PODCAST · health
Practical AI in Healthcare
by Steven Labkoff
AI promises to transform healthcare—but real, scalable impact remains rare. Practical AI in Healthcare cuts through the noise to showcase real-world use cases delivering business value today. Hosted by senior leaders— former VPs of life science technology groups, clinical informatics professionals from top-tier organizations, and a former Big Four consultant—each episode features candid conversations with the people making AI work inside the healthcare enterprise
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S1, E36 - David Hidalgo-Gato, Founder & CEO, Cleo Health: Going a Mile Deep on Emergency Medicine — Specialization, Design Partnerships, and the Acute Care OS
David Hidalgo-Gato is the founder and CEO of Cleo Health. While more than 100 competitors were building generic ambient AI scribes, David's team chose emergency medicine and stayed with one design partner for nine months and roughly 50 product iterations before launching. The result: an average 54-minute time savings per shift, a patient-assignment tool that turned a four-hour process into 15 to 20 minutes, and use across 400+ hospitals nationwide. The conversation covers why ED workflow breaks generic ambient scribes, why generative AI fits patient assignment specifically, and David's argument that workflow understanding is the moat AI cannot commoditize.https://practicalaiinhealthcare.com/
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S1, E35 - Barry P. Chaiken, MD, MPH: Physician-as-Patient Perspective on AI in Healthcare
When physician Barry Chaiken was diagnosed with prostate cancer, his clinical training gave way to fear. It took a friend asking, "What are you doing?" to snap him back into doctor-mode thinking. That experience reshaped how he sees AI in healthcare. In this episode, Chaiken draws on his dual perspective as physician and two-time cancer survivor to argue that consumer health AI is failing patients, not because the models are bad, but because patients don't know how to use them. He shares a practical framework for AI-assisted patient education, makes the case for an aviation-style safety reporting system for healthcare AI, and explains why interoperability is an incentive problem, not a technology problem.
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S1, E34 - Matt Truppo, PhD, Part 2: AI-Driven Drug Development at Sanofi: Clinical Trials, Regulatory, and Personal AI
In Part 2 of our conversation with Matt Truppo, Global Head of Research Platforms and Computational R&D at Sanofi, we move from discovery to development, where the real stakes begin. Matt unpacks the promise and limitations of “digital patient twins,” a concept often described as the holy grail of drug development. With nearly 90% of drugs failing in clinical trials, even modest gains in predicting efficacy or patient response could transform the industry. Through real-world examples, including Dupixent and rare disease therapies, Matt shows how quantitative systems pharmacology (QSP) and AI-driven simulations are already shortening timelines, reducing patient burden, and, in some cases, eliminating the need for entire trials.But the story doesn’t stop at modeling. We explore how AI is reshaping clinical operations, from Sanofi’s “clinical control tower” that integrates trial data across 4,000 users, to generative AI tools that are cutting regulatory document creation time by more than a third. Matt also shares a personal experiment, building a network of AI agents modeled on his own workflow, reclaiming 30% of his time and offering a glimpse into a more “agentic” future of work. The throughline is clear: AI is not replacing human expertise, but amplifying it, helping the industry finally bend the cost and time curve of drug development.
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S1, E33 - Ted Shortliffe, MD, PhD: 50 Years of Clinical AI
Ted Shortliffe built MYCIN at Stanford in the 1970s, one of the first medical AI systems ever deployed in a clinical setting. Five decades later, he joins Steve and Leon to examine what has persisted in clinical decision support — above all, the demand for explainability — what has changed (computational power finally caught up to the ideas), and what the field may have lost along the way. The conversation includes a direct response to Bob Wachter's claim from S1E24 that AI in healthcare decision support was "too hard a problem to start with," and a case for why structured knowledge representation deserves a second look in the age of LLMs. For anyone tracing the arc of medical AI history, this episode is a rare primary source.
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S1, E32 - Matt Truppo, PhD: AI-Driven Drug Discovery at Sanofi
AI in drug discovery has been long on promise and short on delivery. Matt Truppo, Global Head of Research Platforms and Computational R&D at Sanofi, presents a different picture. His team used AI to identify 10+ novel drug targets in 12 months, screen 30 million target combinations in days, and produce AI-designed compounds with 75% synthesizability. But Truppo is equally candid about the gaps: data integration, explainability, and change management remain real barriers. In Part 1 of this two-part conversation, hosts Steve Labkoff and Leon Rozenblit explore what happens when AI moves past pilot projects into core pharmaceutical science.
