PODCAST · health
Longevity Optimization with Kayla Barnes-Lentz
by Kayla Barnes-Lentz
Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.
Episodes
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Dr. Kutluk Oktay, MD, PhD: Ovarian Aging, Fertility Preservation, and Delaying Menopause
Menopause does not begin when periods stop. Ovarian reserve and egg quality have been declining for decades, and that decline accelerates for many women in their late 30s. I sat down with Kutluk Oktay, MD, PhD, FACOG, a reproductive endocrinologist, ovarian biologist, and pioneer in ovarian…
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Carolina Reis Oliveira, PhD: Senescent Cells, Retinol Myths, and the Skin Barrier Body Connection
Most skincare is designed to improve how aging looks. But can it change what is happening inside the skin itself? In this conversation, I sit down with Carolina Reis Oliveira, PhD, co-founder and CEO of OneSkin, to explore what actually drives skin aging at the cellular level. Carolina explains…
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Dr. Abud Bakri, MD: Thymus Health, Circadian Biology, and the Truth About Peptides
Most longevity conversations focus on the brain, heart, muscle, and metabolism. Far less attention goes to the thymus, an immune organ that starts shrinking almost as soon as puberty ends, and new research suggests it may be quietly linked to fertility, hormones, and even how millions of women...
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Dr. Will Cole: How to Heal Your Cells, Leaky Gut, Light Exposure, and Why Your Gut Sets the Pace To Aging
We talk about aging like it happens to a whole person at once. It doesn't. It happens organ by organ, at different speeds, and most people never find out which part of them is running ahead until something breaks. Dr. Will Cole has spent sixteen years running one of the first functional medicine...
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Dr. Tania Dempsey, MD: Mast Cell Activation Syndrome, PMOS, and the Hidden Cause of Women's Chronic Symptoms
Most women who deal with unexplained allergies, stubborn inflammation, heavy periods or a PMOS (formerly PCOS) diagnosis are never told to look at the same underlying cause: an immune cell most doctors were never taught to test for. Dr. Tania Dempsey, MD, trained in internal medicine at Johns...
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Dr. Margie Davenport, PhD: Exercise in Pregnancy, the 140 BPM Myth, and Why Pregnancy Complications Predict Heart Disease
Pregnancy has long been treated as a season to slow down and play it safe. The data tells a different story, and it starts with a number most women were taught to fear. Dr. Margie Davenport, PhD, is an exercise physiologist and professor at the University of Alberta who has spent over a decade...
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Dr. Gabrielle Lyon, DO: Muscle as the Organ of Longevity, Protein Mistakes, and the Truth About Menopause Muscle Loss
Muscle is not just something you build in the gym. Dr. Gabrielle Lyon has spent her career arguing it's the organ that actually determines how well you age, and almost none of us have been taught to think about it that way. Dr. Gabrielle Lyon, DO, is the founder of Muscle-Centric Medicine and the...
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Dr. Christin Glorioso, MD, PhD: The Alzheimer's Blood Test, How to Cut Your Dementia Risk by 30%, and Why Women Are at Higher Risk
Brain aging does not start when memory loss shows up. It starts around age 25, decades before anyone notices anything is different. By the time a symptom appears, the window for the highest-leverage prevention has usually already closed. Today I'm talking with Dr. Christin Glorioso, an MD and PhD...
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Dr. Colleen Cutcliffe, PhD: Natural GLP-1 Production, Fiber Deficiency, Akkermansia and the Gut Microbiome Connection
Most people think of the gut as a digestive organ. It is not. It is the upstream controller of your metabolism, immune function, brain health, skin, and hormones and almost everyone is running it on a depleted, misfed microbiome without knowing it. Dr. Colleen Cutcliffe, PhD is the co-founder and...
