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#26 Your mitochondria run the engine. MOTS-C keep it firing. episode artwork

Mar 15, 2026 15 min

#26 Your mitochondria run the engine. MOTS-C keep it firing.

from Peptalk: Peptides Unpacked Hosted by Dr. Kylie Burton & Jessica Briecke

MOTS-C is a peptide your mitochondria actually produce — a native signal that tells your cells to pull in glucose, burn fat, and build new energy infrastructure. When that signal fades with age, the results are familiar: stubborn weight, sluggish energy, brain fog, and workouts that stop paying off. This episode breaks down exactly how MOTS-C flips your body's master energy switch, AMPK, in plain English — no biology degree required. We cover who benefits most, from blood sugar swings and weight plateaus to athletic performance and longevity, and why women in menopause are finding it especially powerful without touching hormones. We also answer the question everyone's thinking: are peptides even natural? Spoiler — your body's been making them all along. By the end you'll know: Why mitochondrial decline tracks directly with aging and metabolism How to pair MOTS-C with training, nutrition, and sleep for compounding results Which labs and performance cues to track progress This isn't a miracle. It's a map — rooted in how your cells already work. MOTS-C just became available this month — it's next for Jess and I. Get it on your list. Where do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.com Ready to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform at drkylieburton.com/shop. Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com/peptidesaffiliate. You can also get started through Jessica's platform at B2BwithJess.com. Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary. You have the science. You have the tools. Now it's time to take the next step. This is PepTalk: Peptides Unpacked—science made simple, re...

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MOTS-C is a peptide your mitochondria actually produce — a native signal that tells your cells to pull in glucose, burn fat, and build new energy infrastructure. When that signal fades with age, the results are familiar: stubborn weight, sluggish energy, brain fog, and workouts that stop paying off. This episode breaks down exactly how MOTS-C flips your body's master energy switch, AMPK, in plain English — no biology degree required. We cover who benefits most, from blood sugar swings and wei...

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#26 Your mitochondria run the engine. MOTS-C keep it firing.

0:00 15:08

Chapters

  1. 0:02 Setting The Mission: Peptides Made Clear
  2. 0:22 The MOTS C Shock: Aging And Metabolism
  3. 1:17 What MOTS C Is In Plain English
  4. 3:27 AMPK: Flipping The Energy On Switch
  5. 4:22 When Signals Fade With Age
  6. 5:27 Who Benefits: Metabolism, Weight, Longevity
  7. 8:29 Big Longevity Claims And Caution
  8. 9:36 Menopause, Metabolism, And MOTS C
  9. 10:42 Natural Vs Synthetic: Peptides Explained
  10. 12:03 Peptides As Biology’s Text Messages
  11. 12:25 How To Start And Where To Learn
  12. 14:06 Personal Protocols And Next Steps
  13. 14:42 Pick One Peptide And Begin

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The Hunter Williams Podcast Hunter Williams Average health is a choice. And it's the wrong one.The Hunter Williams Podcast goes where mainstream medicine won't — deep into the science of peptides, hormone optimization, metabolic health, and biohacking protocols that actually move the needle.Every week, I sit down with elite researchers, doctors, and high-performers to cut through the noise and hand you biological leverage most people will never have access to.This isn't wellness. This is optimization.Subscribe. Take control of your biology. The LongHer Life Brittany Ford The LongHer Life is the women's longevity podcast that says the quiet part out loud. Science backed and soul led, in the same episode, from the same person.Host Brittany Ford is a Registered Holistic Nutritionist and the founder of Biohacking Brittany. Every week she breaks down what's actually working for women's health: peptides, hormone testing, fertility and postpartum, metabolic health, mitochondria, nervous system regulation, longevity protocols, perimenopause, and the soul work underneath all of it.You'll get real protocols with the dosing and the tradeoffs, her own lab results read out loud, honest reviews of what she's testing on herself, and long conversations with the doctors, researchers and founders she actually trusts. No wellness theatre, no supplement she hasn't taken herself.If you want to feel good in your body now and still be strong at 90, you're in the right place.Formerly Biohacking with Brittany. New episode every week. The Human Upgrade: Biohacking for Longevity & Performance Dave Asprey For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger The Peptide Podcast The Peptide Queen The Peptide Podcast makes health and wellness decisions SIMPLE, FAST, and FUN. In less than 15 minutes each weekday, you'll get accurate, unbiased updates on peptides—from disease prevention and performance health to anti-aging and more.Hosted by The Peptide Queen, a clinical pharmacist with more than 15 years of experience, the show cuts through internet confusion to give you clear, reliable information so you can choose what's best for you.

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How long is this episode of Peptalk: Peptides Unpacked?

This episode is 15 minutes long.

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This episode was published on March 15, 2026.

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Yes, a full transcript is available for this episode. You can read the complete transcript on the episode page.

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