All Episodes

Anthropic’s push into finance

The artist AI can’t kill

Divine intervention in AI

Netflix co-founder Reed Hastings: stories, schools, superpowers

The grid(lock) slowing AI down

AI’s expanding attack surface

Should we give AI a bank account?

After SaaS

Humans secretly prefer AI writing

The AI Kept Choosing War

How Notion rebuilt for the age of AI

Network effects, AI medicine, and the fight for free speech

Does AI really save time?

Making sense of the layoff wave

CryptoPunks creators: from art experiment to cultural movement

Reid Riffs with Parth Patil on AI-Native Startups (Part 3 of 3)

Reid Riffs with Parth Patil on Enterprise AI Integration (Part 2 of 3)

Reid Riffs with Parth Patil on Individual AI Mastery (Part 1 of 3)

Amjad Masad on vibe coding, AI agents, and the end of boilerplate

BONUS: Conversations with Coleman: Big Tech, Politics, and Trust in Institutions

Stephen Colbert on connection, discovery, and human nature

The power of AI, from curing cancer to ballot boxes

The AI energy war is here

R.I.P. Computer Keyboard (1964 – 2025)

AI’s Influence On The Church, Cybersecurity, and Disney

Our AI blindspot: incentives over intentions

How we regulate AI could decide the next century

Reid riffs on NVIDIA's chips, China’s AI ambitions, and the push to pause AI

Steve Kerr and Kris Brown on Leadership, Purpose, and Innovation in Sport and Society

Aza Raskin on interspecies communication, empathy, and AI’s next frontier

Reid riffs on fostering trust with founders, in boardrooms, and in AI

David Fajgenbaum on drug repurposing, AI, and saving his own life

Reid riffs on Trump’s $100K visa fee, 3-day work weeks, and AI trust issues

Lisa Su on semiconductors, compute, and big bets

Reid Riffs on AI translations, Apple Intelligence, and OpenAI’s Critterz

Stephen Colbert on connection, discovery and human nature

Reid riffs on AI adoption, NVIDIA, and AI’s impact on entry-level jobs

MacKenzie Price on AI-Powered K-12 Schools

Reid riffs on GPT-5, Figma's IPO, and the end of AOL dial-up

Audrey Tang and Divya Siddarth on Outfitting Democracy for the AI Era

Reid riffs on the energy arms race and AI addressing climate change

Tony Marx on the Future of Libraries, AI, and Trust

Reid riffs on AI adoption, sensitive data, and digital twins

Reid riffs on acquihires, agents, and new startup norms

Reid riffs on cryptocurrency, stablecoins and regulation

David Autor on AI’s impact on jobs, expertise, and labor markets

Reid riffs on massive AI acquisitions, robotics, and headcount trimming

Hannah Fry on AI, Algorithms, and Human Nature

Reid riffs on if AI can become conscious

Yuval Noah Harari on trust, the dangers of AI, power, and revolutions

Reid riffs on AI companions, human friends, and age gates

Alexis Ohanian on the future of online and offline communities

Reid riffs on PBCs, jobs and automation, and AI access for kids

Jane Goodall on Hope, AI, and the Natural World

Reid riffs on antitrust, AI coworkers, and Chinese manufacturing

Derek Thompson on AI, abundance, and human progress

Reid riffs on Tobi’s memo, AI and play, and the tweet that cost trillions

Demis Hassabis on AI, game theory, multimodality, and the nature of creativity

Reid riffs on Signal, AI for cancer detection, and GPT-4o image generation

Andrew Bosworth on AI, wearables, and mixed reality

Re-release of Trevor Noah | Celebrating two years of Possible!

