The DeSci Podcast

What if we stopped treating aging as “natural” and started treating it like a disease?In this episode of the Molecule Podcast, Ella McCarthy-Page (Sci Comms Lead at Molecule)and Alana Tara Singh (Behavioural Strategist) unpack a seismic shift in how governments are approaching longevity science. The German National Academy of Sciences has officially defined aging as a disease target, opening the door for clinical trials, new drug development, and the first regulatory frameworks focused on reversing age-related decline.They’re joined by Michael Torres (co-founder, R10 Bio & VITA RNA), who shares why he’s launching a human clinical trial targeting post-chemo aging in Abu Dhabi, a country now fast-tracking longevity drugs under radical new trial standards.You’ll learn:* Why aging wasn’t treatable (until now)* What Germany’s new policy really means* How Rapamycin exposed the flaws in current regulation* Why Abu Dhabi is leading the longevity race* The role of DeSci in decentralized drug development* How R10 Bio used Molecule’s IP-NFT model to raise funds* The real story behind Michael’s anti-aging therapyWelcome to the future of proactive medicine! Let’s reimagine aging before it redefines us.Timestamps:00:00 – Intro with Ella & Alana00:34 – Germany now targets aging as a disease01:30 – Why regulators blocked anti-aging drugs02:40 – Rapamycin and the loophole problem04:00 – Why off-label drugs are risky05:20 – Germany’s surprise leadership in longevity06:00 – Abu Dhabi’s radical trial reforms09:15 – Raves, cappuccinos & Gen Z health trends10:00 – Can we prevent cancer by targeting aging?10:50 – What is R10 Bio’s therapy actually doing?12:00 – The DeSci fundraising journey with Molecule13:10 – From mutation suppression to clinical readiness14:00 – Why Abu Dhabi was chosen for trials14:40 – Michael Torres on aging post-chemo16:00 – Defining a huge market with aging-related outcomes17:00 – Why rare disease trials don’t scale18:00 – How Abu Dhabi is implementing FDA “guidance”

What if your healthspan was backed by a token? What if trading fees funded science? And what if longevity wasn’t just about “not dying”, but about living better for the ones you love?In this episode of the Molecule Podcast, we dive deep with Jillian and Benji, the team behind Pump Science, a protocol that combines crypto markets with open scientific experimentation to find real longevity compounds. But this episode isn’t just technical. It’s deeply human.From bonding curves and tokenomics to holding your child longer, this is what decentralized science looks like when purpose meets protocol.We cover:* The emotional “why” behind longevity research* How crypto markets fund real scientific experiments* Testing pipeline: from worms to flies to mice to humans* The design of the Pump Science game, and how it rewards curiosity* How you can submit your own idea for a longevity compound* What’s next for Pump ScienceThis is more than a podcast, it’s a thesis on how the future of health could be fun, fair, and radically open.—Timestamps:0:00 – Intro: Do you want to live for tomorrow?1:45 – A mother’s promise: holding her son longer5:35 – Longevity as emotional responsibility8:12 – Why crypto is the only viable engine10:10 – Pump Science protocol explained from first principles14:42 – Launching a compound via bonding curve17:55 – Who are the players? Drug devs & gem hunters24:18 – What happens when a token “migrates”29:34 – How token trading fees fund real experiments32:20 – The buyback & burn mechanic37:02 – The new standard for supplement + data39:15 – Why not wait for human data? Worms, flies & predictive efficiency48:04 – Pump Science vs other longevity efforts (Brian Johnson, etc.)50:25 – How much has actually been studied in longevity?55:00 – Why this system must exist, or nothing will change57:02 – Making science fun again: designing a game people want to play1:00:00 – Fly racing & the next experimental features1:02:30 – Launching more tokens, testing more ideas1:04:05 – How you can submit your own compound1:05:40 – Final vision: best products, open data, real change🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] thanks to: ______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone

What if your immune cells came with a smart upgrade?In this episode of the DeSci Podcast, we speak with Dr. Henry Erdlei, medical doctor, cancer researcher, and founder of GoCart, a new cell therapy platform building safer, modular CAR-T therapies through decentralized science.Henry breaks down:* How CAR-T cell therapies work* The real-world risks of immune overactivation* Why cancer is hard to distinguish from healthy tissue* The problem with existing logic gates in cell therapies* His own innovation: an external AND-gate adapter system* Why DeSci and IP-NFTs are the right path for early-stage therapeutics🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected]:00 – Intro: What is CAR-T therapy?2:00 – Henry’s background & journey into cancer research4:20 – What T-cells do and why they fail in cancer7:30 – CAR-T vs chemotherapy: cost, complexity, and potential11:00 – Which cancers are eligible for CAR-T treatment?13:10 – Risks: cytokine storms, immune cascades, suicide switches17:30 – Emily Whitehead: the first CAR-T success story20:30 – Current limitations of approved CAR-Ts (CD19, BCMA)23:00 – Introducing GoCart and their “AND gate” design26:00 – Why tumor targeting needs precision logic29:00 – Modular CAR-Ts and the future of personalized medicine32:00 – Why GoCart is building in public with Molecule34:30 – Can DeSci unlock truly customizable cell therapies?37:00 – From research to startup: bridging the valley of death40:00 – How to follow GoCart and get involved______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone

What if you were told that your body is secretly responding to Wi-Fi signals you can't even feel?In episode 49 of the Molecule Podcast we meet Dr. Geoff Anders (Founder, Leverage) and Dr. Clarice D. Aiello (Quantum Engineer), to explore the cutting-edge field where quantum physics meets biology, revealing how the smallest particles in the universe might be controlling the largest processes in life itself. Whether you're a scientist, technologist, or simply curious about the quantum world around us, this deep dive into quantum biology will change how you think about life, technology, and the future of medicine.        • Quantum biology explained in simple terms• Weak magnetic field effects on cellular processes• The radical pair mechanism and quantum sensing in nature• Space exploration and magnetic field implications• DeSci (Decentralized Science) and crypto funding for research• The future of quantum-controlled medicine• Open science and radical transparency in researchTake a leap into the never ending world of science and imagination with this podcast.Timestamps:00:00:02 - Introduction to Quantum Biology00:02:31 - Quantum Physics in Everyday Life00:04:34 - Understanding the Micro to Macro Connection00:08:11 - Weak Magnetic Fields and Cellular Response00:10:31 - Space Exploration and Magnetic Fields00:14:10 - Mars Colonization Challenges00:15:10 - Future Applications00:16:57 - Personal Backgrounds00:18:36 - From Quantum Sensors to Biology00:20:16 - The DeSci Connection00:27:07 - Real-World Applications Vision00:31:09 - Multiple Flavors of Quantum Biology00:35:45 - Music and Plant Growth00:43:19 - The Consciousness Question00:54:06 - Radical Open Science00:55:15 - How to Get Involved00:56:39 - Final Thoughts🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] thanks to: ______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone

What if science wasn’t locked in labs or universities?In episode 47 of the Molecule Podcast, we meet Juan Keymer, Assistant Professor, Shenzhen X-Institute who enlightens us on the existing academic pipeline and how it can be made more flexible with the advancement in AI, DeSci (Decentralized Science), Blockchain Innovation, Open Credentials and more.• Reimagining the future of Science with DeSci.• This is a deep, thoughtful, and radically hopeful conversation about the future of learning, research, and planetary collaboration.• Indulge in a world of Science with Juan Keymer and Ella McCarthy-Page (SciComms Lead at Molecule) away from textbooks and traditional academic systems.In this fascinating episode, we dive deep into reimagining the infrastructure of science away from elite institutions and toward decentralized, gamified systems that anyone can engage in.Timestamps00:00:00 – Introduction: A New Vision for Science00:03:15 – The Problem with Academia & Closed Scientific Systems00:10:47 – Open Degrees & Scope for Open Credentials 00:15:20 – The New Scientific Interface00:20:34 – Biotic Games: How Living Systems Become Game Mechanics00:28:45 – Open Hardware and Decentralized Labs00:35:06 – Rewiring Academia: Parallel Programming & Self-Credentialing00:37:00 – Metaverse & Blockchain-Powered Ecosystems00:41:00 – Fun First, Research Second00:43:00 – Final Reflections: The Power of Play in Scientific Discovery🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected]______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone

Over $2.2 billion in NIH research grants are frozen. Labs are going dark. What happens now?In Episode 46 of the Molecule Podcast, we speak with Aaron Weaver, Chief Commercial Officer at Molecule, about the ongoing NIH funding crisis, its global impact, and how decentralized science (DeSci) is becoming a critical alternative.Aaron brings a unique vantage point from the intersection of venture capital, biotech, and public science funding. This episode unpacks:• The real story behind the NIH funding freeze• Why the budget cuts on indirect costs are threatening university research• What happens when academia loses funding momentum• How DeSci offers new models for sustainability and collaboration• How to get involved — even if you’re not a researcherIf you care about the future of scientific discovery, this episode is essential.Timestamps- 0:00 – Intro: The NIH funding crisis1:30 – What’s actually frozen? Why $2.2B is stalled2:50 – Meet Aaron Weaver: CCO of Molecule & DeSci advocate5:00 – Why indirect costs are at the center of the issue9:00 – How operational freezes threaten lab survival11:30 – The fragility of foundational science13:45 – NIH’s critical role in FDA-approved drugs17:00 – Academic research vs. commercialization pipelines20:15 – Who’s affected most? Young researchers & labs23:00 – Global ripple effects & talent displacement27:00 – Why traditional VC can’t fill the gap30:10 – DeSci as a market structure for resilient funding32:45 – Are universities ready for DeSci?35:20 – Connecting scientists with global communities37:10 – Science as public purpose and personal mission40:00 – How you can get involved in the DeSci movement🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] thanks to: Aaron Weaver : https://x.com/RealAaronWeaverJillian Casalini : https://x.com/JillianCasalini______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone

