Why the Same Antidepressant Hits Different People Completely Differently

Two people, same drug, opposite outcomes. The answer is in your liver enzymes and brain receptors. This episode unpacks how CYP2D6, CYP2C19, and CYP3A4 variants can turn a standard dose into an overdose or a sugar pill — and why brain receptor polymorphisms like 5-HTTLPR and COMT Val158Met matter just as much.

Episode metadata supplied by the publisher feed · Published Jun 5, 2026

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Why the Same Antidepressant Hits Different People Completely Differently

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