All Episodes

Ep202: Becky Pferdehirt on Reimagining Science for the AI Era

Ep201: Jeremy Levin on Biotech in the Balance

Ep200: Richard Pops Reflects on a 35-Year Career in Biotech

Ep199: Martin Burke on Making Small Molecule Medicines for the AI Era

Ep198: Abbas Kazimi on Computation and Culture for Drug Discovery

Ep197: Viswa Colluru on Discovering Drugs Inspired by Mother Nature

Ep196: Otello Stampacchia on Europe's Biotech Crisis

Ep195: Ken Song on T-cell Engagers for Autoimmune Diseases

Ep194: Ansu Satpathy on Cancer and Autoimmune Drug Discovery

Ep193: Ron Renaud on Helping People Lose Weight With GLP-1 Medicines

Ep192: Kate Haviland on Following the Science to Precision Immunology

Ep191: Emily Conley on Small Molecules to Correct a Rare Kidney Disease

Ep190: Neil Kumar on Building a Rare Disease Drug Company

Ep189: Marc Tessier-Lavigne on Reinventing Drug Discovery with AI

Ep188: Art Krieg on Innate Immune System Activators for Cancer

Ep187: Eric Fischer on Creating a New Class of Medicines

Ep186: Bruce Levine & Mags McCarthy on a Song About Science and Hope

Ep185: Dr. Lachelle Weeks on Predicting Leukemia Risk At Scale

Ep184: Jen Adair on Affordable, Accessible Gene & Cell Therapies

Ep183: Sabah Oney on CAR-T Cells Against Solid Tumors

Ep182: Andy Rachleff & Yung Lie on Creative Ways to Back Science

Ep181: Claire Mazumdar on a Two-Pronged Attack Against Cancer

Ep180: John Rinn on Discovering Drugs Based on Long Non-Coding RNA

Ep179: Ethan Weiss & Josh Lehrer on a New Idea for Cardiovascular Disease & Diabetes

Ep178: Peyton Greenside on ML-Guided Biologics Discovery

Ep177: Kevin Parker on Finding Cancer Drug Targets

Ep176: David Roblin on Building a TechBio Company

Ep175: Andy Scharenberg on in vivo CAR-T cell therapies

Ep174: Najat Khan on the TechBio Movement

Ep173: Robert Blum on Building a Fully Integrated Biopharma For Muscle Disorders

Ep172: Mostafa Ronaghi on Studying Live Cells at Scale

Ep171: Ram Aiyar on RNA Editing Medicines

Ep170: David Schenkein on Investing in the Future of Biotech

Ep169: Kevin Fitzgerald on the Past & Future of RNAi Medicines

Ep168: Jonathan Bricker on How to Quit Smoking & Prevent Cancer

Ep167: Leslie Williams on transfer RNA therapies

Ep166: Chris Garcia on Engineering Protein Drugs for Cancer, Autoimmunity

Ep165: Zach Hornby on Tackling Cancer Drug Resistance

Ep164: Ted Love and Alan Anderson on Raising the Bar for Sickle Cell Disease Patients

Ep163: Sarah Boyce on RNA Medicines for Muscle Diseases

Ep162: Sean McClain on AI for Biologic Drug Discovery

Ep161: Jeff Stein on a Long-Lasting Flu Drug

Ep160: Abe Ceesay on Precision Neuroscience

Ep159: Jimi Olaghere on Being Functionally Cured of Sickle Cell Disease

Ep158: David Younger and Randolph Lopez on SynBio & AI for Discovery

Ep157: Vineeta Agarwala of A16Z on Investing in AI for Drug Discovery

Ep156: David Liu on New Tools and Techniques for Biology

Ep155: Valerie Daggett on Early Detection, and Treatment, of Alzheimer's

Ep154: Robert Ang on CRISPR to Protect Bone Marrow & Attack Cancer

Ep153: Rick Young on Studying Gene Expression for Drug Discovery

Ep152: Jens Eckstein on Investing in Healthy Aging

Ep151: Shelley Force Aldred and Nathan Trinklein on Bispecific Antibodies for Cancer