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S1, E31 - Reflections 4: What Does the Infrastructure Actually Look Like?
Every five episodes, Steve and Leon step back to examine what picture forms when you put their guest conversations side by side. This time, five guests from completely different healthcare domains -- data quality, clinical trials, medical translation, patient data, participatory medicine -- independently converged on the same conclusion: the AI works; the infrastructure around it doesn't yet. From Charlie Harp's data quality metrics to Adam Blum's 60-to-90% scaffolding story to Amy Price's reframing of healthcare AI as "unfinished, not broken," Block 4 reveals what industry maturation actually looks like -- not a breakthrough, but a quiet shift in what the conversation is about.
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S1, E30 - Amy Price: Patient Advocacy, Participatory Medicine, and AI Governance
Amy Price survived a car accident that left her with a broken neck, severe brain injury, and $4 million in medical bills. She was told she'd need to be institutionalized. Instead, she earned a DPhil at Oxford and became Editor-in-Chief of the Journal of Participatory Medicine. In this episode, Amy sits down with Leon to discuss why patients belong inside the AI design process, what it really means to have a "knowledgeable human who cares" in the loop, and why healthcare AI is an unfinished system worth building on, not a broken one worth scrapping. She also shares how she uses AI tools for her own health decisions and what she's learned about closing the patient AI literacy gap.
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S1, E29 - Shashi Shankar, Co-founder & CEO, Novellia, Inc.
Shashi Shankar spent nearly a decade at Genentech before a family cancer journey and a broken data landscape pushed him to build something different. His company Novellia works directly with patients — not data brokers — to collect and consolidate health records across multiple providers using SMART on FHIR. The result: longitudinal, patient-authorized real-world data that fills the gaps left by claims databases, single-site EMRs, and health information exchanges. We explore why previous PHR companies failed, how AI catches clinical data errors that humans miss, and whether Big Tech should be trusted with patient data.
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S1, E28 - Adam Blum: AI-Powered Clinical Trial Matching
When Adam Blum was diagnosed with follicular lymphoma, he tried over a dozen commercial trial matchers. None returned actual matches. So the serial AI entrepreneur built CancerBot, a free precision-matching service that assesses 100% of eligibility criteria — not the five surface-level attributes most matchers use. On this episode, Blum explains the Prompt Workbench (where biomedical experts refine extraction prompts to above 90% accuracy), how conjunctive normal form makes complex eligibility logic tractable, and why "best trial" means something different for every patient. A masterclass in AI scaffolding for healthcare.
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S1, E27 - Charlie Harp, Healthcare Data Quality and the PIQI Framework
For 37 years, Charlie Harp heard the same thing from healthcare organizations: "Our data quality is fine." They were right — for billing and scheduling. But AI changed the equation. Harp, founder of Clinical Architecture, built the PIQI framework to measure patient data quality across four dimensions: availability, accuracy, conformance, and plausibility. His PIQXL Gateway scores data on a 1-100 scale before it enters your systems — not after. Early deployments reveal uncomfortable truths: lab data averages 70% quality against USCDI standards, and one facility coded every blood test to a single LOINC code. The framework is now going through HL7 balloting as an open national standard.
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S1, E26 - Discharge Planning Translation Services with Giovanni Donatelli
Every day, patients leave US hospitals with discharge instructions they can't read. Giovanni Donatelli, CEO of The Language Group, built FETCH — a patented AI system embedded in Epic that translates discharge documents in 15 minutes with human review. He did it because he was the 8-year-old interpreting for his immigrant parents at doctor's appointments. Hosts Steve Labkoff and Leon Rozenblit explore the discharge instruction gap, the tragic cases that make it personal, FETCH's three-layer translation pipeline, the case for keeping humans in the loop, and why healthcare executives think they've already solved a problem that doesn't yet have a solution.
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S1, E25 - Reflections 3: What Happens When Principles Meet Reality
Steve and Leon have reviewed blocks of guest episodes twice before on Practical AI in Healthcare. Both times the themes snapped into place. This time they didn't -- and the disagreement between them became the episode. Across five recent conversations, they found stories that kept spilling past the edges of their framework: AI that works but can't get paid, laws that already apply but nobody realizes it, and a scientific record under threat from AI-generated paper mills. The hosts' attempt to make sense of it all reveals where their thesis holds, where it breaks, and what needs to change.
