EPISODE · Dec 4, 2025 · 48 MIN
#5 GLP-1 vs. GIP: Understanding the Peptides Behind Ozempic, Wegovy, and Mounjaro
from Peptalk: Peptides Unpacked · host Dr. Kylie Burton
The rules of metabolism are being rewritten—and the script is simpler than you've been told: your body runs on signals.In this episode, Dr. Kylie Burton and Jessica Briecke dive into GLP-1 and GIP—the gut-brain messengers behind Ozempic, Wegovy, Mounjaro, and Zepbound—and show you how they restore the conversation between your pancreas, liver, and brain.When those messages are clear, blood sugar steadies, cravings quiet down, and energy lasts. When they're muffled by stress, poor sleep, and inflammation, insulin resistance takes over and everything feels harder than it should.What We Cover:How GLP-1 and GIP work as gut-brain messengers to restore metabolic communicationInsulin resistance explained with a lock-and-key model you can picture instantlyHow insulin resistance connects to fatty liver, rising cholesterol, and brain fogSemaglutide (GLP-1) vs. Tirzepatide (GLP-1/GIP dual agonist): what's the difference and why it mattersWhy the GIP layer often means gentler tolerance and broader metabolic benefitsCandid talk on side effects, microdosing, and smart titration strategiesHow peptides ease whole-system strain across cortisol, thyroid, and sex hormonesWhat long-term wins actually look like: steadier energy, better focus, and a healthier liverFor Anyone Ready to Stop Chasing Skinny and Start Chasing Stability: This episode gives you a clear path forward—grounded in science, free of hype, and focused on what actually works.Where do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.comReady to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform at drkylieburton.com/shop. Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com/peptidesaffiliate. You can also get started through Jessica's platform at B2BwithJess.com. Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary.You have the science. You have the tools. Now it's time to take the next step.This is PepTalk: Peptides Unpacked—science made simple, re...
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The rules of metabolism are being rewritten—and the script is simpler than you've been told: your body runs on signals. In this episode, Dr. Kylie Burton and Jessica Briecke dive into GLP-1 and GIP—the gut-brain messengers behind Ozempic, Wegovy, Mounjaro, and Zepbound—and show you how they restore the conversation between your pancreas, liver, and brain. When those messages are clear, blood sugar steadies, cravings quiet down, and energy lasts. When they're muffled by stress, poor sleep, and...
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#5 GLP-1 vs. GIP: Understanding the Peptides Behind Ozempic, Wegovy, and Mounjaro
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