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PODCAST · science

The Journal Club

by Tom Jaramillo

Stay on the cutting edge of science without reading every journal. The Journal Club is an AI-generated podcast powered by Google Notebook LM that delivers smart, engaging discussions on the latest research published in top-tier journals like Science, Nature Neuroscience, Cell, and more. Each episode synthesizes emerging scientific findings into concise, thought-provoking commentary—designed for researchers, students, and science enthusiasts who want to stay informed without the information overload.

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Episodes

  1. The Science of Chocolate

    Gopaulchan, D., Moore, C., Ali, N. et al. A defined microbial community reproduces attributes of fine flavour chocolate fermentation. Nat Microbiol (2025). https://doi-org.ccmain.ohionet.org/10.1038/s41564-025-02077-6

  2. Molecular Mechanisms Underlying Fear Learning and Memory

    mWAKE in the Central Amygdala Regulates Fear Learning and MemoryJiali Xiong, Anuradha Mehta, Qiang Liu, Anna X. Luo, Pan P. Li, Patricia H. Janak, Mark N. WuJournal of Neuroscience 20 August 2025, e0225252025; DOI: 10.1523/JNEUROSCI.0225-25.2025

  3. Your Brain's Invisible Shield: How Anticipation Primes Your Immune System

    Trabanelli, S., Akselrod, M., Fellrath, J. et al. Neural anticipation of virtual infection triggers an immune response. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-02008-y

  4. Pancreas-Brain Feedback in Bipolar and Depression

    Liu, YN., Wang, QW., She, XY. et al. A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-02040-y

  5. AMPA Receptor Activity and Myelinated Axon Loss in Neuroinflammation

    Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation

  6. Targeting AMPA Receptors to Restore Synapses in Autoimmune Demyelination

    Mey GM, Evonuk KS, Shelestak J, Irfan M, Wolfe LM, Laye SE, Schafer DP, DeSilva TM. Inhibiting AMPA receptor signaling in oligodendrocytes rescues synapse loss in a model of autoimmune demyelination. iScience. 2024 Oct 22;27(11):111226

  7. The use of behavioral test batteries: effects of training history

    McIlwain KL, Merriweather MY, Yuva-Paylor LA, Paylor R. The use of behavioral test batteries: effects of training history. Physiol Behav. 2001 Aug;73(5):705-17.

  8. Human CLOCK's Role in Cognitive Flexibility

    Liu, Y., Fontenot, M.R., Kulkarni, A. et al. Human CLOCK enhances neocortical function. Nat Neurosci (2025)

  9. Unlocked a New Method of Treating Alzheimer's Disease and other Cognitive Decline

    Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction

  10. The Neural Circuit Governing Sleep Homeostasis

    Lee SS, Liu Q, Cheng AHR, Kim DW, Boudreau DM, Mehta A, Keles MF, Fejfer R, Palmer I, Park KH, Münzberg H, Harris TD, Graves AR, Blackshaw S, Wu MN. Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep. Science. 2025 Jun 19

  11. Olfactory Bulb and Memory Dysfunction in Neuropsychiatric Disorders

    Parbst F, Kostka JK, Günther A, Chen YN, Hanganu-Opatz IL, Bitzenhofer SH. Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-Challenged Disc1+/- Mice. J Neurosci. 2025 Jun 18

  12. SCN GRPNs: Modulatory Role in Circadian Photic Entrainment

    Li R, Inoue R, Mori H, Hirano A, Sakurai T. Functional Roles of Gastrin-Releasing Peptide-Producing Neurons in the Suprachiasmatic Nucleus: Insights into Photic Entrainment and Circadian Regulation. J Neurosci. 2025 Jun 18

  13. Hippocampal Ripples Decrease During Physical Actions in Rodents

    Sakairi T, Kawabata M, Rios A, Sakai Y, Isomura Y. Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents. J Neurosci. 2025 Jun 18

