All Episodes
The Bio Report — 636 episodes · page 2 of 7
Targeting the Dark Matter of the Genome to Treat Diseases
Using AI to Discover Small Molecule Alternatives to Biologics
A BET on a Novel Approach to Treat Autoimmune Conditions
Cell Therapies that Can Do a Solid for People with Cancer
Going to Extremes to Discover New Drugs
Targeting Senescent Cells to Treat Aging-Related Diseases
Bringing Cellular Diversity into Sharper Focus
Developing Cancer Therapies for When Damage Control Goes Awry
Delivering the Goods
Swimming in the New Oil
Does This Drug Represent “A Paradigm Shift for Small Molecule Drug Development?”
Exploring the Promise and Peril of CRISPR
Transforming Protein Engineering with Generative AI
Delivering Peptide Therapies Orally
Creating A Drug Delivery ARMMs Race
A Seek and Destroy Approach to Disease-Causing Proteins
Teaching Tolerance to Address Autoimmune Diseases
A Bet That the Next Blockbuster May Already Be Inside You
A Big Mac Attack to Fight Cancer
Getting Animated about Bioliteracy
Reshaping Clinical Trial Designs with Real-World Data
Using Generative AI to Produce Precise Gene Editors
Enabling the Nervous System to Repair Itself
Overcoming Barriers to Delivering Large Molecules to the Brain
Developing Complex Therapies to Tackle Complex Diseases
How Solving a Problem with Genetic Medicines May Solve Another with Infectious Diseases
Boosting the Power of Dendritic Cancer Vaccines
Overcoming Resistance in Cancer with Chemistry
Teaching an Old Drug a New Trick to Prevent Lyme Disease
A New Class of Cell Therapies to Target Solid Tumors
Targeting the Tumor Microenvironment with Lipid-Based Immunotherapies
A Company Born from a Father Who Wore His Heart on His Sleeve
Using AI to Improve Burn Care
A Home for Biotech in the City that Never Sleeps
Biopharma R&D Growing Stronger
The Benefits of Having a Multitude of Cins
Making ADCs Smarter and Safer with a Simple Twist of Fate
Targeting a Natural Repair System to Restore Brain Health
Programing Cells in a Predictable and Scalable Way
Why DNA May Be the Data Storage Medium of the Future
Scouring Genetic Variation within Our Cells for Drug Targets
Correcting Gene Dysregulation to Treat Diseases
Using Technology to Regain Abilities after Spinal Cord Injury
Why Drug Developers Have a Growing Interest in Targeting Mitochondria
Beefing Up Computational Muscle to Understand Molecular Activity of Drug Candidates
Targeting a Multitude of CIN in Cancer Cells
The Year in Biotech and What’s Ahead in 2024
Transforming Healthcare with Data
Realizing the Promise of IL-2 Therapies with AI
Unlocking Real-World Data to Improve Outcomes
A Silicon Valley Entrepreneur Investing at the Intersection of Tech and Biotech
A Company Betting Its Physics-Based AI Will Fuel a Quantum Leap in Drug Discovery
Detecting Alzheimer’s Disease Early through a Blood Test
Addressing Supply-Chain Challenges Underlying Drug Shortages with Synthetic Biology
Building Better and More Affordable Vaccines
Overcoming Resistance to Targeted Therapies
Using Tumor Gene Therapy to Overcome Barriers to Immunotherapies
Using AI to Generate Mini-Protein Therapeutics
Inhibiting Cell Death to Preserve Vision in Retinal Diseases
Leveraging Generative AI to Design Therapeutic Antibodies
Managing Pain without Addiction
Using AI to Match Cancer Patients to their Best Treatment Options
A Venture Capitalist’s View of the Current Biotech Landscape
Realizing the Therapeutic Potential of Cytokines by Making them Context Dependent
Targeting Cancer and Autoimmune Conditions with Donor-Derived EBV T Cells
Reprogramming the Tumor Microenviroment to Activate an Immune Response
Making Safer and More Effective Vaccines with Targeted mRNA
Addressing a Global Need with RNA Vaccines and Immunotherapies
Targeting Bacteria in Chronic Diseases
Targeting Solid Tumors with Off-The-Shelf CAR T Therapies
Reimagining the Development of Immunotherapies with a Venture Studio
Repairing the Body with Advanced Cell Therapies
Achieving Precision with AI Pathology
Inducing Potent and Durable T Cell Responses to Fight Disease
Developing Immunotherapies that Target the Drivers of Cancer
Using Phase 0 Trials to Bring Precision Medicine to Treating Brain Tumors
Restoring Feeling and Function to Damaged Nerves
Enlisting Vaccines in the Fight Against Chronic Diseases
Extending the Reach of Protein Degradation Therapies
Growing the Bioeconomy
Developing Targeted Therapies to Address Resistance in Cancer
It Takes a Village
Bringing Stick-to-itiveness to Regenerative Medicine
A Biopharma Downturn or Return to Trend
Treating Aging-Related Disease by Targeting Molecular Drivers of Aging
Engineering Better Cell Therapies for Cancers
Targeting a Regulator of Inflammation to Treat Alzheimer’s Disease
Enabling Regenerative Therapies without Immunosuppression
Making Vaccine and Biotherapeutic Production Fast and Affordable
Forcing Cancers to Reveal Themselves
Making Clinical Trials Diverse and Accessible
Mining Bugs for Drugs
A Company That Bets Its Therapies Will Click with Patients
A Company Where It takes Guts and Brains to Develop Drugs
Changing Outcomes with Data
Treating Psychiatric Conditions with Tripless Psychedelics
How AI Is Finding Its Way into Unexpected Places in Biopharma Companies
Searching the Dark Matter of the Proteome to Develop New Therapies
The Year in Biotech and What’s Ahead in 2023
Targeting a Novel Checkpoint to Treat Cancer and Autoimmune Conditions