All Episodes

#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book

#125 - John Arnold: The most prolific philanthropist you may not have heard of

#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more

#123 - Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19

#122 - Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health

#121 - Azra Raza, M.D.: Why we're losing the war on cancer

#120 - AMA with Dom D'Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

#119 - Terry Real: Breaking the cycle of shame, anger, and depression

#118 - Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

#117 - Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

#116 - AMA with Dom D'Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

#115 - David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19

#114 - Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

#113: Normative errors—a conversation with my daughter about current events

#112 - Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

#111 - AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity

#110 - Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K

#109 - John Dudley: The beauty in archery, the love of practice, and a model system for life

#108 - AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity

#107 - John Barry: 1918 Spanish flu pandemic—historical account, parallels to today, and lessons

#106 - Amesh Adalja, M.D.: Comparing COVID-19 to past pandemics, preparing for the future, and reasons for optimism

#105 - Paul Conti, M.D.: The psychological toll of a pandemic, and the societal problems it has highlighted

#104 - COVID-19 for kids with Olivia Attia

#103 - Looking back on the first 99 episodes: Strong Convictions, Loosely Held

#102 - Michael Osterholm, Ph.D.: COVID-19—Lessons learned, challenges ahead, and reasons for optimism and concern

#101 - Ryan Holiday: Finding stillness amidst chaos

#100 - Sam Harris, Ph.D.: COVID-19—Comprehending the crisis and managing our emotions

#99 - Peter Hotez, M.D., Ph.D.: Continuing the conversation on COVID-19

Qualy #129 - Evolutionary reasons to sleep

#97 - Peter Hotez, M.D., Ph.D.: COVID-19: transmissibility, vaccines, risk reduction, and treatment

Qualy #125 - Hierarchies in healthcare, physician burnout, and a broken system

#96 - David Epstein: How a range of experience leads to better performance in a highly specialized world

Qualy #121 - The "art" of longevity: the challenge of preventative medicine and understanding risk

#95 - Luke Bennett, M.D.: The emotional, cognitive, and physical demands that make Formula 1 a unique and special sport

Qualy #120 - What is the difference between ketone salts and esters?

#94 - Mark Hyman, M.D.: The impact of the food system on our health and the environment

Qualy #116 - Dealing with anger in spots where you know it's coming

#93 - AMA with Jason Fried: Work-life balance, avoiding burnout, defining success, company culture, and more

Qualy #109 - How does one select the right physician as a patient?

92 - AMA #12: Strategies for longevity (which don't require a doctor)

Qualy #106 - Does LDL cause heart disease?

#91 – Eric Topol, M.D.: Can AI empower physicians and revolutionize patient care?

Qualy #102 - Is the food industry still saying that all calories contribute equally to adiposity and insulin resistance?

#90 - Ryan Holiday: Stillness, stoicism, and suffering less

Qualy #99 - The steroid controversy: Mark's use of them and Peter's perspective

#89 - AMA #11: All things fasting

Qualy #94 - Comparing the two broad types of meditation, and Peter's favorite meditation apps

Qualy #89 - Cortisol and healthy aging

#87 - Rick Johnson, M.D.: Fructose—The common link in high blood pressure, insulin resistance, T2D, & obesity?

Qualy #85 - The past, present, and future of medicine, hospitals, and healthcare

#86 - Damon Hill: Overcoming loss, achieving success, and finding one's identity

Qualy #82 - What is the most common first presentation of heart disease?

#85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health

Qualy #80 - The four pillars of charity: water that helped it overcome the stigma of nonprofits and become successful

#84 - AMA #10: Low testosterone, hypothyroidism, building muscle (and preserving it while fasting)

Qualy #73 - How can we change the food system when 10 companies control almost 90 percent of the calories we consume in the US?

#83 - Bill Harris, Ph.D.: Omega-3 fatty acids

Qualy #69 - Advice to parents and kids for creating a sustainable environment that's going to prevent them from running into metabolic problems

#82 - Mark Messier: Leadership, personal growth, and performing under pressure

Qualy #65 - The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak test

#81 - Debra Kimless, M.D. & Steve Goldner, J.D.: Cannabis – the latest science on CBD & THC

Qualy #61 - Rapamycin in cancer treatment

#80 - Celebrity AMA #1: Fasting, rapamycin, performance vs. longevity, and more

Qualy #57 - A primer on NAD+/NADH, its effect on lifespan/healthspan, and a review of the supplements

#79 - Ric Elias: Earning the gift of life

Qualy #53 - Screening for prostate cancer

#78 - Sasha Cohen: The price of achievement, and redefining success

Qualy #52 - Insights about berberine

#77 – AMA #2 with sleep expert, Matthew Walker, Ph.D.: short sleep mutants, optimal sleep environment, sleep apnea, & rapid fire questions

Qualy #46 - Rapamycin's effects on cancer, cardiovascular disease, and neurodegeneration

#76 - Kyle Kingsbury: Finding meaning, depression, and psychedelics

Qualy #43 - What are Peter's thoughts on fasting and ketosis for females?

#75 - David Light: Zantac recall due to cancer concerns – what you need to know

Qualy #38 - Finding meaning in struggle and why we are less happy than ever (David Foster Wallace)

#74 – Jason Fried: Optimizing efficiency and work-life balance

Qualy #33 - How silent bravado and incessant striving can lead to a functional (and actual) death, and why Paul is critical of the current state of psychiatry

#73 - AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more

#72 - Dan Harris: 10% happier – meditation, kindness, and compassion

Qualy #26 - What is Peter looking to achieve and monitor with his blood glucose monitor?

#71 - Katherine Eban: Widespread fraud in the generic drug industry

Qualy #24 - What are the "ABCs" of Alzheimer's prevention?

#70 - David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)

Qualy #19 - A unifying theory of aging

#69 - Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly

Qualy #16 - How much does cognitive activity ward off cognitive decline?

#68 - Marty Makary, M.D.: The US healthcare system—why it's broken, steps to fix it, and how to protect yourself

Qualy #9 - The importance of exercise for brain health

#67 - AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more

Qualy #6 - What are the best lab tests to request specifically for longevity

#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer's disease, and Parkinson's disease – do all roads lead to mitochondria?

Qualy #1 - What are Peter's thoughts on alcohol consumption and health?

#65 - Rick Doblin, Ph.D.: MDMA— the creation, scheduling, toxicity, therapeutic use, and changing public opinion of what is possibly the single most important synthetic molecule ever created by our species

#64 - Zol Kryger, M.D.: Navigating the sometimes shady world of plastic surgery—understanding potential complications of common procedures and how to reduce your risk by choosing the right doctor and asking the right questions

#63 - AMA #7: Exercise framework, deadlifting, lower back pain, blood pressure, nootropics, CGM, and more

#62 - Keith Flaherty, M.D.: Deep dive into cancer—History of oncology, novel approaches to treatment, and the exciting and hopeful future

#61 - Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology

The one-year anniversary episode with Olivia Attia: Reflecting on the past year and looking forward to exciting times ahead

#60 - Annie Duke, decision strategist: Poker as a model system for life—how to improve decision making, use frameworks for learning, and apply 'backcasting' to boost your odds for future success

#59 - Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness

#58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping better, and avoiding things that are disrupting sleep