  14. DDX3X Mutations: Sex-Specific Effects on Brain Development

    Mossa, A., Dierdorff, L., Lukin, J. et al. Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X. Nat Commun 16, 4512 (2025)

  15. Autism and Social Avoidance: Neural Circuitry of Touch Discrimination

    Chari, T., Hernandez, A., Couto, J. et al. A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism. Nat Commun 16, 4600 (2025). https://doi.org/10.1038/s41467-025-59852-6

  16. Autism associated Chd8 Gene Duplication and Neurodevelopmental Defects in Mice

    Kawamura, A., Fujii, K., Tamada, K. et al. Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice. Nat Commun 16, 4641 (2025). https://doi.org/10.1038/s41467-025-59853-5

  17. Precision nutrition for Cardiometabolic Diseases

    Guasch-Ferré, M., Wittenbecher, C., Palmnäs, M. et al. Precision nutrition for cardiometabolic diseases. Nat Med 31, 1444–1453 (2025)

  18. Health impacts of exposure to synthetic chemicals in food

    Muncke, J., Touvier, M., Trasande, L. et al. Health impacts of exposure to synthetic chemicals in food. Nat Med 31, 1431–1443 (2025)

  19. How you breathe is like a fingerprint that can identify you

    Soroka T, Ravia A, Snitz K, Honigstein D, Weissbrod A, Gorodisky L, Weiss T, Perl O, Sobel N. Humans have nasal respiratory fingerprints. Curr Biol. 2025 May 30

  20. Microbiome Signatures of Parkinson’s Disease Revealed Through AI

    Romano, S., Wirbel, J., Ansorge, R. et al. Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease. Nat Commun 16, 4227 (2025)

  21. Climate Change Linked to Sleep Apnea

    Lechat, B., Manners, J., Pinilla, L. et al. Global warming may increase the burden of obstructive sleep apnea. Nat Commun 16, 5100 (2025)

  22. Neural Flexibility: A Possible Autism Intervention

    Watanabe, T., Yamasue, H. Noninvasive reduction of neural rigidity alters autistic behaviors in humans. Nat Neurosci 28, 1348–1360 (2025)

  23. How Exercise Rewires the Brain

    da Rocha, J.F., Lance, M.L., Luo, R. et al. Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing. Nat Neurosci (2025).

  24. Why don’t bats get cancer?

    Athar, F., Zheng, Z., Riquier, S. et al. Limited cell-autonomous anticancer mechanisms in long-lived bats. Nat Commun 16, 4125 (2025)

  25. Psilocybin Remodels Cortical Neurons and Behavior

    Shao, LX., Liao, C., Davoudian, P.A. et al. Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors. Nature 642, 411–420 (2025)

  26. Why a Boy Could Not Feel Pain

    CRISPR helps to show why a boy felt no pain. Nature. 2025 Jun; Antunes FTT, Gandini MA, Garcia-Caballero A, Huang S, Ali MY, Gambeta E, Souza IA, Harding EK, Ferron L, Stray-Pedersen A, Gadotti VM, Zamponi GW. A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to...

  27. How to keep weight off after obesity drugs

    Nature 11 June 2025 How to keep weight off after obesity drugs by Elie Dolgin Rodriguez, P. J. et al. JAMA Netw. Open 8, e2457349 (2025). Eisenberg, D. et al. Surg. Obes. Relat. Dis. 18, 1345–1356 (2022) Itani, M. I. et al. Obes. Surg. 32, 381–390 (2022). Maselli, D. B. et al. Gastroenterology…

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  28. World first: brain implant lets man speak with expression ― and sing

    Nature 11 June 2025 World first: brain implant lets man speak with expression ― and sing by Miryam Naddaf Singer-Clark T, Hou X, Card NS, Wairagkar M, Iacobacci C, Peracha H, Hochberg LR, Stavisky SD, Brandman DM. Speech motor cortex enables BCI cursor control and click. J Neural Eng. 2025 May 14

  29. Emergence and Development of a Gender Gap in Mathematics

    Martinot, P., Colnet, B., Breda, T. et al. Rapid emergence of a maths gender gap in first grade. Nature (2025)

  30. Changes in the auditory cortex of children receiving gene therapy for deafness.

    Changes in the auditory cortex of children receiving gene therapy for deafness. Nat Hum Behav (2025).

