Talking Biotech with Dr. Kevin Folta

This episode explores the latest advancements in personalized DNA and RNA technologies for early cancer detection, diagnostics, and treatment monitoring. Dr. Nathan Montgomery from Neo Genomics Laboratories discusses how molecular residual disease testing, liquid biopsies, and genomic sequencing are transforming oncology care.

Chronic kidney disease (CKD) is a pressing health issue that affects over a billion people worldwide, yet it often goes unnoticed until it's too late. In this post, we'll explore insights from Dr. Salvadore Viscomi, the CEO and founder of Carna Health, who sheds light on the alarming prevalence of CKD, its underlying causes, and the innovative solutions being implemented to address this global health crisis.Resources & Links:Carna Health Official WebsiteLinkedIn Profile of Salvadore ViscomiSiemens Biomarker Testing SolutionsFDA Clearances for Point of Care Testing DevicesConnect with Dr. Salvador Viscome:LinkedInTwitter

This week's Talking Biotech Podcast examines the realistic potential of AI in cancer research and healthcare, emphasizing data quality, individualization, and system reform. Guest: Dr. Emilia Javorsky, Future of Life Institute.  Future of Life InstituteAI and Cancer: A New Frontier

This episode explores the pioneering work on ice minus bacteria and their role in frost damage prevention in plants. Dr. Steven Lindow shares insights into early biotech innovations, regulatory challenges, and the potential for modern applications of this technology.

In this episode of the Talking Biotech podcast, Dr. Karsten Eastman discusses the significance of peptides in biology and their therapeutic potential. He explains the roles of peptides, particularly GLP-1 therapeutics, and the challenges associated with their stability and bioavailability. The conversation delves into nature's strategies for enhancing peptide stability and how Sathera Therapeutics is innovating in this space to create more effective peptide-based therapies. The discussion also touches on the business model of Sathera and its focus on rare cancers and anti-inflammatory treatments.

In this episode of the Talking Biotech podcast, Dr. Danelle Seymour discusses the genetic anomoliies observed in the vegetative propagation of tree crops, particularly citrus. The conversation delves into the importance of preserving genetic material through grafting, the challenges of genetic variation in vegetatively propagated plants, and the role of mutations in these processes. Dr. Seymour shares insights from her research on the historic Washington Naval orange tree and the implications of somatic mutations for breeding and disease resistance in citrus.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta speaks with Dr. Neela Patel and Dr. Diane Hollenbaugh from Bonum Therapeutics about the emerging field of conditionally active biologics. They discuss the challenges of current therapies, the innovative mechanisms behind their drug development, and the potential of immuno-oncology to revolutionize cancer treatment. The conversation also covers the market landscape, the origin story of Bonum, and the future directions for their pipeline, emphasizing the importance of targeted therapies in improving patient outcomes.

In this episode of the Talking Biotech podcast, host Dr. Kevin Folta engages with Dr. Alex Schneider, CEO and founder of CureLab, to discuss innovative approaches to cancer treatment, particularly focusing on the challenges posed by refractory cancers such as triple-negative breast cancer and platinum-resistant ovarian cancer. Dr. Schneider emphasizes the evolution of cancer therapies from traditional chemotherapy to more sophisticated immunotherapies, highlighting the importance of understanding immune responses in combating cancer. He introduces Elanogen, a plasmid-based therapy designed to enhance immune presentation and combat chronic inflammation, which can hinder the effectiveness of conventional treatments like gemcitabine....

This conversation explores the intersection of biotechnology and the beauty industry, highlighting how biotech is revolutionizing the production of cosmetic ingredients. The discussion covers the slow pace of innovation in beauty, the debate between natural and synthetic ingredients, and the role of AI in discovering new active compounds. The conversation also delves into specific examples like carmine production, the business model of Debut Biotech, and the regulatory challenges faced in bringing new products to market.

2025 saw some of the giants in molecular biology leave us.  Those that made seminal discoveries in DNA science to those that put it to work in describing the underpinnings of life left an indelible mark on history, and it is fitting that we commemorate their discoveries and contributions. 