Ep150: Jeff Jonker on the Small Molecule Drug Discovery Renaissance

Ep149: Nancy Stagliano on Precision Neuroscience

Ep148: Diana Brainard on the Fight Against Infectious Disease

Ep147: Reid Huber on Investing in the Future of Medicine

Ep146: Jeff Huber on Life in Tech and Biotech

Ep145: Lori Lyons-Williams on Targeted Radiopharmaceuticals for Cancer

Ep144: Turning the Tables, Rob Perez Interviews Me

Ep143: Zach Weinberg and Alexis Borisy on Freeing the Biotech Founders

Ep142: Fred Appelbaum on how 'Living Medicine' Came to Be

Ep141: Colin Hill on Digging Deep into Data, Finding New Drug Targets

Ep140: Yung Lie on Supporting Young Scientists with Bold, Brave Ideas

Ep139: Kevin Conroy on Early Detection of Cancer

Ep138: Jodie Morrison on Becoming a Biotech CEO

Ep137: Aaron Ring on Immunotherapy for Cancer & More

Ep136: Deborah Palestrant on Building Biotech Startups

Ep135: John Maraganore on Developing a New Class of Medicines

Ep134: Emile Nuwaysir on In Vivo Gene Editing Therapies

Ep133: Catherine Stehman-Breen on Epigenetic Editing Therapies

Ep132: Eric Dobmeier on Treating Kidney Disease

Ep131: Ryan Watts on Neuroscience Drug R&D

Ep130: David Hallal on a Life in Biotech & the Cell Therapy Wave

Ep129: Joanne Smith-Farrell on Engineered B-Cell Therapies

Ep128: Rick Berke on Building a Biotech Journalism Outlet to Last

Ep127: Jeb Keiper on Computational Drug Discovery

Ep126: DA Wallach on Becoming a Biotech VC

Ep125: Barry Greene on a New Drug for Depression

Ep124: Shehnaaz Suliman on Delivery of Genetic Medicines

Ep123: Tariq Kassum on Single-Cell Analysis for Drug Discovery

Ep122: Aetna Wun Trombley on Extracellular Protein Degraders

Ep121: Samantha Truex on Going Upstream Against Severe Asthma

Ep120: Tim Lu on Gene Circuits for Cell Therapy

Ep119: Jo Viney on Discovering Treatments for Autoimmune Disease

Ep118: Ivan Liachko on Assembling Accurate Genomes and Interactomes

Ep117: Dr. Sanduk Ruit on Restoring Eyesight in the Developing World

Ep116: Ivana Magovcevic-Liebisch on Precision Neuroscience

Ep115: Rahul Singhvi on Reimagining Biotech Manufacturing

Ep114: Chris Gibson on Industrializing Drug Discovery

Ep113: Lewis Cantley & Siddhartha Mukherjee on Fighting Cancer with Food and Drugs