What if your next spine surgery was coordinated by a DAO?In Episode 48 of the Molecule Podcast, we’re joined by Vincent Challier, spine surgeon and co-founder of SpineDAO, and Virginie Lafage, medical strategist and Core Team member, to explore how decentralized science can transform a field as specialized and critical—as spinal health.SpineDAO is building one of the first focused medical DAOs on the Bio Launchpad. In this episode, we cover:• Why spinal health is overlooked in innovation• The power of patient and clinician-led DAOs• Challenges of onboarding medical professionals into DeSci• Real-world use cases for DAOs in healthcare• Why Solana? Technical decisions behind the DAO’s designWhether you’re into biotech, DAOs, or the future of decentralized medicine, this conversation bridges science, surgery, and Web3 in a way you’ve never heard before.⏱️ Timestamps 0:00 – Intro: Meet Vincent & Virginie from SpineDAO2:10 – How they met and started the DAO5:18 – From spine surgery to decentralization: Why this field?8:50 – Building a community around spine health12:42 – Why spinal innovation is long overdue17:20 – Challenges patients face in current medical systems24:10 – How DAOs can unlock patient-centric research29:45 – Engaging surgeons and clinicians in DeSci36:30 – Building accessibility into Web3 onboarding40:00 – Why SpineDAO chose Solana44:23 – The Bio Launchpad auction and what’s next49:04 – A message to their future community52:10 – The real-world use case for SpineDAO______🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected]_________Special thanks to: Vincent Challier : https://x.com/challaireVirginie Lafage : https://x.com/VirginieLafageElla McCarthy-Page :https://x.com/EMcCarthyPage______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone

What if we could reinvent intellectual property for science? In this episode of Molecule’s DeSci Podcast, Kevin Noessler - Product Head at Molecule - joins us to talk about the next frontier of DeSci Science: Proof of Invention.Kevin unpacks how Molecule is building infrastructure for decentralized IP creation, ownership, and attribution. This episode zooms in on how DeSci tools can validate and tokenize early-stage scientific ideas—before patents or papers.We cover:• Kevin’s background and his role in shaping Molecule’s product roadmap• What “Proof of Invention” really means—and how it works onchain• Rethinking IP and scientific reputation through cryptographic primitives• UX challenges when designing for biotech DAOs• The difference between building SaaS vs protocols in DeSci• How open-source values translate into credible scientific infrastructureWhether you’re an innovator, researcher, or builder—this episode is a roadmap for the future of intellectual property in science.⏱ Timestamps:00:00 - Intro01:10 - Kevin’s background & journey to Molecule05:00 - What does a Product Head do in a decentralized org?09:20 - SaaS vs Protocol: Rethinking product building13:00 - Contributors, not customers: the shift in stakeholder models17:15 - UX challenges for onchain science tools21:40 - What makes a product work in DeSci?26:00 - Building with researchers in mind30:30 - Kevin’s long-term vision for Molecule35:00 - Advice for builders entering DeSci39:20 - Outro ________🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected]______Special thanks to: - Kevin Noessler: https://x.com/Noesslek- Ella McCarthy-Page: https://x.com/EMcCarthyPage______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone

What if the future of science and biotech was built on legal frameworks that empower communities, not corporations?In Episode 44 of the Molecule Podcast, we sit down with Jesse Hudson — lawyer, anthropologist, and Chief Legal Architect at Molecule. Jesse is a pioneer in building legal infrastructure for decentralized science (DeSci), DAOs, and intellectual property (IP) tokenization.This episode dives deep into:- The failure of the current global IP system- IP as cultural infrastructure- IP tokenization and why it matters for DAOs- Licensing, enforcement, and the problem of patent trolls- How indigenous IP and cultural property are being reclaimed through blockchain- New models for governance, dispute resolution, and community-owned IPJesse’s unique experience working with Amazonian tribes, biotech DAOs, and legal DAOs brings one of the most profound and ethical perspectives to the DeSci conversation.Timestamps:0:00 – Intro: Why IP matters2:13 – Meet Jesse Hudson: Legal architect & anthropologist5:05 – From anthropology to biotech DAOs7:44 – IP in the digital age: Why it’s grown 70x11:02 – How IP impacts individuals: NIL rights & personal brands15:10 – IP basics: Trademark, copyright, patents20:05 – Patent trolls & the licensing problem27:01 – Is the IP system serving the public?30:10 – Tesla & IP strategy: When to share vs protect33:42 – DAOs as IP holders: SideDAO & decentralized licensing36:10 – IP tokens & collective governance38:18 – Indigenous cultural IP: Working with the Shipibo tribe44:20 – NFT royalties & licensing for indigenous art48:52 – IP ethics: Alternative models beyond Western frameworks53:22 – DAO-based dispute resolution & legal evolution59:50 – Closing thoughts: Cultural values driving IP systems🔗 Learn more at https://molecule.xyz

The psychedelic industry is booming, but a major battle is unfolding: Who will control the future of these powerful medicines? Will open science prevail, or will corporations dominate through patents? In this episode, we sit down with Graham Pechenik, a leading expert in psychedelic patent law, to unravel the complexities of intellectual property in the space.Graham Pechenik is the founder of Calyx Law, a law firm specializing in psychedelic and cannabis patents. With a background in neuroscience and law, he provides deep insights into the legal landscape shaping the future of psychedelic medicine.Topics Discussed:• The role of patents in psychedelic research• Controversies around corporate control and monopolization• How open-source models could challenge big pharma• What legal battles mean for researchers, startups, and patients• The future of psychedelic accessibilityTune in to get expert insights from one of the leading voices in psychedelic IP law.______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] thanks to: Ella McCarthy-Page - https://x.com/EMcCarthyPageGraham Pechenik - https://x.com/calyxlaw______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone

Biotech is at a crossroads—AI, intellectual property, and startups are reshaping the future. But who really controls the breakthroughs? In this episode, Sara Holland, an IP advisor, explores how patents impact biotech, the challenges startups face against big pharma, and whether AI will change everything.What You’ll Learn in This Episode:- The hidden barriers to biotech innovation- How AI is transforming drug discovery and synthetic biology- The role of patents in protecting—or stifling—progress- Why decentralized science (DeSci) could be the key to the future______Special Thanks To:Ella McCarthy-Page : https://x.com/EMcCarthyPageSara HollandChris BrynesMark Nichols______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.com/invite/moleculedao______Molecule - The future of medicine belongs to everyone

Welcome to another episode of the DeSci Podcast. Today, we are discussing a critical issue that affects over 30 million people in the United States—Rare Diseases. Despite being more prevalent than cancer and HIV combined, rare diseases remain underfunded, overlooked by Big Pharma, and trapped in a broken system.Our Guest: This episode features Ethan Perlstein, founder of CureTopia, an initiative using Decentralized Science (DeSci) and blockchain to revolutionize rare disease research. Why does the current system fail millions of patients, and how can decentralized models change that?What You’ll Learn in This Episode:-The reality of rare diseases and why the term "rare" is misleading-How patients and parents are taking control of scientific research-Why Big Pharma does not prioritize rare diseases and the funding challenges involved-How DeSci and blockchain can disrupt traditional biotech and accelerate drug development-The vision behind CureTopia and how it is reshaping research for rare disease treatmentsResources Mentioned:CureTopia: https://curetopia.xyzDeSci Podcast: https://www.molecule.xyzFeel free to navigate through any of the topics discussed in the podcast using the timestamps below.___⭐ Timestamps:0:00 - Introduction: The Rare Disease Crisis2:14 - Why Rare Diseases Are More Common Than People Think5:13 - Challenges in Rare Disease Advocacy9:25 - How Parents Become Scientific Experts in Their Child’s Disease13:50 - Why Big Pharma Ignores Rare Diseases17:16 - The Role of Decentralized Science (DeSci) in Drug Development22:41 - The Funding Challenges in Rare Disease Research27:34 - How Blockchain and Smart Contracts Can Help Rare Disease Research33:04 - The Power of Community in Rare Disease Advocacy38:26 - What Is CureTopia and How Does It Work?43:57 - The Future of Rare Disease Research and Biotech Innovation49:14 - Ethan Perlstein’s Vision for CureTopia54:10 - Closing Thoughts and Where to Learn More______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] thanks to:Jillian Casalini: https://x.com/JillianCasaliniEthan Perlstein: https://x.com/eperlste____Let's connect: Website: https://bit.ly/3d6nh2CX: https://twitter.com/Molecule_daoDiscord: https://discord.com/invite/moleculedaoMolecule - The future of medicine belongs to everyone!

