Healthier World with Quest Diagnostics

More than 80% of patients with celiac disease remain undiagnosed or misdiagnosed. In this episode, Maeson Latsko, PhD, explores the reasons for the diagnostic odyssey in celiac disease, from the disease’s wide range of symptoms to common pitfalls in testing. Celiac disease triggers a specific autoimmune response where the body attacks its own small intestines after gluten exposure, leading to malabsorption and comorbid conditions. Providers can screen for celiac disease using a serologic panel that detects key autoantibodies like tTG-IgA and accounts for IgA deficiency. This episode will Describe the autoimmune mechanism in celiac disease, including the role of tissue transglutaminase (tTG) and the HLA-DQ2/DQ8 genetic predisposition (2:00) Identify the key serologic markers used for diagnosis, including tTG-IgA, endomysial antibody (EMA), and the purpose of IgG-based backup tests for patients with IgA deficiency (2:40) Outline the clinical pathway for diagnosis, from initial testing with an automated reflex panel to the role of gut biopsy and follow-up monitoring (5:10) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: May 2026 Speaker(s):  Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Frank Samarro; Adrienne Uzonyi; Aixa Santos; Trisha Winchester, PhD; Additional Resources: Quest Diagnostics Clinical Education Center [Link] Celiac Disease Comprehensive Panel with Gliadin Antibody (IgG) | Test Detail | Quest Diagnostics HLA Typing for Celiac Disease | Test Detail | Quest Diagnostics Tissue Transglutaminase (tTG) Antibody (IgA) | Test Detail | Quest Diagnostics IgA | Test Detail | Quest Diagnostics Gliadin (Deamidated) Antibody (IgA) | Test Detail | Quest Diagnostics References:     Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease. Am J Gastroenterol. 2013;108(5):656-676.   Fasano A, Catassi C. Celiac Disease. N Engl J Med. 2012;367(25):2419-2426.   Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005;40(1):1-19.   Celiac Disease Foundation. Celiac Disease Facts and Figures. Accessed April 15, 2026.

More than 36 million Americans are living with type 2 diabetes, and an estimated 30%-50% of patients remain uncontrolled. In this episode, Maeson Latsko, PhD, explores an under-recognized contributor to difficult-to-control diabetes: hypercortisolism. Hypercortisolism disrupts glucose metabolism and insulin function, leading to elevated HbA1c that isn’t as responsive to traditional treatment. Providers can screen for hypercortisolism using an overnight dexamethasone suppression test. This episode will Review the clinical characteristics of difficult-to-control diabetes and when hypercortisolism should be considered (1:00) Explain how hypercortisolism contributes to type 2 diabetes (2:25) Outline the clinical approach to screening for hypercortisolism (4:50) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: April 2026 Speaker(s):  Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Gregory Buchan, PhD; Sanjay Dixit, MD   Additional Resources Quest Diagnostics Clinical Education Center [Link]   Hypercortisolism in Difficult-To-Control Type II Diabetes | Quest Diagnostics   Ordering information: Dexamethasone Suppression Test (DST), 1 Specimen | Test Detail | Quest Diagnostics Dexamethasone | Test Detail | Quest Diagnostics

Cervical cancer is the fourth most common cancer in women globally, and Human papilloma virus (HPV) causes nearly all cases. Laboratory screening can detect infection or abnormal cells early, so clinicians can intervene before cancer develops. Screening options include Pap testing, HPV testing, and co-testing, and guidelines recommendation different combinations of these tests based on age and clinical presentation. This episode will Explain what HPV testing is and why HPV drives nearly all cervical cancers (1:00) Compare Pap testing, HPV testing, and co-testing (2:00) Summarize guideline-based screening options by age (3:30) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: March 2026 Speaker(s):  Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD, MBA; Pat Alagia, MD, MBA; Lisa Smith; Paula McCollem   Additional Resources Quest Diagnostics Clinical Education Center [Link] Quest Diagnostics Cervical Cancer Portfolio Brochure ASCCP Management Guidelines Web Application Ordering information: ThinPrep Automated Test Code Aid Age 21-29 Pap alone ThinPrep® Automated Pap | Test Detail | Quest Diagnostics Pap reflex to HPV DNA ThinPrep® Automated Pap Reflex HPV DNA (16,18,Other High Risk) PCR,Cervical | Test Detail | Quest Diagnostics Pap reflex to HPV mRNA ThinPrep® Automated Pap with Reflex to HPV mRNA E6/E7 | Test Detail | Quest Diagnostics   Age 30-65 Pap and HPV DNA ThinPrep® Automated Pap and HPV DNA (16, 18, Other High Risk) PCR, Cervical | Test Detail | Quest Diagnostics Pap and HPV mRNA reflex to genotypes 16, 18/45 ThinPrep® Automated Pap and HPV mRNA E6/E7 with Reflex to HPV 16,18/45 | Test Detail | Quest Diagnostics HPV Primary reflex to Pap HPV DNA (16,18, Other High Risk), PCR with Reflex to ThinPrep® Automated Pap | Test Detail | Quest Diagnostics HPV Self-Collection HPV DNA (16, 18, Other High Risk), PCR, Vaginal Self-Collected | Test Detail | Quest Diagnostics  

Chronic kidney disease (CKD) is a major healthcare crisis, impacting about 35 million people in the US. In this episode, Maeson Latsko, PhD and Ines Dahne discuss end-stage kidney disease management in a nephrology setting, and how Quest Diagnostics is providing continuity of care for patients across primary care, nephrology, dialysis, hospitals, and transplant settings. This episode will Explain the nephrologist’s role in managing complex CKD patients across clinics, dialysis centers, and hospitals (3:00) Discuss how the strategic Fresenius–Quest Diagnostics partnership will ensure business and medical continuity for nephrologists and their patients (8:15) Describe the frequency of lab monitoring in nephrology, and how this partnership will support broader testing and to help manage cardiometabolic and autoimmune comorbidities and reinforce prevention given low CKD awareness (14:40) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: March 2026 Speaker(s):  Maeson Latsko, PhD; Ines Dahne Contributor(s): Maeson Latsko, PhD; Ines Dahne; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC; Rohit Joshi; Nathan Adamo; Mouris Saghir, PhD   Additional Resources Quest Diagnostics Clinical Education Center [Link]    

Approximately 55 million people have dementia. Alzheimer’s disease (AD) is the most common form of dementia, impacting nearly 7 million Americans. Blood-based biomarkers such as the beta amyloid 42/40 ratio and phosphorylated tau (p-tau217) are now providing earlier and more accessible insights into Alzheimer's pathology. These markers help differentiate Alzheimer's from other dementias, support early intervention, and improve diagnostic confidence. The Quest Diagnostics panel combines these biomarkers to generate a highly accurate likelihood score for Alzheimer's pathology, enhancing clinical decision-making and care planning. This episode will Describe the pathology of AD (2:00) Summarize the role of blood-based biomarkers in the evaluation of suspected AD (3:00) Explain how biomarkers can support patient evaluation and help clinical decision-making (6:30) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: March 2026 Speaker(s):  Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Amanda Backner; Kenneth French; Michael Prouse, PhD; Mouris Saghir, PhD; Matthew Stroh, PhD; Michael Racke, MD   Additional Resources Quest Diagnostics Clinical Education Center [Link] Test Summary: AD Detect FAQ: AD Detect Ordering information: AD-Detect™ ABeta 42/40 and p-tau217 Evaluation, Plasma   References:     Alzheimer's Association. Alzheimer’s Disease Facts and Figures. Alzheimer’s Disease and Dementia. Published 2025. https://www.alz.org/alzheimers-dementia/facts-figures ‌World Health Organization. Dementia. World Health Organization. Published March 31, 2025. https://www.who.int/news-room/fact-sheets/detail/dementia Palmqvist S, Whitson HE, Allen LA, et al. Alzheimer's Association Clinical Practice Guideline on the use of blood-based biomarkers in the diagnostic workup of suspected Alzheimer's disease within specialized care settings. Alzheimers Dement. 2025;21(7):e70535. doi:10.1002/alz.70535

