All Episodes
No Priors: Artificial Intelligence | Technology | Startups — 168 episodes
Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown
Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
We Need An Ecosystem in AI, And Every Company Can Win A Place In It
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott
The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire
AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari
From SaaS to AI-First: How Companies Are Reshaping Innovation
Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe
Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki
Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming
No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai
AI and the Future of Warfare with US Under Secretary of War Emil Michael
NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative
The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad Gil
The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati Staniszewski
Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra
Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi
How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara
Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy
The Best of 2025 (So Far) with Sarah Guo and Elad Gil
Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd
Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell
Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman
The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora
Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang
Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI
A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler
Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg
How Agentic AI is Transforming The Startup Landscape with Andrew Ng
Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel
The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince
America’s Plan to Dominate the Full AI Stack with Sriram Krishnan
The Power of Quality Human Data with SurgeAI Founder and CEO Edwin Chen
Asimov: Building An Omniscient RL Oracle with ReflectionAI’s Misha Laskin
Why Platforms Win and Point Solutions Fail with Rippling CEO Parker Conrad
Chai-2: The AI Model Accelerating Drug Discovery with Chai Discovery Co-Founders Jack Dent and Joshua Meier
Meet AlphaEvolve: The Autonomous Agent That Discovers Algorithms Better Than Humans With Google DeepMind’s Pushmeet Kohli and Matej Balog
The Operating System for Self Driving Cars (and Tanks, and Trucks...) With Qasar Younis and Peter Ludwig of Applied Intuition
Will we have Superintelligence by 2028? With Anthropic’s Ben Mann
Teaching AI to Understand the Physical World, with Dr. Fei-Fei Li of World Labs
AI Consolidation, Biotech Opportunities, and World Models with Sarah and Elad
AI is Making Enterprise Search Relevant, with Arvind Jain of Glean
Gaming as the Future of Education with Duolingo CEO Luis von Ahn
O3 and the Next Leap in Reasoning with OpenAI’s Eric Mitchell and Brandon McKinzie
Inside Deep Research with Isa Fulford: Building the Future of AI Agents
Predicting the Earth with Josh Goldman: How KoBold Uses AI to Find Critical Minerals
From Job Displacement to AI Trainers, Brendan Foody on Work in the AI Age
Public Markets, Image Gen, and Specialized Models, with Sarah and Elad
Conversations Are the Source of Truth in Healthcare with Abridge CEO Shiv Rao
The Robotics Revolution, with Physical Intelligence’s Cofounder Chelsea Finn
Copilot, Agent Mode, and the New World of Dev Tools with GitHub’s CEO Thomas Dohmke
National Security Strategy and AI Evals on the Eve of Superintelligence with Dan Hendrycks
Building the Platform for Scientific Breakthrough, with Noubar Afeyan of Moderna and Flagship Pioneering
Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio with Vevo Therapeutics and the Arc Institute
Building Hard Tech in Hard Markets: Kyle Vogt on Cruise, Twitch, and The Bot Company
How Harvey AI is Changing the Legal Industry with Winston Weinberg
DeepSeek, Deep Research, and 2025 Predictions with Sarah and Elad
Rick Caruso on LA’s Wildfires, Policy Failures, and the Path Forward
What Can We Do About Wildfires? With Convective Capital’s Bill Clerico
How AI Agents Are Transforming Customer Support, with Decagon’s Jesse Zhang
Erik Bernhardsson on Creating Tools That Make AI Feel Effortless
The Best of 2024 with Sarah Guo and Elad Gil
Revolutionizing Customer Success with Agency’s Elias Torres
How Diamond Cooling Could Power the Future of AI, with Akash Systems
Bolt’s Eric Simons on Enabling Everyone to Generate Websites with AI
Model Plateaus and Enterprise AI Adoption with Cohere's Aidan Gomez
AI and the Future of Math, with DeepMind’s AlphaProof Team
NVIDIA's Jensen Huang on AI Chip Design, Scaling Data Centers, and his 10-Year Bets
Forecasting the Future with Kalshi: America’s First Regulated Prediction Market
Waymo’s Journey to Full Autonomy: AI Breakthroughs, Safety, and Scaling
Gaming, Nobel Prizes and At-Risk Businesses in the AI Era
Launching AI products with Braintrust’s CEO Ankur Goyal
The Sheriff of Silicon Valley: Lina Khan’s FTC agenda for M&A, AI Acquisitions, and Non-Competes
Using AI to evaluate employee performance with Rippling’s COO Matt MacInnis
Transforming Customer Service through Company Agents, with Sierra’s Bret Taylor
Future of LLM Markets, Consolidation, and Small Models with Sarah and Elad
The Road to Autonomous Intelligence with Andrej Karpathy
Building toward a bright post-AGI future with Eric Steinberger from Magic.dev
Cloud Strategy in the AI Era with Matt Garman, CEO of AWS
The marketplace for AI compute with Jared Quincy Davis from Foundry
How AI can help build smarter systems for every team with Eric Glyman and Karim Atiyeh of Ramp
Innovating Spend Management through AI with Pedro Franceschi from Brex
Google DeepMind's Vision for AI, Search and Gemini with Oriol Vinyals from Google DeepMind