Welcome to another episode of the DeSci Podcast! Today, we’re excited to host Joshua Bate, Founder of DeSciWorld. DeSciWorld is a community-driven initiative dedicated to facilitating the onboarding of individuals into the Decentralized Science (DeSci) space. It provides users with the tools to view, engage with, and understand everything happening in the world of decentralized science. In this episode, Joshua shares the vision behind DeSciWorld and its role as a global hub for the decentralized science community. We touch on Joshua's frank thoughts on the DeSci movement and how open discussion and unadultered knowledge transfer, alongside powerful incentives, are necessary to grow the space. We also discuss the “Proof of Knowledge protocol”, DeSciWorld's upcoming technical product where users can upload data and receive incentives whenever their contributions are utilized. Joshua addresses concerns about spam and low-quality dataset submissions, as well as potential technical approaches to ensure that the data used to train AI remains high-quality and reliable. DeSci World: https://desci.world/ SynapseDAO: https://synapse-dao.webflow.io/ Feel free to navigate through any of the topics discussed in the podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:28 Overview of DeSci World 04:24 About “Proof of Knowledge” protocol 7:07 Ensuring high-quality datasets 14:04 Common misconceptions about DeSci 16:28 How incentives can drive DeSci adoption in Academia 20:10 Underappreciated aspects of Decentralized Science 22:10 Recommendations for getting started in DeSci 24:23 Competition vs. collaboration in the Web3 space 25:48 Scope of biotech 30:59 The future of of Decentralized Science 33:55 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea: https://twitter.com/lealeata Joshua: https://twitter.com/jb87ua ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

In this episode, we're diving deep into Molecule's Catalyst, an incentive-driven funding system for basic research. We begin by exploring the significant challenges posed by traditional funding models. We then touch on the "Valley of Death"—a critical juncture where many groundbreaking ideas fail often due to a lack of financial support. We discuss why early-stage research often struggles to gain traction and the barriers that prevent innovative ideas from reaching their full potential. Catalyst is at the forefront of addressing these issues with its decentralized approach. By realigning incentives and democratizing access to research funding, Catalyst fosters collaboration and makes science more inclusive and inviting. We also explore the role of IP tokens (IPTs) in decentralized science and how they democratize access to and control over scientific advancements. Additionally, we explain Catalyst’s bonding curve, which features dynamic pricing that rewards early backers with lower token prices and ensures fair pricing as more tokens are minted. This system not only incentivizes early support but also maintains a transparent and equitable funding environment. Tune in to discover the potential of decentralized funding in science and how you can get involved. Whether you're a researcher, an investor, or simply curious about the future of science, this episode is packed with insights you won't want to miss. ___ ⭐ Timestamps: 0:00 Intro 18:04 Challenges of traditional funding models 19:47 The valley of death; how it impacts research 24:30 Difficulty in getting involved in early-stage ideas 31:20 Using IP as a tool to realign incentives 35:01 Why IP is the ideal use case for bringing ideas on-chain 42:05 Decentralized funding in science 48:44 Introduction to Catalyst 55:26 How Catalyst works 59:36 Catalyst bonding curve explained 1:03:22 The negotiation period in Catalyst fundraising 1:09:22 Final remarks ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Jillian: https://twitter.com/JillianCasalini Benji: https://twitter.com/benjileibo Kevin: https://www.linkedin.com/in/kevin-noessler Learn more about Catalyst here: https://catalyst.molecule.xyz/ ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

In this episode, we have the pleasure of hosting Alok Tayi, the co-founder of Vibe Bio.Vibe Bio is a life science company dedicated to investing in biotech firms, with a special focus on rare and overlooked diseases. In this episode, Alok shares his personal story of how medical conditions in his family led to the creation of Vibe Bio, and how the company aims to identify diseases with unmet needs, leveraging AI to find medicines with the highest chances of providing cures. We discuss the complexities of drug development, the advantages of DAOs as an organizational structure and common misconceptions within the Biopharma industry. Alok also shares his insights on the transformative role of AI in drug discovery, discussing its utilization, the methods used for training AI models, the issue of AI bias, and the current limitations and challenges faced in leveraging AI to advance drug development. Feel free to navigate through any of the topics discussed in the podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 01:51 What led you to create Vibe 02:52 Diseases Vibe Focuses On 04:37 Complexities in Drug Development 7:49 Advantages of DAOs 12:00 Misconceptions in Academia & the Private Sector 16:53 Areas you’re willing to explore with more funding. 23:59 Utilizing AI tools in Drug Discovery 28:50 Bias in AI 32:54 AI Training Methods 36:58 Limits of AI in Drug Discovery 39:56 Implicit Knowledge in Drug Development 49:30 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea: https://twitter.com/lealeata Alok: https://twitter.com/aloktayi Learn more about Vibe Bio here: https://vibebio.com/ ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we're joined by Justin, Head of Growth at Hippocrat, a collaborative healthcare data protocol that aims to transform healthcare by empowering individuals to take control of their health data through blockchain and zero-knowledge proof technologies. In this episode, we discuss the importance of data sovereignty, exploring how Hippocrat's innovative approach ensures secure and private data management, enabling safe and transparent data sharing with healthcare providers. Justin emphasizes the need for decentralized data provision in healthcare, stressing that shifting from centralized to decentralized data management addresses the longstanding issue of individuals lack of control over their health data, which in turn advances personalized healthcare and research. We also explore Hippocrat's collaboration with Research HUB, aimed at identifying potential populations and regions where Hippocrat's telemedicine application, ‘Hippodoc’, could be effectively deployed to bridge healthcare accessibility gaps. Feel free to navigate through any of the topics discussed in the podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:28 About Hippocrat 2:37 Why data sovereignty is important 7:55 The inspiration behind Hippocrat 11:48 Moving from Web 2 to Web 3 healthcare 13:39 How Hippocrat improves Data security 22:27 $HPO token utility and upcoming airdrop 26:58 Collaboration with Research HUB 38:25 How the Hippodoc app works 41:27 Hippocrat role in the DeSci space 45:30 Hippocrat in 10 years 49:18 How to get involved ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Ella McCarthy-Page: https://twitter.com/EMcCarthyPage Justin Kim: (email: [email protected] / telegram: just_in_1) Special Airdrop for DeSci Podcast listeners: https://gleam.io/cLiQO/100-hippocrat-x-desci-podcast-giveaway Learn more about Hippocrat here: https://link3.to/hippocrat ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

In this episode we're joined by Dr. Sönke Bartling, Founder of Blockchain for Science, an initiative that aims to open up science and knowledge creation through web3. In this episode, we explore Decentralized Science (DeSci) and its potential to revolutionize research, publishing, and innovation! We dive deep into how blockchain technology can transform scholarly publishing by making it more transparent, efficient, and trustworthy. We also discuss how DeSci can address funding inequality by supporting both high-profile topics, such as longevity research, and smaller yet vital fields. This, in turn, enables DeSci to promote diversity in research and unlock breakthroughs in overlooked areas. We further discuss how DeSci can revolutionize the peer review process and explore the future of patents in a DeSci landscape, where research is incentivized without hindering collaboration, and how this can lead to more innovative scientific discoveries. Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below. ___ ⭐ Timestamps: 0:00 Intro 1:46 Blockchains in the Future of Science and Research 4:25 Blockchain Adoption in Publishing 5:45 Underappreciated Aspects of DeSci 12:06 Radical Guidelines for Web3 17:19 Transitioning more Scientists to DeSci 25:26 What limits Institutional Change with Technology 30:22 Incentivising Foolproof DeSci 33:12 Plausibility and Reproducibility in Peer Review 36:16 Standards for Peer Review 39:14 DeSci for Publishing 40:25 The Private Sector and Academia 43:59 Non-monopolizing Patents with Web3 46:36 Further Questions ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Dr. Sönke Bartling: https://twitter.com/soenkeba ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