Pharmacogenetics (PGx) testing is a field that can transform how clinicians select and dose medications by accounting for individual genetic variability in drug metabolism, transport, and response. In this episode, Maeson Latsko, PhD, and Kathleen O’Brien, CGC, DABMG, discuss the clinical utility of PGx testing and how providers can integrate it into routine care. This episode will Describe pharmacogenetics (PGx) testing (2:45) Review different types of pharmacogenes and their clinical utility (12:15) Walk through Quest Diagnostics PGx test offerings (16:30) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: February 2026 Speaker(s):  Maeson Latsko, PhD; Kathleen O’Brien, CGC, DABMG Contributor(s): Maeson Latsko, PhD; Kathleen O’Brien, CGC, DABMG; Rebecca Johnson, CGC; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC   Additional Resources Quest Diagnostics Clinical Education Center [Link] Test summary: Pharmacogenomics   Ordering information: Pharmacogenomics Panel with Coriell Life Sciences (CLS) Report | Test Detail | Quest Diagnostics Pharmacogenomics Panel | Test Detail | Quest Diagnostics References:     Ingelman-Sundberg M. Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy. Journal of Internal Medicine. 2001;250(3):186-200. doi:10.1046/j.1365-2796.2001.00879.x   Chanfreau-Coffinier C, Hull LE, Lynch JA, et al. Projected prevalence of actionable pharmacogenetic variants and level a drugs prescribed among US veterans health administration pharmacy users. JAMA Netw Open. 2019;2(6):e195345. doi:10.1001/jamanetworkopen.2019.5345   Swen JJ, van der Wouden CH, Manson LE, et al. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet (London, England). 2023;401(10374):347-356. Doi:10.1016/S0140-6736(22)01841-4   Bousman CA, Stevenson JM, Ramsey LB, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants. Clin Pharmacol Ther. 2023;114(1):51-68. doi:10.1002/cpt.2903   Johnson JA, Caudle KE, Gong L, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. Clin Pharmacol Ther. 2017;102(3):397-404. doi:10.1002/cpt.668   Oslin DW, Lynch KG, Shih MC, et al. Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial. JAMA. 2022;328(2):151-161. doi:10.1001/jama.2022.9805 Bradley P, Shiekh M, Mehra V, et al. Improved efficacy with targeted pharmacogenetic-guided treatment of patients with depression and anxiety: A randomized clinical trial demonstrating clinical utility. J Psychiatr Res. 2018;96:100-107. doi:10.1016/j.jpsychires.2017.09.024 Greden JF, Parikh SV, Rothschild AJ, et al. Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study. J Psychiatr Res. 2019;111:59-67. doi:10.1016/j.jpsychires.2019.01.003 Swen JJ, van der Wouden CH, Manson LE, et al. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet. 2023;401(10374):347-356. doi:10.1016/S0140-6736(22)01841-4

In this special episode of Healthier World designed to give you Instant Insights, Dr Maeson Latsko discusses the critical role of inflammation in cardiovascular events, focusing on the importance of high-sensitivity C-reactive protein (hsCRP) levels. Cardiovascular events often stem from the rupture of soft plaque, which is fueled by inflammation. Hs-CRP can be used to gauge cardiovascular risk, above even when LDL-C is considered normal. Hs-CRP should be thought of as a red flag for chronic conditions that increase risk for CVD, such as metabolic syndrome, diabetes, and hypertension, emphasizing the importance of addressing inflammation to prevent heart attacks and strokes. This episode will Differentiate hs-CRP from general CRP levels in the context of acute and chronic inflammation (1:10) Introduce hs-CRP as a critical biomarker for assessing cardiovascular risk (1:50) Highlight the integration of hs-CRP into cardiovascular prevention guidelines (5:00) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 1/2026 Speaker(s):  Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC; Mouris Saghir, PhD    Additional Resources: Quest Diagnostics Clinical Education Center [Link] Test summary: hs-CRP Ordering information: Hs-CRP | Test Detail | Quest Diagnostics   References:   Ridker PM, Everett BM, Thuren T, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017;377 (12):1119-1131. doi:10.1056/NEJMoa1707914 Singh TP, Morris DR, Smith S, et al. Systematic review and meta-analysis of the association between C-reactive protein and major cardiovascular events in patients with peripheral artery disease. Eur J Vasc Endovasc Surg. 2017;54 (2):220-233. doi:10.1016/j.ejvs.2017.05.009 Jellinger PS, Handelsman Y, Rosenblit PD, et al. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of dyslipidemia and prevention of cardiovascular disease. Endocr Pract. 2017;23 (suppl 2):1-87. doi:10.4158/EP171764.APPGL US Preventive Services Task Force. Risk assessment for cardiovascular disease with nontraditional risk factors: US Preventive Services Task Force recommendation statement. JAMA. 2018;320 (3):272-280. doi:10.1001/jama.2018.8359 Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139 (25):e1082-e1143. doi:10.1161/CIR.0000000000000625 Ridker PM, Bhatt DL, Pradhan AD, et al. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. 2023;401(10384):1293-1301. doi:10.1016/S0140-6736(23)00215-5 Alam M, Kontopantelis E, Mamas MA, et al. Meta-analysis of the effect of colchicine on C-reactive protein in patients with acute and chronic coronary syndromes. Coron Artery Dis. 2023;34(3):210-215. doi:10.1097/MCA.0000000000001220 Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107 (3):499-511. doi:10.1161/01.cir.0000052939.59093.45  

Metabolic dysfunction is a common root cause of many cardiometabolic conditions that burden the healthcare system. This episode will address insulin resistance, a syndrome that underlies metabolic dysfunction, and how tools can catch risk early, allowing actions that may prevent and reverse the onset of chronic illness. Today’s episode is with Quest Diagnostics experts Kenneth French, Senior Clinical Consultant, and Maeson Latsko, PhD, Clinical and Education Specialist.  This episode will Identify how early identification of insulin resistance can prevent the rise in metabolic dysfunction and Type II Diabetes (3:00) Describe the insulin resistance panel with score (8:11)  Elucidate how identifying insulin resistance can prevent other chronic illness, such as liver related disorders and kidney disease (12:41)  The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 09/2024 Speaker(s): Kenneth French; Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Kenneth French   Additional Resources: Podcast: Action from Insight: Tackling Insulin Resistance (18 min) Webinar: Early Identification of Type 2 Diabetes Risk for the Primary Care Setting Ordering information: Insulin Resistance Panel with Score | Test Detail | Quest Diagnostics Insulin Resistance Panel with Score | Test Summary | Quest Diagnostics         References: Ward ZJ, Bleich SN, Cradock AL, et al. Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity. N Engl J Med. 2019;381(25):2440-2450. doi:10.1056/NEJMsa1909301 Abbasi F, Shiffman D, Tong CH, et al. Insulin resistance probability scores for apparently healthy individuals. J Endocr Soc. 2018;2(9):1050-1057. doi:10.1210/js.2018-00107 Bril F, McPhaul MJ, Kalavalapalli S, et al. Intact fasting insulin identifies nonalcoholic fatty liver disease in patients without diabetes. J Clin Endocrinol Metab. 2021;106(11):e4360-e4371. doi:10.1210/clinem/dgab417 Healy, M. By 2030, nearly half of all U.S. adults will be obese, experts predict. New York Times. https://www.latimes.com/science/story/2019-12-18/nearly-half-of-us-adults-will-be-obese-by-2030 Khan RMM, Chua ZJY, Tan JC, et al. From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research. Medicina (Kaunas). 2019;55(9):546. doi:10.3390/medicina55090546

