PODCAST · health
The IC Chat
by asper1971
Intended to help Interventional Cardiologists with critical appraisal of clinical trials
Episodes
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REBOOT PARADOX: Does TAVR Improve Outcomes in Paradoxical Low‑Flow, Low‑Gradient AS?
In this episode host Ashish Pershad reviews and critically appraises the REBOOT PARADOX randomized trial of TAVR versus optimal medical therapy in patients with paradoxical low‑flow, low‑gradient severe aortic stenosis. He summarizes trial design, patient selection, methods, and the challenges…
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Functional Angio vs. Angio-Only: AIR-STEMI and Culprit alone versus Complete PCI in STEMI with MVD
Host Ashish Pershad breaks down the AIR-STEMI (ARISTEMI) trial presented at ESC, explaining how physiology-guided (functional angiography) complete revascularization compares to angiography-guided approaches in STEMI patients with multivessel disease. He reviews study design, key results showing...
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LAA Occlusion vs DOACs: Meta-Analysis Sparks Debate and is IVL superior to RA for calcified lesions
Host Ashish Prasad critically appraises two important interventional cardiology studies: a Taiwanese meta-analysis of four randomized trials comparing left atrial appendage occlusion to DOACs, and the ICARE randomized trial comparing intravascular lithotripsy (IVL) with rotational atherectomy for...
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Leave Nothing Behind? The Real Story on Drug‑Eluting Balloons
In this episode of IC Chat, host Ashish Pershad reviews drug‑eluting balloons for coronary disease, appraising two landmark trials: AGENT‑IDE (in‑stent restenosis) and SOLUTION de novo (de novo lesions). He explains device pharmacology (paclitaxel vs. sirolimus), trial designs and results,...
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RESHAPE HF II vs COAPT & MITRAL‑FR: Unraveling the MitraClip Debate
Welcome to IC Chat with host Dr. Ashish Pershad. In this episode we examine the controversial role of transcatheter edge-to-edge mitral valve repair for functional mitral regurgitation, focusing on the COAPT, MITRAL‑FR and the newer RESHAPE Heart Failure II trials. We summarize trial differences…
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ORBITA CTO: The Sham-Controlled Trial That Shook CTO-PCI
In this episode host Ashish Pershad reviews the ORBITA CTO randomized, double-blind, sham-controlled trial that compared CTO-PCI to a placebo procedure, explaining the rigorous design, patient selection, masking methods, and statistical approach. Pershad summarizes the results showing significant...
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The IC CHAT episode 17 —Is the MFP necessary for all HR-PCI cases? CHIP-BCIS answers this very question
Host Dr. Ashish Pershad introduces IC Chat’s mission to help clinicians interpret evidence-based medicine and translate trial data into everyday patient care. In this episode he appraises the CHIP-BCIS-3 randomized trial (ACC 2026 / NEJM) comparing prophylactic microaxial flow pump (Impella)…
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CHAMPION‑AF Decoded: Watchman Flex vs DOACs
In this episode of ICChat, Dr. Ashish Pershad MD MS reviews and critiques the CHAMPION‑AF trial comparing Watchman Flex left atrial appendage occlusion to DOACs for atrial fibrillation. He explains the trial design, endpoints, and statistical choices, and contrasts the published results with...
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Long term TAVR data
Critical appraisal of the 6-year Evolut low risk trial data and a one on one with Steve Yakubov one of the senior authors on the paper for his take on TAVR adoption in low-risk patients
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IC CHAT Episode 13-SHORTCUT and VICTORY Trials
Appraisal of the SHORTCUT and VICTORY trials comparing IVL to CB and OPN balloons plus a bonus interview with Ajay Kirtane MD deconstructing the trials
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THE IC CHAT -CREST 2 Trial
A critical appraisal of the CREST 2 clinical trial 4-year outcomes comparing carotid revascularization with current medical therapy in asymptomatic patients with high grade carotid artery stenosis.
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The IC Chat -Encircle Trial
A critical appraisal of ENCIRCLE and a follow up interview with Encircle Co-PI David Daniels MD make for an interesting episode.
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IC CHAT episode 11 - Transcatheter treatment of pure AI
A Critical appraisal of dedicated TAVR valve trials for AI and a general overview of the status of AI treatment in 2025.
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IC Chat Episode 10 - BEV vs SEV in Bicuspid Aortic Valve Stenosis
A deep dive into bicuspid aortic valve stenosis and the choice of BEV vs SEV- A propensity matched observational study critically appraised.
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IC CHAT Episode 9- IVI in Contemporary PCI
A deep dive into 2 network metanalysis looking at IVI in contemporary PCI.
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IC Chat Episode 8- PLATO and all the controversy associated with it
A critical appraisal of PLATO (Ticagrelor versus Clopidogrel) and the recent controversies
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IC CHAT Episode 7 - TAP IT TRIAL
A decades long practice of routinely tapping effusions upfront in patients with heart failure is challenged with this simple and elegantly conducted clinical trial from Denmark. The TAP IT clinical trial is critically appraised in this month's edition of IC CHAT
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IC CHAT Episode 6- FAME 3 Clinical Trial
Critical appraisal of the FAME 3 Clinical Trial 5-year data presented at ACC 2025
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PROTECTED TAVI TRial
A critical appraisal of the Protected TAVI trial, comparing Cerebral Embolic Protection with standard of care for routine TAVR cases. Bibliography: 1. Kharbanda RK, Kennedy J, Jamal Z et al; BHF PROTECT-TAVI Investigators. Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve...
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IC Chat Episode 4 : TRISCEND 2
A critical appraisal of a RCT comparing transcatheter tricuspid valve replacement to medical treatment in patients with symptomatic severe tricuspid regurgitation.
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IC Chat Episode 3 DANGERSHOCK Trial
A critical appraisal of the DANGER SHOCK Trial comparing the micro-axial flow pump Impella CP with standard of care in patients with acute myocardial infarction complicated by cardiogenic shock
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IC CHAT Episode 2
A critical appraisal of the OPTION trial comparing a strategy of AF ablation plus LAAO versus AF ablation plus DOACS.
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IC Chat - Episode 1: Early TAVR
An opportunity for practicing Interventional Cardiologists to critically appraise the Early TAVR trial - A strategy trial comparing TAVR to clinical surveillance in asymptomatic patients with severe Aortic valve stenosis. This podcast is intended for health care professionals and practicing...
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Frequently Asked Questions
How many episodes does The IC Chat have?
The IC Chat currently has 23 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is The IC Chat about?
Intended to help Interventional Cardiologists with critical appraisal of clinical trials
How often does The IC Chat release new episodes?
The IC Chat has 23 episodes. Check the episode list to see recent publication dates and frequency.
Where can I listen to The IC Chat?
You can listen to The IC Chat on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts The IC Chat?
The IC Chat is created and hosted by asper1971.
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