In this episode, we discuss the problem of declining R&D efficiency with Dr. Jack Scannell, a scientist and entrepreneur who is well known for coining the term “Eroom’s law,” which highlights the decline in pharmaceutical research and development (R&D) productivity over several decades. In this episode, Jack sheds light on the root causes of this decline, beginning with a critique of the poor quality of diagnosis surrounding the R&D productivity problem. He also talks about the challenges in accurately measuring progress in drug research, highlighting the "measurement problem" in the drug industry. Jack suggests adopting a model akin to the "Stern Review” to improve the diagnosis of these challenges. Jack also addresses topics such as the shift in the frequency of serendipitous drug discoveries, the Eroom’s law article, the entanglement of science, money and drug development and many more. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 01:40 Poor quality of diagnosis of the R&D productivity problem 04:01 The measurement problem 09:21 Chesterton’s fence of R&D 14:38 Science, Drug development, Money. 20:46 The role of Serendipity in drug discovery 26:34 Economics in the drug industry. 34:43 Implicit knowledge within Biotech 41:43 Eroom's Law paper ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Jack Scannell: https://twitter.com/JackScannell13 ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we were joined by Jeffrey Koury, Director & Business Development Lead at ResearchHub, and Jonathan Heppner, Marketing & Social Media Lead. ResearchHub is a platform designed to accelerate the pace of scientific research by providing a modern mobile and web application where people can collaborate on scientific research more efficiently. It aims to make scientific research accessible, collaborative, and prioritized for everyone. In this episode, we delved into the shortcomings of the current scientific research model and the need to make science open to everyone. Our dialogue centered on advocating for a shift from the traditional model towards a more inclusive and transparent system. Central to this shift is the necessity of building better incentive structures, which would drive collaboration among scientists and facilitate accelerated progress in scientific research. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:30 What is Research Hub? 03:05 Onboarding process. 05:40 What drove your interest in building Research Hub? 12:16 Past efforts in promoting open science 18:32 The role of Research Hub in scientific literature 26:19 How Research Hub differs from traditional journals 35:14 Public versus Anonymous Peer Review 39:20 Most contentious topics within your field 48:50 Ensuring high quality science 52:35 Why books are important 59:13 How to get involved 59:47 How Research Hub has evolved over the years 1:05:13 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Jeffrey Koury: https://twitter.com/jeffyfish9 Jonathan Heppner: https://twitter.com/EnactJohnny ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Today we are delighted to host Seemay Chow, Co-founder and CEO of Arcadia Science, a for-profit research institute with a specific focus on novel model organisms that haven't been traditionally studied in the lab and translating discoveries into commercial ventures. In this episode, we discuss Arcadia’s mission, structure and approach, emphasizing the importance of providing scientists with the context needed to understand the practical applications of their research. Seemay explains how this approach fosters a different kind of creativity among researchers, thus increasing the likelihood of research success. We also explore the limitations researchers face in the traditional setting while further highlighting the strengths and weaknesses of Academia and industry. Other topics we touched on include notions of diversity in science, strategies for spotting the best talents and ideas to fund, and many more. Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below. ___ ⭐ Timestamps: 0:00 Intro. 0:49 Effects of running a for-profit venture on Arcadia’s structure. 3:05 What is Arcadia? 7:35 Researchers limitations in Academia. 11:45 Academia vs the private sector. 16:21 Insights gained from building Arcadia. 27:54 Arcadia structure. 30:38 Diversity in science. 35:24 Strategies for discovering the best talents. 43:28 Contextualizing science. 49:50 Outro. ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Seemay Chou: https://twitter.com/seemaychou ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci podcast. Today, we were joined by Alfred Brown, co-founder of Desci London, a community dedicated to transforming science through web3 technology. In this episode, we talked about the DeSci London conference (scheduled for Saturday, 23 Mar 2024, 09:30 - Sunday, 24 Mar 2024, 16:30 GMT). This two-day event aims to spotlight the transformative potential of blockchain technology in the field of science, covering agendas such as Longevity research, Rare diseases, DeSci Tooling and Infrastructure, Climate tech innovations, Women’s health, and more. Alfred shares insights into the event's objectives, potential speakers, and details on how to livestream for those unable to attend in person. In addition to the main discussion, we explored the intersection between web3 and science, the importance of community in Desci, and several other topics. Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below. ___ ⭐ Timestamps: 0:00 intro 1:16 Alfred’s journey into DeSci. 04:57 What was your experience diving into blockchain as a beginner? 07:12 Recommendations for scientists venturing into DeSci. 11:34 DeSci London event. 16:55 How to apply for the travel grant. 22:38 The role of art and creativity in science. 28:33 Community-building in DeSci. 29:54 How to find the DeSci London monthly meetups. 30:46 Insights for aspiring Desci community builders. 37:22 Potential speakers for the event. 45:36 How to live stream the DeSci London event. 49:29 Other notable DeSci events. 52:23 Impact of younger generations in DeSci. 56:00 Molecule and Nucleate partnership. 58:48 The necessity of community in Desci. 1:08:09 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Ella McCarthy-Page: https://twitter.com/EMcCarthyPage Alfred Brown: https://twitter.com/AlfredJBrown99 ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! Today, we are delighted to host Stuart Buck. Stuart serves as a Senior Advisor at the Social Science Research Council and is the Executive Director of the Good Science Project—an organization dedicated to enhancing the funding and practice of science. In this episode, Stuart addresses key challenges in the scientific landscape, such as bureaucratic obstacles to funding and the distinction between basic and applied science. He emphasizes the interconnected nature of basic and applied research, highlighting how discoveries from basic research lay the foundation for applied innovations and challenges addressed through applied science inspire new questions in basic research. Moving further, Stuart shares his view on the metaphor of failure in science. According to him, failure is not synonymous with defeat; instead, encountering failures in scientific endeavors indicates that one is posing pertinent questions and pushing the boundaries of knowledge. Other topics covered in the podcast include scientific reproducibility, the measurement problem in science, enforcing data accessibility, and many more. Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below. ___ ⭐ Timestamps: 0:00 Intro 01:27 Good science project main focus. 03:37 Stuart’s theory of social change 10:04 Areas that need improvement 13:00 Recommendation for young researchers 17:35 Why grantmakers tend to be conservative in funding basic science 21:45 Basic vs Applied research 24:15 The notion of failure in science 30:59 Revisiting anti-portfolio 37:37 The value of funding replication in research 43:45 The problem with metrics 46:49 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Stuart Buck: https://twitter.com/stuartbuck1 ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! Today we were joined by Brian Margierski, Brian is the CEO and Founder of Cerebrum DAO, an open, global community that seeks to reimagine impact funding to advance brain longevity and accelerate solutions and cures to Alzheimer’s disease and other neurological disorders. In this episode, Brian delves into Cerebrum DAO, outlining its mission and commitment to advancing brain health research. He sheds light on the motivating factors behind his interest in this field and elaborates on why he opted for the DAO model as the most fitting framework to achieve these objectives. We also discuss how the DAO model enables entrepreneurship by creating an environment for innovation and empowering individuals to propose and pursue unconventional projects without the constraints typically associated with centralized funding models. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 01:04 Cerebrum DAO’s mission 02:54 What drove your interest in brain health research? 07:05 What made you choose the DAO model? 13:37 Cerebrum DAO structure. 18:14 Collaborating with biotech companies 20:37 Maintaining scientific quality in decentralized funding 24:50 How DAOs enables entrepreneurship 30:12 Contentious topics in your workplace. 32:05 How to get involved. 35:05 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Brian Magierski: https://twitter.com/bmagierski ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