 The holidays are a time of celebration, but they can also be a challenging time to maintain heart-healthy habits. In today’s episode, Maeson Latsko, PhD and Patty Bianchi, MS, RDN discuss how disrupted routines, rich foods, and elevated stress can impact well-being. We discuss realistic, evidence-based ways to enjoy the holidays while supporting cardiometabolic health. This episode will Discuss common challenges faced during the holiday season (2:15) Review ways to avoid holiday weight gain (5:42) Provide practical tips to enjoy the holiday season while supporting your physical health, mental health and well-being (15:10)   To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: December 2025 Speaker(s):  Maeson Latsko, PhD; Patty Bianchi, MS, RDN Contributor(s): Maeson Latsko, PhD; Patty Bianchi, MS, RDN; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC   Additional Resources Quest Diagnostics Clinical Education Center [Link]

Most people recognize that acute inflammation occurs when a person experiences a viral illness. However, many people are unaware that this inflammatory response can increase risk for cardiometabolic events. In this episode, Dr Marc Penn and Maeson Latsko, PhD, discuss how viral infections such as influenza and SARS-CoV-2 trigger inflammation, which can destabilize plaque, accelerate atherosclerosis, and increase the likelihood of cardiovascular events. A cardiometabolic risk assessment is an essential tool to reduce cardiovascular events linked to viral illnesses. This episode will Explain how acute and chronic viral illness increase cardiovascular risk and how vaccinations and infection prevention strategies are key for lowering viral-related cardiovascular complications (1:00) Highlight how metabolic dysfunction such as insulin resistance, dyslipidemia, obesity, and MASLD amplifies the cardiovascular impact of viral infections (7:00) Demonstrate how noninvasive screening tools such as the FIB-4, hs-CRP, and ApoB help identify high-risk patients (9:00) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: December 2025 Speaker(s):  Maeson Latsko, PhD; Marc Penn, MD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC   Additional Resources Quest Diagnostics Clinical Education Center [Link] Website: Cardiometabolic disease | Quest Diagnostics Ordering information: Cardiometabolic Disease Assessment (CMDA) Panel References:   Kawai K, Muhere CF, Lemos EV, Francis JM. Viral infections and risk of cardiovascular disease: Systematic review and meta-analysis. J Am Heart Assoc. 2025;14(21):e042670. doi:10.1161/JAHA.125.042670 Kobayashi E, Linden-Santangeli NJ, Chan N, et al. Longitudinal metabolic trajectories in diabetes prevention program participants reveal subgroups with varying micro- and macrovascular complication risks. Diabetes Care. 2025;48(10):1704-1712. doi:10.2337/dc25-0866

Type 1 Diabetes (T1D) is an autoimmune disease that remains underrecognized, especially in adults. Once thought of as a childhood condition, nearly half of new cases are now diagnosed in adulthood. T1D can lead to serious complications, including diabetic ketoacidosis, severe hypoglycemia, and eventually cardiometabolic disease. In today’s episode, Maeson Latsko, PhD and Franklin Warren discuss the T1D screening recommendation by the American diabetes Association and how this guidance gives physicians the opportunity to provide more timely, effective interventions, increasing the possibility of preventing complications. This episode will Outline what T1D is and the prevalence of T1D in both children and adults (2:00) Recognize the risk and complications associated with delayed or missed diagnosis, including diabetic ketoacidosis and long-term organ damage (6:20) Review the latest ADA recommendations for screening and early detection of T1D (8:00) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: November 2025 Speaker(s):  Maeson Latsko, PhD; Franklin Warren Contributor(s): Maeson Latsko, PhD; Franklin Warren; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC   Additional Resources Quest Diagnostics Clinical Education Center [Link] T1D Autoantibody Panel Overview T1D Autoantibody Panel Test Summary FAQ: Autoantibodies and Type 1 Diabetes (T1D) Staging presymptomatic patients using Diabetes Type 1 Autoantibody Panel   Ordering information: Diabetes Type 1 Autoantibody Panel | Test Detail | Quest Diagnostics   References:   Smith R, Eisenberg S, Turner-Pfifer A, et al. We are on the verge of breakthrough cures for Type 1 Diabetes, but who are the 2 million Americans who have it? J Health Econ Outcomes Res. 2024;11(2):145-153. doi:10.36469/001c.124604 Leslie RD, Evans-Molina C, Freund-Brown J, et al. Adult-onset Type 1 Diabetes: Current understanding and challenges. Diabetes Care. 2021;44(11):2449-2456. doi:10.2337/dc21-0770 American Diabetes Association Professional Practice Committee. 2. Diagnosis and classification of Diabetes: Standards of care in diabetes-2025. Diabetes Care. 2025;48(1 Suppl 1):S27-S49. doi:10.2337/dc25-S002 Roche EF, Menon A, Gill D, Hoey H. Clinical presentation of Type 1 Diabetes. Pediatr Diabetes. 2005;6(2):75-78. doi:10.1111/j.1399-543X.2005.00110.x Phillip M, Achenbach P, Addala A, et al. Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 Type 1 Diabetes. Diabetes Care. 2024;47(8):1276-1298. doi:10.2337/dci24-0042 Krishnan S, Short KR. Prevalence and significance of cardiometabolic risk factors in children with Type 1 Diabetes. J Cardiometab Syndr. 2009;4(1):50-56. doi:10.1111/j.1559-4572.2008.00034.x Type 1 Diabetes Complications - Breakthrough T1D (https://www.breakthrought1d.org/t1d-resources/complications/) Accessed 10.28.2025

In this special episode designed to give you Instant Insights, we explore how protein in the urine is a powerful marker for both kidney and cardiovascular health. We break down how albumin leaks into the urine when the kidney’s filtration barrier is damaged, review traditional cut points for albumin-to-creatinine ratio (uACR), and discuss emerging evidence showing that even “normal” or low-level albuminuria predicts vascular dysfunction, chronic kidney disease progression, and increased cardiovascular risk. This episode will Explain how albumin appears in the urine and what this indicates about kidney damage (1:00) Discussed different nomenclature used for albuminuria (1:45) Interpret the clinical significance of uACR values (2:15) Describe why albumin levels in the upper end of the normal range may still represent vascular or renal dysfunction (3:00) Recognize that any degree of proteinuria signals increased risk for chronic kidney disease and cardiovascular events (4:30)   To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 11/2025 Speaker(s):  Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD, Millicent Kee, MSN, FNP-BC, Nathan Adamo     Additional Resources   Quest Diagnostics Clinical Education Center [Link]     Ordering information:  Albumin, Random Urine with Creatinine Kidney Profile   References:   Verma A, Schmidt IM, Claudel S, Palsson R, Waikar SS, Srivastava A. Association of Albuminuria With Chronic Kidney Disease Progression in Persons With Chronic Kidney Disease and Normoalbuminuria : A Cohort Study. Ann Intern Med. 2024 Apr;177(4):467-475. doi: 10.7326/M23-2814. Epub 2024 Apr 2. PMID: 38560911; PMCID: PMC12124184

One in three adults worldwide are affected by fatty liver disease, and most are unaware that they have it. Today’s conversation between Andrew Hunt and Maeson Latsko, PhD will dive into Metabolic Associated Steatotic Liver Disease (MASLD), a new terminology that replaces NAFLD, emphasizing the close relationship with metabolic risk factors like obesity, diabetes, and dyslipidemia. We focus on the importance of identifying patients at risk for advanced fibrosis early—before irreversible liver damage occurs. A key tool in this early identification is the use of a fibrosis 4 (FIB-4) score, which is a noninvasive blood-based biomarker that uses age, AST, ALT, and platelet count to estimate fibrosis risk and guide next steps in management. We discuss follow-up testing for some at-risk patients using the Enhanced Liver Fibrosis (ELF) test and the need for continued monitoring  of comorbid cardiometabolic conditions. This episode will Explain the shift in terminology from NAFLD to MASLD (4:00) Highlight the importance of early identification of fatty liver disease using the FIB-4 score (5:45) Outline appropriate follow-up testing, including the use of the ELF test to assess liver fibrosis (9:00) Explore the link between MASLD and other cardiometabolic conditions (12:10)   To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 10/2025 Speaker(s):  Andrew Hunt; Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Andrew Hunt; Trisha Winchester, PhD, Millicent Kee, MSN, FNP-BC     Additional Resources   Quest Diagnostics Clinical Education Center [Link]  ELF test detail  FIB4 test summary  2022 AACE algorithm for fatty liver assessment   Ordering information:  CMP + Fib4  Enhanced Liver Fibrosis Score    References:   Ciardullo S, Vergani M, Perseghin G. Nonalcoholic fatty liver disease in patients with type 2 diabetes: Screening, diagnosis, and treatment. J Clin Med. 2023;12(17):5597. doi:10.3390/jcm12175597  Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-1835. doi:10.1097/HEP.0000000000000323  Cusi K, Isaacs S, Barb D, et al. American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD). Endocr Pract. 2022;28(5):528-562. doi:10.1016/j.eprac.2022.03.010  Stern C, Castera L. Identification of high-risk subjects in nonalcoholic fatty liver disease. Clin Mol Hepatol. 2023;29(Suppl):S196-S206. doi:10.3350/cmh.2022.0431 

