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PODCAST · health

The Human Upgrade: Biohacking for Longevity & Performance

by Dave Asprey

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger

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Episodes

  1. John Gray: Why Men Stop Wanting Their Wives : 1556

    The king is back! You probably recognize his name as the author of the famous book, Men Are From Mars, Women Are From Venus. But what's especially exciting is how John has evolved his insights to address the changing dynamics between men and women in the modern world, as he highlighted in his…

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  2. Sleep Expert: 80% of Sleep Problems Come From THIS : 1555

    Sleep Anxiety, Insomnia, Circadian Rhythms, Chronotypes, Sleep Trackers & How to Sleep Better with Dr. Michael Breus Host Dave Asprey sits down with Dr. Michael Breus, clinical psychologist, sleep specialist, and internationally recognized sleep expert known as The Sleep Doctor, to explore...

  3. The Science Behind Joint and Cartilidge Repair : 1554

    Explore Calroy's vascular health and joint support supplements, including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave Cartilage Regeneration, Joint Pain, Nitric Oxide, Blood Flow, Muscle Strength & Longevity with Kiran Krishnan Host Dave Asprey sits down with Kiran Krishnan,...

  4. Your Brain Has a Focus Switch (Here's How to Turn It On) : 1553

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ This video reveals that the brain has a documented neurological focus state driven by prefrontal cortex activation and norepinephrine…

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  5. Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552

    Infections Were Linked to About 1 in 8 Cancer Cases Worldwide A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B…

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  6. How to Unlock Psychic Abilities to Know When You’ll Die : 1551

    Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/ Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie Ryan Host Dave Asprey sits down with Julie Ryan, psychic, medical intuitive, inventor,...

  7. How to Live Healthier Without Obsessing Over Health : 1550

    Grab 20% off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E. Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr Host Dave Asprey sits down with Miranda Kerr, founder of KORA Organics, entrepreneur, model, and longtime wellness…

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  8. It's Boring, But It Slashed ALL My Visceral Fat In My 50s : 1549

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I'm in the best shape of my life, and it has nothing to do with working harder. In this video, I break down the 5 unconventional hacks that...

  9. Vagus Nerve Memory, Cat Cancer Genes, Inherited Intelligence, Mulberry Microbes, and Vitamin D : 1548

    Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts of the ear improved by an average of 3.2 points on a general cognitive test, compared…

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  10. Dave’s Anti-Aging Skincare Routine: Exosomes, Methylene Blue & NAD+ : 1547

    Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode. Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young Goose Host Dave Asprey sits down with Amitay Eshel and Anastasia Khodzhaeva,...

  11. The Silent Fatty Liver Epidemic: Why Thin, Sober People Are Still at Risk : 1546

    Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in...

  12. Every Way to Melt Visceral Fat FAST In 14 Minutes : 1545

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey This video explains the most effective ways to lose visceral fat,...

  13. Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more : 1544

    Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has not announced a hair-loss drug, clinical trial,...

  14. The Best Singular Hack To Change EVERYTHING About Your Life : 1543

    Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand...

  15. 15g Every Morning for Anti-Aging Mitochondria : 1541

    Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and Longevity Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. Could one of the oldest foods on Earth also be one of the most overlooked tools for mitochondrial health, brain function…

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  16. I Wasted 10 Years Stuck With Brain Fog Until I Learned This : 1540

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey If you're waking up exhausted, foggy, or inflamed and nothing seems to…

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  17. Teal Swan - Beyond the Veil of Ego, AI & Wisdom : 1539

    Back with another all-time classic. Teal's is one of those episodes I keep going back to because it was just that good. Now more than ever, we need to ask ourselves: what is the role of Ego? Do we need to worry about AI killing us? Is there hope for the future of our species? These are just a few...

  18. How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP! : 1538

    Dr. Michael Leon on Smell Training, Memory, Sleep, Alzheimer’s Risk, and Brain Longevity Your sense of smell may reveal more about your brain health than you realize, and stimulating it while you sleep may improve memory, sleep quality, and cognitive function. **Visit https://memoryair.com/ and…

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  19. Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537

    **Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!** At 53, Josh Duhamel says he feels better than he did in his 30s. Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood…

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  20. The Peptide Secrets to a Youthful Face : 1536

    Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent Cells Your skin is likely biologically older than you are, but new research suggests some of that aging may be reversible. **For Dave’s listeners only, visit oneskin.co/Dave for exclusive early...

  21. What 36 Hours Without Sugar Does to Your Body : 1535

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey This video walks you through the complete biological timeline of a…

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  22. New Seafood Superfood, Apple Watch Health Age, Botanical Drugs, Cannabis IQ, and Blueberries : 1534

    Sea Squirt Plasmalogens Show Brain And Aging Benefits In Old Mice Aged mice given purified plasmalogen supplements showed better memory performance, healthier synaptic structure, lower neuroinflammation, and increased signaling tied to neurite growth and synapse development, with treated mice…

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  23. Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533

    Dr. Karan Rajan on Fiber Fermentation, Sodium Myths, and What Your Poop Reveals About Disease Risk Your poop is more predictive than almost any other health signal, and you are flushing that data away every single day without a second look. Watch this episode on YouTube for the full video...

