PODCAST · health
Longevity Roadmap
by Buck Joffrey
Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.
Episodes
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169: Protein Folding Errors Contribute to Aging and Disease
In this episode, we are joined by Dr. Judith Frydman to explore proteostasis: the tightly regulated systems that ensure proteins are correctly folded, maintained, and cleared before they become toxic. As these systems degrade with age, misfolded proteins accumulate, cellular signaling falters…
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168: Best of 2025
Over the past year, we covered a wide range of ground—from clinicians working directly with patients to top scientists studying the underlying biology of aging. This episode is a chance to look back at some of the more interesting conversations we had on Longevity Roadmap in 2025. Looking ahead,...
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167: Why Bats Don't Age and Why You Should Care with Dr. Emma Teeling
Aging is usually linked to size, metabolism, and inevitable decline—but bats defy all three. In this episode, Dr. Buck Joffrey speaks with Dr. Emma Teeling about why bats are rewriting the rules of longevity science. The discussion explores how bats live far longer than expected for their size...
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166: BioXcellerator - The Cutting Edge of Stem Cell Therapy
Longevity medicine is moving beyond symptom management—and regenerative therapies are forcing a deeper look at how healing actually works. In this episode, Dr. Buck Joffrey speaks with the team at BioXcellerator about what separates rigorous regenerative medicine from hype-driven shortcuts. The...
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165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
Aging begins when cellular quality-control systems lose their precision. In this episode, Professor Ana Maria Cuervo outlines how chaperone-mediated autophagy (CMA)—a selective lysosomal degradation pathway essential for proteostasis—progressively declines with age, triggering downstream failures...
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164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray
In this episode, we are joined by Dr. Tony Wyss-Coray to discuss his groundbreaking research on brain resilience and aging. He explains how systemic factors, particularly proteins in the blood, influence cognitive function and the aging process. The discussion covers the role of proteomics…
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163: How Mitochondrial Decline Drives Brain Aging with Dr. Francisco Gonzalez-Lima
In this episode, we are joined by Dr. Francisco González-Lima to delve into the metabolic mechanisms that drive brain aging and cognitive decline. He begins by outlining how reductions in cytochrome oxidase activity, disruptions in oxidative phosphorylation, and the accumulation of mitochondrial...
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162: The Habits of Healthy Aging with Dr. Kate Wolin
We are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real world. From frictionless habit design and daily self-monitoring to movement, sleep, and the muscle-preserving realities...
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161: The Future of Tissue Regeneration with Dr. Jennifer Elisseeff
In this episode, we are joined by Dr. Jennifer Elisseeff to discuss the evolving field of tissue engineering and its applications in regenerative medicine. She explains the shift from using stem cells to focusing on immune cells for tissue repair, the challenges of regenerating cartilage, and the...
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160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum
Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging. She explains how these simple organisms helped uncover key longevity pathways—like insulin/IGF-1 signaling and sirtuins—that...
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159: How DNA Mutations and Epigenetic Drift Cause Aging with Prof. Jan Vijg
This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging. He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes. The...
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158: Sitting Is the New Smoking with Dr. Keith Diaz
In this episode, we are joined by Dr. Keith Diaz to discuss the significant health risks associated with prolonged sitting, likening it to smoking in terms of its dangers. He emphasizes the importance of regular movement, introducing the concept of 'movement snacks'—short bursts of activity that...
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157: The Role of Surgery in Diabetes and Obesity with Dr. Mitchell Roslin
In this episode, we are joined by Dr. Mitchell Roslin to discuss the complexities of obesity. We explore the role of GLP-1 medications in weight management, the evolution of bariatric surgery, and the innovative SIPS procedure. Dr. Roslin emphasizes that obesity is not merely a result of poor...
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156: Investing in the Business of Aging with Dr. Karl Pfleger
In this episode, Dr. Karl Pfleger joins us to discuss the evolving landscape of longevity research and investment. He emphasizes the shift from disease-specific approaches to understanding aging as a multifaceted process that underpins many chronic diseases. Dr. Pfleger outlines his investment...