This special episode of Healthier World designed to give you Instant Insights discusses the importance of screening and managing fatty liver disease, a condition affecting 1 in 3 Americans and over 70% of patients with type 2 diabetes. The episode covers the transition from the term NAFLD to MASLD, discusses the AACE-recommended testing algorithm for MASLD using the fibrosis-4 (FIB-4) score and the enhanced liver fibrosis (ELF) and highlights the importance of early identification and intervention for proper management of underlying metabolic conditions. This episode will Review the implications of the shift in terminology from NAFLD to MASLD (1:00) Discuss the progression of MASLD (1:25) Walk through the testing algorithm for MASLD, starting with the first-line screening assessment using the FIB-4 and when the follow up with the ELF score is recommended (2:30) Highlight the importance of early identification and prevention in managing MASLD and comorbid cardiometabolic conditions (5:45) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: October 2025 Speaker(s):  Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC   Additional Resources Quest Diagnostics Clinical Education Center [Link] ELF test detail FIB4 test summary 2022 AACE algorithm for fatty liver assessment Ordering information: CMP + Fib4 Enhanced Liver Fibrosis Score   References:   Ciardullo S, Vergani M, Perseghin G. Nonalcoholic fatty liver disease in patients with type 2 diabetes: Screening, Diagnosis, and Treatment. J Clin Med. 2023;12(17):5597. doi:10.3390/jcm12175597 Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-1835. doi:10.1097/HEP.0000000000000323 Cusi K, Isaacs S, Barb D, et al. American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD). Endocr Pract. 2022;28(5):528-562. doi:10.1016/j.eprac.2022.03.010 Stern C, Castera L. Identification of high-risk subjects in nonalcoholic fatty liver disease. Clin Mol Hepatol. 2023;29(Suppl):S196-S206. doi:10.3350/cmh.2022.0431

Coronary calcium scores are highly utilized to spot hidden cardiovascular risk, and  new research suggests that timing is important. Today’s conversation between Maeson Latsko, PhD and Millicent Kee, MSN, FNP-BC will break down how timing plays a role in proper assessment of calcium scoring, and how biomarker testing such as Apolipoprotein B, Myeloperoxidase, Lp-PLA2, and hs-CRP can be paired with physiological assessments like calcium scoring to help guide patient care, especially when calcium scoring doesn’t tell the full story. This episode will Review what calcium scoring is (1:30) Discuss how timing of calcium scoring can influence interpretation of results (3:15) Explain why statin-treated patients should not monitor their risk using a calcium score (7:00) Discuss ways biomarker testing such as ApoB, MPO, Lp-pla2, and hs-CRP can reveal hidden risk outside of the window indicated for calcium scoring (11:30; 14:30)   To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 9/2025 Speaker(s):  Maeson Latsko, PhD; Millicent Kee, MSN, FNP-BC Contributor(s): Maeson Latsko, PhD; Millicent Kee, MSN, FNP-BC; Trisha Winchester, PhD; Kathryn Morales, MS     Additional Resources: Apolipoprotein B | Test Detail | Quest Diagnostics hs-CRP | Test Detail | Quest Diagnostics Lp-pla2 | Test Detail | Quest Diagnostics Myeloperoxidase | Test Detail | Quest Diagnostics

In this episode of Healthier World designed to give you instant insights, we introduce the Cleveland HeartLab and its role as a Center of Excellence for cardiometabolic, endocrine, and wellness testing at Quest Diagnostics. In this episode, Dr. Maeson Latsko hosts a segment featuring various leaders from Cleveland HeartLab and Quest Diagnostics, including Marc Penn, MD, PhD, Mouris Saghir, PhD, Tim Collier, PhD and Jim Davis. They discuss their mission to improve heart disease prevention and associated metabolic conditions through cutting-edge research and personalized care. This episode will  Discuss the need for better chronic disease prevention (1:40) Review the cardiometabolic approach to healthcare (2:15) Highlight the technology behind Cleveland Heartlab testing (2:45) Introduce Cleveland Heart Lab as the center of excellence (3:30)   To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 8/2025 Speaker(s):  Maeson Latsko, PhD Contributor(s):  Maeson Latsko, PhD; Trisha Winchester, PhD, Millicent Kee, NP

Obesity affects over 40% of adults in the United States. Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications initially developed for the treatment of type 2 diabetes, have shown significant efficacy in promoting weight loss and are increasingly prescribed for obesity management. In today’s episode, Millicent Kee, MSN, FNP-BC, Clinical and Education Specialist, and Patty Bianchi, MS, RDN, CDCES, Clinical Educator at Quest Diagnostics Center of Excellence at Cleveland HeartLab, will discuss GLP-1 receptor agonists, their actions in the body, and the important role of nutrition, exercise, and lifestyle alongside these medications. This episode will Discuss the actions of GLP-1 receptor agonists in the body (1:38) Discuss how GLP-1s influence appetite and hunger (3:18) Discuss the role of nutrition, exercise, and lifestyle while on GLP-1 therapy (6:38) Discuss how weight loss may also improve cardiometabolic health and lower insulin resistance utilizing a patient example (18:00) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 8/2025 Speaker(s):  Millicent Kee, MSN, FNP-BC; Patricia Bianchi, MS, RDN, CDCES Contributor(s): Millicent Kee, MSN, FNP-BC; Patricia Bianchi, MS, RDN, CDCES; Maeson Latsko, PhD; Trisha Winchester, PhD   Additional Resources Quest Diagnostics Clinical Education Center [Link]   References: Neff LM, Kushner RF. Emerging role of GLP-1 receptor agonists in the treatment of obesity. Diabetes Metab Syndr Obes. 2010 Jul 20; 3:263-73. doi: 10.2147/dmsott. s6816   Stierman B, Afful J, Carroll MD, et al. National Health and Nutrition Examination Survey 2017–March 2020 prepandemic data files development of files and prevalence estimates for selected health outcomes. Natl Health Stat Report. 2021;158. doi: 10.15620/cdc:106273   Related Content: FAQ CardioIQ® Insulin Resistance Panel with Score | Quest Diagnostics   Additional Resources Weight management and cardiometabolic health | Quest Diagnostics   Audio Podcast Instant Insight: Metabolic Risk Panel | Quest Diagnostics Action From Insight: Tackling Insulin Resistance | Quest Diagnostics   Conference Presentation Measures of Insulin Resistance (IR) Increase with Increasing BMI in a Population of Normoglycemic Working Adults | Quest Diagnostics   On-Demand Webinar Detecting and Managing Insulin Resistance | Quest Diagnostics