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S1, E24 - Bob Wachter, MD | A Giant Leap: AI in Healthcare
Bob Wachter wrote the book on the EHR disaster. Now he's written one about AI.The UCSF Chair of Medicine joins hosts Steve Labkoff and Leon Rozenblit to discuss A Giant Leap, his argument that AI doesn't need to be perfect—it needs to beat a healthcare system already failing at scale. They cover Watson's $3B collapse, why ambient scribes became AI's first clinical success story, the human-in-the-loop problem that nobody has solved, and the dangerous gap between how experts and novices use AI tools.Key topics: productivity paradox, complementary innovations, clinical decision support design, AI literacy, and the "compare me to the alternative" thesis.The link to the book can be found here: https://a.co/d/07JFNwIw
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S1, E23 - CHiRP: AI-Enabled Early Detection of Psychosis Risk with Amar Mandavia, PhD & Enrique "Kike" Gutiérrez, PhD
What if early signs of psychosis could be detected from how patients speak—not what they say, but how they organize their thoughts?Amar Mandavia (VA Boston, Boston University) and Enrique "Kike" Gutiérrez (Polytechnic University of Madrid) join hosts Steve Labkoff and Leon Rozenblit to discuss CHiRP, an AI tool that identifies formal thought disorder from routine clinical conversations. They explain why the gold-standard manual test takes 5+ hours, how their system reduces that to minutes, and the hard ethical questions around labeling patients as "at risk."Key topics: prodromal psychosis detection, NLP in mental health, clinical workflow integration, MIT linQ Catalyst, and the payer challenges that make prevention hard to fund.
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S1, E22 - Aaron Kamauu, MD, MS, MPH | RWE Design in the Age of Data
Real-world evidence was supposed to accelerate drug development. Instead, we've created definitional chaos—over 100 data vendors, inconsistent definitions, and studies that can't be compared.Dr. Aaron Kamauu, CEO of Navidence and co-host of Real World Wednesday, explains why one missing diagnosis code can exclude 30% of your cohort, how GLP-1 eligibility criteria vary wildly between NHS and US guidelines, and what it means to document "the seven definitions you chose NOT to use."A conversation about the unsexy infrastructure that makes evidence trustworthy.
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S1, E21 - Jeff Chuang, PhD, The Jackson Laboratory
In this episode of Practical AI in Healthcare, we sit down with Dr. Jeff Chuang, a computational biologist at The Jackson Laboratory, to explore how AI is reshaping cancer diagnostics, starting with pediatric sarcoma. Jeff shares his journey from physics and protein folding to computational pathology, where machine learning is being applied to standard H&E pathology slides to deliver faster, cheaper, and more accurate diagnoses.The conversation dives into how AI models trained on relatively small but carefully curated image datasets can outperform traditional diagnostic approaches, especially in rare cancers where expertise is scarce. We also explore the challenges of data sharing, IRB approvals, and real-world deployment, along with a glimpse into the future of spatial genomics and ultra-high-resolution tissue analysis. This episode is a powerful example of how practical AI can directly improve patient care today.
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S1, E20 - Josh Geleris, MD, CPO, SmarterDx
In this episode of Practical AI in Healthcare, we sit down with physician–informaticist Josh Geleris, MD, co-founder and Chief Product Officer of SmarterDx, to unpack one of healthcare’s most overlooked AI opportunities: revenue cycle intelligence. Drawing on his clinical training, deep technical background, and firsthand experience inside large health systems, Josh explains how AI can bridge the gap between clinical reality and billing documentation. The conversation explores how machine learning and large language models translate thousands of data points from an inpatient stay into accurate, compliant coding, helping health systems reduce revenue leakage while staying firmly within regulatory guardrails. From SQL queries to post-trained LLMs, Josh walks us through the evolution of SmarterDx’s AI stack and why human-in-the-loop design remains essential. This is a grounded, practical look at AI delivering real value where healthcare operations and clinical truth collide.