This is a throwback to episode 484, a very important correction of their episode on glyphosate. With so much controversy around this compound it is critical to keep the information correct and consistent with a 50 year body of evidence when discussing risk and benefit. Veritassium made some mistakes, so here they are corrected so that you can participate effectively in these discussions. 

This episode originally aired on December 18, 2021.  Cindy Graham was diagnosed with glioblastoma in her late 40s. She fought the disease, and ultimately donated her tissues to research to study the nature of glioblastoma and identify potential vulnerabilities that could underlie a cure. This episode first features Dr. Shiela Singh, glioblastoma expert who has performed analysis of Cindy's cells in search of a cure.  The second part is an interview with her husband, Dr. Thomas Graham. He speaks of the power of her gift, Cindy's legacy, and the hope that cures may come because of her contribution. The fund supports gl...

In today's throwback to 2022, Dr. Avindra Nath of the NIH reviews research efforts in proteins expressed from human endogenous retroviruses. It is a fascinating discussion of how genome relics may be contributing to insidious human disease. 

This throwback episode to 2018 is an interview with plant breeding pioneer Dr. Maxine Thompson. 

In this episode of the Talking Biotech podcast, Dr. Kevin Folta and Dr. Zack Abbott discuss the critical role of dietary fiber in human health, the alarming statistics regarding fiber deficiency in the population, and the innovative solutions being developed by Zbiotics to address this issue. They delve into the science behind genetically engineered probiotics that can convert sugars into fiber, enhancing gut health and microbiome diversity. The conversation also touches on future possibilities for probiotic technology and its potential to solve modern health challenges.

This cross-platform podcast is shared on Science Facts and Fallacies as well as Talking Biotech.  Cameron English, Dr. Liza Lockwood and Dr. Kevin Folta discuss the comments made during a rant on the Science Facts and Fallacies podcast concerning the rigor of peer review and alledged lack of self policing in academic publishing.  They discuss several papers in the recent public eye, with an emphasis on the process, the media response, and the nuance that is used in academic publishing, review and editorial oversight.  

In this episode of the Talking Biotech podcast, Dr. Jonathan Howard discusses his experiences during the COVID-19 pandemic, the rise of disinformation, and the anti-vaccine movement. He reflects on his role as a physician at Bellevue Hospital, the impact of misinformation on public health, and the key players who have influenced the narrative surrounding vaccines and COVID-19. Dr. Howard emphasizes the need for the medical community to stand against misinformation and the importance of engaging in public discourse to restore trust in science and public health institutions.

SummaryIn this episode of the Talking Biotech Podcast, Dr. Matthew Disney discusses the potential of RNA as a therapeutic target, exploring its historical context, pathogenic roles in diseases, and the challenges and innovations in drug design. The conversation delves into specific diseases like myotonic dystrophy, ALS, and various cancers, highlighting the advantages of small molecules in treatment and the future directions of RNA therapeutics.

In this episode of the Talking Biotech podcast, Dr. Max Scott discusses the significant threat posed by screw worms, a parasitic insect that lays eggs in live animals, leading to severe economic and health impacts on livestock. The conversation covers the historical eradication efforts using the sterile insect technique, the current resurgence of screw worms in North America, and the innovative biotechnology approaches being explored to control their populations, including gene drive technology. The episode also addresses the public perception of genetic technologies in agriculture and the importance of continuous monitoring and advocacy for effective pest management.

In this episode of the Talking Biotech podcast, Dr. Jackie Douglas discusses the emerging field of neoantigens and their significance in cancer immunotherapy. Neoantigens, which are unique to cancer cells, offer a promising target for personalized immunotherapies. The conversation covers the formation of neoantigens, the role of HLA alleles in their presentation, recent advances in research, and various therapeutic strategies being explored. Challenges such as patient response variability and the need for affordable treatments are also highlighted, along with the potential for future developments in the field.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Derek Small, co-founder and CEO of Syndeoo, focusing on the increasing prevalence of neurological disorders and the challenges in developing effective therapies. They discuss the importance of synaptic function in mental health and neurodegenerative diseases, the innovative Boost platform for drug development, and the potential of event-driven pharmacology. The conversation highlights the hope for new treatments in the pipeline for conditions like depression and Alzheimer's disease.

