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Aging-US

by Aging Podcast

Aging is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.Read about the Aging Scientific Integrity Process: https://aging-us.com/scientific-integrity

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Episodes

  1. Behind the Study: Drug Combo Targets Cancer & Senescent Cells, Extends Lifespan in Old Mice

    Aging Editorial Board member Dr. Irina Conboy and Dr. Zachery Robinson from the Department of Bioengineering and QB3 Institute at the University of California, Berkeley, present their findings in the research paper, “Selective targeting of cancer and senescence via shared metabolic shifts extends...

  2. Longevity & Aging Series (S4, E7): Dr. Irina Conboy and Dr. Zachery Robinson

    In this episode of the Longevity & Aging Series (S4, E7), Dr. Irina Conboy and Dr. Zachery Robinson from the Department of Bioengineering and QB3 Institute at UC Berkeley, CA, join host Dr. Yuan Zhao to discuss their research paper, published in Volume 18 of Aging, titled “Selective targeting of...

  3. Editors’ Choice: Social determinants of health and risk of dementia in people with and without type 2 diabetes

    This month’s Editor’s Choice features the #research paper recently #published in Aging, titled “Social determinants of health and risk of dementia in people with and without type 2 diabetes – findings from two large national-scale cohorts.” Analyzing data from two large national-scale cohorts,...

  4. New Control Theory Framework Proposes a Safer Approach to Aging Drug Discovery

    BUFFALO, NY — October 15, 2026 — A new #research paper was #published in Volume 18 of Aging on September 16, 2026, titled “Control theory of aging and longevity for gerotherapeutic drug discovery: state space, vector fields, modalities, safety, and the minimum safe cost of functional…

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  5. New Gene–Phenotype Catalogue Maps the Genetic Landscape of Premature Aging

    Rare genetic disorders that cause features of aging to appear much earlier than expected can offer an unusual window into the biology of human aging. Yet information about these conditions is scattered across publications and databases, and the same genes or syndromes are sometimes described…

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  6. Targeting PLA2G15 Reduces Senescence and Alters Lipid Metabolism in Kidney Cells

    BUFFALO, NY — October 13, 2026 — A new #research paper was #published in Volume 18 of Aging on September 16, 2026, titled “Targeting phospholipase Pla2g15 reduces long-chain BMP phospholipids abundance and senescence in kidney cells.” The study found that disrupting the gene Pla2g15 reduced...

  7. Behavioral Complexity Could Offer New Insights Into Aging and Frailty

    BUFFALO, NY — October 8, 2026 — A new #commentary was #published in Volume 18 of Aging on September 12, 2026, titled “Complexity, variability, and the behavioral layer of gerophysics: a commentary on Unfried et al. (2026).” The commentary proposes expanding the emerging field of gerophysics to...

  8. Mini-GRID Radiotherapy Reduces Senescence While Preserving Growth Inhibition in Glioma Cells

    BUFFALO, NY — October 6, 2026 — A new #research paper was recently #published in Volume 18 of Aging, titled “Spatially fractionated mini-GRID radiotherapy differentially modulates radiation-induced senescence in murine glioma and normal cells.” The study found that spatially fractionated…

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  9. Aging Supports the 11th International Cell Senescence Association Conference

    BUFFALO, NY — October 5, 2026 — Aging is pleased to support the 11th International Cell Senescence Association (ICSA) Conference, taking place November 3–5, 2026, at Seoul National University’s Siheung Convention Center in South Korea. The conference will bring together researchers from around…

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  10. Adverse Social Determinants Linked to Higher Dementia Risk in People With Type 2 Diabetes

    BUFFALO, NY — October 1, 2026 — A new #research paper was #published in Volume 18 of Aging on September 10, 2026, titled “Social determinants of health and risk of dementia in people with and without type 2 diabetes – findings from two large national-scale cohorts.” The study found that…

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  11. ATF5 Helps Preserve Mitochondrial Quality and Muscle Endurance During Aging

    Aging is commonly associated with the gradual loss of skeletal muscle mass and function. While preserving muscle mass is important, muscle health also depends on the mitochondria that provide energy for contraction and help muscles respond to physical stress. A new study suggests that a protein...

  12. Developmental Senescence Emerges as a Candidate Mechanism in CHARGE Syndrome

    BUFFALO, NY — September 29, 2026 — A new #review was #published in Volume 18 of Aging on September 8, 2026, titled “Developmental senescence misregulation in congenital disorders: CHARGE syndrome as a candidate model.” The article proposes that disruption of developmental senescence—a tightly...