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155: Can Psilocybin Extend Cellular Lifespan? with Dr. Louise Hecker
In this episode, Dr. Louise Hecker joins us to discuss her groundbreaking research on psilocybin, exploring its potential to extend cellular lifespan and improve health outcomes in aging. We delve into the mechanisms behind psilocybin's effects, findings from animal studies, and the challenges...
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154: Is Telomere Length Shortening the Master Switch of Aging? with Dr. Bill Andrews
In this episode, Dr. Bill Andrews joins Dr. Buck Joffrey to discuss the critical role of telomeres and telomerase in aging and cellular health. He explains how telomeres shorten with each cell division, leading to aging and cellular senescence. Dr. Andrews emphasizes the importance of inducing...
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153: T Cells, Aging, and Extreme Life Extension with Dr. Derya Unutmaz
Dr. Derya Unutmaz joins Dr. Buck Joffrey to discuss the critical role of T cells in the immune system, their changes with aging, and the implications for chronic diseases. He emphasizes the importance of thymus regeneration and the microbiome's influence on health. The discussion also covers...
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152: The Role of Vitamin A in Brain Health with Prof. Peter McCaffery
In this episode, Professor Peter McCaffery joins Dr. Buck Joffrey to discuss the multifaceted role of Vitamin A in brain health, particularly its function as a signaling molecule that influences neuroplasticity and cognitive functions. He elaborates on the challenges of Vitamin A supplementation,...
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151: Does Astaxanthin Increase Longevity? with Dave Watumull
In this episode, Dave Watumull joins Dr. Buck Joffrey to discuss the benefits and mechanisms of astaxanthin, a powerful antioxidant and anti-inflammatory compound. He explains its role in longevity, particularly through the Interventions Testing Program (ITP), where astaxanthin was shown to…
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150: The Microbiome's Role in Aging and Healthspan with Dr. Sean Gibbons
Dr. Sean Gibbons joins Dr. Buck Joffrey to discuss the complexities of the gut microbiome, its evolution, and its significant role in health and longevity. He explains how our microbiome is established at birth, how it changes throughout life, and the impact of diet and lifestyle on its...
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149: How Dental Health Impacts Longevity with Dr. Ellie Phillips
Dr. Ellie Phillips, DDS, joins Dr. Buck Joffrey to explain how oral pathogens contribute to chronic inflammation and conditions such as cardiovascular disease, Alzheimer's, and adverse pregnancy outcomes. She shares the science behind xylitol, saliva-driven remineralization, and practical...
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148: Dr. Kevin J. Tracey - Stimulating the Vagus Nerve to Reduce Inflammation and Improve Healthspan
Dr. Kevin J. Tracey, neurosurgeon, immunologist, and pioneer in bioelectronic medicine, discusses the discovery of the inflammatory reflex and how vagus nerve stimulation can precisely regulate immune activity without immunosuppression. He explains its clinical application in rheumatoid…
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147: The Wrong Vitamin E Supplement Can Hurt You with Dr. Barrie Tan
In this conversation, Dr. Barrie Tan joins Dr. Buck Joffrey to discuss the significance of tocotrienols—a lesser-known form of vitamin E—and their potential role in preventing chronic disease and promoting healthy aging. Dr. Tan explains the differences between tocopherols and tocotrienols, the...
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146: AMA President Dr. Bobby Mukkamala - Healthspan-Centric Medical Care in America
Joining Dr. Buck Joffrey this week, Dr. Bobby Mukkamala shares his journey from aspiring cardiothoracic surgeon to becoming the president of the American Medical Association. He discusses his personal health challenges, including a brain tumor diagnosis, and how it has shaped his perspective on...
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145: Why Some Animals Live Longer Than Others with Dr. Steven Austad
In this conversation, Dr. Buck Joffrey and Dr. Steven Austad discusse the biology of aging, the evolutionary aspects of longevity, and the potential for genetic technologies to extend human health span. Dr. Austad emphasizes the complexity of aging, the importance of glucose control, and the need...
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144: Why the Brain is Especially Vulnerable to Aging with Dr. Julie Andersen
In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain's heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges…
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143: The Longevity Dividend with Prof. Jay Olshansky
In this conversation, Professor S. Jay Olshansky discusses the evolution of aging science, the realistic limits of human life expectancy, and the concept of the Longevity Dividend, which emphasizes the health and economic benefits of modulating the aging process. He also explores the potential of...