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Dr. Elizabeth Yurth, MD: Muscle Building in Midlife, Joint Regeneration, Peptide Protocols, and Why Osteoarthritis Is Not Wear and Tear
Dr. Elizabeth Yurth, co-founder of Boulder Longevity Institute, is one of the rare physicians who spent 30 years in orthopedic and sports medicine before pivoting to longevity and regenerative medicine. This episode covers joint health in women, osteoarthritis, bone density, peptides,...
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Dr. Wendy Troxel, PhD: Insomnia, Sleep Apnea, Perimenopause Sleep, and the Treatment That Outperforms Every Medication
Sleep is not just something women need more of. It is something women struggle with in ways that are fundamentally different from men and almost nobody explains why. Dr. Wendy Troxel, PhD is one of the most respected sleep scientists in the world. Her research has shaped sleep policy in the US...
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Dr. Sharon Horesh Bergquist, MD: Hormetic Stress, Women’s Resilience, and the 5 Stressors That Support Longevity
Avoiding stress at all costs may actually be making you less resilient. In this episode, Dr. Sharon Horesh Bergquist reframes stress as one of the body’s most overlooked tools for longevity. The right kind of challenge can activate repair, strengthen resilience, improve metabolic health, and help...
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Dr. Martha Gulati, MD: Women's Heart Disease, Female-Specific Risk Factors, and What Medicine Gets Wrong About Cardiovascular Health
Heart disease is not only a man's disease. It is the number one killer of women, responsible for ten times more deaths than breast cancer. And yet most women have never had a real conversation about their cardiovascular risk, because the medical system was not built to catch it in them. Dr.…
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Dr. Jolene Brighten, ND - Endometriosis, Adenomyosis, PMDD, PMOS and Postpartum Hormones
Women are often told that painful periods, irregular cycles, bloating, mood changes, fatigue, brain fog, postpartum symptoms, and hormonal shifts are “normal.” But common does not mean something should be ignored. In this episode, Dr. Jolene Brighten, ND joins me for a practical deep dive into...
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Dr. Izabella Wentz: IBS Root Causes, Leaky Gut, Autoimmunity, and How To Start Healing Your Gut
Less than 25% of people with IBS get real relief from conventional medicine. That number tells you everything about how the current approach is failing. Most people with IBS have been told it is stress, told to take medication, and sent home. But irritable bowel syndrome is not one condition, it…
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Dr. Scott Sherr, MD: Why Stress Blocks Healing: Mitochondria, Immune Aging, Hyperbaric Oxygen, and Methylene Blue
There is a state where the body gets locked in sympathetic activation and mitochondrial dysfunction at the same time and no matter what supplements you take, no matter what protocols you run, nothing actually works. Dr. Scott Sherr calls it the sympathetic spiral of doom, and in this episode we...
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Dr. Poonam Desai: The 5 Labs Women Need, Heart Disease Risk, Microplastics, and Perimenopause
Most women have had bloodwork done. What most women haven't had is the right bloodwork. In this episode, Dr. Poonam Desai, double board certified in lifestyle and emergency medicine, NAM certified in menopause care, and founder of Longevity Place and Her Longevity, breaks down the five labs she...
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Prof. Belinda Beck, PhD: Bone Health: Building Strong Bones, Preventing Age-Related Loss, And Reversing Osteoporosis With Evidence-Based Exercise
Most women are not thinking about their bones until a fracture happens or a scan comes back alarmingly. By then, the window for the most impactful intervention has often been narrowing for decades. Bone density peaks around age 18, not 30 as widely believed and the slow decline that follows is...
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Dr. Dawn Mussallem, DO: Cancer Prevention, Early Detection, Exercise, Metabolic Health and Breast Cancer Screening
In this episode, I’m joined by Dr. Dawn Mussallem, DO, an integrative oncologist, lifestyle medicine specialist, cancer survivor, heart transplant recipient, and the newly appointed Chief Medical Officer of Fountain Life. We talk about why cancer rates are rising, what we actually know about...