In this episode, we're joined by Keith Comito, a computer programmer, mathematician, and President at Lifespan. Lifespan.io is a non-profit advocacy foundation dedicated to accelerating initiatives aimed at addressing age-related diseases and extending the healthy human lifespan. Extending the human lifespan has been a captivating and often controversial topic. Over the years, focus has shifted from merely treating end diseases to addressing the fundamental mechanisms of aging itself. In this episode, Keith shares with us the factors that inspired his commitment to work on aging research. We also discuss how societal attitudes on extending lifespan have changed over the years and the philosophical implications of infinite lifespan. In conclusion, Keith underscores the paramount importance of attaining the goals of aging research, emphasizing the positive impact such accomplishments would have on the well-being and advancement of humanity. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 01:09 About Keith 02:09 What drew you to work on Lifespan.io 03:05 The relevance of studying history in Tech 07:05 Evolution of attitudes towards life extension. 09:25 Limits to extending lifespan. 11:33 Pros and cons of traditional science methods 14:25 Critiques of DeSci 15:44 Traditional institutions' views on DeSci 17:37 Contentious topics within your field 19:54 Religion influence on perspectives of aging 22:05 Life extension without limits 26:17 Recurring challenges in your career 29:31 Things you wish you knew earlier 30:51 Recommendations for young people 32:17 Why aging research is important for society. 35:12 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Keith Comito: https://twitter.com/KeithComito ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we had the privilege of having Michael Baran as our guest. Michael Baran, MBA, Ph.D. is Executive Director, WRDM, and partner at Pfizer Ventures. In this episode, Michael discusses the unique features of DeSci, highlighting how it is reshaping the scientific landscape and redefining traditional paradigms. We also explored the significant risks in early-stage science investment and discussed key factors deterring investors from entering the cryptocurrency and blockchain sectors. Michael draws insightful comparisons between DeSci and the Traditional model, exploring both their similarities and differences. Other topics we discussed are the underappreciated values of traditional biotech, common misconceptions about Biopharma, the need for maintaining scientific quality, and many more. Feel free to navigate any topics discussed in the Podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:07 What is the strong case for DeSci? 2:57 Advantages of DeSci Over Traditional Biotech 3:00 Risks associated with investing in early-stage science 4:35 DeSci vs. Traditional Model: Similarities and differences 7:38 Strongest critique of Desci 11:09 Measuring success 13:26 Underexplored areas in Biopharma 15:32 Common misconceptions about Biopharma 16:51 Pfizer partnership models 23:40 Underappreciated values of traditional Biotech 26:43 Maintaining scientific quality 28:40 Contentious topics within your field 31:14 Implicit knowledge in Biopharma 34:26 Recurring challenges in Michael's career 35:42 Selecting the best ideas 39:18 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Michael Baran: https://twitter.com/scienceman2023 ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we were joined by Dr. Jocelynn Pearl, a biotech scientist and the co-founder of LabDAO, an online life science research community whose mission is to accelerate progress in the life sciences by making scientific tools more accessible. In this episode, Jocelynn shares insights on the factors and events that birthed the idea of Decentralized Biotech and the importance of incentivizing knowledge sharing so it becomes accessible to other researchers. We also discuss the pros and cons of centralization within the Biotech sector, the limits of online collaboration, and many more. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:34 The decentralized biotech movement 4:03 Incentivizing knowledge sharing 06:38 What sparked your interest in decentralized science? 13:36 Downsides of centralization in the Biotech sector 16:29 Limits of online collaboration 18:46 Sharing tacit knowledge 20:32 New scientist entrepreneurs you have come across 23:16 Positive aspects of centralization. 26:22 Insights gained over the last few years 27:46 Implicit knowledge in Biotech 29:50 Ensuring funding for good projects 32:38 Contentious topics within LabDAO 34:33 Why Biotech companies prioritize experienced teams for funding 41:01 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Dr. Jocelynn Pearl: https://twitter.com/JocelynnPearl ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we were joined by Juan Benet, the founder of Protocol Labs, an open-source research, development, and deployment laboratory. In this episode, Juan shares the story of his journey, the origins of Protocol Labs, and how he got involved in building IPFS and Filecoin. We uncover the underlying issues hindering technological advancements and dive deep into the translational science problem which Juan Benet believes is the biggest challenge facing science today. Juan emphasized the need to facilitate the translation of scientific discoveries and knowledge into real-world applications and solutions that can improve human health and benefit society at large. Moving forward, we explore the impact of cryptocurrency on scientific research and its transformative potential. Other topics we discussed on the podcast include intersection of Artificial Intelligence and the future, risks associated with Advanced General Intelligence systems and how AGI could potentially shape the future of society. Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below. ___ ⭐ Timestamps: 00:00 Intro 01:32 Background story of Juan Benet 09:28 Fundamental issues holding back technological advancements 14:36 Structural difference between the private sector and academia 21:17 Cryptocurrency's impact on scientific research 30:13 How Protocol Labs is structured 39:19 Protocol Labs' objectives and metrics measurement approach 44:59 Underexplored areas in scientific research 1:02:53 AI and the future 1:11:13 Risks associated with AGI systems 1:22:40 How AGI would shape the future society 1:41:24 What ideas are you most excited about? 1:51:48 Recommendations ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Vincent Weisser: https://twitter.com/vincentweisser Juan Benet: https://twitter.com/juanbenet ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of The DeSci Podcast. Today, we're joined by Niklas Anzinger, the founder and GP of Infinita, the first VC fund based in a modern charter city (Prospera), investing in founders overcoming regulatory bottlenecks in bio-/healthtech, hardware & crypto-finance through network states & startup cities. In this episode, Niklas shares insights on Infinitia Funds and how it supports innovative ventures and technological startups. Niklas also sheds light on Prospera's mission to create a self-sustaining and efficient business environment for entrepreneurs and innovative minds to thrive. We further discuss how poor governance hinders human potential and causes economic stagnation. This highlights the pressing need for an alternative and improved regulatory system, which would revolutionize the startup landscape, fostering growth and progress. We also explored how Network States and Startup Cities can positively impact fields like Longevity and Science in general. As the discussion progressed, we delved into other projects such as Zuzalu, which aims to build new cities and states with better regulatory systems to foster innovation in extending human lifespans and enhancing overall health outcomes. Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below. ___ ⭐ Timestamps: 0:00 Intro 0:58 About Niklas Anzinger 2:08 Infinitia VC Funds and its initiatives 5:24 Stranded Technologies Podcast 8:00 Infinitia’s areas of interest 14:36 The need for an alternative regulatory system 17:33 Competitive governance 28:42 How better regulatory structures would benefit Longevity and DeSci 47:58 Prospera and its mission 51:32 Sebastian’s thoughts on an ideal country to settle in 54:14 How to get involved ____ If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to Sebastian Brunemeier: https://twitter.com/sebastian_gero Niklas Anzinger: https://twitter.com/NiklasAnzinger ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we were joined by Jesse Hudson, the Chief Legal Architect at Molecule, Chris Byrnes, an IP Legal Advisor also representing Molecule, and Benji Leibowitz, Product Manager at Molecule. The existing intellectual property (IP) system faces several challenges that hinder its effectiveness and innovation potential. Patent trolls, the system's lack of efficiency, and the high transaction costs associated with acquiring and enforcing IP rights further burden inventors, researchers, and scientific enterprises. In this episode, we explore the groundbreaking concept of IP Tokens and how they can help solve the issues plaguing the current IP system. We explain what IP Tokens are and how they differentiate from IP-NFTs. We also discuss how IP tokens could facilitate scientific entrepreneurship and how they open up decentralization in science by enabling a system where the community can partake in the governance processes. Navigate the various topics covered in the Podcast using the timestamps below. ____ ⭐ Timestamps: 0:00 Intro 2:11 About Jesse Hudson 2:54 About Chris Byrnes 5:47 Fundamental issues within the IP system 11:16 How Molecule facilitates Scientific entrepreneurship 20:12 Overview of Intellectual Property 32:09 What is an IP-NFT? 37:05 IP Tokens and why they matter. 51:11 Digitizing the process of IP licensing 1:02:41 IP Tokens and Decentralization 1:10:16 IP financing 1:16:31 Enforcing IP rights 1:22:22 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to: Benji Leibowitz: https://twitter.com/benjileibo Jesse Hudson: https://twitter.com/jsshdsn Chris Byrnes: https://twitter.com/reimagineIP ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! Today, we were joined by Ben Reinhardt, founder of Speculative Technologies, a nonprofit research organization that runs coordinated research programs to unlock groundbreaking innovations. In this episode, we explore the qualities that make funders exceptional and the key factors that contribute to successful startup grants. We also shed light on the social and financial asymmetries between grantor and grantee, highlighting their negative impact on the funding process. Other topics we discussed are the differences between small and large grants, limitations of grant-making programs, common misconceptions between the public and private sector and many more. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ____ ⭐ Timestamps: 0:00 Intro 1:46 Characteristics of good funders 6:39 Key factors for successful startup grants 13:02 Asymmetries in grantor-grantee relationships 16:20 Small and large grants 19:09 Coordination in research 26:50 Pros and cons of grants 30:28 Limitations and drawbacks of grant-making programs 36:10 Common misconceptions between the public and private sector 38:07 Contentious issues within your field 42:42 Reforming science funding 44:20 How do you approach research management? 46:52 Topics Ben wants to write about 52:04 Outro ____ If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to: Lea Degen (host): https://twitter.com/lealeata Ben Reinhardt: https://twitter.com/Ben_Reinhardt ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! We are excited to have Nadia Asparouhova, an independent researcher and author of "Working in Public: The Making and Maintenance of Open Source Software", as our guest today. In this thought-provoking episode, we delve into the world of early-stage science funding and philanthropy. We discuss the role philanthropy plays in society and how it has evolved over the years. We also explore new funding mechanisms that have emerged to revolutionize the landscape of early-stage science, as well as the limitations and setbacks associated with these new funding mechanisms. Additionally, we discuss the political challenges of early-stage science funding and the pivotal role that government and individual patrons should play in supporting early-stage science. Please refer to the timestamps below to navigate through any of the topics discussed in the podcast. ____ ⭐ Timestamps: 00:00 Intro 01:40 The role of philanthropy. 03:16 What drove your interest in science funding? 05:00 The uniqueness of tech 06:19 Understanding early stage science 08:27 New funding mechanisms for early stage science 13:02 Limitations to the new funding mechanisms 16:09 Importance of peer review 18:25 Common misconceptions about early stage science funding 21:47 Evolution of philanthropy 27:18 Philanthropy and the government 29:35 Political Challenges of early-stage science Funding 35:25 Legitimacy in early stage science funding 41:47 Science philanthropy: Then & Now 47:23 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to: Lea Degen (host): https://twitter.com/lealeata Nadia: https://twitter.com/nayafia ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we had the privilege of having Dr. Martin-Immanuel Bittner as our guest. He is the CEO of Arctoris, which is the world's first fully automated platform for drug discovery, focused on accelerating the drug discovery process. In this episode, we explore a variety of fascinating topics related to drug discovery. Dr. Bittner shares insights on the story behind building Arctoris and its mission to accelerate the drug discovery process. We also talk about how the drug development process has evolved over the years and the need to automate drug discovery research. Other topics discussed were challenges stemming from the lack of rigorous funding in biotech, common misconceptions about automation, and many more. Please feel free to navigate through any of the topics discussed in the podcast using the timestamps below. ____ ⭐ Timestamps: 0:38 Intro 1:18 About Arctoris 2:52 What drove your interests in building Arctoris 4:23 Learnings from running Arctoris 5:53 What area needs more focus 8:03 Common misconceptions about automation 10:01 Flexibility in automation 13:44 Underexploited areas 16:09 Antibiotic resistance problem 17:58 Funding structures for Biotech companies 20:15 Investing in Biotech 22:38 The private sector and Academia 25:00 Changing beliefs on the need of automation in drug discovery 27:08 Contentious issues within your field 29:06 Implicit knowledge in drug discovery ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to: Lea Degen (host): https://twitter.com/lealeata Martin: https://www.linkedin.com/in/martinimmanuelbittner/?originalSubdomain=uk ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! Today, we had the privilege of having Martin Karlsson as our special guest. Martin is the CEO of Lateral, an innovative web app designed for scientists, enabling them to read, find, share, and organize their research seamlessly in a single platform for enhanced efficiency. In this episode, we delve into a wide range of intriguing topics. Martin shares insights on Lateral's AI tools and the best way to effectively utilize these tools. We also dive into the future of research, gaining profound insights into the untapped potential within the field. We then explored the cutting-edge capabilities of AI, the importance of retaining human agency in the research process, and the need to ensure the transfer of knowledge across generations. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ____ ⭐ Timestamps: 0:48 Intro 1:26 About Lateral 2:35 Best way to utilize Lateral AI tools 3:40 Key takeaways from building Lateral 06:09 What drove your interest in DeSci 07:47 The Future of Research 11:03 Underexploited areas in DeSci 12:50 Managing differing opinions in DeSci 14:22 Limits of outsourcing research 16:00 Retaining human agency in the research process 20:36 What key areas would you develop if Lateral secured more funding? 21:53 Challenges of running Lateral 25:05 What are you skeptical about? 26:28 Valuable tacit knowledge about Desci 30:55 Learnings from past experiences ____ If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to: Lea Degen (host): https://twitter.com/lealeata Martin: https://twitter.com/jmartink ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! In this one, we were joined by Niklas Rindtorff, a physician-scientist and co-founder of LabDAO, an online community of life scientists collaborating to make life scientific tools more accessible. In this episode, Niklas shares insights about the benefits of conducting life science research online, how scientific research has evolved over the years and the importance of collaboration within the scientific community. Going further, we delve into the complex topic of ownership rights within decentralized autonomous organizations (DAOs) and how LabDAO navigates this space. We also highlight some underappreciated aspects of academia and compare the dynamics of building in the private and public sectors as well as common misconceptions about these sectors. Niklas also shares some valuable knowledge about Decentralized Science, drawing from his own personal experiences and expertise. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ____ ⭐ Timestamps: 0:54 Intro 1:33 About LabDAO 3:32 Why do life science research online? 06:42 Ownership rights within DAOs 12:11 Valuable insights you wish you had before starting LabDAO 13:19 How have these new insights shaped LabDAO's structure? 15:18 Overlooked areas in Decentralized Science 16:43 Differences in the private and public sector 18:48 Building in the public sector vs private sector 23:23 Underappreciated aspects of Academia 26:20 Conflicting viewpoints on LabDAO’s operational strategies 31:46 Valuable tacit knowledge about DeSci. 36:18 What key areas would you build on if LabDAO secured more funding? 