Listener Request!  The YouTube channel Veritasium has been recognized by scientists and the public as a great source for scientific information. So what happened in the recent episode?  The episode originally entitled "Exposing the Monsanto Conspiracy" attempts to link the historic horrors of Agent Orange and contaminated herbicides with current claims against the herbicide glyphosate. To build the story this science channel relies on horrible sources and poor scholarship to build the illogical conclusion that because a company had a bad past, and anti-biotech activists and money-hungry lawyers build a narrative, then the herbicide must cause cancer. This, despite th...

Anti-vaccination activists, including the US Health and Human Services Secretary, decry the risk of vaccination. In two recently developed vaccines the emerging story is that there is risk in not being vaccinated.  Analysis of large data sets shows that over the last 20 years, those vaccinated with the HPV vaccine have a lower incidence of cervical, penile and anal cancers, as they should.  But they also show lower incidence of other cancers as well, such as lung, blood and nervous system cancers. The shingles vaccines seem to have protective effects against dementia, heart disease and stroke. All of thse findings su...

In this episode of the Talking Biotech podcast, Dr. Andrey Zarur, CEO of Greenlight Biosciences, discusses the innovative applications of RNA technology in agriculture. The conversation covers the challenges of food security, the role of RNA in pest control, and the regulatory advantages of RNA-based products. Dr. Zarur highlights the efficacy and safety of RNA insecticides, fungicides, and herbicides, as well as the company's efforts to address bee health. The discussion also touches on public perception and the importance of transparent communication in biotechnology.00:00Introduction to RNA and Its Role in Agriculture02:02Challenges...

SummaryIn this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Dr. Robert Tarone, a retired scientist with extensive experience in cancer statistics and experimental design. They discuss the controversial IARC monograph that classified glyphosate as a probable human carcinogen, the flaws in the evaluation process, and the implications of this classification on legal actions against glyphosate manufacturers. Dr. Tarone critiques the evidence used by IARC, emphasizing the lack of credible data linking glyphosate to cancer, and highlights the importance of rigorous scientific methodology in evaluating such claims.

In this episode of the Talking Biotech podcast, Kevin Folta and Dr. David Zaruk discuss the complexities surrounding glyphosate, particularly in light of the IARC Monograph 112 published a decade ago. They explore the implications of the reclassification of glyphosate as a probable carcinogen, the ensuing litigation, influence and corruption, and the ethical concerns regarding scientific integrity. The conversation delves into the role of the media, the influence of litigation finance, and the future of glyphosate in agriculture, emphasizing the need for transparency and evidence-based discussions over jury decisions.

This conversation explores the domestication of pigs, highlighting their importance in human society, the historical evidence of their domestication, and innovative research methods used to study their relationship with humans. Dr. Jiajing Wang from Dartmouth College discusses the significance of dental calculus in elucidaing pig diets and behaviors, as well as the complex interactions between humans and pigs throughout history.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta speaks with Dr. Pascal Geldsetzer about the relationship between the shingles vaccine and dementia. They discuss the prevalence of shingles, the current vaccination rates, and the potential implications of shingles vaccination on cognitive decline. The data come from a clever analysis of public health data that revealed this surprising result. Dr. Geldsetzer shares insights from his research, which suggests that the shingles vaccine may significantly reduce the risk of developing dementia. The conversation also covers the methodology behind the research, findings from various populations, and future directions for...

SummaryIn this episode of the Talking Biotech Podcast, Kevin Folta speaks with Maria Rodtersman, a Ph.D. candidate at UC Davis, about her research on developing wheat to reduce gluten content, specifically targeting immunogenic proteins that trigger celiac disease. They discuss the significance of wheat as a staple crop, the differences between celiac disease and gluten sensitivity, and the use of radiation-induced mutations, the old-school brute force genetic methods used to create wheat lines with lower immunogenicity. The conversation also covers the challenges of wheat's hexaploid nature, the testing of modified wheat for bread quality and...

