Venture Capital and Cornell professor
Warren Hatch, superforecaster, PhD Kremlinologist, hedge fund manager and President of Good Judgment Inc on the Fox and the Hedgehog
Michael Ruse, philosopher of science, evolution, foxes and hedgehogs kicks off my series on styles of thinking
David Klein of CommonBond on tackling the student debt apocalypse; $2.5bn down, $2 trillion to go
Heini Zachariassen, creator of the world’s largest wine platform (Vivino) and from one of the world’s tiniest states
Fabrice Grinda, 400X angel (Alibaba, Knotel, OpenDoor, Flexport) and manyX co-founder of Auclan, Zingy, OLX and company-builder FJ Labs
Alex Mashinsky, visionary founder of Arbinet, the proto-Lyft/Uber GroundLink, Transit Wireless and now a crypto bank talks about making things big
Will Herman, author of The Startup Playbook, 2x billion-dollar founder, 200x startup-advisor on how to lead people to greatness
Dane Madsen, wiseman of transformation who led YellowPages.com, on how to transform yourself and your people
Anthemos Georgiades, CEO of Zumper, classicist and first-time founder of Kleiner-backed apartment-leasing giant
Safi Bahcall, scientist, inventor, founder, CEO, policy advisor and author of “Loonshots”
Shira Atkins, cofounder of the Women Belong in the House series and Wonder Media Network
Martha Stewart, lifestyle icon, brand dealmaker, and omnimedia revolutionary
Money Mark, super-producer to the Beastie Boys, David Byrne, Yeah Yeah Yeahs, and his own hits
Stephen Wolfram, yes the Stephen Wolfram, sits down to talk…management
Amol at SxSW talking cities of the future with Amy Nelson of Venture for America and more
John Gauntt, podcast superhost of TheAugmented.City and from Economist Group, teaches Amol how to podcast
Samar Birwadkar, People Genius, founder of Goodco (acq by Axel Springer), on People Metrics and Leading Growing Teams
Sophia Swire, Adventurer, International Development Expert and Radio Journalist
Hussein Kanji, Founding Partner of Hoxton Ventures
ShaoLan Hsueh, author of Chineasy, on Her Visions of The Future
Andrew Rasiej, Founder & CEO at Civic Hall
Ronda Carnegie, from The New Yorker, TED Talks, Sundance, and New Lab
Ryan Rzepecki of Jump (Acquired by Uber)
Kevin Ryan, founder of MongoDB, Gilt Groupe, and Business Insider
Amy Cuddy, the psychologist, power researcher, and TED superstar
German radio journalist Felix Zeltner