37:10 Misconceptions about Web 3 39:28 Overlooked areas in Decentralized Science 40:37 What we are building at LabDAO and how to get involved ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to: Lea Degen (host): https://twitter.com/lealeata Niklas: https://twitter.com/Niklas_TR ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, we were joined by Dr. Emil Kendziorra and Kai Micah Mills, co-initiators of CryoDAO, a decentralized community dedicated to advancing cryopreservation research. In this podcast, we discuss the field of cryonics, including its origins and how it has evolved over the years. Dr. Emil and Mills also explain how cryopreservation works, the underexploited areas in the field of Cryonics, and how it should be Improved. We also address some of the common misconceptions about cryopreservation and recommended resources for those interested in learning more about Cryonics. Finally, our guests share their thoughts on what the future of cryonics might hold and discuss some of the most contentious topics in the field. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ____ ⭐ Timestamps: 0:00 Intro 1:07 Brief overview of the field of Cryonics 3:45 Origin and Evolution of Cryonics 5:51 How does Cryopreservation work? 7:00 What drove your interest in Cryonics? 10:13 Underexploited areas in Cryonics. 11:36 What is the strongest argument against Cryonics? 13:35 How public perception of Cryonics has developed over the years. 16:29 Why pets instead of humans? 18:08 Why did you become a DAO? 22:43 Areas of overlap in cryonics. 25:32 The future of Cryonics. 28:37 What is the most contentious topic in Cryonics? 30:44 Common misconceptions about cryopreservation 33:27 Resources for people interested in the field of Cryonics. 35:39 How to get involved. ____ Special thanks to: Lea Degen (host): https://twitter.com/lealeata Kai Micah Mills: https://twitter.com/kaimicahmills Dr. Emil Kendziorra: https://www.linkedin.com/in/emilkendziorra/ ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this one, we had the pleasure of talking with Laura Minquini, who is leading AthenaDAO, a community-led movement that is improving female reproductive health through the identification, financing, and support of research projects that are working on its potential cures. We talked about Laura's story, the global panorama of the problem that she is solving, and the journey and projections of the organization that she founded and bio.xyz helped shape. Navigate through the topics discussed in this podcast using the timestamps below. ____ ⭐ Timestamps: 0:55 Intro 1:50 About Laura Minquini 8:36 About AthenaDAO 11:21 Research in Female Reproductive Health Overview 15:49 AthenaDAO structure and projects in its pipeline 23:26 AthenaDAO's first IP-NFT 26:10 Aging & Fertility 33:41 Why scientists choose to join AthenaDAO 39:44 Bio.xyz acceleration journey 43:23 Strategies to raise awareness 47:35 How to Contribute to AthenaDAO 51:34 What would happen if AthenaDAO succeeds 54:18 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to: Aastha (host): https://twitter.com/aasthajs Laura Minquini: https://twitter.com/LauraMinquini ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, we were joined by ValleyDAO's Co-founder, Albert Anis, and Communications Lead, Morgan Richards. In this video, Albert Anis and Morgan Richards provide a deep dive into the interesting field of Synthetic Biology, and the significant role that ValleyDAO plays in driving innovation in this area. We also explored the traditional funding model for Synthetic Biology and the difficulties it presents for researchers. They then emphasize the need for a new, decentralized approach to funding and the importance of collaboration in the research field. Albert and Morgan also go on to discuss the challenges of building in DeSci, and ValleyDAO's unique approach to incubating new projects, which involves providing funding, expertise, and a supportive community for researchers. Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. ____ ⭐ Timestamps: 0:40 Intro 1:18 Albert Anis’ Background 6:26 What drove your interest in Synthetic Biology? 11:19 About Valley DAO 15:33 What is Synthetic Biology? 19:58 The problem of the traditional model of funding Synthetic Biology. 24:42 What areas are ValleyDAO focused on? 31:26 ValleyDAO’s process of incubating other projects 36:23 Value of Web 3 tools to Synthetic Bio Researchers 41:20 Challenges of building in DeSci 45:50 Areas of Overlap in ValleyDAO 47:40 ValleyDAO upcoming projects 50:14 How to get involved 50:41 Outro ____ Special thanks to: Alex LaBossiere (Host): https://twitter.com/adlabossiere Albert Anis: https://twitter.com/thealbertanis Morgan Richards: https://twitter.com/Mxltiplex ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, we had the pleasure of talking with Andrew Verbinnen and Andrew Bakst from HairDAO, the second BioDAO ever to mint an IP-NFT. Their mission is to turn hair loss into a problem of the past by funding assets that they believe will accelerate its cure. Throughout the conversation, we delve into a variety of fascinating topics related to hair loss. We explore the bigger picture of this issue and highlight the crucial role of DeSci in expediting the discovery of solutions. And our guests also provide valuable insights gained from their experience in building in this ecosystem, shining a light on the HairDAO community, as well as the exciting projects that they have funded and upcoming initiatives. Navigate through the topics discussed in this podcast using the timestamps below. ____ ⭐ Timestamps: 0:23 Intro 01:08 About Andrew Verbinnen 03:01 About Andrew Bakst 04:11 Why HairDAO 05:50 Hair Loss Research & Solutions State 10:17 Hair Loss Multiphase Problem 11:57 HairDAO Community 15:05 HairDAO’s First IP-NFT 16:53 Study of Prof. Ralf Paus 19:41 Crypto & Global Cooperation 20:37 First Patient Database in DeSci 22:43 Importance of IP-NFTs 25:02 Learnings from Building a BioDAO 27:01 HairDAO Vision 27:58 HairDAO Upcoming Initatives 31:11 Outro ____ If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] Special thanks to: Alex LaBossiere (Host): https://twitter.com/adlabossiere Andrew Verbinnen: https://twitter.com/VerbinnenAndrew Andrew Bakst: https://twitter.com/andrew_bakst ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to this episode of the DeSci Podcast, where we dive deep into the technology behind IP-NFTs and explore the possibilities of decentralized data storage.  In this episode, Stefan Adolf, a senior web3 engineer at Molecule, and Benji Leibowitz, a former biotech venture capitalist and now a product manager at Molecule, discuss the modularity of IP-NFTs, the advantages of ERC721, 1155, and 3525 token standards. We also discuss the benefits of Arweave and IPFS for metadata and storage, Lit Protocol and unlocking data, custodial wallets and MPC providers, the SDK for developers, and the possibilities of permissionless minting and open source strategies with v2 and v3 of the IP-NFT. We hope you can learn a lot about the amazing possibilities of the decentralized tech stack and how you can build with IP-NFTs with this episode and feel free to use the timestamps below to navigate through the episode.  Navigate through the topics discussed in this podcast using the timestamps below. ____ Timestamps: 00:00 - 01:42 Intro 01:42 - 04:30 What is the IP-NFT and who should use it? 04:30 - 08:40 Token Advantages (ERC721, 1155, and 3525) 08:40 - 11:18 IP-NFT V2 (Mint-passes and Reservations) 11:18 - 12:40 Who is the ideal user for a min-pass? 12:40 - 17:24 Where is the metadata of an IP-NFT stored, and how is it structured? 17:24 - 25:19 Difference between web3 and web2 storage 25:19 - 29:21 Content gating with DAO tools 29:21 - 34:56 The role of Lit-Protocol within the IP-NFT 34:56 - 49:00 Frontend of the IP-NFTs and on web3 wallets 49:00 - 51:59 When can people start building on this technology (wen SDK?) 51:59 Outro ____ If you want to watch the Podcast on YouTube, you can find all the important links below. And if you want to join us on the show as a speaker or have guest ideas; please mail us at [email protected] linktr.ee/thedescipodcast Special thanks to:  Heinrich Tessendorf (Host): https://twitter.com/Heintess_GM Stefan Adolf: https://twitter.com/stadolf Benji Leibowitz: https://twitter.com/benjileibo ____ Let's connect: Website: https://molecule.to/ Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, Vera Gorbunova, endowed Professor of Biology at the University of Rochester, co-director of the Rochester Aging Research Center, and co-founder of the new journal Aging Biology, run by scientists for scientists, shares with us a bit of her vast knowledge in the field of Longevity. She talked about the problems of the current scientific system, the partnership that her laboratory made with VitaDAO, and about the research that she is currently carrying out.   Navigate through the topics discussed in this podcast using the timestamps below.  ____  Timestamps:  0:42 Intro 2:53 Vera's Life Story & Background 7:44 Comparative Longevity Approach 14:12 Serendipitous Discoveries 15:34 DNA Repairing Fidelity & Epigenetics Reprogramming 24:46 Who are the heroes of Vera 27:09 What Vera strongly believes and that other people disagree 32:28 Possible Nobel Prize-winning work 35:14 Chromatin: Hallmark of Aging 39:25 HSC Stem Cells   45:20 Extracellular Matrix 50:12 VitaDAO x Vera’s Lab Partnership on Naked Mole Rats 1:00:26 Programmed vs Damage Theory of Aging 1:11:07 Issues between Scientific Journal Publishers, Editors and Reviewers 1:17:42 Potential of Decentralized Scientific Journals & Peer-review 1:32:18 Final Conclusions   ____   Special thanks to:   Sebastian Brunemeier (Host): https://twitter.com/sebastian_gero   Vera: https://www.linkedin.com/in/vera-gorbunova-64a97b46/   ____   Let's connect:   Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, Michael Gibson, co-founder and general partner of the 1517 fund, author of the new book ‘Paper Belt on Fire: How Renegade Investors Sparked a Revolt Against the University’ and one of the key people involved in launching the Thiel Fellowship in 2010 (where he helped Vitalik Buterin shape Ethereum), tells us about his vision of legacy institutions and how we can modernize them to encourage great global innovations once again.   You can already get his excellent book, discussed in the episode, on Amazon: https://www.amazon.com/Paper-Belt-Fire-Fight-Progress-ebook/dp/B099FZR4C3  Navigate through the topics discussed in this podcast using the timestamps below. ____   ⭐ Timestamps:  0:00 Intro 4:03 Book: ‘Paper Belt on Fire’ 9:26 Michael’s Background 14:20 Innovation in America is slowing down 19:20 Why Michael drop out the Academia 24:08 ‘If the college degree were a drug they would not be passed by the FDA’ 29:07 Cloud Universities 30:23 How to rebuild the Scientific Structure 38:59 VitaDAO and Alternative Funds 40:39 Accredited Investors 42:33 Investment Issues 44:26 Public Companies 46:00 New Disclosure Standard 49:03 Reproducibility Issues 53:42 Decentralized Science 1:07:00 How to motivate the next generation of great scientists   ____  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  Special thanks to:   Sebastian Brunemeier (Host): https://twitter.com/sebastian_gero   Michael: https://twitter.com/William_Blake   ____   Let's connect:   Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Today we have a special one! In this episode, we have Vitalik Buterin as a guest, interviewed by Vincent Weisser.  They discuss the intersection of science and cryptocurrency, focusing on the concept of "decentralized science."  Vitalik explains how decentralized technologies, such as cryptocurrency, can improve science and the institutions of science by allowing for more diverse funding and collaboration among people. He also mentions specific tools, such as quadratic funding and decentralized autonomous organizations (DAOs), that can be used to fund and structure scientific projects.   He also highlights his current project, "Balvi", which is focused on addressing the COVID-19 situation and is funded by cryptocurrency. He also mentions the challenges of scaling up quickly and how this can be a good approach for established donors and talks about the use of technology such as DeSci and reputation systems to help solve the problem of determining who is trustworthy.    There is undoubtedly much more to be found in this episode and we hope you enjoy this conversation between Vitalik Buterin and Vincent Weisser. Make sure to skip between the timestamps below to find your favorite topics and learn more about the discussed topics through all the linked resources below. ____  Some of the resources discussed.  - Vitaliks blog: https://vitalik.ca/ - Vitaliks twitter: https://twitter.com/vitalikButerin - Decentralized Science Explainer https://ethereum.org/en/desci/ - Ending Aging book: https://en.wikipedia.org/wiki/Ending_Aging- Science DAOs like: http://vitadao.com/ - Some of the projects he supported https://cryptorelief.in/, https://impetusgrants.org/, https://www.sens.org/, https://arcinstitute.org/ - Balvi (Pandemic Prevention): https://twitter.com/VitalikButerin/status/1522017142320685057 - Quadratic Payments by Vitalik: https://vitalik.ca/general/2019/12/07/quadratic.html - DeSoc Paper by Puja, Glen and Vitalik: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4105763 - Progress: https://www.theatlantic.com/science/archive/2019/07/we-need-new-science-progress/594946/ - Network States: https://vitalik.ca/general/2022/07/13/networkstates.html - RadicalxChange: https://www.radicalxchange.org/ - The most important century https://www.cold-takes.com/most-important-century/ - Curveballs: pandemics, existential, risks from nuclear, ai, bio, wars - Recommend reading: https://80000hours.org/ - DeSoc x DeSci by Puja: https://www.youtube.com/watch?v=MUzwSPmP4nY ____   Timestamps:   00:00 - 00:37 Intro 00:37 - 06:36 Vitalik's definition of DeSci and what he is most excited about.   06:36 - 09:32 Improvements to retroactive or quadratic funding. 09:32 - 11:30 Vitalik on DeSoc in the context of science (Decentralized Society).   11:30 - 12:51 What to build at the intersection of DeSci and DeSoc?   12:51 - 13:46 Which areas of Science is Vitalik most excited about? 13:46 - 17:17 How the Shiba Inu tokens actually funded Covid research. 17:17 - 22:40 Why crypto is such an excellent funding method. 22:40 - 31:00 Which learnings did he incorporate into other projects like "Balvi"? 31:00 - 38:33 What's holding back scientific progress, and what is he most excited about?   38:33 - 44:37 The most important century ever? Vitalik on AI progress, Singularity, and existential risks.   44:37 - 46:47 What to build in the DeSci space? 46:47 - Vitalik's content recommendations in the science space. ___   Let's connect:   Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, Stanley Bishop, AKA Science Stanley, data scientist and head of data science at LabDAO talks about AI, what it means to be a data scientist and how it intersects with decentralized approaches. We also talk about how this can be applied across individual health, collective health, the planets, genome sequencing and language models and what this could mean for the future of the organization and the future of work.   Stanley Bishop also talks about LabDAO’s collaboration with "Research to the People" in order to build an integrated and traditional data marketplace where treatments can be shared between physicians so they can compare notes and figure out the best clinical path for their patients which can be impactful for patients that might have rare or complex conditions, New Atlantis DAO and its mission to provide a solution for climate change and many more.   Navigate through the topics discussed in this podcast using the timestamps below.  ____   Timestamps:   0:00 Intro 1:38 What is a data scientist? 3:09 How has that led you to Lab DAO? 04:51 What does being a data scientist within a DeSci organization look like? 06:15 What projects are LabDAO working on right now? 09:18 LabDAO overall structure. 11:56 LabDAO's partnership with Research to the people. 16:17 The future of translational research. 18:36 What else is possible with DeSci? 23:42 New Atlantis DAO. 31:07 Recommendations for scientists transitioning into Web 3. 34:09 Collaboration with TalentDAO. 42:13 Other use cases of TalentDAO. 46:16 What AI trend do you expect to gain traction in the future? 50:39 Remunerating contributors.  ____  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]   Special thanks to:   Erin Magennis (Host): https://twitter.com/erinmagennis Stanley:https://twitter.com/ScienceStanley ____   Let's connect:   Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to episode Nr. 7 of the DeSci Podcast! In this episode, Tyler Golato, Co-founder and CSO of Molecule DAO joins us as we discuss the problems of scientific research and funding and necessary changes that need to be made in the way funding is done.   We talk about the impact of decentralization in research, the requirements for allocating funds for research, and the future of Molecule and Bio-DAOs in general.  Tyler also shares his background in biochemistry, molecular biology, and oncology research, and how his experiences led him to Molecule. We hope you enjoy this episode and you can go through any of the topics discussed in the Podcast using the timestamps below.  ____  Timestamps:    0:40 Background story of Tyler Golato. 01:16 What drove your interest in healthcare? 12:45 What is the argument that research can be carried out in a decentralized manner and why does it matter? 18:17 What is the level of domain expertise needed to allocate funds for high-quality research? 21:20 What problems of scientific research and funding do you think requires decentralization to solve? 25:52 What is your vision for the future of Molecule and Bio-DAOs? 31:24 What other changes do you think need to be made in the way funding works? 34:52 What do you think about incentives in DeSci? 40:16 How would you approach the problem of waiting governance? 45:03 How do you determine success and measure outcomes? 47:20 What would you say is the bull case and bear case for DeSci? 51:05 How to get involved. 52:17 Outro  ____  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]   Special thanks to:   Alex LaBossiere (Host): https://twitter.com/adlabossiere (Check Alex his own podcast here: https://open.spotify.com/show/7lf0G6SBTArFlJYuHlPPoy?si=adcfa5f7a82d4708) Patrick Malone: https://twitter.com/GolatoTyler ____   Let's connect:   Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao  Molecule - The future of medicine belongs to everyone

