EPISODE · Jun 8, 2026 · 27 MIN
Can We Build a Bionic Gallbladder?
from My Weird Prompts
Twenty percent of gallbladder removal patients develop chronic post-cholecystectomy syndrome — diarrhea, bile reflux, and nutrient malabsorption. The obvious question: has anyone built a replacement? This episode traces the history of failed attempts, from 1970s external bile bags to a DARPA-funded shape-memory polymer pouch at MIT and a bioartificial gallbladder grown from pig scaffolds at Wake Forest. We break down why the gallbladder is harder to replace than it looks, and what the closest working prototypes actually do.
What this episode covers
Twenty percent of gallbladder removal patients develop chronic post-cholecystectomy syndrome — diarrhea, bile reflux, and nutrient malabsorption. The obvious question: has anyone built a replacement? This episode traces the history of failed attempts, from 1970s external bile bags to a DARPA-funded shape-memory polymer pouch at MIT and a bioartificial gallbladder grown from pig scaffolds at Wake Forest. We break down why the gallbladder is harder to replace than it looks, and what the closest working prototypes actually do.
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Can We Build a Bionic Gallbladder?
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