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Dr. Brian Kennedy, PhD: The Real Science of Longevity: mTOR, Rapamycin & How to Measure Biological Age
Brian Kennedy is one of the world’s leading researchers studying the biology of aging. In this conversation, we break down what longevity science actually shows about extending healthy lifespan and the everyday habits that appear to influence how we age. Dr. Brian shares insights from decades of...
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GLP-1 Crisis for Women, Gut Health, Bone Loss with Dr. Sara Szal, MD
We're back with Dr. Szal! Today we are discussing a variety of topics: Gut health, peptides, hormone health , GLP-1's, bone health and so much more!In this conversation, Dr. Sara G dives into the gut-brain connection and explains how disrupting the microbiome can directly affect mood, anxiety…
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Dr. Bérénice Benayoun, PhD: Why Your Ovaries Age (And the Gut Connection)
Bérénice Benayoun, PhD, explains why ovarian aging may be one of the earliest and most important drivers of female aging, influencing the brain, immune system, metabolism, and long-term disease risk far beyond reproduction. She breaks down what we actually know so far, including DNA damage,...
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Dr. Deb Rivera, PhD: The Missing Link Between Stress, Aging, and Resilience
Most people can feel when stress is affecting them. Far fewer know whether their body is adapting well or quietly being pushed toward dysfunction. In this episode, Dr. Deb Rivera, PhD in neuroengineering, explains the hidden biological system that helps determine how well your body handles…
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Dr. Eboni Cornish, MD: Brain Longevity, Neuroinflammation, and What Quietly Damages the Brain
Brain health problems rarely begin where most people look. Memory issues, low mood, poor focus, anxiety, and even early cognitive decline can be driven by hidden inflammation and root-cause imbalances long before they show up the way most people expect. In this episode, Dr. Eboni Cornish explains...
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Jessie Inchauspé Glucose Goddess on CGMs, Crashes & The Biggest Glucose Mistakes
Blood sugar stability may be one of the most important levers for long term health, yet most people never look at it.In this episode, I am joined by Jessie Inchauspé, widely known as the Glucose Goddess, to examine what glucose spikes are actually doing inside the body and why they matter even if...
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Dr. Deanna Minich, PhD: How Women Should Structure Macros in Their Meals
Women are told to fast, cut carbs, eat high protein, avoid seed oils, and track macros, but most of that advice ignores female physiology. In this episode, I’m joined by Dr. Deanna Minich, PhD, certified functional medicine practitioner and nutrition scientist. We walk through the Female…
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Dr. Susanna Søberg, PhD: The Science of Cold Plunges for Women
Cold exposure is not a badge of toughness. It’s a stressor. And if you do it wrong, you can absolutely overdo it. In this episode, I’m joined by Dr. Susanna Søberg, PhD, scientist and educator specializing in metabolism, cold and heat exposure, and longevity. We break down what cold exposure is...
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Dr. Stephanie Riley Hahn: Pelvic Floor Optimization, Leaks, Sex, And Prolapse
Pelvic floor problems are not a “just do more kegels” issue.For a lot of women, kegels are either not specific enough, or they make symptoms worse. In this episode, Dr. Stephanie Riley Hahn, pelvic floor physical therapist and founder of Longevity and Pilates, breaks down what pelvic floor...
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Dr. Aimie Apigian, MD: The Biology of Trauma + Nervous System Safety
Longevity isn’t just workouts, supplements, and recovery tools, it starts with nervous system health. In this episode, Dr. Aimie Apigian explains what trauma actually is (not a label, but a measurable physiological response), how the body shifts from stress into overwhelm, and why “pushing…
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I Became the First Woman in the World to Test Her Ovarian Age
For the first time in history, ovarian biological age can be measured, and I became the first woman in the world to take the test. Until now, women have had no real way to understand how their ovaries are aging beyond rough estimates like AMH. But this new machine-learning algorithm, trained on...