Welcome to episode Nr. 6 of "The DeSci Podcast"! In this episode, Patrick Malone, a physician-scientist turned investor at KDT Ventures where he invests in early-stage life science and healthcare, tells us about what drove his interest in investing in healthcare, what Tech-Bio is, and how it relates to the traditional understanding of Biotech.  He also explains, why machine learning is effective in drug discovery, the biggest problem facing scientific research and funding models today, the future of scientific research, and much more. Patrick Malone argued that rewarding negative findings which help to discover what doesn’t work or what isn’t true in a previous research publication will greatly reduce the problem of reproducibility.    Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.  ____   Timestamps:   0:00 Intro 0:44 Background story of Patrick Malone 1:25 What drove your earlier interests in Academia? 5:53 Why was Investing of major interest to you? 8:36 What is TechBio and how does it compare to the traditional understanding of Biotech? 13:19 How can TechBio deliver up to the expectations of people towards it? 18:13 Which other fields can the principles of TechBio be applied to? 21:54 Why is there a lesser ROI in TechBio and Biotech compared to other technologies? 25:24 What drives you to write? 27:34 How was your experience with working with both Academia and Ventures? 30:04 What is the biggest problem facing scientific research and funding models today? 32:25 How would not having to apply for grants change the research focus of scientists? 34:25 What is your take on making research open source? 37:27 How can these new developments come into actualization? 39:52 What happens when scientific discoveries are no longer understandable by humans? 43:28 What do you think more people should be paying attention to? 46:11 Ending and outro.   ____   If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]   Special thanks to:    Alex LaBossiere (Host): https://twitter.com/adlabossiere (Check Alex his own podcast here: https://open.spotify.com/show/7lf0G6SBTArFlJYuHlPPoy?si=adcfa5f7a82d4708) Patrick Malone: https://twitter.com/patricksmalone ____   Let's connect:   Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao  Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 5 of the DeSci Podcast! In this Episode, Allison Duettmann, President and CEO of Foresight Institute tells us how she got into futurism, why people are so pessimistic about the future, how Foresight chose the most important things to work on, Allison's positive visions of the future for humanity, what are Tech Trees and more! We hope you enjoy!   ____   Timestamps:  0:00 - Nanobots & Cryonics 0:27 - Allison & Foresight Intro 1:29 - How Allison got into futurism 4:36 - Positive visions of the future for humanity and raising reality to meet your expectations 8:16 - Optimism 11:52 - Why people are so pessimistic about the future 16:58 - Areas where people are too optimistic 19:12 - Foresight - how they found the most important things to work on (referring to decentralized computing, molecular machines, biotech for health extension, neurotech and space tech) 20:30 - Decentralized Computing 22:00 - Biotechnology for rejuvenation, longevity & cryonics 22:58 - Molecular and Nanotechnology 24:18 - Neurotechnology 26:01 - Spacetech 26:42 - What are Tech Trees? 32:27 - Surprising/Technological Bottlenecks 34:38 - Areas of Overlap between Tech Trees 38:40 - The unlock that DeSci Provides for Allison's work at Foresight 43:24 - Vetting people for domain expertise to participate in DeSci 46:52 - The Longevity Prize 50:00 - What excites Allison the most in DeSci and the technologies Foresight covers   52:55 - How to get involved at Foresight  ____   Links mentioned:   Balaji on Tech Trees: https://twitter.com/balajis/status/1456163613857570821?s=20&t=XP1sJ8gBEKNw-V7fPHsNpw Starships & Tokens (The Map) by Trent McConaghy https://medium.com/@trentmc0/starships-and-tokens-d8c32728a24b Aaron King: Longevity Tech Tree: https://www.youtube.com/watch?v=yg9Jpk2dLQM&t=164s  ____   Notable quotes from Allison:  "I got interested in Technologies through a wish for a longer happier life for myself and for civilization."   "Despite the fact that life has been improving pretty steadily over the last hundreds of thousands of years, our realization that it has been has not been steadily adjusting. Most of the time if you ask around people think that things are getting worse, that violence is increasing, and pretty substantial societal flaws are increasing and so I think it doesn't often match with the actual improvement in living conditions that many of us were fortunate enough to receive over the past few hundred thousand years."    "A positive outlook I think starts with a gratitude for how far we've come and just realizing what our ancestors put forth and how much they paid forward for us to get to where we are."   "Rather than having this more default vision on the future of what would the path be in which we all self-destruct (which is certainly a morbid fantasy) which is easier to think about and somehow weirdly more attractive to our human minds actually, rather asking the other question of what would it mean to actively put a foundation in place in which we could build wonderful worlds."   ____   If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]   ____   Let's connect:   Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao  Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 4 of the DeSci Podcast - Today we're exploring the decentralized science space together with Jack Scannell! Jack coined the term Eroom's Law, which notes that the cost of new drug approvals is rising exponentially, in contrast to Moore's law, which notes that the number of transistors on a microchip doubles about every two years, though the cost of computers is halved.   In this podcast, Jack talks about how we can do better drug discovery, specifically, the tools and frameworks we can use to choose the right drug discovery model and feed that into investment decisions. His new paper in Nature Reviews Drug Discovery addresses exactly that: https://rdcu.be/cWTtO  In this podcast, Jack argues that quality beats quantity when it comes to assays, but actually the best thing is quality AND quantity. So it's better to test a small number of therapeutic candidates in a really good model than it is to test a very large number of computer candidates selected from the same universe in a model of low validity - the best example of this is in antimicrobials discovered around 1930 by Gerhard Domagk. Jacks says that the model validity used in Germany in the 1930's is better than the model validity used in the early 90's.   The technological barrier in drug R&D has shifted from chemistry to effectively the tools that tell you whether or not that chemistry is useful. It's not that we can't make compounds, we probably can in many cases make those compounds but what we can't do is we can't distinguish the ones that do something useful from the ones that don't. It's not that we can't identify targets, we can, but we can't tell the good ones from the bad ones - so the critical resource in drug R&D is probably the models, which Jack's paper calls "decision tools" that let you sift the good stuff from the bad stuff.    Jack on what interested him about VitaDAO and Molecule: You create value not by making current markets a little bit more efficient, you create value by making markets exist where none existed before. Outside of a few well-ventured universities, universities are terribly under-ventured and also the people at those universities don't have the right tools to present their material in such a way that it could be ventured so it struck him that providing a low transaction cost, standardized platform to make an eBay for IP might be an extremely valuable thing to do because you could create markets where none existed before. Important links mentioned in the episode: The new Nature Reviews Drug Discovery paper. “Predictive validity in drug discovery: what it is, why it matters, and how to improve it”: https://rdcu.be/cWTtOThe Emulate (organ chip) pre-print: “Qualifying a human Liver-Chip for predictive toxicology”:  https://www.biorxiv.org/content/10.1101/2021.12.14.472674v4 ____   A huge thanks again to Sebastian and Jack for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]   You'll also find all links to YouTube, Discord, Twitter and our website via the following link - https://linktr.ee/thedescipodcast _____   Special thanks to:    Sebastian Brunemeier (Host): https://twitter.com/sebastian_gero Jack Scannell: https://twitter.com/JackScannell13 ______   Let's connect:   Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao  Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 3 of the DeSci Podcast - Today we're exploring the decentralized science space together with our CEO of Molecule and Vincent Weisser, our Chief Ecosystem Officer!   We're incredibly proud to finally speak in depth about our new project bio.xyz - Next to that, we are also digging into a lot of other interesting decentralized science topics. You can find all of them below, so you can skip around to find your favorite ones!    Topics & Timestamps:   00:00 - Intro   01:31 - Background Story of Paul   09:27 - Background Story of Vincent 13:43 - Why DeSci makes sense? (Valley of Death) 18:09 - How can BioDAOs solve current bottlenecks in science?   21:29 - How does a BioDAO work internally and what part plays Molecule here?   31:41 - What is bio.xyz and how does it relate to Molecule?   35:10 - bio.xyz cohort; PsyDAO   39:48 - bio.xyz cohort; AthenaDAO 42:30 - bio.xyz cohort; ValleyDAO 46:05 - bio.xyz cohort; HairDAO 50:00 - Structure of bio.xyz   51:13 - How can one apply for bio.xyz and advice for people who are interested to join 54:52 - How does the future of BiotechDAOs look like? (Vincent) 57:50 - How does the future of BiotechDAOs look like? (Paul) 01:02:52 - Ending & Outro   ____   A huge thanks again to Vincent & Paul for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.  Feel free to skip around the timestamps to find your favorite topics and thanks again for tuning in! If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]   You'll also find all links to YouTube, Discord, Twitter and our website on linktree here - https://linktr.ee/thedescipodcast _____   Special thanks to:    Alex LaBossiere (Host): https://twitter.com/adlabossiere (Check Alex his own podcast here: https://open.spotify.com/show/7lf0G6SBTArFlJYuHlPPoy?si=adcfa5f7a82d4708) Vincent Weisser (Chief Ecosystem Development Officer of Molecule): https://twitter.com/vincentweisser Paul Kohlhaas (CEO Molecule): https://twitter.com/paulkhls   Find out more about bio.xyz here:   Website: https://www.bio.xyz/ Twitter: https://twitter.com/bio_xyz Discord: https://discord.gg/6ZeDSjhM2g ______   Let's connect:   Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao   Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 2 of the DeSci Podcast - Today we're exploring the decentralized science reformation together with no other than Balaji Srinivasan! We're incredibly proud to be joined by such a smart and well-known mind as a second guest on "The DeSci Podcast" show!     Topics of this episode:   → Key factors holding back scientific progress and how to change it (also via DeSci). 🧪 → What role does AI play here? → The future of human optimalism. → How to make predictions in technology? (+ many more & some great advice for DeSci builders at the end from Balaji)   Due to his nature, we're slipping in many other interesting topics while tackling those above! 💙   A huge thanks again to Balaji for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.   Feel free to skip around the timestamps to find your favorite topics and thanks again for tuning in! Also, if you prefer listening to podcasts on audio apps, feel free to search for "How To DeSci" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps and the show-notes below.    If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]   You'll also find all links to Spotify, Discord, Twitter and our website via the link below - https://linktr.ee/thedescipodcast _____   Special thanks to:    Alex LaBossiere (Host): https://twitter.com/adlabossiere Vincent Weisser (Chief Ecosystem Development Officer of Molecule): https://twitter.com/vincentweisser Balaji Srinivasan: https://twitter.com/balajis https://balajis.com/ https://balajis.com/the-purpose-of-technology/ https://thenetworkstate.com/ ______  Timestamps:   00:00 - Intro   01:30 - Introduction of Balaji & The Network State 06:45 - Key factors holding back scientific progress 14:17 - How to change the research & funding structure 21:00 - Commonalities between New York Times and the nature of the Scientific Journals 38:00 - How does scientific progress unfold? 44:50 - Can AI be a dominant driver here? 49:10 - How to make predictions in technology 54:40 - The cyclical approach of history   01:02:48 - Advice for builders in the DeSci space 01:04:29 - Last words, book advice & outro   ______ Show-notes of the episode:    https://twitter.com/balajis https://balajis.com/ https://balajis.com/the-purpose-of-technology/ https://thenetworkstate.com/ https://nexus.od.nih.gov/all/2021/11/18/long-term-trends-in-the-age-of-principal-investigators-supported-for-the-first-time-on-nih-r01-awards/ https://newscience.org/nih/ https://twitter.com/patrickc/status/1544067890403389441 https://project-evidence.github.io/ https://www.quantamagazine.org/in-new-math-proofs-artificial-intelligence-plays-to-win-20220307/ https://github.com/camoverride/lit/blob/master/The-Princeton-Companion-to-Mathematics.pdf ______   Let's connect:   Website: https://bit.ly/3BXtFUn Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao Molecule - The future of medicine belongs to everyone