  13. Longevity & Aging Series (S4, E6): Dr. Adam Bohnert

    In this episode of the Longevity & Aging Series (S4, E6), Dr. Adam Bohnert from the Department of Biological Sciences at Louisiana State University (Baton Rouge, LA) joins host Dr. Yuan Zhao to discuss the research paper he co-authored in Volume 18 of Aging, titled “Inhibition of peroxisomal...

  14. Exceptional Longevity Across Species Linked to DNA Maintenance, Stemness and Stress Resistance

    BUFFALO, NY — September 24, 2026 — A new #review was #published in Volume 18 of Aging on September 8, 2026, titled “How to live for centuries: common denominators of organisms with exceptional longevity.” The review examines what some of the world’s longest-lived organisms may reveal about the...

  15. The “Guardian Paradox” Links Chronic DNA Damage Response to Aging

    BUFFALO, NY — September 21, 2026 — A new #review was #published in Volume 18 of Aging on August 31, 2026, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.” The review presents a new framework...

  16. EDITORS’ CHOICE: Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging

    A research paper recently published in Aging, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging,” investigated how a human-relevant mutation in the PTPN6 gene, which encodes the immune and metabolic regulator SHP-1, affects immune and liver function during...

  17. Human-Relevant Ptpn6 Mutation Reveals Complex Links Between Immunity, Metabolism and Liver Aging

    BUFFALO, NY — September 16, 2026 — A new #research paper was #published in Volume 18 of Aging on August 28, 2026, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.” The study examines how a mutation affecting the immune and metabolic regulator SHP-1 reshapes...

  18. Evidence for Cellular Senescence as a Driver of Aging Stronger Than for Somatic Mutations

    BUFFALO, NY — September 14, 2026 — A new #review was #published in Volume 18 of Aging on August 26, 2026, titled “Assessing mechanisms and evidence of a causal role for cellular senescence and somatic mutations in aging.” The review examines two biological processes strongly associated with...

  19. Misha Blagosklonny’s Ideas Reshaped Thinking About Aging

    Scientific progress often begins with questioning assumptions that have shaped a field for decades. Few researchers embodied this approach as strongly as Dr. Mikhail “Misha” Blagosklonny, an oncologist and biogerontologist whose unconventional theories challenged traditional explanations of why...

  20. Reduced Insulin/IGF-1 Signaling Dramatically Extends Male Lifespan in C. elegans

    BUFFALO, NY — September 10, 2026 — A new #research paper was #published in Volume 18 of Aging on August 24, 2026, titled “Disruption of the insulin/IGF-1 signaling pathway in Caenorhabditis elegans dramatically increases male longevity and enhances reproductive health late in life.” The research...

  21. Three Herbal Extracts Protect Mitochondrial Function in a Cellular Model of Parkinson’s Disease

    BUFFALO, NY — September 9, 2026 — A new #research paper was #published in Volume 18 of Aging on August 13, 2026, titled “Protective effects of three herbal extracts on mitochondrial dysfunction in VPS13C-knockdown SH-SY5Y cells: implications for Parkinson’s disease.” The study was led by co-first...

  22. Behind the Study: How Aging Impairs Tuberculosis Clearance

    Dr. Falak Pahwa, Dr. Ranjan Kumar Nanda, and Mr. Ashish Gupta from the International Centre for Genetic Engineering and Biotechnology (ICGEB) in New Delhi, India, discuss their research paper, recently published in Volume 18 of Aging, titled “Host immunosenescence compromises Mycobacterium...

  23. Indy Gene Reduction Linked to Healthier Gut Microbiota and Longer Lifespan in Fruit Flies

    BUFFALO, NY — September 3, 2026 — A new #research paper was published in Volume 18 of Aging on August 12, 2026, titled “Indy reduction decreases aging-related dysbiosis in Drosophila.” The study was led by first author Danielle N. A. Lesperance from the University of Connecticut. Corresponding...

  24. Developmental Programs Could Help Drive the Aging Process

    Why do we age? For decades, one of the dominant explanations has been that cells and tissues gradually accumulate molecular damage until they can no longer function normally. DNA mutations, damaged proteins, mitochondrial dysfunction, epigenetic alterations, and other forms of cellular wear have...

  25. Higher TMAO Levels Linked to Cardiometabolic Risk and Brain Atrophy in Older Adults

    BUFFALO, NY — August 31, 2026 — A new research paper was published in Volume 18 of Aging on August 11, 2026, titled “TMAO is associated with higher age, cardiometabolic risk factors and degenerative alterations of the brain in healthy elderly adults.” The study was led by first author Gunter…

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  26. Metformin Emerges as a Promising Candidate at the Intersection of Aging and Longevity

    BUFFALO, NY — August 26, 2026 — A new #review was #published in Volume 18 of Aging on August 10, 2026, titled “Metformin at the convergence of aging and longevity.” The review was authored by Jarra Manneh, May Alasmar and Nady El Hajj from the College of Health and Life Sciences at Hamad Bin...