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142: The Gut-Muscle Axis with Dr. Michael Lustgarten
In this episode, Dr. Michael Lustgarten discusses his research on the gut microbiome, serum metabolome, and muscle health in older adults. He shares insights from his journey into the world of aging, the importance of data in health optimization, and the emerging concept of the gut-muscle axis.…
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141: A Thermostat for Your Body Fat with Dr. Stephan J. Guyenet
In this conversation, Dr. Stephan J. Guyenet joins Dr. Buck Joffrey to discuss the complex mechanisms of body fat regulation, focusing on the role of the lipostat and leptin. He explains how the body regulates fatness through hormonal signals and the implications of leptin resistance in obesity....
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140: Inside the Inflammatory Clock - Measuring and Reversing Biological Age with Dr. David Furman
Dr. David Furman and Dr. Buck Joffrey discuss the complexities of immune aging, the role of inflammation in age-related diseases, and how artificial intelligence is being utilized to enhance research in this field. He introduces the concept of the inflammatory age clock, which measures biological...
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139: Rebuilding the Aging Brain - The Role of Neural Stem Cells with Dr. Tara Walker
In this conversation, Dr. Tara Walker discusses the fascinating topic of adult neurogenesis, the brain's ability to produce new neurons throughout life. She explains how this process is crucial for cognitive function and how it declines with age. The discussion highlights the significant role of...
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138: Sleep Impact on Longevity and Health with The Sleep Doctor
Sleep is the secret weapon for a longer, healthier life—and Dr. Michael Breus is here to show you how to use it. In this episode of Longevity Roadmap, Buck Joffrey dives deep into the science of sleep with the world-renowned sleep doctor himself. Discover why sleep is the third pillar of…
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137: Dr. Joan Mannick - Targeting mTOR to Improve Immune Function and Healthspan
What if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role...
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136: Why is Vitamin D So Important in Health and Longevity? with Dr. Michael Holick
Vitamin D is more than a vitamin—it's a hormone that influences everything from your immune system to cardiovascular health, cognition, and longevity. In this conversation, Dr. Michael Holick breaks down the science of vitamin D synthesis, the truth about sun exposure vs. supplements, and why...
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135: The Aging Brain - From Memory Lapses to Measurable Prevention with Dr. Mitchell Clionsky
Is your memory decline normal—or something more? Clinical neuropsychologist Dr. Mitchell Clionsky breaks down what healthy aging looks like from a cognitive perspective and where concern might be warranted. He introduces the Memory Orientation Screening Test (MOST)—a powerful yet quick tool to...
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134: Can You Boost Stem Cells Naturally? with Dr. Christian Drapeau
What if your body already had everything it needs to heal itself—naturally? In this episode, neurophysiologist and stem cell researcher Dr. Christian Drapeau breaks down the science of stem cell therapy, explaining how adult stem cells, embryonic stem cells, and exosomes play a central role in...
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133: Can We Reverse Immune System Aging? T Cells, Telomeres, and the Fight Against Senescence with Dr. Alessio Lanna
Is it possible to rejuvenate the immune system as we age? In this episode, Dr. Alessio Lanna breaks down the science of immune aging, focusing on the critical role of T cells, telomere shortening, and senescence. He explains how T cells lose their effectiveness over time—and shares emerging...
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132: Dr. Mark Tarnopolsky's Mitochondrial Cocktail for Cellular Health
Are your mitochondria aging faster than you are? In this episode, Dr. Mark Tarnopolsky breaks down the central role of mitochondria in aging, longevity, and overall metabolic health. Learn how mitochondrial dysfunction drives age-related decline, including neurodegenerative diseases, and what you...
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131: Matt Kaeberlein - Aging, mTOR, Epigenetic Clocks, and more!
What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He...
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130: Does the Gut Control the Brain? with Dr. Michael Gershon
Dr. Michael Gershon—legendary Columbia professor and author of The Second Brain—joins us to explain why your intestines might just be running the show. From guinea pig guts that "blew back" to the real reason stress wrecks your digestion, this episode dives deep into the mysterious world of the...