In this special episode of Healthier World designed to give you Instant Insights, we review a panel that takes a deeper look at cardiovascular, renal, hepatic, endocrine, and metabolic health—a network of systems that work together to determine a person’s long-term health. Today we will break down what this panel includes and how it can help prevent the onset of chronic disease years before symptoms start. This episode will Explain why this panel was created (1:10) Examine how the panel provides a comprehensive view of cardiovascular, metabolic, endocrine, renal, and hepatic risk (3:35) Discuss the clinical relevance of this panel in prevention screening and risk stratification for cardiometabolic conditions (5:30) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 8/2025 Speaker(s):  Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC; Kathryn Morales; Abhi Patel   Resources Quest Diagnostics Clinical Education Center [Link] Podcast: The Cardiometabolic approach to modern disease risk assessment   Ordering information: Cardiometabolic Disease Assessment (CMDA) Panel | Test Detail | Quest Diagnostics    

In this special episode of Healthier World designed to give you Instant Insights, we explore a vascular-specific inflammatory marker that can indicate risk for cardiometabolic disease and all-cause mortality—myeloperoxidase. In this episode, we break down the biology and function of MPO, its contribution to vascular inflammation, and its potential as a biomarker of vulnerable soft plaque in the arteries. This episode will Define myeloperoxidase (MPO) and describe its biological function (1:20) Explain the relationship between MPO and vascular inflammation (2:15) Recognize the role of MPO in cardiometabolic disease (2:55) Review treatment considerations for elevated MPO (3:45) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 7/2025 Speaker(s):  Maeson Latsko, PhD Contributor(s):  Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC   Additional Resources Ordering information: MPO ordering information MPO Test Summary Quest Diagnostics Clinical Education Center [Link]     References:    Iakoubova OA, Haji-Sheikhi F, Louie JZ, et al. Association of MPO levels with cardiometabolic disease stratified by atherosclerotic cardiovascular risk and intensity of therapy in a workforce population. Sci Rep. 2025;15(1):12244. Published 2025 Apr 10. doi:10.1038/s41598-025-89373-7

Inflammation plays a critical role in cardiometabolic diseases, but traditional risk markers like LDL-C and hs-CRP don’t tell the whole story. Myeloperoxidase (MPO), an enzyme linked to oxidative stress and immune activation, may offer a deeper look into hidden cardiovascular and metabolic risk. In this episode, Dr Marc Penn unpacks the new research examining the association between MPO and the risk for chronic kidney disease (CKD) and  nonalcoholic fatty liver disease (NAFLD) across atherogenic cardiovascular disease (ASCVD) risk groups and what it might mean for prevention and tailored treatment.   This episode will Define MPO (1:30, 5:00) Explain the role of MPO as an inflammatory biomarker and how it differs from traditional cardiometabolic risk markers (2:00) Reveal relationships between MPO, CKD, and NAFLD (7:00) Outline how providers can use MPO to enhance risk stratification and personalize treatment strategies (9:25) Inform listeners on the importance of early detection and prevention of risk factors for cardiometabolic risk (13:00)   The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 6/2025 Speaker(s):  Maeson Latsko, PhD; Dr Marc Penn Contributor(s):  Maeson Latsko, PhD; Trisha Winchester, PhD; Kathryn Morales, MS   Additional Resources Ordering information MPO ordering information  Quest Diagnostics Clinical Education Center [Link] References Iakoubova OA, Haji-Sheikhi F, Louie JZ, et al. Association of MPO levels with cardiometabolic disease stratified by atherosclerotic cardiovascular risk and intensity of therapy in a workforce population. Sci Rep. 2025;15(1):12244. Published 2025 Apr 10. doi:10.1038/s41598-025-89373-7

In this special episode of Healthier World designed to give you Instant Insights, we dive into advanced lipid testing—going beyond a standard lipid panel. Today, we will explore two powerful tools used to look at lipoprotein fractionation: ion mobility and nuclear magnetic resonance (NMR). We will look at how these tests work and how they can uncover hidden risk for cardiovascular disease. This episode will Expand on the importance of lipoprotein fractionation by ion mobility and nuclear magnetic resonance (NMR) (1:15) Interpret key lipid analytes provided using two methodologies, NMR and ion mobility, as they relate to cardiovascular disease risk (LDL: 3:00, HDL: 4:40, VLDL: 5:30, LDL pattern and LDL peak size: 6:00) Evaluate report analytes and risk cut points between methods (6:45) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 6/2025 Speaker(s):  Maeson Latsko, PhD Contributor(s):  Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC; Abhi Patel   Additional Resources Ordering information: Quest Diagnostics Clinical Education Center [Link]   Fractionation, Ion Mobility Fractionation, NMR   References:           Cromwell WC, Otvos JD, Keyes MJ, et al. LDL Particle Number and Risk of Future Cardiovascular Disease in the Framingham Offspring Study - Implications for LDL Management. J Clin Lipidol. 2007;1(6):583-592. doi:10.1016/j.jacl.2007.10.001   German CA, Shapiro MD. Assessing Atherosclerotic Cardiovascular Disease Risk with Advanced Lipid Testing: State of the Science. Eur Cardiol. 2020;15:e56.  doi:10.15420/ecr.2019.18   Quesada JA, Bertomeu-González V, Orozco-Beltrán D, et al. The benefits of measuring the size and number of lipoprotein particles for cardiovascular risk prediction: A systematic review and meta-analysis. Clin Investig Arterioscler. 2023;35(4):165-177. doi:10.1016/j.arteri.2022.11.001

In this special episode of Healthier World designed to give you Instant Insights, we take a look at primary aldosteronism (PA)- an often underdiagnosed, yet prevalent cause of hypertension. In this episode, we challenge traditional screening methods and introduce a streamlined diagnostic approach. By recognizing the signs of Primary Aldosteronism earlier, providers can improve patient outcomes and avoid increased risk for cardiovascular and metabolic conditions associated with untreated PA. This episode will Explain the mechanisms underlying PA and how they disrupt the normal renin-aldosterone feedback system (1:15) Highlight the limitations of traditional methodology, including the aldosterone-renin-ratio (ARR) (2:25) Introduce a streamlined approach focused on the detection of suppressed renin followed by evaluation of aldosterone levels (3:00) Walk through an example comparing the ARR with the suppressed renin approach for assessing PA (5:05)   The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 6/2025 Speaker(s): Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC; Akhil Singh Additional Resources: https://www.questdiagnostics.com/healthcare-professionals/about-our-tests/endocrine-disorders/primary-aldosteronism Ordering information: Plasma Renin Activity with Reflex to Aldosterone | Test Detail | Quest Diagnostics   References: Marcelli M, Bi C, Funder JW, McPhaul MJ. Comparing ARR Versus Suppressed PRA as Screening Tests for Primary Aldosteronism. Hypertension. 2024;81(10):2072-2081. doi:10.1161/HYPERTENSIONAHA.124.22884   Dogra P, Bancos I, Young WF Jr. Primary Aldosteronism: A Pragmatic Approach to Diagnosis and Management. Mayo Clin Proc. 2023;98(8):1207-1215. doi:10.1016/j.mayocp.2023.04.023