Welcome to the very first episode of "The DeSci Podcast" - On this show, we talk to the leaders of the decentralized science world about the future of biotech. Thanks for being here and enjoy the very first episode of this new podcast, brought to you by Molecule.   In this first episode, we talk to Tim Peterson, Sebastian Brunemeier & Laurence Ion from  @VitaDAO  - VitaDAO is the first ever created BioDAO and just recently celebrated its first year anniversary. So we wanted to know - What where the challenges and learnings of this year? How does the future look like in this space and what even is VitaDAO and DeSci?    Feel free to skip around the timestamps to find your favorite topic and thanks again for tuning in! Also, if you prefer listening to podcasts on audio apps, feel free to search for "How To DeSci" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links below.    If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]   You'll also find all links to Spotify, Discord, Twitter and our website via the link below - https://linktr.ee/thedescipodcast ______   Thanks to today guests of todays show:    Alex LaBossiere (Host): https://twitter.com/adlabossiere Tim Peterson: https://twitter.com/timrpeterson Sebastian Brunemeier: https://twitter.com/sebastian_gero Laurence Ion: https://twitter.com/longevion ______   Timestamps:  00:00 - Intro   02:32 - Introductions   07:25 - What is Decentralized Science (DeSci)   09:57 - What got you interested in this space? 17:30 - What is "longevity escape velocity"?   21:48 - What is VitaDAO and how is Molecule related? 32:54 - What problems are DAO structures solving in research 41:18 - Highlights, Learnings and Challenges of the first year with VitaDAO 47:16 - How does the future of BioDAOs look like? 58:33 - How can people get involved? 01:04:16 - Outro   _____   Let's connect:   Website: https://www.molecule.to/ Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao Molecule - The future of medicine belongs to everyone