#6 Losing 55 Pounds, Gaining Everything: GLP-1s Done Right with Karli Sine

from Peptalk: Peptides Unpacked · host Dr. Kylie Burton & Jessica Briecke

Six million people are on GLP-1s. But how many are actually using them right?In this episode, we sit down with Karli Sine—a real person with a real story—who lost 55 pounds while gaining so much more: confidence, energy, and a completely transformed relationship with her body and health.Karli opens up about her journey with PCOS, insulin resistance, and the frustration of trying everything before finding a protocol that actually worked. This isn't a quick-fix story. It's about rebuilding metabolism, protecting muscle, and creating sustainable habits that make results last.What We Cover:How Karli used GLP-1s as a tool, not a crutch—and what that actually meansThe protein-first strategy that protected her muscle while fat melted offWhy microdosing can smooth out side effects and create a gentler journeyThe myth of salads as "safe food" and the simple rule that changed everything: make every bite countHydration, electrolytes, mineral repletion, and gut/liver support during weight lossHair shedding and skin changes during rapid fat loss—plus how GHK-Cu can help restore hair and skin qualityUsing BPC-157 for joint comfort and recovery as movement becomes easier and more frequentSemaglutide vs. tirzepatide: what the real difference feels like in your bodyMaintenance microdoses: keeping appetite calm without flattening your energyThe BIG shift: playing harder with her kids, feeling good in her clothes, and silencing the inner criticEmerging research on GLP-1s and neuroinflammation, including potential support in conditions like Parkinson'sFor Listeners Looking at Losing Weight with GLP-1s: You'll walk away with practical steps to steady blood sugar, protect lean mass, and build a plan you can actually stick with.This episode is for anyone ready to use peptides intelligently—with intention, support, and a long-term vision for their health.To connect with Karli, visit her Instagram @karli.sine or on Youtube at https://www.youtube.com/@KarliSineYour Turn: What's the one habit from this episode you'll start today? Share this podcast episode on your socials, leave us a review and let us know—we are honored to have you join us.Want to connect more with the hosts? We'd love it! Connect with Jess at B2BwithJess.com/peptides or on Instagram @jessb.talkshealth. Grab your Blood Work & Peptides Mini Guide for free at drkylieburton.com. Ready to explore peptide therapy for yourself? Visit the company we recommend for pharmaceutical peptides and receive all the one-on-one support that comes included at drkylieburton.comWant to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.comLegal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary.You have the science. You have the tools. Now it's time to take the next step.This is PepTalk: Peptides Unpacked—science made simple, results made real.

What this episode covers

NOW PLAYING

0:00 50:29

1×

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

Share this episode

Similar Episodes

Burnham, Binface & Posh Boy Summer

Jul 10, 2026 ·30m

Jordan Harbinger: Fight-or-Flight, Two Kidnappings, and the Wallet Ruining Your Spine : 1499

Jul 10, 2026 ·68m

Is Burnham Too Soft?

Jul 9, 2026 ·29m

How Fast Retatrutide works?

Jul 9, 2026 ·8m

The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498

Jul 9, 2026 ·53m

The Jews of 1789: The Constitution (Part 2)

Jul 9, 2026 ·44m

Similar Podcasts

Circana Unpacked Circana Circana Unpacked delves into the data to reveal consumer, shopper, and other insights that fuel market changes and growth for those in the CPG, retail, health care and media industries. Join Circana thought leaders, industry partners and guests to learn how opportunities, trends and market disruptions will impact your business. Out of the Box Judaism Podcast Out of the Box Judaism Podcast by Esther Goldenberg This podcast is for people who are interested in Out-of-the-Box Judaism -- whether Jewish or not.What does out of the box mean?Out-of-the-Box can mean… thinking outside the box. Many people have an impression or idea of what it means to be Jewish or what you have to do to be Jewish or what you have to believe to be Jewish. Out-of-the-Box can mean thinking outside the box of preconceived notions and creating the Jewish experience that is right for you.Out-of-the-Box can mean… being outside of the synagogue. Many people feel that joining or going to a synagogue doesn’t fulfill their desire for a deeper connection. Out-of-the-Box can mean finding and creating meaningful spiritual experiences on your own, with your family, or with a community that is not based in a synagogue.Out-of-the-Box can mean… unpacking your heritage. If you or someone in your family is Jewish, you have a box of hand-me-downs and treasures waiting to be unpacked. Out-of-the-Box can mean examining those contents, Politics Unpacked Times Radio Hugo Rifkind unpacks the the politics of the day - and the stuff that's even more important - with the brightest brains from the Times and Sunday Times.You can listen to Hugo on DAB, smart speaker or app 10am-1pm Monday to Friday. If you like what you hear, then read more at http://www.thetimes.com/ Hosted on Acast. See acast.com/privacy for more information. The Human Upgrade: Biohacking for Longevity & Performance Dave Asprey For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger

Frequently Asked Questions

How long is this episode of Peptalk: Peptides Unpacked?

This episode is 50 minutes long.

When was this Peptalk: Peptides Unpacked episode published?

This episode was published on December 1, 2025.

What is this episode about?

Is there a transcript available for this episode?

Yes, a full transcript is available for this episode. You can read the complete transcript on the episode page.

Can I download this Peptalk: Peptides Unpacked episode?

Yes, you can download this episode by clicking the download button on the episode player, or subscribe to the podcast in your preferred podcast app for automatic downloads.

URL copied to clipboard!