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S1, E 19 - Dr. Alvin Liu and AI Diabetic Retinopathy Screening
In this episode of Practical AI in Healthcare, we sit down with Dr. Alvin Liu, retinal surgeon and Professor of Artificial Intelligence and Ophthalmology at Johns Hopkins University, to explore one of the earliest and most successful real-world deployments of medical AI.Dr. Liu walks us through the evolution of autonomous AI for diabetic retinopathy screening, from FDA approval to large-scale clinical implementation across health systems. We unpack what it really takes to move AI from validation to impact, including workflow integration, sensitivity and specificity tradeoffs, reimbursement challenges, and post-market monitoring. The conversation also looks ahead to emerging AI applications using retinal imaging to predict cardiovascular disease, dementia, and kidney disease at the population level.This episode is a masterclass in how AI can meaningfully improve access, equity, and outcomes in healthcare when deployed thoughtfully and responsibly.
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S1, E18 - Tiffany Leung, MD - Scientific Editorial Director, JMIR
In this episode of Practical AI in Healthcare, we sit down with Dr. Tiffany Leung, Scientific Editorial Director at JMIR Publications, to explore how artificial intelligence is reshaping scientific publishing from the inside out. As open access journals face unprecedented volumes of submissions, AI is simultaneously enabling faster discovery and creating new challenges around research integrity, peer review, and trust in the scientific record.Tiffany shares how journals are adapting to generative AI tools, from policy development and disclosure norms to editorial decision support systems that help identify potential risks without stifling innovation. The conversation moves beyond hype to examine how AI can act as a co scientist, streamline editorial workflows, and potentially redefine peer review itself. This episode offers a rare look at how AI is influencing not just what gets published, but how knowledge is validated and shared globally.
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S1, E17: Kathy Roe & Kenny White: The Legal Realities of AI in Healthcare
In this episode, Steven Labkoff and Leon Rozenblit explore the legal, regulatory, and risk-management challenges introduced by AI with two top experts in the field: Kathy Roe, Principal at Health Law Consultancy, and Kenny White, Director of the Managed Care Industry Group at Alliant Insurance Services. Together, they unpack how AI intersects with medical malpractice, product liability, HIPAA privacy, de-identification, intellectual property, contractual risk, and insurance coverage. Kathy and Kenny explain why AI is not yet the standard of care — but why clinicians and health systems must develop AI literacy now as the legal landscape evolves.A must-listen episode for healthcare leaders navigating the risks and realities of AI adoption.
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S1, E16: Reflections II - Episodes 9-15
In our second Reflections episode, Steve Labkoff and Leon Rozenblit synthesize the most meaningful insights from guests across Episodes 9–15. Drawing on conversations with Orr Inbar, Martin Leach, Ing Ho, Yuri Quintana, and patient advocate E-Patient Dave, this episode highlights the themes shaping practical AI adoption in today’s healthcare landscape.Key topics include the inflection point AI has created across clinical care, research, and patient engagement; the need for stronger data stewardship to support trustworthy automation; and the emerging promise of AI-driven clinical trial optimization and simulation. We also explore how patients are engaging with AI tools independently, raising new questions about literacy, safety, and empowerment.Additional themes include the cultural alignment required for tools like ambient listening and chart summarization to succeed and what it will take for AI to avoid the missteps of past health-IT transitions.The episode closes with a preview of upcoming guests discussing AI in law, payer innovation, psychiatric diagnostics, and the future of scientific publishing.