  24. If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey Most people fail to lose weight because they have a metabolic block…

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  25. Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531

    Raw Garlic "Ultimate Biohack" Trend Faces Scientific Scrutiny Raw garlic has gone viral as a morning ritual, with fans crushing a clove, mixing it with honey, and crediting it with everything from lower cholesterol and better insulin sensitivity to cleared acne, eliminated brain fog, and colds...

  26. Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530

    Jenny McCarthy on Reversing Autism, Healing Mold Toxicity, and the Biohacking Protocol Big Pharma Doesn't Want You to Know Back with another long one! Autism, mold poisoning, and cognitive decline share more root causes than most doctors admit, and this episode hands you the biohacking playbook…

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  27. 3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529

    The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks…

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  28. 7 Brain Compounds I Take For Superhuman Focus : 1528

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey The most powerful energy compounds aren't in your local supplement…

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  29. Change Your Morning, Change Your Life! Hal Elrod : 1527

    Starting your weekend off right, with the king of mindset. We had to replay this one because it's too goo not to! Meet a man who makes miracles happen. Today, I’m joined in the studio by Hal Elrod, author of the international bestseller The Miracle Morning and his newest book, The Miracle…

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  30. Learn THIS And You’ll Become Impossible To Trigger : 1526

    Jonny Miller on Nervous System Mastery, Grief, and Why High Performers Can't Afford to Stay Stuck in Their Heads Your nervous system is running every decision, relationship, and reaction in your life, and you won't notice how much it's costing you until something breaks. This episode gives you…

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  31. Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525

    Jim Kwik on Memory, AI, and Why Natural Intelligence Beats Artificial Intelligence Your brain is quietly outsourcing itself to AI, and you won't notice until it's gone. This episode gives you the exact framework to use artificial intelligence as a tool for brain optimization instead of a crutch...

  32. The Most Important Longevity Molecule I've Ever Found : 1524

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey Most people see the physical decline of aging as an inevitable process...

  33. The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523

    This Friday, I had to play back an all-time favorite. I was honored and grateful to bring you a conversation that I recorded in person with Gurudev Sri Sri Ravi Shankar at the Art of Living Center in Los Angeles. Gurudev Sri Sri Ravi Shankar is a leader of an international movement with more than...

  34. The Wild New Theory of Cancer (It's GOOD For You?) : 1522

    Quantum Scientist Patrick Coles Reveals How Tumors Protect Your Mitochondria From Toxic Overload Cancer might not be the enemy your doctor says it is. What if tumors are actually your body's emergency detox system, built on purpose to protect you from something far more dangerous? Watch this...

  35. Scream Cream and Weekly Injections (Double Episode) | Gabby Reece : 1521

    Dave Asprey and Gabby Reece Talk Testosterone Therapy, Scream Cream, Autism as a Superpower, Cancer Protocols, and Surviving Fame in This Double Interview Episode Mega-Episode time! Your hormones might be causing symptoms you've been blaming on aging, stress, or your heart. This double interview...

  36. It's Weird, But It Turns On Your Anti-Aging Switch : 1520

    Save Up To $600: SUNLIGHTEN.COM/DAVE Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this...

  37. Depressing Fruit, Vitamin (C)ancer, Sheep Wool, Oral GLP-1s, Endless Exercise, and more : 1519

    PhenoNet Cleared By FDA To Begin Phase 3 Trial Of Inhaled Alzheimer's Drug PhenoNet has received FDA clearance to begin a Phase 3 trial of PHENOGENE-1A, an inhaled formulation of cromolyn sodium, an asthma drug with decades of safety data. Unlike most Alzheimer's therapies, which target only…

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  38. Dave Solo Pod: The Original Smart Drug Masterclass : 1518

    Piracetam, Racetams & Nootropics: Dave Asprey on the Original Smart Drug, Brain Optimization and How to Biohack Memory, Focus and Cognitive Decline We're excited to bring you another Dave solo education masterclass, this one breaking down the molecule that started the entire nootropics industry:...

  39. Steven Greer | UAP’s and Remote Viewing Techniques for Non-Human Life : 1517

    UFOs, UAPs, Non-Human Contact & Zero-Point Energy: Dr. Steven Greer on Government Disclosure, Consciousness and the Truth About Extraterrestrial Intelligence Get ready to have your entire understanding of reality challenged. This episode reveals the science behind non-human intelligence contact,...

  40. 300mg Improves Appearance of Wrinkles In 7 Days (Study) : 1516

    This video reveals how your skin uses glutathione to defend itself, how Dr. Nayan Patel solved its delivery problem, and why his topical antioxidant serum was clinically shown to improve the appearance of fine lines, wrinkles, and skin tone in just 1 week. You’ll also learn: The molecule...