  27. Targeting POLG Reduces Breast Cancer Stemness Through Mitochondrial Dysfunction

    BUFFALO, NY — August 24, 2026 — A new research paper was published in Volume 18 of Aging on August 8, 2026, titled “Investigating POLG-driven modulation of cancer stemness: a pilot study in breast cancer cells.” The study was led by first author Chiara Chinigò from the Italian National Research...

  28. Aging Partners with Aging Research and Drug Discovery Meeting (ARDD) as Media Partner

    BUFFALO, NY — August 24, 2026 — Aging is pleased to announce its partnership as a media partner of the 13th Aging Research and Drug Discovery Meeting (ARDD), taking place October 1–3, 2026, at the David Rubenstein Treehouse at Harvard University in Boston, Massachusetts. ARDD brings together...

  29. EDITORS’ CHOICE: Slowing intervertebral disc aging in mice through long-term systemic treatment

    A #Research paper recently #Published in Volume 18 of Aging, titled “Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b,” examines whether the senolytic PROTAC 753b can slow age-related...

  30. Transcriptomic Aging Clock Reveals Age-Related Molecular Patterns in Opioid Dependence

    BUFFALO, NY — August 12, 2026 — A new #research paper was #published in Volume 18 of Aging on July 27, 2026, titled “Transcriptomic aging clock analysis identifies key genes in opioid dependence.” The study was led by first author Hai Duc Nguyen from the Division of Microbiology, Tulane National...

  31. Misha Blagosklonny’s Scientific Legacy Continues to Shape Modern Aging Research

    BUFFALO, NY — August 10, 2026 — A new #essay was #published in Volume 18 of Aging on August 6, 2026, titled “Misha Blagosklonny: a life of ideas.” The article was written by Aging Editorial Board member David Gems from the Institute of Healthy Ageing and Research Department of Genetics, Evolution...

  32. Hyperfunction Theory Offers a New Perspective on Why We Age

    BUFFALO, NY — August 6, 2026 — A new #research perspective was #published in Volume 18 of Aging on July 24, 2026, titled “A brief history of the hyperfunction theory of aging and future directions.” The article was written by João Pedro de Magalhães from the Genomics of Ageing and Rejuvenation…

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  33. Longevity & Aging Series (S4, E5): Dr. Kan Cao

    In this episode of the Longevity & Aging Series (S4, E5), Dr. Kan Cao of the Department of Cell Biology and Molecular Genetics at the University of Maryland joins host Dr. Yuan Zhao to discuss the research paper she co-authored in Volume 18 of Aging, titled “Methylene blue protects hair follicle...

  34. Fatty Liver Disease Linked to Early Cardiovascular and Cognitive Changes

    BUFFALO, NY — August 5, 2026 — A new #research paper was #published in Volume 18 of Aging on July 23, 2026, titled “Adipo-neuroinflammation, cognitive impairment and surrogate markers of cardiovascular risk in patients with Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD).” The...

  35. Hypertonic Saline Plus Furosemide Improves Heart Failure Biomarkers in Randomized Trial

    Heart failure remains one of the leading causes of hospitalization among older adults worldwide. During episodes of acute decompensated heart failure (ADHF), excess fluid builds up in the lungs and body, making breathing difficult and increasing the risk of serious complications. Although...

  36. New Drug Combination Targets Cancer and Senescent Cells While Extending Lifespan in Old Mice

    BUFFALO, NY — August 3, 2026 — A new #research paper was #published in Volume 18 of Aging on July 17, 2026, titled “Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.” The study was led by first author Zachery R. Robinson, and corresponding…

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  37. Italy Proposes a Healthspan-Focused Framework for Healthy Aging

    BUFFALO, NY — July 30, 2026 — A new #research perspective was #published in Volume 18 of Aging on July 16, 2026, titled “Towards integration of healthspan strategies into the Italian National Health Service.” The article was led by co-first authors Nicola Marino, affiliated with the AEON…

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  38. Senolytic PROTAC Slows Age-Related Intervertebral Disc Degeneration in Male Mice

    BUFFALO, NY — July 27, 2026 — A new #research paper was #published in Volume 18 of Aging on July 13, 2026, titled “Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b.” The study was led by…

    more

  39. New Surface Marker Could Advance Precision Therapies for Type 2 Diabetes

    BUFFALO, NY — July 23, 2026 — A new #research paper was #published in Volume 18 of Aging on July 8, 2026, titled “TM4SF1 is a surface marker of senescent pancreatic β-cells.” The study was led by first author Ana Beathriz Leite Lorente from Joslin Diabetes Center and Harvard Medical School, and…

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  40. Brain Flexibility Is Linked to Hand Coordination During Aging

    Coordinating both hands is something most people take for granted. Everyday activities such as buttoning a shirt, preparing a meal, driving, or using a knife and fork all depend on the brain’s ability to precisely control movements on both sides of the body. As people age, however, these tasks...