Understanding the diagnosis and treatment in primary aldosteronism (PA) often feels elusive to most providers. PA is marked by the elevation of aldosterone and the suppression of renin leading to a disproportionately higher risk of cardiovascular, kidney, and metabolic disease compared to those patients with essential hypertension, yet this condition is often undiagnosed. This episode will discuss the use of the Plasma Renin Activity lab to screen for primary aldosteronism and guideline-directed care of PA.  In today’s episode, Maeson Latsko, PhD and Millicent Kee, MSN, FNP-BC, Clinical and Education Specialists at Quest Diagnostics Center of Excellence at Cleveland Heartlab, will discuss the next steps in care once primary aldosteronism has been identified. This episode will Discuss the prevalence of PA and its impact on health (1:30) Discuss use of the PRA lab to screen for PA (4:15) Review current diagnosis and treatment guidelines for PA (mineralocorticoid receptor antagonist (MRA) treatment: 6:50, MRA considerations: 13:00) Discuss how providers can utilize current treatment guidelines (referral: 9:45, imaging: 11:00, surgical evaluation: 11:45) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 5/2025 Speaker(s):  Millicent Kee, MSN, FNP-BC; Maeson Latsko, PhD Contributor(s):  Maeson Latsko, PhD; Millicent Kee; MSN, FNP-BC; Trisha Winchester, PhD; Sanjay Dixit, MD; Akhil Singh   Additional Resources Ordering information: Quest Diagnostics Clinical Education Center [Link]   Plasma Renin Activity with Reflex to Aldosterone | Test Detail | Quest Diagnostics   https://www.questdiagnostics.com/healthcare-professionals/about-our-tests/endocrine-disorders/primary-aldosteronism   References:  Auchus RJ. Approaching Primary Aldosteronism as a Common Disease. Endocr Pract. 2023;29(12):994-998. doi:10.1016/j.eprac. 2023.08.014   Brown JM, Tsai LC, Abel EE, et al. Nationwide, Pragmatic, Direct-to-Patient Primary Aldosteronism Testing Program. Hypertension. 2025 Feb 21. doi: 10.1161/HYPERTENSIONAHA.125.24648.   Funder JW, Carey RM, Mantero F, et al. The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(5):1889-1916. doi:10.1210/jc.2015-4061   Marcelli M, Bi C, Funder JW, McPhaul MJ. Comparing ARR Versus Suppressed PRA as Screening Tests for Primary Aldosteronism. Hypertension. 2024;81(10):2072-2081. doi:10.1161/HYPERTENSIONAHA.124.22884

Cardiovascular disease (CVD) is the leading cause of death in men and women, yet 45% of women don’t know it’s their leading cause of death. A staggering 71% of women never discuss heart health with their physicians. This episode will explore this gender disparity and elucidate why women carry unique risk for cardiovascular and metabolic diseases. Today’s episode is with clinical educators Trisha Winchester, PhD and Maeson Latsko, PhD. This episode will Discuss the gender gap in cardiovascular disease (1:15) Review risk factors for CVD that are unique to women (4:00), such as PCOS (6:00), adverse pregnancy outcomes (9:00, gestational diabetes: 13:00, pre-eclampsia 15:15), and menopause (19:30) Review what laboratory tools providers can utilize to better indicate and track risk in women overtime (14:30, 17:45) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings, as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 04/2025   Speaker(s): Trisha Winchester, PhD; Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC; Abhi Patel   Additional Resources: Women in CV risk article References: Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association. Circulation. 2019;140(9):e543. doi:10.1161/CIR.0000000000000728 Vilmi-Kerälä T, Palomäki O, Vainio M, Uotila J, Palomäki A. The risk of metabolic syndrome after gestational diabetes mellitus - a hospital-based cohort study. Diabetol Metab Syndr. 2015;7:43. Published 2015 May 12. doi:10.1186/s13098-015-0038-z Vounzoulaki E, Khunti K, Abner SC, Tan BK, Davies MJ, Gillies CL. Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis. BMJ. 2020;369:m1361. Published 2020 May 13. doi:10.1136/bmj.m1361 Kramer CK, Campbell S, Retnakaran R. Gestational diabetes and the risk of cardiovascular disease in women: a systematic review and meta-analysis. Diabetologia. 2019;62(6):905-914. doi:10.1007/s00125-019-4840-2 Brown MC, Best KE, Pearce MS, Waugh J, Robson SC, Bell R. Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis. Eur J Epidemiol. 2013;28(1):1-19. doi:10.1007/s10654-013-9762-6 Leslie MS, Briggs LA. Preeclampsia and the Risk of Future Vascular Disease and Mortality: A Review. J Midwifery Womens Health. 2016;61(3):315-324. doi:10.1111/jmwh.12469 PCOS (polycystic ovary syndrome) and diabetes. Centers for Disease Control and Prevention. Reviewed March 24, 2020. Accessed August 18, 2022.https://www.cdc.gov/diabetes/basics/pcos.html  

Approximately 120 million people in the US have hypertension, which is about half of the adult population. Identifying the mechanisms that cause hypertension is crucial for the proper treatment of patients, yet 9 out of 10 patients do not know the origin of their hypertension. New research reveals that up to 30% of patients suffer from hypertension due to primary aldosteronism (PA). With less than 1% of patients with hypertension being screened for hypertension, today’s episode is designed to bring awareness to PA and discuss the breakthrough research that may help drive screening for PA. Today’s episode is with Maeson Latsko, PhD, Clinical and Education Specialist at Quest Diagnostics Center of Excellence at Cleveland Heartlab, Dr Sanjay Dixit, and Dr Marco Marcelli, board certified endocrinologists and medical directors with Quest Diagnostics. This episode will Define hypertension and PA (3:30, 6:15) Describe the intricate link between hypertension and PA (5:40) Review current screening tools for PA (6:35) Discuss how novel research can capture even more patients with hypertension due to PA (9:50) Discuss who should be screened for PA (17:15) Outline how a diagnosis of PA can influence treatment considerations (18:50) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 3/2025 Speaker(s): Sanjay Dixit, MD; Marco Marcelli, MD; Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD, Trisha Winchester, PhD; Sanjay Dixit, MD; Marco Marcelli, MD; Maeson Latsko, PhD; Akhil Singh Additional Resources: https://www.questdiagnostics.com/healthcare-professionals/about-our-tests/endocrine-disorders/primary-aldosteronism Ordering information: Plasma Renin Activity with Reflex to Aldosterone | Test Detail | Quest Diagnostics   References: Marcelli M, Bi C, Funder JW, McPhaul MJ. Comparing ARR Versus Suppressed PRA as Screening Tests for Primary Aldosteronism. Hypertension. 2024;81(10):2072-2081. doi:10.1161/HYPERTENSIONAHA.124.22884   Brown JM, Siddiqui M, Calhoun DA, Carey RM, Hopkins PN, Williams GH, Vaidya A. The unrecognized prevalence of primary aldosteronism: a cross-sectional study. Ann Intern Med. 2020;173:10–20. doi: 10.7326/M20-0065   Vaidya A, Hundemer GL, Nanba K, Parksook WW, Brown JM. Primary Aldosteronism: State-of-the-Art Review. Am J Hypertens. 2022;35(12):967-988. doi:10.1093/ajh/hpac079 Auchus RJ. Approaching Primary Aldosteronism as a Common Disease. Endocr Pract. 2023;29(12):994-998. doi:10.1016/j.eprac.2023.08.014   Ostchega Y, Fryar CD, Nwankwo T, et al. Hypertension Prevalence Among Adults Aged 18 and over: United States, 2017-2018. April 2020. Accessed November 20, 2024. Products - Data Briefs - Number 364 - April 2020   Dogra P, Bancos I, Young WF Jr. Primary Aldosteronism: A Pragmatic Approach to Diagnosis and Management. Mayo Clin Proc. 2023;98(8):1207-1215. doi:10.1016/j.mayocp.2023.04.023   Funder JW, Carey RM, Mantero F, et al. The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(5):1889-1916. doi:10.1210/jc.2015-4061

More than 1 in 7 US adults are estimated to have chronic kidney disease, or CKD, and as many as 9 in 10 don’t know they have it.  Damage to your kidneys cannot be reversed, but if found early, there are ways to prevent its progression such as following a healthy eating plan and being physically active.  Today’s episode is with Patty Bianchi, Registered Dietitian Nutritionist and Certified Diabetes Care and Education Specialist, and Maeson Latsko, PhD, Clinical and Education Specialist at Quest Diagnostics Center of Excellence at Cleveland HeartLab.  This episode will Review function of the kidneys (1:20) Identify causes and risk factors of chronic kidney disease (3:00) Review lifestyle changes to prevent the progression of kidney disease (7:50, 17:00) Discuss how limiting salt intake (10:00), animal protein (12:15), and mineral content (14:30) should be a focus for patients with CKD  The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date:  03/2025 Speakers(s):  Patty Bianchi, RDN, CDCES; Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Patty Bianchi, RDN, CDCES; Trisha Winchester, PhD Additional Resources:   Instant Insights: Kidney Profile and eGFR with creatinine and cystatin-C Quest Diagnostics Clinical Education Center [Link]  References: National Institute of Diabetes and Digestive and Kidney Disease. Kidney Disease Statistics for the United States. September 9, 2024. Accessed February 2025 Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314. doi:10.1016/j.kint.2023.10.018 Key Takeaways People Living with CKD