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S1, E15 - Adam Rodman: Rethinking Clinical Reasoning in the Age of AI
We just released one of the most intellectually energizing conversations we’ve had on Practical AI in Healthcare. Our guest this week is Dr. Adam Rodman, physician, informatician, historian of medicine, and one of the most original thinkers at the intersection of AI and clinical reasoning.Adam brings a rare perspective to the field: before becoming an AI researcher, he spent years studying how humans make medical decisions — how clinicians reason, where cognition breaks down, and how technology reshapes the way we conceptualize disease. His reflections on the evolution from QMR and INTERNIST-1 to today’s large language models are a must-hear.In this episode, we explore:• Why LLMs challenge 50 years of clinical decision support assumptions• New collaboration models for doctors, patients, and AI — not just “human in the loop,” but truly redesigned workflows• What’s holding back clinical AI adoption (spoiler: it’s not accuracy)• The regulatory gap—and why the FDA’s old device mindset won’t work for generative models• How urgent-care AI companies are early signals of a broader shiftAdam also discusses what the next 3–5 years may actually look like — and why change will be slow…until the moment it becomes very fast.Listen here and join the conversation on the future of practical, safe, and human-centered AI in healthcare.Apple Podcasts: https://podcasts.apple.com/us/podcast/practical-ai-in-healthcare/id1837172964Spotify: https://open.spotify.com/show/63NBSNTdKsLHO7jmNxiZHv?si=277e9a14c24f41d9Amazon Podcasts: https://music.amazon.com/podcasts/8ed0ba60-15f4-419b-85f1-c4b85af81b41/practical-ai-in-healthcare#HealthcareAI, #ClinicalAI #MedicalInformatics #ClinicalDecisionSupport #AIinMedicine #DigitalHealth #HealthTech #FutureOfHealthcare #GenerativeAI #AIGovernance #DiagnosticExcellence #PatientCareInnovation #HealthcareTransformation #AIThoughtLeadership #PracticalAI
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S1, E14 - Orr Inbar, CEO Quant Health - AI Simulations of Clinical Trials
Practical AI in Healthcare just released one of our most eye-opening conversations yet, featuring Orr Inbar, CEO & Co-Founder of QuantHealth.QuantHealth is pushing the boundaries of what’s possible in clinical development with AI-driven clinical trial simulation. Orr walked us through how modern deep learning, massive biological knowledge graphs, and patient-level real-world data can now simulate clinical trials with 80–90% accuracy — across dozens of indications, modalities, and trial phases.In our conversation, we cover:• How QuantHealth models patient-drug interactions at massive scale• Why trial design is still the most critical (and fixable) failure point in drug development• How simulation is becoming the new starting point for protocols• What AI-first trial design could mean for speed, cost, and reducing avoidable trial failures• Where the field is headed in the next 5–10 years — including the provocative question of how far simulation can replace human trialsOrr also discusses the acceleration of biological data, the maturity of real-world data, and transformer-based AI — the perfect storm that made this moment possible.This is one of the best deep dives yet into the practical future of drug development.
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S1, E13 - Part 2 of 2: Dr. Yin Ho's discussion of her new book, Rushing Headlong: Health IT’s Legacy and the Road to Responsible AI
In the conclusion of our two-part conversation with Dr. Yin Ho, author of Rushing Headlong: Health IT’s Legacy and the Road to Responsible AI, we explore how healthcare can avoid repeating its digital past. Dr. Ho and hosts Dr. Steven Labkoff and Dr. Leon Rozenblit dive into small language models, decision support vs. decision control, the pitfalls of ambient scribing, and why “rage-building” the next generation of EHRs might be the most responsible act of all.
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S1, E12: Part 1 of 2: Dr. S. Yin Ho discusses her new book
The newest episode of Practical AI in Healthcare features Dr. Yin Ho—physician, entrepreneur, and author of Rushing Headlong: Health IT's Legacy and the Road to Responsible AI.In Part 1 of our two-part conversation, Dr. Ho joins Dr. Steven Labkoff and Dr. Leon Rozenblit to unpack 25 years of digital health transformation—from the dawn of electronic medical records to the market and policy forces that shaped today’s health IT landscape.Together, we explore how well-intentioned decisions created a fragmented system that prioritizes billing over care—and why understanding that history is essential to building a responsible AI future.#HealthcareAI #DigitalHealth #HealthIT #PracticalAIinHealthcare #Podcast
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S1, E11: Dr. Yuri Quintana from the DCI Network reviews our latest Meeting
Dr. Yuri Quintana, Director of the Division of Clinical Informatics at Beth Israel Deaconess Medical Center, joins us this week to discuss the DCI Network’s mission: turning AI in healthcare from theory into practice.The conversation traces DCI’s evolution as a multi-stakeholder “action tank” focused on collaboration, transparency, and patient safety. Quintana recounts the success of the Signal Through the Noise conference and the insights that emerged—chief among them that “mundane AI” (like triage, scheduling, and documentation tools) is quietly creating real value.The episode also explores topics like AI literacy, governance, transparency (“AI nutrition (model) labels”), and post-market surveillance for clinical AI—ending with a call to action: keeping healthcare innovation grounded in what truly matters to patients.