  41. Preserving Peroxisomes Helps Maintain Mitochondrial Health and Extend Lifespan in C. elegans

    BUFFALO, NY — July 21, 2026 — A new #research paper was #published in Volume 18 of Aging on July 6, 2026, titled “Inhibition of peroxisomal protein PRX-11 promotes longevity in Caenorhabditis elegans via enhancements to mitochondria.” The study was authored by Yash Flora, Dhriti Shastri, Kathryn…

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  42. EDITORS’ CHOICE: The multifaceted inducers of cellular senescence

    Each month, we will highlight a paper published in Aging chosen as the “Editors’ Choice.” These selections are handpicked by our editors and accompanied by a brief summary, showcasing research with significant impact and novel insights in aging and age-related diseases. Cellular senescence is a...

  43. Senescent Cells Found to Accumulate Lipid Droplets Across Aging and Alzheimer’s Disease

    BUFFALO, NY — July 16, 2026 — A new #research paper was #published in Volume 18 of Aging on July 1, 2026, titled “Senescent cells accumulate lipid droplets.” The study was led by first author Noa Rachmian-Cooper and corresponding author Valery Krizhanovsky from the Department of Molecular Cell...

  44. Sex-Specific Hormones Could Hold the Key to Better Sarcopenia Treatments

    BUFFALO, NY — July 13, 2026 — A new #review was #published in Volume 18 of Aging on June 26, 2026, titled “Hormonal dimorphism in sarcopenia disease.” The review was led by first author Romain Menard and corresponding author Romain Madelaine from the MDI Biological Laboratory, Kathryn W. Davis...

  45. Longevity & Aging Series (S4, E4): Dr. Maria Blasco

    In this episode of the Longevity & Aging Series (S4, E4), Dr. Maria Blasco of the Spanish National Cancer Centre (CNIO) joins host Dr. Yuan Zhao to discuss the research paper she co-authored in Volume 18 of Aging, titled “Cross species activity of TERT human telomerase component.” Interview video…

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  46. Multiple Biological Triggers Shape Cellular Senescence in Aging and Disease

    BUFFALO, NY — July 7, 2026 — A new #review was #published in Volume 18 of Aging on June 22, 2026, titled “The multifaceted inducers of cellular senescence.” The review was led by first author Hilah Gal and corresponding author Valery Krizhanovsky from the Department of Molecular Cell Biology,...

  47. Plant-Based Dietary Patterns Are Associated With Slower Biological Aging

    As people live longer, maintaining good health is becoming just as important as extending lifespan. While chronological age simply reflects the number of years a person has lived, biological age measures how well the body is functioning and may better predict future health. Researchers have...

  48. Comprehensive Individual-Patient Analysis Clarifies Life Expectancy Across Rare Progeria Disorders

    BUFFALO, NY — July 6, 2026 — A new systematic #review was #published in Volume 18 of Aging on June 18, 2026, titled “Life expectancy and causes of death in classical laminopathic progeroid syndromes: systematic review with individual-patient data synthesis.” The study was led by co-first authors...

  49. Nonhuman Primate Research Reveals How Aging, Stress, Behavior May Interact to Increase Disease Risk

    BUFFALO, NY — July 1, 2026 — A new #review was #published in Volume 18 of Aging on June 11, 2026, titled “Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior.” The review, dedicated to the late Dr. Mikhail (Misha) Blagosklonny, was...

  50. Cellular Senescence and Stem Cells Share a More Complex Relationship Than Previously Recognized

    BUFFALO, NY — June 29, 2026 — A new #review was #published in Volume 18 of Aging on May 30, 2026, titled “The love and hate relationship between cellular senescence and stemness.” The review was led by first author Angelos Papaspyropoulos and corresponding author Vassilis G. Gorgoulis from the...

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ABOUT THIS SHOW

Aging is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.Read about the Aging Scientific Integrity Process: https://aging-us.com/scientific-integrity

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Aging Podcast

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science

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Aging is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates...

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