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129: Does Too Much Muscle Shorten Your Life? with Dr. Keith Baar
Can muscle growth and longevity coexist? Dr. Keith Baar breaks down the science of exercise, diet, and aging—focusing on the mTOR pathway, muscle hypertrophy, and how resistance vs. endurance training impacts long-term health. Learn how personalized health strategies, isometric exercises, and...
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128: C15 - The Most Underrecognized Anti-Aging Supplement? with Dr. Stephanie Venn-Watson
Could an essential fatty acid discovered in Navy dolphins unlock the secret to healthier aging? In this episode of Longevity Roadmap, Dr. Stephanie Venn-Watson reveals the groundbreaking science behind C15, an essential fatty acid linked to longevity and reduced disease risk. Learn how…
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127: The Impact of Depression on Longevity and Healthspan with Dr. Peter Franz
Suicide rates are rising—and the impact on longevity is profound. In this eye-opening episode of Longevity Roadmap, Dr. Peter Franz dives deep into the intersection of mental health, suicide prevention, and lifespan. He explores why nearly 50% of Americans experience depression, how loneliness...
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126: Fahy Protocol - Regrow the Thymus, Reverse Your Age
Can we reverse aging by regenerating the thymus? In this groundbreaking conversation, Dr. Greg Fahy shares his pioneering research on the thymus gland's role in immune function, longevity, and epigenetic age reversal. We dive deep into the TRIM study, which demonstrated for the first time that...
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125: Reversing Skin Age - Tackling Senescence with OS-01 with Dr. Carolina Reis Olivera
Visit oneskin.co/BUCK and use code BUCK at checkout for 15% off your first purchase! Dr. Carolina Reis Olivera shares her journey in aging and longevity research, highlighting the development of the OS-01 peptide—a breakthrough targeting cellular senescence to improve skin health. She delves into...
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124: How the Gut Influences Health and Longevity with Dr. Michael Miller and Dr. Jacob Allen
Buck Joffrey welcomes Dr. Michael Miller and Dr. Jacob Allen for an in-depth discussion on gut health and its vital role in overall well-being. They explore the gut microbiome's composition, how diet and lifestyle influence its dynamic nature, and the significance of fermented foods and dietary...
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123: What is Metabolic Dysfunction and Why is it Killing Americans with Dr. Robert Lustig
Dr. Robert Lustig joins Buck to discuss the alarming state of metabolic health in America, where only 7% of the population is considered metabolically healthy. He breaks down metabolic dysfunction, linking it primarily to mitochondrial inefficiency, and explains how sugar—especially…
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122: How Your Taste Buds Shape Metabolic Health with Dr. Marta Yanina Pepino
In this conversation, Dr. Marta Yanina Pepino discusses her research on taste perception and its implications for metabolic health. She explores how individual differences in taste can influence eating behaviors and obesity risk, the relationship between taste and digestion, and the role of...
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121: How Long-Lived Species Could Revolutionize Human Aging with Dr. Vera Gorbunova
In this episode, Dr. Vera Gorbunova unpacks the secrets of nature's longest-lived species—like the naked mole rat and bowhead whale—to uncover the biological mechanisms that keep them healthier for longer. We explore the role of DNA repair, transposable elements, and epigenetics in aging and what...
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120: Andrea Maier's Personalized Approach to Longevity Medicine with Prof. Andrea B. Maier
Buck Joffrey interviews Professor Andrea B. Maier, a leading expert in geroscience and healthy aging. They discuss the evolution of longevity research, the importance of distinguishing between lifespan and healthspan, and the biological mechanisms of aging. Professor Maier emphasizes the need for...
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Frequently Asked Questions
How many episodes does Longevity Roadmap have?
Longevity Roadmap currently has 171 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Longevity Roadmap about?
Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.
How often does Longevity Roadmap release new episodes?
Longevity Roadmap publishes regularly with 171 episodes available. Check the episode list for the typical release schedule.
Where can I listen to Longevity Roadmap?
You can listen to Longevity Roadmap on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Longevity Roadmap?
Longevity Roadmap is created and hosted by Buck Joffrey.
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