  41. Longevity Music, Anti-Aging Nasal Spray, How To Look 20, and more... : 1515

    Subtitle: A Nasal Spray Longevity Screen, Why Less Protein May Age You Better, Cadaver Skin Injectables, Art's Effect on Biological Age, and Which Anti-Aging Interventions Actually Move the Needle Nasal Spray Ingredient Emerges As Unexpected Longevity Candidate In Massive Drug Screen Researchers...

  42. Here's How You Can Have a 3-hour Orgasm (real!) : 1514

    The Orgasm Code: How Pleasure Rewires Your Nervous System for Longevity & Healing | Regena Thomashauer (Mama Gena) Most people think pleasure is a distraction from performance. This episode proves the opposite: your orgasm is a biohacking tool wired directly into your nervous system, your…

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  43. I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic : 1513

    The Gut-Lung Axis: The Missing Link in Chronic Inflammation & Aging | Dr. Vivek Lal Your lungs have a microbiome, and almost no one is talking about it. This episode reveals the hidden pathway behind asthma, chronic inflammation, and slow aging, and gives you a science-backed way to biohack your...

  44. I Wish I Knew This Anti-Aging Hack Sooner : 1512

    There is one molecule your body already makes that helps protect your cells from aging, but your production of it drops as you get older. In this video, I explain why glutathione is known as the body’s master antioxidant and why it plays a critical role in cellular defense, mitochondrial energy,...

  45. Chicken Diarrhea, TV Kills You Quicker, CO2 for Health, Deadly Hot Neighborhoods, and more... : 1511

    Viagra's Cancer Signal, TV's Toll on Your Brain, Heat and Accelerated Aging, and a New Way to Flush Your Brain Explained Viagra's Active Ingredient May Block Cancer From Spreading A study published in Cancer Research from the Weizmann Institute of Science, in collaboration with Clalit and the…

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  46. The $18 Million Pills Nobody Can Explain | Igniton : 1510

    Inside Igniton: The Quantum Supplement Science Boosting Memory, Sleep, and Longevity There's a subatomic particle most scientists don't even know exists, and one entrepreneur just spent $18 million building a private lab to prove it can upgrade your longevity, focus, and sleep. This episode goes...

  47. I Grew My Penis 2 Inches (What Works, And What Doesn't) | Alex Tatem : 1509

    Urologist Dr. Alex Tatum on Girth Enhancement, Testosterone, and Peptide Therapy Most men will never ask their doctor the questions this episode answers. From safe, non-surgical girth enhancement to daily testosterone dosing to the peptides fighting for FDA access right now, this conversation...

  48. Does This Sleep Fasting Hack Actually Cut Cortisol? : 1508

    You’ve probably tried everything to sleep better. Magnesium. Melatonin. Blackout curtains. Maybe even expensive sleep gadgets. But what if the real reason your sleep feels broken has nothing to do with any of those things? In this video, Dave Asprey explains a hidden biological process that...

  49. Diet Soda Brain Aging, Hidden Heart Attack Risk, New Cholesterol Pill, Lettuce Recall, and more... : 1507

    Artificial Sweeteners & Cognitive Decline, Myosteatosis on Coronary CT, Merck's Oral PCSK9 Inhibitor, Cyclospora Outbreak, Gut-Brain Synchronization, and the Banana Smoothie Mistake Explained Artificial Sweeteners Linked To 62% Faster Cognitive Decline In Landmark Brazilian Study A study tracking...

  50. The Toxin In Your Gut That's Slowly Killing You (here's the fix) : 1506

    Fix Leaky Gut, Boost Testosterone & Slash Endotoxins with Spore-Based Probiotics | Kiran Krishnan Your bad gut bacteria might be the reason your testosterone, your immune system, and even your sperm count are struggling, and most probiotics never survive long enough to fix it. This episode…

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ABOUT THIS SHOW

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger

HOSTED BY

Dave Asprey

Frequently Asked Questions

How many episodes does The Human Upgrade: Biohacking for Longevity & Performance have?

The Human Upgrade: Biohacking for Longevity & Performance currently has 1000 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.

What is The Human Upgrade: Biohacking for Longevity & Performance about?

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in...

How often does The Human Upgrade: Biohacking for Longevity & Performance release new episodes?

The Human Upgrade: Biohacking for Longevity & Performance releases new episodes frequently with a large back catalog of 1000 episodes. Check the episode list for recent publication dates.

Where can I listen to The Human Upgrade: Biohacking for Longevity & Performance?

You can listen to The Human Upgrade: Biohacking for Longevity & Performance on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.

Who hosts The Human Upgrade: Biohacking for Longevity & Performance?

The Human Upgrade: Biohacking for Longevity & Performance is created and hosted by Dave Asprey.
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