The elucidation of DNA's structure led to questions about how it was replicated. Today's Talking Biotech Podcast commemorates the landmark experiments by Dr. Franklin Stahl, who died recently at the age of 95. The experiments have beed described as amont the most elegant in the history of biology, and used a simple test to determine the physical nature of DNA replication. This is a must-know story for the molecular biologist, and a spectacular example of a clever and definitive experiment for anyone that appreciates science. 

In this episode of the Talking Biotech Podcast, Dr. Kevin Folta discusses the challenges of misinformation in food science with Dr. Cami Ryan and registered dietitian Connie Diekman. They explore the role of social media and traditional media in spreading misinformation, the difficulties scientists face in communicating effectively, and the importance of peer review and other information-honing strategies to reinforce legitimate claims and de-fuse false information. The conversation emphasizes the need for better communication strategies, building trust with the public, and the necessity of teaching critical thinking and media literacy to consumers.

In this episode of the Talking Biotech Podcast (464) host Dr. Kevin Folta engages with journalist and author Michael Grunwald about his book 'We Are Eating the Earth.' They discuss the complex relationship between food production, climate change, and biotechnology, emphasizing the need for multifaceted solutions rather than single silver bullet approaches. Grunwald shares insights from his journey into understanding food production's impact on the environment, agroecology and regenerative farming, the challenges of public perception regarding biotechnology, and the importance of innovative practices in agriculture. The conversation also touches on the issues of food waste, biofuels, and the necessity...

In this episode of the Talking Biotech podcast, Dr. Roger Cone discusses the complexities of obesity and eating disorders, emphasizing the role of brain circuits in regulating feeding behaviors. He explains the significance of GLP-1 agonists and melanocortin receptors in developing therapeutic approaches for conditions like obesity, anorexia, and cachexia. The conversation highlights the potential of combining these therapies to enhance treatment efficacy and the implications for public health. But most importantly, the approaches offer potential new therapies to address anorexia and cachexia that may prove to be as effective as GLP1 agonists have been for addressing obesity. </p

This episode of the Talking Biotech podcast features Dr. Anita Shukla discussing the critical issue of antibiotic resistance and the innovative engineering solutions being explored to combat it. The conversation covers the evolutionary nature of antimicrobial resistance (AMR), the importance of antibiotics in healthcare, and the collaborative efforts of the Engineering Research Visioning Alliance (ERVA) to identify research priorities and strategies. Dr. Shukla emphasizes the need for novel therapeutic approaches, improved drug delivery systems, and the integration of advanced detection methods to address the growing challenge of AMR.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Dr. Sarah Taber, who shares her journey from agricultural consulting to running for Ag Secretary in North Carolina. It is mostly a story of dedication to changing the norms and changing the rules to benefit more farmers, trying to break deeply entrenched interests to create real change. The conversation explores the challenges facing North Carolina agriculture, the need for innovative ideas to shift from traditional crops to more profitable produce, and the political landscape that influences agricultural policies. Sarah discusses her motivations for running, the strategies she...

In this episode of the Talking Biotech podcast, Dr. Kevin Folta discusses the current state of avian influenza, particularly the H5N1 strain, its history, zoonotic potential, and the implications for both poultry and human health. Into 2025 it was being detected in wild birds,domestic flocks, cattle and humans. Where did it go?  He highlights the importance of surveillance, the impact of the virus on domestic poultry production, and the ethical concerns surrounding euthanization methods. Folta also explores potential solutions, including vaccination and transgenic strategies that go unused although they are known to be effective. Finally, what is the s...

This episode of the Talking Biotech podcast delves into the evolutionary significance and domestication history of corn (maize). Dr. Kevin Folta hosts a discussion with Regina Fairbanks and Dr. Jeffrey Ross-Ibarra from UC Davis, exploring the traits that enabled maize's domestication, the role of the TGA gene, and the implications for modern breeding. The conversation highlights the importance of understanding maize's genetic diversity and how modern tools may be used to unravel long standing questions about maize domestication.

