Fluid Administration in Septic Shock

For the past two decades, large amounts of isotonic fluids have been the first step in treating septic shock despite adverse events of fluid overload, coagulopathy, and pulmonary edema. A new NIH study evaluates this strategy. Join host, Geoff Wall, with guest, Matt Trump, DO, as they evaluate initial septic shock management.The GameChangerLiberal fluid management (30 mL/Kg) in the early phase of septic shock may not result in lower mortality than a more restrictive strategy. However, vasopressor predominant strategy may be used in its place.Show Segments00:00 - Introductions01:08 - Background on Fluid Administration in Septic Shock05:44 - Looking at the Study15:55 - The GameChanger: Shapiro et al Results21:21 - Connecting to Practice: What Should We Takeaway34:31 - Closing RemarksHostGeoff Wall, PharmD, BCPS, FCCP, CGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint HealthMatt Trump, DOIowa ClinicsReferences and ResourcesEarly Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.Redeem your CPE hereCPE (Pharmacist)Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)Pharmacists: Get a membershipCE InformationLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Discuss the background of fluid administration in septic shock2. Describe the results of the Shapiro et al study0.05 CEU/0.5 HrUAN: 0107-0000-23-103-H01-PInitial release date: 03/13/2023Expiration date: 03/13/2024Additional CPE and CME details can be found here.Follow CEimpact on Social Media:LinkedInInstagram