As many as 45% of Americans have a chronic disease. Shared cardiometabolic risk factors contribute to related conditions, such as cardiovascular disease, poor glycemic control, chronic kidney disease, fatty liver disease, and common endocrine disorders. As evidence demonstrating the interrelationships between chronic cardiometabolic diseases continues to expand, establishing a personalized approach to reduce risk is crucial. This episode is with Quest Diagnostics® experts Maeson Latsko, PhD, Clinical and Education Specialist, and Dr Marc Penn, founder and chief medical officer for Cleveland Heart Lab at the Quest Cardiometabolic Center of Excellence™ in Cleveland, Ohio.  Dr Penn is also a board-certified cardiologist and director of research at Summa Cardiovascular Institute. This episode will Review how the risk factors for cardiovascular disease have changed (1:15) Discuss how the cardiometabolic approach brings attention to related conditions, such as cardiovascular disease, chronic kidney disease, fatty liver disease, and dysglycemia (3:00) Describe the importance of evaluating endocrine disorders when assessing risk for cardiometabolic conditions (6:45) Walk through a clinical example of how to implement the cardiometabolic approach (8:50) Discuss how to implement prevention with clinical solutions to improve patient care (3:45, 14:00) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 2/2025 Speaker(s): Maeson S Latsko, PhD; Marc Penn, MD, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Mouris Saghir, PhD Ordering information: Cardiometabolic Disease Assessment (CMDA) Panel References:  Fuster V, García-Álvarez A, Devesa A, et al. Influence of Subclinical Atherosclerosis Burden and Progression on Mortality. J Am Coll Cardiol. 2024;84(15):1391-1403. doi:10.1016/j.jacc.2024.06.045 Correia LC. Ezetimibe: Clinical and Scientific Meaning of the IMPROVE-IT Study. Arq Bras Cardiol. 2016;106(3):247-249. doi:10.5935/abc.20160033 Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344(8934):1383-1389. Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023;389(24):2221-2232. doi:10.1056/NEJMoa2307563   Additional Resources: Website: Cardiometabolic disease | Quest Diagnostics

1in 7 US adults are estimated to have chronic kidney disease, or CKD. Because early stages of the disease are often clinically silent, 90% of individuals with CKD don’t know they have it. This podcast highlights the importance of early CKD detection and the need for proper screening, especially in individuals with hypertension and diabetes. The Kidney Profile aligns with guidelines and includes the urine-albumin-creatinine ratio and eGFR. The new 2024 guidelines recommend using both creatinine and Cystatin C in estimating eGFR in certain populations, which provides a more accurate risk assessment for CKD and other cardiometabolic conditions like heart disease and stroke. By adopting this dual approach, healthcare providers can improve early detection, staging, and management of CKD, leading to better patient outcomes. This episode will Explore the role of the Kidney Profile in CKD diagnosis and how it aligns with the 2024 KDIGO guidelines. (1:40, 5:15) Identify at-risk populations for CKD, including those with hypertension and diabetes, and understand the importance of early screening and management. (1:30) Investigate how combining creatinine and cystatin C in eGFR improves the prediction of CKD progression and associated cardiometabolic risks. (4:30) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 12/2024 Speaker(s): Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD Additional Resources: Quest Diagnostics Clinical Education Center [Link] Ordering information:  Kidney Profile [link] Kidney Profile Test Summary [link] eGFR with Creatinine and Cystatin C [link] References:   Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314. doi:10.1016/j.kint.2023.10.018 National Kidney Foundation. Kidney Disease: Fact Sheet. National Kidney Foundation. August 6, 2024. Accessed December 19, 2024. https://www.kidney.org/about/kidney-disease-fact-sheet  

Increased rates of obesity and type 2 diabetes are increasing rates of cardiometabolic conditions. Identifying and intervening in early stages of metabolic dysfunction is crucial in order to delay and prevent disease progression. The Metabolic Risk Panel is a comprehensive test that helps identify individuals at risk for metabolic dysfunction, insulin resistance, and cardiovascular disease. The panel includes Hemoglobin A1C, Insulin Resistance Panel with Score, Lipid Panel, and Apolipoprotein B (apoB), which together provide a more detailed picture of cardiometabolic health than traditional tests alone. By incorporating these biomarkers, clinicians can detect metabolic risks earlier, enabling proactive interventions to prevent conditions like Type 2 Diabetes, Cardiovascular Disease, and other related cardiometabolic conditions.   This episode will Outline the components of the Metabolic Risk Panel, including Hemoglobin A1C, insulin resistance panel with score, lipid panel, and Apolipoprotein B, and how they improve risk assessment. (0:33) Explain the role of insulin resistance in the development of metabolic dysfunction and its connection to early signs of type 2 diabetes. (2:25) Recognize the importance of apolipoprotein B (apoB) in evaluating lipid metabolism and its role in cardiovascular risk assessment, especially in patients with insulin resistance or metabolic syndrome. (3:15) Identify how combining traditional and advanced biomarkers in the Metabolic Risk Panel helps clinicians catch metabolic and cardiovascular risks early, enabling more effective prevention and management. (4:30) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.  Date: 12/2024 Speaker(s): Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD Additional Resources: Quest Diagnostics Clinical Education Center [Link] Ordering information: Metabolic Risk Panel [link] References:   Cannon A, Handelsman Y, Heile M, Shannon M. Burden of illness in type 2 diabetes mellitus. J Manag Care Spec Pharm. 2018;24(9-a Suppl):S5-S13. doi:10.18553/jmcp.2018.24.9-a.s5 Johannesen CDL, Langsted A, Nordestgaard BG, Mortensen MB. Excess apolipoprotein B and cardiovascular risk in women and men. J Am Coll Cardiol. 2024;83(23):2262-2273. doi:10.1016/j.jacc.2024.03.423   Centers of Medicare & Medicaid Services. Diabetes Screening & Definitions Update: CY 2024 physician fee schedule final rule. June 25, 2024. Accessed December 19, 2024. https://www.cms.gov/files/document/mm13487-diabetes-screening-definitions-update-cy-2024-physician-fee-schedule-final-rule.pdf   Centers for Disease Control and Prevention. (2017). National diabetes statistics report, 2017: Estimates of Diabetes and its Burden in the United States. Retrieved from https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf

Identifying insulin resistance offers significant—and often untapped—clinical value and can help healthcare providers and their patients take action with diet and lifestyle choices to avoid or change the progression to prediabetes and diabetes. Today’s episode features Patty Bianchi, Registered Dietitian Nutritionist and Certified Diabetes Care and Education Specialist and Trisha Winchester, PhD, Quest Diagnostics Sr Manager for Clinical & Education. This episode will Review glucose regulation by insulin (1:15)  Discuss how insulin resistance is measured (3:00)  Review actionable ways to reduce insulin resistance through lifestyle (4:00), exercise (6:30), diet (8:50), stress and sleep (11:50) Discuss the 4myheart patient education program offered through Quest Diagnostics Center of Excellence at Cleveland Heartlab (14:30) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 11/2024 Speaker(s): Patty Bianchi, RDN, CDCES; Trisha Winchester, PhD Contributor(s): Trisha Winchester, PhD; Patty Bianchi, RDN, CDCES; Maeson Latsko, PhD   Additional Resources: Podcast: The Insulin Resistance Revolution: The Key to Preventing Chronic Conditions (17 min) Webinar: Early Identification of Type 2 Diabetes Risk for the Primary Care Setting Ordering information: Insulin Resistance Panel with Score | Test Detail | Quest Diagnostics Insulin Resistance Panel with Score | Test Summary | Quest Diagnostics