In this episode of the Talking Biotech podcast, Kevin Folta and Luis Ventura discuss the recent constitutional ban on genetically engineered corn in Mexico. They explore the implications of this regulation, the disinformation surrounding it, and the challenges faced by Mexican farmers. The conversation also touches on the broader impact of this ban on biotechnology in Latin America and the potential economic consequences for trade between Mexico and the United States.

This conversation explores the complex relationship between corn and Mexico, focusing on its cultural, economic, and agricultural significance. The discussion highlights the moratorium on genetically engineered (GM; GMO) corn, the public perception of biotechnology, and the impact of environmental NGOs on policy decisions. The conversation also delves into the perspectives of farmers regarding the need for access to biotechnology and the implications of recent presidential decrees on corn production in Mexico.

This conversation explores the intersection of natural products and synthetic biology, emphasizing the importance of science communication and outreach. Julia Ball shares her passion for connecting the public with plant science, while Dr. Philip Zerbe discusses the potential of synthetic biology in producing valuable natural products, particularly terpenoids. The discussion highlights the challenges and opportunities in educating the public about biotechnology and the role of synthetic biology in sustainable drug production. In this conversation, Dr. Philipp Zerbe discusses the intersection of synthetic biology and natural products, focusing on the advancements in omics technologies and their role in bioactivity screening...

In this episode of the Talking Biotech podcast, Dr. Kevin Folta speaks with Steph van Grieken, CEO of Cradle, about the revolutionary intersection of AI and protein engineering. They discuss the central role of proteins in biological systems, the innovative software Cradle is developing to enhance protein design, and the implications of these advancements for therapeutics and industrial applications. The conversation also touches on the ethical considerations and potential misuse of this technology, as well as the future of AI in biology and its impact on environmental sustainability.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta discusses the introduction of the Purple Tomato by Norfolk Healthy Produce. Dr. Nathan Pumplin, CEO of Norfolk Healthy Produce, shares insights on the development, consumer reception, and regulatory landscape surrounding this innovative product. The conversation highlights the importance of consumer education and the potential for biotechnology to address health and nutritional needs. Dr. Pumplin discusses the technology and genetic engineering involved, the importance of plant breeding, and the health benefits associated with anthocyanins. He emphasizes the company's commitment to creating high-quality products while addressing public perceptions of GMOs...

Social media teems with false information about food and farming.  Influencers cover Instagram and Facebook with claims that food is poison and farmers are "dousing" crops in dangerous chemicals. It is a disinformation campaign that is founded on the fact that Americans make poor food and lifestyle choices, but instead of blaming our behaviors, they blame food and medicine, pushing bogus high-profit alternatives. But is there something nefarious here?  Has this online suspicion of our medical and food systems seeded by interests wishing to turn citizens against farmers and regulators, opting instead for fake alternatives and bogus nostrums?  It is...

In this episode of the Talking Biotech podcast, Kevin Folta interviews John Rizk, a pharmacist and epidemiologist, about M-Pox (formerly known as monkeypox). They discuss the emergence of M-Pox, its characteristics, transmission, symptoms, and recovery. The conversation also covers risk factors, diagnosis, vaccination strategies, treatment options, and the importance of health equity in access to vaccines. John emphasizes the need for more research and randomized control trials to better understand and manage M-Pox.

n this episode, Dr. Kevin Folta speaks with Joe Damond about the rapidly evolving landscape of life sciences, particularly focusing on gene and cell therapies. They discuss the exciting advancements in medical technology, the economic challenges associated with developing new therapies, and the implications for healthcare systems and patient access. The conversation also touches on the role of providers in administering these advanced treatments, the global disparities in access to innovative therapies, and the regulatory challenges that need to be addressed. Finally, they explore the potential of AI in transforming healthcare and the importance of ensuring equitable access to...