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Cynthia Thurlow, NP: Perimenopause, Insulin Resistance and Midlife Metabolism
Perimenopause is not just about hormones, it’s a metabolic transition that affects insulin sensitivity, gut health, stress tolerance, and long-term disease risk. In this episode, Cynthia Thurlow, board-certified nurse practitioner and functional medicine expert, explains how women’s metabolism...
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Dr. Chris Masterjohn, PhD - Mitochondria, Micronutrients, and How Nutrition Actually Drives Longevity
When cellular energy production is impaired, no diet, supplement, or health protocol can work as intended. In this episode, Dr. Chris Masterjohn, nutrition scientist and expert in micronutrients and metabolism, explains why mitochondrial function is the limiting factor behind stalled progress,...
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Dr. Jessica Shepherd, MD – Menopause, Hormone Therapy and Bone Health
In this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years. We discuss what actually happened with the WHI study that created all the fear around estrogen and...
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Dr. Khanh Nguyen - The Blood Swap: Why Doctors Are Replacing Your Plasma With THIS
What if your blood is what’s making you sick and the key to reversing it is removing it? In this episode, I sit down with Dr. Khanh Nguyen, a regenerative and anti-aging physician, to explore therapeutic plasma exchange and the rising use of young plasma. We talk detox, autoimmune disease, aging,...
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Dr. Ann Shippy, MD - The Fertility Alarm: Why 1 in 31 Kids Now Has Autism
Is your environment silently sabotaging your fertility? Dr. Ann Shippy joins the show to reveal how hidden toxins, mold, and overlooked cellular damage may be accelerating ovarian aging and how to reclaim your fertility before it’s too late. From infertility misdiagnoses to rising autism rates…
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Ashley Koff, RD - Dietitian Reveals: The Hormone Problem That Makes You Eat Everything
Ashley Koff is a registered dietitian and author who spent 20 years discovering that weight and health aren't separate issues, they're connected through "weight health hormones." After her own struggles with restrictive eating despite doing everything "right," a functional medicine doctor helped...
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Dr. Will Bulsiewicz, MD - The #1 Nutrient for Longevity That Everybody Still Ignores
In this video, Dr. Will Bulsiewicz shares his transformation from an overweight, depressed gastroenterologist to a gut health expert after meeting his now-wife changed his entire approach to food. He reveals why 95% of Americans are fiber deficient and how this single nutrient could be the key to...
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How to Make 2026 Your Healthiest Year Ever (Complete Guide)
Women don’t fail January — January fails women. Nearly 80% of New Year health goals are abandoned within weeks, not because of discipline, but because most plans ignore female biology. That’s why I created the 30-Day Female Longevity Challenge — a physiology-first way to prepare calmly and build...
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Dr. Sarah E. Hill, PhD - PMS Expert: Get Through Your Cycle Easier With These Simple Tricks
In this conversation, Kayla sits down with Dr. Sarah E. Hill, PhD to talk about the science behind PMS, cycle syncing, and why most health advice completely fails women. Dr. Hill explains the three main causes of PMS symptoms, natural hormonal shifts, one-size-fits-all protocols designed for men,...
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Dr. Deanna Minich, PhD - Doctor Shares: 5 Superfoods Women MUST Eat to Balance Hormones
For years, functional medicine has focused on lab results and supplement protocols. Dr. Deanna Minich knows there's a deeper layer most practitioners miss. As a nutrition scientist who worked under Dr. Jeffrey Bland and educated for the Institute for Functional Medicine, she's witnessed how...
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Dr. Aly Cohen, MD - The Autoimmune Epidemic: Why Everyone You Know Is Sick Now
Everyday “healthy” choices might be silently rewiring your immune system—from canned soup and tap water to perfume, makeup, and even your couch—while autoimmune diseases quietly explode, especially in women. In this gripping conversation, Dr. Aly Cohen reveals how under-regulated chemicals…
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Dr. Karan Rajan, MD - Gut Surgeon: STOP Probiotics (Heal Your Gut Like THIS Instead)
In this episode, Kayla sits down with Dr. Karan Rajan, who is one of the most followed medical professionals on social media, and he breaks down the gut microbiome like you've never heard before. If you've ever felt bloated after eating fiber, tried keto and felt amazing temporarily, or wondered...
