Vitamin D, Safe and effective

Association between vitamin D supplementation and COVID-19 infection and mortality https://www.nature.com/articles/s41598-022-24053-4 (12th November 2022) Johns Hopkins University of Michigan National Bureau of Economic Research Department of Medicine, University of Chicago Department of Veterans Health Affairs Department of Medicine, University of Chicago, Chicago Vitamin D deficiency, associated with reduced immune function, can lead to viral infection Vitamin D deficiency, associated, increases the risk of COVID-19 But is it a treatment / prognosis improver? Population of US veterans, we show that Vitamin D2 and D3 fills Associated with reductions in COVID-19 infection After applying all restrictions 220,265 supplemented with vitamin D3 34,710 supplemented with vitamin D2 407,860 untreated patients. Study design Retrospective cohort Supplemented (before and during the pandemic), versus untreated controls One to one matches D2, D3, or calcifediol Veterans Administration Corporate Data Warehouse (CDW) electronic health records. Vitamin D levels typically respond to treatment following two months of exposure D3 cohort COVID-19 rates for the treated = 2.66% COVID-19 rates for the untreated = 3.30% D3 20%, reduction D2 28% reduction Mortality within 30-days of COVID-19 infection Infection ending in mortality within 30 days D3 group Treated group death rate after infection = 0.23% Untreated group death rate after infection = 0.35% Vitamin D3 33% mortality lower (HR, 67%) P  less than  0.001 Vitamin D2 25% lower (HR, 75%) (but not significant) Veterans receiving higher dosages of Vitamin D obtained greater benefits from supplementation than veterans receiving lower dosages. Vitamin D blood levels between 0 and 19 ng/ml, exhibited the largest decrease in COVID-19 infection and mortality following supplementation (0–19 ng/ml, 20–39 ng/ml, and 40 + ng/ml) Dosage options, 20 IU, 40 IU, 100 IU, 125 IU, 200 IU, 250 IU, 400 IU, 500 IU, 800 IU, 1000 IU, 2000 IU, 5000 IU, 8000 IU, and 50,000 IU Black veterans received greater associated COVID-19 risk reductions, with supplementation than White veterans As a safe, widely available, and affordable treatment, Vitamin D may help to reduce the severity of the COVID-19 pandemic. More background Vitamin D insufficiency and deficiency affect approximately half of the US population, with increased rates in people with darker skin, reduced sun exposure, people living in higher latitudes in the winter, nursing home residents, and healthcare workers Populations with low levels of Vitamin D have also experienced higher rates of COVID-19 New mechanism Vitamin D is needed to allow T helper cells to control and reduce Interferon gamma (IFN-γ) production Conclusions These associated reductions in risk are substantial and justify more significant exploration and confirmation using RCTs. This is particularly important given the high rates of vitamin D deficiency in the US population and COVID-19. Extrapolate, D3 supplementation to the entire US population in 2020 4 million fewer COVID-19 cases (19,860,000 actual cases) 116,000 deaths avoided (351,999 actual deaths) Given our findings, the absence of severe side effects, the widespread availability of vitamin D3 at low cost, vitamin D3 presents a unique opportunity to reduce the spread and severity of the COVID-19 pandemic. K2, MK-7 Supplement, probably 100 micrograms per day Nato, 1,000 micrograms per 100 g Cheese, typically 50 micrograms per 100 g Safe and effective UK, GP incentives to vaccinate Home, £30 Standard reimbursement to Primary Care Networks (which then gets passed to GPs) £15 New contract, £12.58 each Lawrence I have heard that Dr. John Campbell is in the pocket of Big Overhead Projector Lobby. Rumour is that he has accepted tens of dollars of under the table e