BME 695L Lecture 7: Assessing Zeta Potentials

What this episode covers

See references below for related reading.7.1      Introduction – the importance of the zeta potential7.1.1    nanoparticle-nanoparticle interactions7.1.2    nanoparticle-cell interactions7.1.3     part of the initial nanomedical system-cell targeting process7.1.4     low zeta potential leads to low serum protein binding and potentially longer circulation7.2      Zeta potential basics7.2.1     What is the zeta potential?         7.2.1.1 surface layer potential         7.2.1.2 Stern layer potential         7.2.1.3 slip layer         7.2.1.4 zeta potential layer7.2.2     How is it measured?         7.2.2.1 electrophoresis         7.2.2.2 conversion of electrophoretic mobility to zeta potential7.2.3     Zeta potential is the potential barrier to cell-nanoparticle interactions7.2.4     Optimal zeta potential is complicated but some general advice7.3      Some factors affecting the zeta potential7.3.1    pH7.3.2     ionic strength7.4       Some zeta potential experiences7.4.1     Size and zeta potential changes during LBL assembly of NPs7.4.2     Effects of pH and dilution on NP zeta potential7.5       "Zeta sizing" measuring size on a zeta potential instrument7.5.1     DLS (Dynamic Light Scattering) sizing7.5.2     Relating scattering intensity to diffusion coefficients and hydrodynamic size7.5.3     Computing the hydrodynamic radius from the Stokes-Einstein equation7.5.4     Actual versus measured DLS values

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