  31. How Single Neurons in the Amygdala and Hippocampus encode face identity

    Cao, R., Wang, J., Lin, C. et al. Feature-based encoding of face identity by single neurons in the human amygdala and hippocampus. Nat Hum Behav (2025)

  32. Identical Twins, Unequal Outcomes: The Genetics of Sensitivity

    Assary, E., Coleman, J.R.I., Hemani, G. et al. Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes. Nat Hum Behav (2025)

  33. Ozempic, Mounjaro & the Drop-Off Effect: What the Data Says

    Gasoyan H, Butsch WS, Schulte R, Casacchia NJ, Le P, Boyer CB, Griebeler ML, Burguera B, Rothberg MB. Changes in weight and glycemic control following obesity treatment with semaglutide or tirzepatide by discontinuation status. Obesity (Silver Spring). 2025 Jun 10

  34. Popular Sugar Substitute May Impair Brain Blood Vessel Health

    Berry AR, Ruzzene ST, Ostrander EI, Wegerson KN, Fersiva NO, Stone MF, Valenti WB, Izaias JE, Holzer JP, Greiner JJ, Garcia VP, DeSouza CA. The Non-Nutritive Sweetner Erythritol Adversely Affects Brain Microvascular Endothelial Cell Function. J Appl Physiol (1985). 2025 Jun 3

  35. Breakthrough for HIV cure using mRNA-based T cell therapeutics

    Cevaal, P.M., Kan, S., Fisher, B.M. et al. Efficient mRNA delivery to resting T cells to reverse HIV latency. Nat Commun 16, 4979 (2025)

  36. Iron Deficiency Leads to Mouse Sex Reversal

    Okashita, N., Maeda, R., Kuroki, S. et al. Maternal iron deficiency causes male-to-female sex reversal in mouse embryos. Nature (2025).

  37. Is Myelin a Source of Energy During a Marathon?

    Ramos-Cabrer, P., Cabrera-Zubizarreta, A., Padro, D. et al. Reversible reduction in brain myelin content upon marathon running. Nat Metab 7, 697–703 (2025)

  38. Excessive Oliec Acid in Olive Oil Drives Fat Cell Growth

    Wing A, Jeffery E, Church CD, Goodell J, Saavedra-Peña RDM, Saha M, Holtrup B, Voisin M, Alavi NS, Floody M, Wang Z, Zapadka TE, Garabedian MJ, Varshney R, Rudolph MC, Rodeheffer MS. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Rep. 2025 Apr 22

  39. Flush Out Alzheimer's Toxins

    Chen K, Morizawa YM, Nuriel T, Al-Dalahmah O, Xie Z, Yang G. Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau. Neuron. 2025 May 19

  40. Why Casinos use blue light

    Lander, A.C., Burge, M.T., Thomas, B.G. et al. Circadian photoreception influences loss aversion. Sci Rep 15, 13051 (2025)

  41. Early exposure to dogs could help protect against eczema

    Standl M, Budu-Aggrey A, Johnston LJ, Elias MS, Arshad SH, Bager P, Bataille V, Blakeway H, Bønnelykke K, Boomsma D, Brumpton BM, Bustamante Pineda M, Campbell A, Curtin JA, Eliasen A, Fadista JPS, Feenstra B, Gerner T, Medina-Gomez C, Grosche S, Gutzkow KB, Halling AS, Hayward C, Henderson J,...