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S1, E10: AI in Healthcare: A Patient's Perspective with ePatient Dave
In this episode of Practical AI in Healthcare, Dr. Steven Labkoff and Dr. Leon Rozenblit speak with ePatient Dave DeBronkart, a globally recognized advocate for patient empowerment. Dave shares his journey from a life-threatening kidney cancer diagnosis in 2007 to becoming one of the earliest champions of open data, patient access to medical records, and of late, patient use of AI tools to help empower them along their medical journey.He recounts how the ability to access information, share data, and join online patient communities helped save his life—and how those lessons now translate into how patients use generative AI. Dave highlights stories where AI enabled patients to identify rare diagnoses, manage health conditions, and even prepare for clinical visits.The discussion examines how AI literacy and trust can empower patients, the ethical boundaries of sharing health data, and the evolution of patient–clinician partnerships in the era of AI.
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S1, E9: Martin Leach, PhD, MBA, CDO of Black Canyon Consulting
This week’s episode of Practical AI in Healthcare dives into AI, truth, and the future of data in the government with Dr. Martin Leach, Chief Data Officer at Black Canyon Consulting. Dr. Martin Leach, PhD, is a data, science, and technology leader with a career spanning some of the most innovative organizations in life sciences and academia. A self-described “data geek,” Martin began his career as a molecular neuropharmacologist before shifting from the bench to data-driven discovery. Over the past two decades, he has held senior roles at Merck, Biogen, Alexion, and AstraZeneca, and was the inaugural Chief Information Officer at the Broad Institute of MIT and Harvard.Today, Martin serves as Chief Data Officer at Black Canyon Consulting, where he works these organizations on projects that unite bioinformatics, AI, and data federation — from building semantic knowledge graphs to creating “gold-standard” datasets for model validation. His work bridges the worlds of science, computation, and policy, shaping how government and industry can responsibly harness AI to advance biomedical research and healthcare delivery.From building gold-standard datasets to exploring quantum AI, Martin shares how these projects are shaping the next generation of healthcare data science.
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S1, E8: Reflections on Our First 7 Episodes
In this week's episode, Leon and Steve unpack and digest the various pearls provided by our first 7 podcasts. From frameworks to consider concerning AI in the business and healthcare setting to AI Literacy, we highlight the various lessons learned as we move into our third month of the Podcast.
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S1, E7: Brendan Arbuckle, CIO, The Jackson Laboratory
This episode of Practical AI in Healthcare features Brendan Arbuckle, CIO of The Jackson Laboratory (JAX). Brendan shares how a world-leading genetics institute is deploying AI to advance research, streamline operations, and raise AI literacy across its organization. From ethical sandboxes to research breakthroughs and “everyday AI” that saves clinicians time, he offers a refreshingly grounded take on what responsible AI looks like in practice.Listen now to learn how JAX balances innovation with rigor and why Brendan believes AI is “bigger than IT—it’s a new language of discovery.”
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S1, E6: John Glaser: Lessons from a Healthcare IT Pioneer on the Future of AI
Season 1, Episode 6 welcomes John Glaser—executive in residence at Harvard Medical School, former SVP at Cerner, past CEO of Siemens Health Services, and a pioneer in healthcare IT. Join hosts Dr. Steve Labkoff and Dr. Leon Rozenblit as they explore Glaser’s unique perspective on the trajectory of AI in healthcare, drawing lessons from over 40 years of industry transformation. Find out:Why every breakthrough, from the mainframe to mobile, set the stage for today’s AI revolution.How practical deployments—like specialized AI for prior authorizations—deliver true value, while hype often fills the void left by a lack of hands-on experience.The importance of focusing on real-world ROI, efficiency, and smart clinical capacity management, with less emphasis on “sexy” use cases and more on what genuinely reshapes healthcare for the better.Essential insights on domain specificity: why expert models outperform generic AI in high-stakes environments, and how learning from implementation drives success.Why building successful AI adoption means mitigating risks, fostering literacy—not just technical training—and evolving governance to match pace with technology.Glaser’s message is clear: “This is a remarkable time. This is remarkable technology. Extraordinarily powerful. ... But the way you deal with this kind of stuff is one step at a time.” Join the conversation and stay practical about what’s next in healthcare AI.