Low-Code in the Age of AI and Going Enterprise, with Howie Liu from Airtable
How AI is opening up new markets and impacting the startup status quo with Sarah Guo and Elad Gil
The Best of 2024 (so far) with Sarah Guo and Elad Gil
State Space Models and Real-time Intelligence with Karan Goel and Albert Gu from Cartesia
Can AI replace the camera? with Joshua Xu from HeyGen
How the ARC Prize is democratizing the race to AGI with Mike Knoop from Zapier
The evolution and promise of RAG architecture with Tengyu Ma from Voyage AI
How YC fosters AI Innovation with Garry Tan
The Data Foundry for AI with Alexandr Wang from Scale
Music consumers are becoming the creators with Suno CEO Mikey Shulman
Context windows, computer constraints, and energy consumption with Sarah and Elad
Cognition’s Scott Wu on how Devin, the AI software engineer, will work for you
OpenAI’s Sora team thinks we’ve only seen the "GPT-1 of video models"
The Future of AI Artistry with Suhail Doshi from Playground AI
Hyperscaler strategy in AI, the application landscape heats up, and what we know now about agents with Sarah and Elad
The argument for humanoid AI robots with Brett Adcock from Figure
Open sourcing AI app development with Harrison Chase from LangChain
Speed will win the AI computing battle with Tuhin Srivastava from Baseten
Designing the Future: Dylan Field on AI, Collaboration, and Independence
Big tech earnings and the current AI debates, with Sarah Guo and Elad Gil
Competition makes for better chip design with AMD CTO Mark Papermaster
Improving search with RAG architecture with Pinecone CEO Edo Liberty
RAG is the key for smarter productivity tools with Notion CEO Ivan Zhao
Build AI products at on-AI companies with Emily Glassberg Sands from Stripe
The Copilot for Ecommerce with Shopify VP of Core Product Glen Coates
Building the factories of the future with Covariant CEO Peter Chen
Coding in Collaboration with AI with Sourcegraph CTO Beyang Liu
A No Priors clip show: the best of 2023
The case for AI optimism
How AI can help small businesses
AI is the new enterprise UI with Clara Shih, CEO Salesforce AI
Open AI leadership shuffle, new diffusion models, and starting the cult of Q*
AI Agents That Reason and Code with Imbue Co-Founders Kanjun Qiu and Josh Albrecht
Mistral 7B and the Open Source Revolution With Arthur Mensch, CEO Mistral AI
What is Digital Life? with OpenAI Co-Founder & Chief Scientist Ilya Sutskever
AI Threats & Opportunities in Cyber Security With Material Security Co-Founder Ryan Noon
What Google Cloud Can Teach Enterprises Developing & Rolling Out AI Tools, With Kawal Gandhi
From App to Suite to Platform, with HubSpot's Co-Founder Brian Halligan
EModel Quality, Fine Tuning & Meta Sponsoring Open Source Ecosystem
If DNA is Code, Can AI Help Write It? Scaling Cell Programming and Synthetic Biology, with Ginkgo Bioworks Co-founder and CEO Jason Kelly
How Replit’s AI Tools are Changing Software Development with Co-founder and CEO Amjad Masad
EThe Intersection of AI and Blockchain, with Transformers author and NEAR founder Illia Polosukhin
The World’s Largest AI Processor with Cerebras CEO Andrew Feldman
AI Superpowers for Frontend Developers, with Vercel Founder/CEO Guillermo Rauch
AI-Powered Biological Software with Jakob Uszkoreit, CEO of Inceptive
The AI Tutor For Every Child and the Next Frontier of Education, From Khan Academy’s Creator Sal Khan
Listener Q&A: 2024 Tech Market Predictions, Long Term Implications of Today’s GPU Crunch, and Will AI Agents Bring Us Happiness?
Eradicating Machine Learning Pain Points with Weights & Biases CEO Lukas Biewald
How Palantir’s AI Bet is Revolutionizing Defense and Beyond, with CTO Shyam Sankar
The Timeline for Realistic 4-D: Devi Parikh from Meta on Research Hurdles for Generative AI in Video and Multimodality
Bringing AI to the Data Cloud, with Snowflake's CEO Frank Slootman
What's for Dinner? AI-Driven Commerce with Instacart CEO Fidji Simo
What happens to Observability If Code is AI-Generated? The Potential for AI in DevOps, with Datadog Co-founder/CEO Olivier Pomel
Listener Q&A: AI Misconceptions, The Reality of Regulation, Infinite Context, Incumbent AI Execution and Startup Ideas
AI & Defense Technology with Anduril CEO Brian Schimpf
Going Full Send on AI, and the (Positive) Impact of AI on Jobs, with Kevin Scott, CTO of Microsoft
The AI Will See You Now: Exploring Biomedical AI and Google’s Med-PaLM2 With Karan Singhal
Will Everyone Have a Personal AI? With Mustafa Suleyman, Founder of DeepMind and Inflection
Personalizing AI Models with Kelvin Guu, Senior Staff Research Scientist, Google Brain
Listener Q&A: AI Investment Hype, Foundation Models, Regulation, Opportunity Areas, and More
The Computing Platform Underlying AI, with Jensen Huang, Founder & CEO of NVIDIA
Your AI Friends Have Awoken, With Noam Shazeer
The Future is Small Models, with Matei Zaharia, CTO of Databricks
What’s Beyond GitHub Copilot? With Copilot's Chief Architect and founder of Minion.AI Alex Graveley
How do we go from search engines to answer engines? With Perplexity AI’s Aravind Srinivas and Denis Yarats
What is the future of search? With Neeva’s Sridhar Ramaswamy
What is the role of academia in modern AI research? With Stanford Professor Dr. Percy Liang
How AI can make drug discovery fail less, with Daphne Koller from Insitro
Why the Future of Machine Learning is Open Source with Huggingface’s Clem Delangue
Founder Stories: What’s behind the largest commercial autonomous system on earth? With Zipline’s Keller Rinaudo Cliffton
How can we make sure that everyone has access to AI? Can small models outperform large models? With Stability AI’s Emad Mostaque
What does AI-powered content creation look like? with Runway ML’s Cristobal Valenzuela
The bot Cicero can collaborate, scheme and build trust with humans. What does this mean for the next frontier of AI? With Noam Brown, Research Scientist at Meta
This is “No Priors”