  42. Daily mango may support postmenopausal woman's health

    Holt RR, Ho E, Li X, Fam VW, Hedayati N, Keen CL, Charoenwoodhipong P, Hackman RM. Short-Term Cardiometabolic Response to Mango Intake in Postmenopausal Women. J Am Nutr Assoc. 2025 Mar 19

  43. Brain Uses Separate Synapses to Balance Learning and Stability

    Yang Y, Wong MH, Huang X, Chiu DN, Liu YZ, Prabakaran V, Imran A, Panzeri E, Chen Y, Huguet P, Kunisky A, Ho J, Dong Y, Carter BC, Xu W, Schlüter OM. Distinct transmission sites within a synapse for strengthening and homeostasis. Sci Adv. 2025 Apr 11

  44. Functional polymorphism of CYCLE underlies the diapause variation in moths

    Zheng S, Wang Y, Li G, Qin S, Dong Z, Yang X, Xu X, Fang G, Li M, Zhan S. Functional polymorphism of CYCLE underlies the diapause variation in moths. Science. 2025 May 29

  45. The Architecture of Enduring Emotion and Anxiety's Origins

    Hanson MA, Gluckman PD. Growing anxious-Are preschoolers matched to their futures? Science. 2025 May 29

  46. Conserved brain-wide emergence of emotional response from sensory experience in humans and mice

    Kauvar I, Richman EB, Liu TX, Li C, Vesuna S, Chibukhchyan A, Yamada L, Fogarty A, Solomon E, Choi EY, Mortazavi L, Chau Loo Kung G, Mukunda P, Raja C, Gil-Hernández D, Patron K, Zhang X, Brawer J, Wrobel S, Lusk Z, Lyu D, Mitra A, Hack L, Luo L, Grosenick L, van Roessel P, Williams LM, Heifets…

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  47. The organ farm

    Cohen J. The organ farm. Science. 2025 May 29

  48. Brain-Wide Reinforcement Learning Through Cortical Oscillation

    Yoshida T, Sugino H, Yamamoto H, Tanno S, Tamura M, Igarashi J, Isomura Y, Hira R. Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia. J Neurosci. 2025 Apr 22

  49. Leptin Directs Motor Control Through Dopamine Pathways

    Mancini M, Hikima T, Witkovsky P, Patel JC, Stone DW, Affinati AH, Rice ME. Leptin activates dopamine and GABA neurons in the substantia nigra via a local pars compacta-pars reticulata circuit. J Neurosci. 2025 Mar 24

  50. Mef2c Guides Callosal Axon Targeting by Regulating Ephrin Repulsion

    Sudarsanam S, Guzman-Clavel LE, Dar N, Ziak J, Shahid N, Jin XO, Kolodkin AL. Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion. J Neurosci. 2025 May 21

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ABOUT THIS SHOW

Stay on the cutting edge of science without reading every journal. The Journal Club is an AI-generated podcast powered by Google Notebook LM that delivers smart, engaging discussions on the latest research published in top-tier journals like Science, Nature Neuroscience, Cell, and more. Each episode synthesizes emerging scientific findings into concise, thought-provoking commentary—designed for researchers, students, and science enthusiasts who want to stay informed without the information overload.

HOSTED BY

Tom Jaramillo

CATEGORIES

science

Frequently Asked Questions

How many episodes does The Journal Club have?

The Journal Club currently has 250 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.

What is The Journal Club about?

Stay on the cutting edge of science without reading every journal. The Journal Club is an AI-generated podcast powered by Google Notebook LM that delivers smart, engaging discussions on the latest research published in top-tier journals like Science, Nature Neuroscience, Cell, and more. Each...

How often does The Journal Club release new episodes?

The Journal Club publishes regularly with 250 episodes available. Check the episode list for the typical release schedule.

Where can I listen to The Journal Club?

You can listen to The Journal Club on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.

Who hosts The Journal Club?

The Journal Club is created and hosted by Tom Jaramillo.
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