Ep112: Bernat Olle on Microbiome Therapeutics

Ep111: Ray Stevens on Structural Biology-Driven Drug Discovery

Ep110: Michele Andrasik on Making Clinical Trials More Diverse

Ep109: Derrell Porter on Cell Therapy Commercialization

Ep108: Praveen Tipirneni on Targeting Integrins With Small Molecules

Ep107: Bassil Dahiyat on Antibody Engineering & Company Building

Ep106: Vineeta Agarwala on Health Data & VC Investing

Ep105: Nello Mainolfi on Targeted Protein Degraders

Ep104: Jeff Bluestone on Treg Cell Therapies for Autoimmunity

Ep103: Ken Song on Targeted Radiopharmaceuticals for Cancer

Ep102: David Baltimore Reflects on a Life in Science

Ep101: Tony Kulesa on Fostering Founder-Led Biotechs

Ep100: Christian Henry on Long Read DNA Sequencing

Ep99: Keolu Fox on Genome Sequencing of Indigenous Populations

Ep98: Mara Aspinall on Diagnostics and COVID-19

Ep97: John Evans on Base Edited Therapeutics

Ep96: Julie Grant and Sam Blackman on Cancer Drugs for Kids

Ep95: Sue Desmond-Hellmann on Becoming a Biotech Leader

Ep94: Jenny Rooke on Investing in Biotech Tools

Ep93: Jay Bradner & Andy Plump on Mentoring Young Scientists

Ep92: Brad Gray on Spatial Biology

Ep91: Daphne Zohar on Biotech Entrepreneurship

Ep90: James Sabry on Partnering Amid Scientific Abundance

Ep89: Emily Leproust on DNA Synthesis at Scale

Ep88: Amy DuRoss on software and logistics for cell and gene therapy

Ep87: Bob Nelsen of ARCH Venture Partners on Biotech Investing

Ep86: Sek Kathiresan on a Gene-Edited Single Shot for Heart Disease

Ep85: Luhan Yang on CRISPR Editing for Organ Transplants

Ep84: Steve Paul on Treatments for Mental Health

Ep83: David Lee on Impact in Pharmaceuticals

Ep82: Andrew Farnum on Medicines From Unusual Traits

Ep81: Simba Gill on Microbiome Therapies

Ep80: Peter Kolchinsky on Pharma's Soul

Ep79: Daphne Koller on Machine Learning for Drug Discovery

Ep78: Pearl Huang on Exoneural Cancer Biology

Ep77: Jennifer Petter on Drugging RNA Targets

Ep76: Otello Stampacchia on Becoming a Biotech VC

Ep75: Rosana Kapeller on Drugging the Repeatome

Ep74: Abe Ceesay's Path to Leadership

Ep73: Kevin Ness on Digital Genome Engineering

Conversation on Race with Ted Love

Ep71: Andy Plump

Ep70: Nina Kjellson

Vaccine Strategy with Larry Corey

Ep68: Emma Hodcroft

Ep67: George Scangos

Ep66: Mike Pellini

Ep65: Alexis Borisy & Melanie Nallicheri

Ep64: Isabella de la Houssaye

Ep63: Jeremy Levin

Ep62: Jane Grogan

Ep61: Sanjiv Patel

Ep60: Tim Mayleben

Ep59: David Baker

Ep58: Jigar Raythatha

Ep57: John Alam

Ep56: Tim Springer

Ep55: John Hawkins & Jim Geraghty

Ep54: Aoife Brennan

Ep53: Phil Sharp

Ep52: Bruce Carter

Ep51: Ted Love

Ep50: Joel Marcus

Ep49: Janelle Anderson

Ep48: Cindy Perettie

Ep47: Laura Shawver

Ep46: Liz O'Day

Ep45: Jay Bradner

Ep44: Sheila Gujrathi

Ep43: Jeff Jonas

Ep42: Carolyn Bertozzi

Ep41: Bob Langer

Ep40: Serge Saxonov

Ep39: Julia Owens

Ep38: Harlan and Chad Robins (Take 2)

Ep37: Bonnie Anderson

Ep36: George Scangos

Ep35: Karen Akinsanya

Ep34: Ron Renaud

Ep33: Krishna Yeshwant

Ep32: Ned David

Ep31: Julie Sunderland

Ep30: Barbara Weber

Ep29: John Wilbanks

Ep28: Sabah Oney

Ep27: Amy Abernethy

Ep26: Meg Tirrell

Ep25: Thong Le

Ep24: Ankit Mahadevia

Ep23: Chris Garabedian

Ep22: Vicki Sato (Take 2)

Ep21: Tony Coles

Ep20: Rob Perez

Ep19: Chip Clark

Ep18: Ethan Perlstein

Ep17: Alice Zhang

Ep14: Michael Gilman

Ep13: Bruce Booth

Ep12: David Schenkein

Ep11: Stephane Bancel

Ep10: Abbie Celniker

Ep9: Bob More

Ep8: BioMarin History

Ep7: Steve Graham

Ep6: Steve Holtzman

Ep5: Elias Zerhouni

Ep4: Richard Pops

Ep3: George Yancopoulos

Ep2: Katrine Bosley

Ep1: John Maraganore