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S1, E5: Yair Saperstein, MD - CEO of AVO
Yair Saperstein, MD, MPH, is CEO and Co-Founder of Avo, the AI engine used by healthcare organizations to improve care and operational outcomes in a way clinicians love. He is a hospitalist at Mount Sinai Hospital. Dr. Saperstein graduated from Albert Einstein College of Medicine with distinction in research in global health and from SUNY Downstate with a Master's in Public Health in hospital policy and management.Avo is the OS for healthcare AI applications, providing a single point of entry for health systems to deploy any AI-powered workflow. Their initial suite of applications focuses on clinical decision support, chart review, scribing, and patient discharges. Yair will discuss the challenges faced by clinicians and how Avo is changing some of the most perplexing issues in the day-to-day practice of medicine.
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S1, E8: Reflections on our first 7 Episodes
This week, Leon Rozenblit and I digest the wonderful wisdom we've heard over the first two months of the podcast. We try to distill all the various pearls that were dropped by our guest speakers. If you missed the first series of episodes, this will help you both catch up and speed through the learnings that came out of these discussions.
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S1, E4: Author, Professor, and Healthcare Executive Scott Snyder
Scott Snyder is many things: a part-time professor at the Wharton School of Business at the University of Pennsylvania, an author on AI, and the Chief Digital Officer of Eversana. In this episode we will explore Scott's various pursuits, his new book, and his view on where AI an Healthcare are intersecting.
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S1, E3: Dr. Dereck Paul and Glass Health
One of the most underserved communities in the world of AI is that of clinicians. But Dr. Dereck Paul of Glass Health is trying to change that. Being a clinician himself, he's bringing a new approach to something that's the bane of a clinician's existence - creating and documenting interactions with patients. Listen in to this young entrepreneur as he unpacks his vision for clinical medicine and how Glass Health is trying to change things for clinicians for the better.
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S1, E2: John Apathy and XponenL's Perspectives on AI
This week we hear from someone in the thick of the AI game, John Apathy from XponenL.AI. John's the Chief Solution's Officer for this recently acquired AI firm that focuses in on the pharmaceutical R&D space. John explains his perspectives as well as some of the work being done by his firm for some of their largest customers.
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Practical AI in Healthcare: Leon Rozenblit of the QED Institute (S1, E1)
When OpenAI released ChatGPT in November 2022, it marked a turning point in the global conversation around artificial intelligence. Virtually overnight, industries across the board began exploring how Generative AI could transform the way we work, think, and solve problems. Healthcare was no exception. From improving clinical workflows and accelerating research, to empowering patients and supporting care decisions, the entire ecosystem began to imagine a future radically reshaped by AI.Fast forward to today: the buzz hasn't faded—but the outcomes are still catching up.Despite a flood of announcements, pilot programs, and innovation initiatives, truly impactful AI implementations in healthcare remain surprisingly rare. The promise was huge. The follow-through? Often underwhelming. For a sector where lives are at stake and progress must be both ethical and measurable, the gap between hype and real-world utility is especially stark.That’s why we launched Practical AI in Healthcare.This podcast is dedicated to surfacing the ideas, projects, and tools that are actually working—today. Not speculative futures or marketing sizzle, but grounded, proven use cases of AI making meaningful change across the healthcare landscape.Each episode features candid conversations with the people driving that change: healthcare leaders, technologists, clinicians, researchers, entrepreneurs, and authors of the latest books and peer-reviewed articles. Together, we explore how they're applying AI to solve real problems—in clinical care, clinical trials, diagnostics, operations, public health, and beyond. We dig into the details: What challenge are they addressing? What did implementation really take? What resistance did they face—and how did they overcome it? Most importantly, what impact are they seeing?In this pilot episode, co-hosts Dr. Steven Labkoff and Dr. Leon Rozinblit introduce the vision behind the podcast and lay the groundwork for future conversations. They discuss why now is the right moment for this kind of show, what defines a “practical” AI solution in healthcare, and how listeners—regardless of their role in the industry—can use these insights to inform their own work.New episodes drop every other week. If you're tired of inflated promises and looking instead for signal in the noise—join us.
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ABOUT THIS SHOW
AI promises to transform healthcare—but real, scalable impact remains rare. Practical AI in Healthcare cuts through the noise to showcase real-world use cases delivering business value today. Hosted by senior leaders— former VPs of life science technology groups, clinical informatics professionals from top-tier organizations, and a former Big Four consultant—each episode features candid conversations with the people making AI work inside the healthcare enterprise
HOSTED BY
Steven Labkoff
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