Reid riffs on AI as “American Intelligence” and a prediction from Anthropic’s CEO

Dana Griffin on AI, belonging, and intergenerational connection

Reid riffs on AI wearables, quantum, and Deep Research

Latanya Sweeney on AI, trust, and privacy

Reid riffs on the AI race with China and if the US should regulate AI

BONUS: Pioneers of AI: Love in the Age of AI

Anja Manuel on AI, China, and national security

Reid and AIs riff on what could go right with AI

Greg Beato on superagency, AI, and the cognitive industrial revolution

Bret Taylor on conversational AI, voice, and agents

Fei-Fei Li on spatial intelligence and human-centered AI

PRESENTING: Pioneers of AI with Dr. Rana El Kaliouby and Musician Taryn Southern

Artful Intelligence | Ep 3: Paul Trillo on Music Video x AI

Artful Intelligence | Ep 2: Elise Swopes on Photography x AI

Introducing: Artful Intelligence | Ep 1: Malick Lombion on Hyperlapse x AI

Spencer Hyman on flavor and chocolate

Reid riffs on AI and public service technology

Devshi Mehrotra on AI, justice, and public defense

Reid riffs on Bill Gates and promising technology developments

Feed Drop: Reid Hoffman: Entrepreneurship, AI, and the Battle for Democracy

Feed Drop: Masters of Scale: President Bill Clinton in conversation with Reid Hoffman

Bill Gates on possibility, AI, and humanity

Reid riffs on iterative development and cultural differences

James Manyika on global AI and inclusion

Reid riffs on the next generation of LLMs

Sean White on Inflection and AI frontiers

Reid riffs on Silicon Valley, politics, and the election

Sarah Longwell on politics, AI, and elections

Reid riffs on his personal history with AI

Daphne Koller on drug discovery and AI

Reid riffs on the future of human connectivity

Nick Thompson on our AI future

Reid riffs on AI regulation

Gina Raimondo on AI, government, and commerce

Reid riffs on AI agents and investments

Ashton Kutcher on AI and investing

Reid riffs on building better cities

Devon Zuegel on the future of cities and community

Reid riffs on California Forever and housing

Jan Sramek on California Forever and the future of cities

Reid riffs on going from idea to launch

Massimo Bottura on the future of food and creativity

Reid riffs on coding and K-12 education

Pat Yongpradit on AI literacy and computer science education

BONUS: Reid Hoffman’s speech: Humanity’s Hegelian Golden Braid

Reid riffs on tech journalism and the TikTok ban

Feed Drop: On with Kara Swisher: Reid Hoffman talks Trump, Thiel & AI

Kara Swisher on AI, media, and accountability

Reid riffs on AI milestones and AI efforts abroad

Kevin Scott on AI and humanism

[BONUS + VIDEO] Reid interviews Reid AI, his AI avatar

Introducing: a new Possible

Reflections on AI and season two

Katherine Maher on the future of trusted information

Kerry Washington on connection, identity and AI

Sal Khan on the future of K-12 education

Van Jones on AI, disruption and inclusion

Phaedra Ellis-Lamkins on the future of social welfare

Sarah Sze on the future of AI and art

Kim Stanley Robinson on narrative and civilization

Peter Lee on the future of health and medicine

Feed Drop: Masters of Scale | Reid Hoffman confronts the AI critics

Siddhartha Mukherjee on the future of disease and diagnostics

Condoleezza Rice on the future of war and geopolitics

Anne-Marie Slaughter on the future of the care economy

Marques Brownlee on the future of creators

Introducing: Possible season two

BONUS: Reid Hoffman’s commencement speech at Bologna Business School

Prompt and process with Ethan Mollick [AI miniseries]

Socially assistive robots with Maja Matarić [AI miniseries]

Personal intelligence with Mustafa Suleyman [AI miniseries]

Reflections on AI and season one

Ariel Ekblaw on the future of space exploration

Sam Altman and Greg Brockman on AI and the future

Jaime Teevan on the future of work

Bryan Stevenson on the future of criminal justice

Janette Sadik-Khan on the future of cities

Ben Nelson on the future of higher education

Saul Griffith on a clean energy future

Dr. Kim Budil on the future of fusion

Trevor Noah on the future of entertainment and AI

Introducing: Possible