הגעתי לארון ממתקים. מה עכשיו? (פרק 37)

עידן, באמת שהכל טוב ויפה עד ש.עד שאני מגיעה הביתה מורעבת ואין לי כוח - ככה שאני פשוט חוטפת את הדבר הראשון שאני רואה בארון.עד שאני מגיע לארוחת הערב עם החברים ומתחיל לנשנש - ופשוט לא מצליח לעצור.עד שאני לא מצליח לשלוט בעצמי ופשוט אוכל.האם גורלנו נחרץ? ולא נצליח לעולם לרדת במשקל?Concept Review By Mass magazine Sternson SM, Eiselt AK (2017) Three pillars for the neural control of appetite. Annual Review Physiology, 79: 401-423. Marx J (2003) Cellular warriors at the battle of the bulge. Science, 299:846-849. Betley JN, Shengjin X, Huang Cao ZF, Gong R, Magnus CJ, Yu Y, Sternson SM (2015) Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature, 521:180-185. Li MD (2011) Leptin and beyond: an odyssey to the central control of body weight. Yale J Biol Med 84:1-7. Pandit R, Beerens S, Adan RAH (2017) Role of leptin in energy expenditure: the hypothalamic perspective. Am J Physiol Regul Integr Comp Physiol, 312:R938-R947. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372:425-432. Kelesidis T, Kelesidis I, chou S, Mantzoros CS (2010) Narrative review: the role of leptin in human physiology: Emerging Clinical Applications. Ann Intern Med, 152:93-100. Myers MG, Leibel RL, Seeley RJ, Schwartz MW (2011) Obesity and leptin resistance: Distinguishing cause from effect. Trend Endocrinol Metab, 21:643-651. Kenny PJ (2011) Reward mechanisms in obesity: new insights and future directions. Neuron, 69:664-679. Finlayson G (2017) Food addiction and obesity: unnecessary medicalization of hedonic overeating. Nat Rev Endocrinol, 13:493-498. Fletcher PC, Kenny PJ (2018) Food addiction: a valid concept? Neuropsychopharmacology, 43:2506-2513. Goldstone AP, Prechtl de Hernandez CG, Beaver JD, Muhammed K, Croese C, Bell G, Durighel G, Hughes E, Waldman AD, Frost G, Bell JD (2009) Fasting biases brain reward systems towards high-calorie foods. Eur J Neurosci 30:1625-1635. Hofmann W, van Koningsbruggen GM, Stroebe W, Ramanathan S, Aarts H (2010). As pleasure unfolds: Hedonic responses to tempting food. Psychol Sci. 21:1863–1870. Meye FJ, Adan RA (2014) Feelings about food: the ventral tegmental area in food reward and emotional eating. Trends Pharamacol Sci, 35:31-40. Gibson EL (2012) The psychobiology of comfort eating: implications for neuropharmacological interventions. Behav Pharmacol, 23:442-460. Frayn M, Livshits S, Knauper B (2018) Emotional eating and weight regulation: a qualitative study of compensatory behaviors and concerns. J Eat Disord, 6:23. Kemp E, Bui M, Grier S (2013) When food is more than nutrition: understanding emotional eating and overconsumption. J Consum Behav, 12:204-213. Posovszky C, Wabitsch M (2015) Regulation of appetite, satiation, and body weight by enteroendocrine cells. Part 2: therapeutic potential of enteroendocrine cells in the treatment of obesity. Horm Res Paediatr, 83:11-18. Carter ME, Soden ME, Zweifel LS, Palmiter RD (2013) Genetic identification of a neural circuit that suppresses appetite. Nature, 503:111-114. Campos CA, Bowen AJ, Schwartz MW, Palmiter RD (2016) Parabrachial CGRP neurons control meal termination. Cell Metab, 23:811-820. Chen JY, Campos CA, Jarvie BC, Palmiter RD (2018) Parabrachial CGRP neurons establish and sustain aversive taste memories. Neuron, 100:891-899. Johnson AW (2013) Eating beyond metabolic need: how environmental cues influence feeding behavior. Trends Neurosci, 36:101-109. Sinha R, Gu P, Hart R, Guarnaccia JB (2019) Food craving, cortisol and ghrelin responses in modeling highly palatable snack intake in the laboratory. Physiol Behav, 208: 112563. Fuster JM (2002) Frontal lobe and cognitive development. J Neurocytol, 31:373-385. Eiselt AK, Chen J, Arnold J, Kim T, Sternson SM (2019) Medial prefrontal cortex guides decision making about hunger and thirst. bioRxiv preprint 620690.