Metabolic dysfunction is a common root cause of many cardiometabolic conditions that burden the healthcare system. This episode will address insulin resistance, a syndrome that underlies metabolic dysfunction, and how tools can catch risk early, allowing actions that may prevent and reverse the onset of chronic illness. Today’s episode is with Quest Diagnostics experts Kenneth French, Senior Clinical Consultant, and Dr Maeson Latsko, clinical and education specialist.  This episode will Identify how early identification of insulin resistance can prevent the rise in metabolic dysfunction and Type II Diabetes (3:00) Describe the insulin resistance panel with score (8:11)  Elucidate how identifying insulin resistance can prevent other chronic illness, such as liver related disorders and kidney disease (12:41)  The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 09/2024 Speaker(s): Kenneth French; Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD; Kenneth French   Additional Resources: Podcast: Action from Insight: Tackling Insulin Resistance (18 min) Webinar: Early Identification of Type 2 Diabetes Risk for the Primary Care Setting Ordering information: Insulin Resistance Panel with Score | Test Detail | Quest Diagnostics Insulin Resistance Panel with Score | Test Summary | Quest Diagnostics         References: Ward ZJ, Bleich SN, Cradock AL, et al. Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity. N Engl J Med. 2019;381(25):2440-2450. doi:10.1056/NEJMsa1909301 Abbasi F, Shiffman D, Tong CH, et al. Insulin resistance probability scores for apparently healthy individuals. J Endocr Soc. 2018;2(9):1050-1057. doi:10.1210/js.2018-00107 Bril F, McPhaul MJ, Kalavalapalli S, et al. Intact fasting insulin identifies nonalcoholic fatty liver disease in patients without diabetes. J Clin Endocrinol Metab. 2021;106(11):e4360-e4371. doi:10.1210/clinem/dgab417 Healy, M. By 2030, nearly half of all U.S. adults will be obese, experts predict. New York Times. https://www.latimes.com/science/story/2019-12-18/nearly-half-of-us-adults-will-be-obese-by-2030 Khan RMM, Chua ZJY, Tan JC, et al. From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research. Medicina (Kaunas). 2019;55(9):546. doi:10.3390/medicina55090546

Despite advances in understanding the pathogenesis and prevention of atherosclerotic cardiovascular disease, coronary heart disease remains the leading cause of death in the United States. Apolipoprotein B (ApoB)—containing lipoproteins more closely identifies atherosclerosis and correlates to atherogenic particles in circulation. This episode will: Review the current state of cardiovascular risk assessment Describe lipoprotein anatomy and ApoB Identify discordance between LDL cholesterol and ApoB Discuss the guideline recommended clinical utility of ApoB in risk identification The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 9/10/24 Speaker(s): Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD Additional Resources: Quest Diagnostics Clinical Education Center [Link] Ordering information: Apolipoprotein B | Test Detail | Quest Diagnostics Apolipoprotein B | Test Summary | Quest Diagnostics Apo B and cardiovascular risk | Quest Diagnostics | Quest Diagnostics   References:   Sniderman AD, Williams K, Contois JH, et al. A meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein b as markers of cardiovascular risk. Circ: Cardiovascular Quality and Outcomes. 2011;4(3):337-345. doi:10.1161/CIRCOUTCOMES.110.959247   Johannesen CDL, Langsted A, Nordestgaard BG, Mortensen MB. Excess apolipoprotein B and cardiovascular risk in women and men. J Am Coll Cardiol. 2024;83(23):2262-2273. doi:10.1016/j.jacc.2024.03.423   Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139(25):e1082-e1143. doi:10.1161/CIR.0000000000000625   Contois JH, McConnell JP, Sethi AA, et al. Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem. 2009;55(3):407-419. doi:10.1373/clinchem.2008.118356

Despite advances in understanding the pathogenesis and prevention of atherosclerotic cardiovascular disease, coronary heart disease remains the leading cause of death in the United States. Lipoprotein (a), or Lp(a), is a particularly atherogenic type of lipoprotein, where excess levels significantly influence cardiovascular risk.   This episode will: Review the significant cardiovascular implications of Lp(a) excess Describe Lp(a) structure Discuss how Lp(a) is measured Review the treatment landscape for Lp(a) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 9/10/24 Speaker(s): Maeson Latsko, PhD Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD   Additional Resources: Ordering information: Lipoprotein (a) | Test Detail | Quest Diagnostics Lipoprotein(a) | Test Summary | Quest Diagnostics   Quest Diagnostics Clinical Education Center [Link]     References: Wilson DP, Jacobson TA, Jones PH, et al. Use of Lipoprotein(A) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association. J Clin Lipidol. 2019;13(3):374-392. doi:10.1016/j.jacl.2019.04.010    Koschinsky ML, Bajaj A, Boffa MB, et al. A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice. J Clin Lipidol. 2024;18(3):e308-e319. doi:10.1016/j.jacl.2024.03.001

Hypogonadism is a common condition in the male population, impacting approximately 35% of men over 45 years of age. Today’s episode is with Quest Diagnostics experts Dr Sanjay Dixit, MD, medical director, and Maeson Latsko, PhD, clinical specialist. This episode will: Review the clinical and biochemical changes seen in male patients with hypogonadism (1:20) Discuss the guideline-recommended methodologies for testosterone analysis (3:24) Learn how to delineate between primary and secondary hypogonadism (7:38) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: May 3, 2024 Contributor(s): Dr. Sanjay Dixit, MD, Maeson Latsko, PhD Additional Resources: Quest Diagnostics Clinical Education Center  Quest Diagnostics Hypogonadism FAQs Clinical Focus: Hypogonadism and Low Testosterone in Men  Adult Male Hypogonadism Diagnostic Algorithm References See Quest Diagnostics Clinical Education Center 

An estimated 20 million Americans have some form of thyroid disease, and up to 60% of them are unaware of their condition. Today’s episode is with Quest Diagnostics experts Dr Sanjay Dixit, MD, medical director, and Sarah Walsh, PA-C, CLS, clinical specialist.    This episode will: Identify common signs and symptoms of thyroid dysfunction Identify lab recommendations to support the diagnosis of hypo- and hyperthyroidism Discuss the association between cardiometabolic conditions and thyroid dysfunction The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.   Date: 4/18/2024 Speaker(s): Dr. Sanjay Dixit, MD; Sarah Walsh, PA-C, CLS  Contributor(s): Sarah Walsh, PA-C, CLS; Dr. Sanjay Dixit, MD; Trisha Winchester, PhD; Maeson Latsko, PhD Additional Resources:  Quest Diagnostics Clinical Education Center Quest Diagnostics Thyroid Disorders  Clinical Focus: Thyroid Dysfunction in Nonpregnant Adults Testing Algorithm for Thyroid Dysfunction in Nonpregnant Adults References See Quest Diagnostics Clinical Education Center

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine diagnoses for reproductive-aged women and carries lifelong cardiometabolic risk. Today’s episode is with Quest Diagnostics experts Dr Sanjay Dixit, MD, medical director, and Sarah Walsh, PA-C, CLS, clinical specialist. This episode will: Review the diagnostic criteria for PCOS (2:00) Identify lab recommendations to support the diagnosis of PCOS (6:00) Discuss associated cardiometabolic conditions and how to screen and monitor for these conditions (14:45) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date recorded: 4/9/2024 Speaker(s): Dr. Sanjay Dixit, MD; Sarah Walsh, PA-C, CLS Contributor(s): Sarah Walsh, PA-C, CLS; Dr. Sanjay Dixit, MD; Trisha Winchester, PhD; Maeson Latsko, PhD Additional Resources: Quest Diagnostics Polycystic ovary syndrome Clinical Focus: Polycystic Ovary Syndrome  Polycystic Ovary Syndrome (PCOS) Diagnostic Algorithm Laboratory Testing in the Differential Diagnosis of PCOS and NCCAH References See Quest Diagnostics Clinical Education Center