Drug Utilization Patterns and Adherence to Guideline-Directed Therapy in Acute Myocardial Infarction: A Prospective Observational Study

Drug Utilization Patterns and Adherenceto Guideline-Directed Therapy in Acute Myocardial Infarction: A ProspectiveObservational StudyInternational Journal of Life Sciences, Biotechnology andPharma Research Vol. 14, No. 10, October 2025 DOI:10.69605/ijlbpr_14.10.2025.11ABSTRACT Background: Acute myocardial infarction (AMI) is aleading cause of morbidity and mortality worldwide. Effective pharmacotherapy plays a crucial role in secondary prevention and improving clinical outcomes. This study evaluates drug utilization patterns in Acute myocardial infarction patients,adherence to guideline-recommended therapies, and factors influencing medication adherence. Methods: A prospective observational study was conducted on 100 Acute myocardial infarction patients. Demographic data, comorbidities, Killip class, left ventricular ejection fraction (LVEF), and drug utilization were analyzed. Adherence to guideline-recommended therapies, including dual antiplatelet therapy (DAPT), beta-blockers, ACE inhibitors/ARBs, statins, and SGLT2 inhibitors, was assessed based on the American College of Cardiology (ACC) and American Heart Association (AHA) guidelines. Results: The study included 100 patients (mean age: 54.27 ± 13.51 years), with 82% males. Most (81%) were Killip class I, indicating mild heart failure. Hypertension (34%) and diabetes (24%) were common, while 58% reported tobaccouse. LVEF was <30% in 18% of patients. Thrombolysis was performed in 95%, predominantly with streptokinase (94%). DAPT adherence was high (98%), with ticagrelor (58%) being the most prescribed. Beta-blockers were used in 62%, andACE inhibitors/ARBs in 44%. PCI was performed in 67%, primarily for Left Anterior Descending  lesions. AWMI was the most common MI type (45%). Adherence to ACC/AHA guidelines was high for antiplatelets (98%) and statins(96%), but suboptimal for betablockers (62%) and ACE inhibitors/ARBs (44%). Older patients had lower adherence to guideline-directed therapies.Conclusion: The study demonstrates high adherence toantiplatelets and statins but suboptimal beta-blocker and ACE inhibitor/ARB use. Streptokinase was the preferred thrombolytic. Targeted interventions are needed to improve adherence, especially in older patients, to optimize Acutemyocardial infarction management and outcomes.Disclaimer:Lupin makes no representation or warranty of any kind, expressed or implied, regarding the accuracy, adequacy, validity, reliability, availability, or completeness of any scientific information shared by the HCP on the ­­­STARUPDATE podcast. You should not allow the contents of this to substitute for your own medical judgment, which you should exercise in evaluating the information on this website.