All Episodes

#220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D.

#219 ‒ Dialectical behavior therapy (DBT): skills for overcoming depression , emotional dysregulation, and more | Shireen Rizvi, Ph.D., ABPP

#218 - AMA #38: Can you exercise too much?

#217 ‒ Exercise, VO2 max, and longevity | Mike Joyner, M.D.

#216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

#215 - The gut-brain connection | Michael Gershon, M.D.

#214 - AMA #37: Bone health—everything you need to know

#213 ‒ Liquid biopsies and cancer detection | Max Diehn, M.D. Ph.D.

Earning the gift of life | Ric Elias (#79 rebroadcast)

#212 - The neuroscience of obesity | Stephan Guyenet, Ph.D.

#211 - AMA #36: Fruits & vegetables—everything you need to know

#210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.

#209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.

#208 - Tragedy, grief, healing, and finding happiness | Kelsey Chittick

#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin

#206 - Exercising for longevity: strength, stability, zone 2, zone 5, and more

#205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)

#204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.

#203 - AMA #34: What Causes Heart Disease?

#202 - Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes

In remembrance of Sarah Hallberg, D.O., M.S. (Ep. #162 Rebroadcast)

#201 - Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)

#200 - AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more

#199 - Running, overcoming challenges, and finding success | Ryan Hall

#198 - Eye health—everything you need to know | Steven Dell, M.D.

#197 - The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D.

#196 - AMA #32: Exercise, squats, deadlifts, BFR, and TRT

#195 - Freedom, PTSD, war, and life through an evolutionary lens | Sebastian Junger

#194 - How fructose drives metabolic disease | Rick Johnson, M.D.

#193 - AMA #31: Heart rate variability (HRV), alcohol, sleep, and more

#192 - COVID Part 2: Masks, long COVID, boosters, mandates, treatments, and more

#191 - Revolutionizing our understanding of mental illness with optogenetics | Karl Deisseroth M.D., Ph.D.

#190 - Paul Conti, M.D.: How to heal from trauma and break the cycle of shame

#189 - COVID-19: Current state of affairs, Omicron, and a search for the end game

Iñigo San Millán, Ph.D.: Zone 2 Training and Metabolic Health (Ep. #85 Rebroadcast)

#188 - AMA #30: How to Read and Understand Scientific Studies

#187 - Sam Apple: The Warburg Effect—Otto Warburg's cancer metabolism theory

#186 - Patrick Radden Keefe: The opioid crisis—origin, guilty parties, and the difficult path forward

#185 - Allan Sniderman, M.D.: Cardiovascular disease and why we should change the way we assess risk

Rick Johnson, M.D.: Metabolic Effects of Fructose (Ep. #87 Rebroadcast)

#184 - AMA #29: GLP-1 Agonists—The Future of Treating Obesity?

#183 - James Clear: Building & changing habits

#182 - David Nutt: Psychedelics & Recreational Drugs

#181 - Robert Gatenby, M.D.: Viewing cancer through an evolutionary lens and why this offers a radically different approach to treatment

#180 - AMA #28: All things testosterone and testosterone replacement therapy

#179 - Jeremy Loenneke, Ph.D.: The science of blood flow restriction—benefits, uses, and what it teaches us about the relationship between muscle size and strength

#178 - Lance Armstrong: The rise, fall, and growth of a cycling legend

#177 - Steven Rosenberg, M.D., Ph.D.: The development of cancer immunotherapy and its promise for treating advanced cancers

#176 - AMA #27: The importance of muscle mass, strength, and cardiorespiratory fitness for longevity

#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process

#174 - Lawrence Wright: The 20th anniversary of the 9/11 attacks: reflections on how they happened, and lessons learned and not learned

#173 - AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions

#172 - Esther Perel: The effects of trauma, the role of narratives in shaping our worldview, and why we need to accept uncomfortable emotions

#171 - Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules

#170 - AMA #25: Navigating the complexities and nuances of cancer screening

#169 - Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation

#168 - Hugh Jackman: Reflections on acting, identity, personal transformation, and the significance of being Wolverine

#167 - Gary Taubes: Bad science and challenging the conventional wisdom of obesity

#166 - Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic disease

#165 - AMA #24: Deep dive into blood glucose: why it matters, important metrics to track, and superior insights from a CGM

#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer's disease, and what we can all learn from patients with dementia

#163 - Layne Norton, Ph.D.: Building muscle, losing fat, and the importance of resistance training

#162 - Sarah Hallberg, D.O., M.S.: Challenging the status quo of treating metabolic disease, and a personal journey through a grim cancer diagnosis

#161 - AMA #23: All Things Nicotine: deep dive into its cognitive and physical benefits, risks, and mechanisms of action

#160 - Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants

#159 - Peter Hotez, M.D., Ph.D.: Evolution of the anti-vaccine movement, the causes of autism, and COVID-19 vaccine state of affairs

#158 - Brian Deer: A tale of scientific fraud—exposing Andrew Wakefield and the origin of the belief that vaccines cause autism

#157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux

#156 - Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii's vulnerable ecosystems

#155 - Chris Sonnenday, M.D.: The history, challenges, and gift of organ transplantation

#154 - Steve Levitt, Ph.D.: A rogue economist's view on climate change, mental health, the ethics of experiments, and more

#153 - AMA #21: Deep dive into olive oil, high-intensity exercise, book update, and more

#152 - Michael Rintala, D.C.: Principles of Dynamic Neuromuscular Stabilization (DNS)

#151 - Alex Hutchinson, Ph.D.: Translating the science of endurance and extreme human performance

#150 - Senator Bill Frist, M.D.: A modern Renaissance man's journey through science, politics, and business

#149 - AMA #20: Simplifying the complexities of insulin resistance: how it's measured, how it manifests in the muscle and liver, and what we can do about it

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program

#147 - Hussein Yassine, M.D.: Deep dive into the "Alzheimer's gene" (APOE), brain health, and omega-3s

#146 - Guy Winch, Ph.D.: Emotional first aid and how to treat psychological injuries

#145 - AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctor

#144 - Phil Maffetone: Optimizing health and performance through maximal aerobic function

#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it

#142 - Robert Abbott: The Bobby Knight story—a cautionary tale of unchecked anger, ego, and winning at all costs

#141 - AMA #18: Deep dive: sugar and sugar substitutes

#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications

#139 - Kristin Neff, Ph.D.: The power of self-compassion

#138 - Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer's disease prevention—patient and doctor perspectives

#137 - Paul Offit, M.D.: An expert perspective on COVID-19 vaccines

#136 - AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico

#135 - BJ Miller, M.D.: How understanding death leads to a better life

#134 - James O'Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.

#133 - Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy

#132 - AMA #16: Exploring hot and cold therapy

#130 - Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonance

#129 - Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology

#128 – Irene Davis, Ph.D.: The evolution of the foot, running injuries, and minimalist shoes

#127 - AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more

#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book

#125 - John Arnold: The most prolific philanthropist you may not have heard of

#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more