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Dr. Tania Elliot - Healing Allergies and Histamine
Your home could be triggering your allergies and nobody's checking. Dr. Tania Elliott sees patients struggling with reactions that disappear before they can get to the doctor's office. That's why she started doing virtual home tours to find what's really causing the problem.In this episode, Dr....
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Lily Nichols, RDN - Fertility Nutrition: These Diet Changes Help You Get Pregnant
Are you planning to get pregnant, currently pregnant, or postpartum? This conversation with dietitian Lily Nichols will change how you think about nutrition during these critical life stages.Lily reveals that over 90% of women have nutrient deficiencies that directly impact fertility, pregnancy...
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Dr. Jessica Peatross, MD: This Hidden Toxin Causes Bad Aging (40% of Homes Have This)
Are you dealing with unexplained fatigue, hormonal imbalances, brain fog, or chronic inflammation that doctors can't figure out? In this episode, Dr. Jess Peatross explains why so many people are sick with "mystery symptoms" that doctors can't solve. She breaks down the toxins and infections…
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Dr. Darshan Shah, MD: The Early Death Metric: This Blood Test Can Predict Cancer & Heart Disease
When a top surgeon faces his own health collapse, he’s forced to question everything he’s ever believed about medicine. In this gripping conversation, Dr. Darshan Shah reveals how hitting rock bottom led him to uncover the true keys to longevity — from biomarker mastery and advanced testing to…
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Dr. Christopher Davis, MD - Heart Doctor: Low-Fat Foods Are Causing More Heart Disease!
Most people think heart disease is just about cholesterol. But what if the real issue is in your genes, your environment, and even your daily stress? In this episode, I’m joined by Dr. Christopher Davis, a triple board-certified interventional cardiologist who’s redefining what it means to take...
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Jim Kwik - This 6-Second Trick Helps You Remember Anything
Brain coach Jim Kwik went from being called “the boy with the broken brain” to teaching millions how to unlock their limitless potential. In this episode, he reveals the simple shifts that supercharge focus, memory, and learning speed—helping you read faster, think clearer, and retain more....
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Dr. Sara Szal-Gottfried, MD - I Do THIS To Slow My Aging (My Longevity Routine)
A lot of women are tired, busy, and trying to stay healthy. But what if you didn’t need to do everything perfectly to feel good? In this episode, we talk about the key parts of health that matter most. You’ll learn how much sleep your body actually needs, what kind of movement helps you stay...
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Dr. Brad Schoenfeld, PhD - Fitness Myths: Why 90% of People Are Working Out Wrong!
Dr. Brad Schoenfeld, PhD is one of the world’s leading researchers on muscle hypertrophy (muscle growth). He is a Professor of Exercise Science at Lehman College in New York, where he directs the Human Performance Laboratory. Over his career, he has published more than 300 peer-reviewed articles,...
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Frequently Asked Questions
How many episodes does Longevity Optimization with Kayla Barnes-Lentz have?
Longevity Optimization with Kayla Barnes-Lentz currently has 172 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Longevity Optimization with Kayla Barnes-Lentz about?
Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.
How often does Longevity Optimization with Kayla Barnes-Lentz release new episodes?
Longevity Optimization with Kayla Barnes-Lentz publishes regularly with 172 episodes available. Check the episode list for the typical release schedule.
Where can I listen to Longevity Optimization with Kayla Barnes-Lentz?
You can listen to Longevity Optimization with Kayla Barnes-Lentz on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Longevity Optimization with Kayla Barnes-Lentz?
Longevity Optimization with Kayla Barnes-Lentz is created and hosted by Kayla Barnes-Lentz.
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