PODCAST · technology
Y Combinator Startup Podcast
by Y Combinator
We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.
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309
Chelsea Finn: This is the State of the Art in Robotics
Robots can already fold laundry, make espresso, clean kitchens, and assemble things. The harder problem is getting them to do those tasks reliably, for long periods of time, without a human babysitting them.At Startup School 2026, Physical Intelligence cofounder Chelsea Finn explains what it takes to build general-purpose robots that work in the real world. She shares how reinforcement learning pushed robot throughput up 2x, how their systems can run autonomously for hours, and why she believes robotics is entering its GPT era: moving from specialized models toward general-purpose systems that can work across tasks, robots, and environments.Transcript: https://www.ycrootaccess.com/p/chelsea-finn-on-the-next-decade-in
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308
Peter Steinberger: "Fun Is Velocity"
Last November, Peter Steinberger was annoyed that there was no good way to talk to his coding agents from his phone, so he built one himself. A few months later, OpenClaw had exploded into one of the biggest open source AI projects in the world, with nearly 3,000 contributors and a peak of 4.7 million weekly downloads.At Startup School 2026, Peter tells the story of what happened when OpenClaw took off, what he got wrong as it grew, and how he eventually stopped using the product he had built for himself.He shares why the best products often start with something that annoys you, why focus matters more as building gets easier, and why, in his words, “fun is velocity.”Transcript: https://www.ycrootaccess.com/p/peter-steinberger-what-happens-when
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307
Max Hodak: How Startups Build Speed
Science is building a retinal implant that restores vision to people who have gone blind. One patient has already used it to read a 300-page novel.Building a company like that requires a lot more than getting the technology right. At Startup School 2026, Science CEO Max Hodak explains how the company buys things and hires people, and why those systems determine how fast it can move.He also gets into why founders can’t delegate their judgment, and why there’s no set of five bullet points that makes a startup work.Transcript: https://www.ycrootaccess.com/p/max-hodak-there-are-no-blanket-rules
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306
How To Design In The Agent Era
AI isn't just changing the tools designers use. It's changing how they build, ship, and stand out. In this episode of Design Review, Stephen Haney, founder of AI-native design tool Paper, joins YC General Partner Aaron Epstein to demo the agent-first workflow that's making Paper one of the fastest-growing design tools since Figma. Using live redesigns of user-submitted websites as examples, they break down the most common AI design tells, show how to fix them in seconds, and explain why the biggest risk for founders isn't moving too slow, it's shipping something that looks like everyone else.
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305
Garry Tan: Own Your Intelligence
The next generation of startups will be built by smaller teams than ever before.At Startup School 2026, YC President & CEO Garry Tan explains why we're entering the era of personal AGI: AI agents that run on your own infrastructure, compound your knowledge over time, and dramatically increase your ability to build. He shares the tools and workflows he uses every day, why every founder should own their intelligence instead of renting it, and what it means to build under your own power.Transcript: https://www.ycrootaccess.com/p/garry-tan-own-your-intelligence
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304
Building the First Data Centers in Space
Philip Johnston is the co-founder and CEO of Starcloud, the company building data centers in space. In November 2025, Starcloud launched an Nvidia H100 GPU into orbit and trained the first large language model in space. They've since raised $200 million, hit a billion-dollar valuation just 17 months after YC demo day, and filed with the FCC to deploy 88,000 more satellites. In this episode, Philip walks us through their wild origin story, the engineering challenges behind the Starcloud-1, why they booked a SpaceX launch before they even knew what they were building, and how data centers in space make sense both economically and politically.
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303
Waymo Co-CEO Dmitri Dolgov: "Move Fast And Ship Safely"
Waymo’s first autonomous demo took eighteen months. The product took fifteen years. Today, the Waymo Driver runs 500,000 trips a week — four million fully autonomous miles across fifteen cities, with 17 times fewer serious-injury crashes than human drivers.At Startup School 2026, Waymo co-CEO Dmitri Dolgov shares the seven lessons behind that journey, from bridging the gap between a demo and a real product to building systems that can safely operate in the physical world.Transcript: https://www.ycrootaccess.com/p/dmitri-dolgov-seven-lessons-from
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302
Patrick Collison: "What If You Succeed?"
In 2009, Patrick and John Collison went to Startup School in Berkeley, got sushi in Potrero Hill afterward, and decided on the walk home to start Stripe. The reasoning, as Patrick remembers it, was that “we might as well because it probably won't be that hard.”It took two years to launch.Seventeen years later, at Startup School 2026, he talks with YC's Harj Taggar about dropping out of MIT twice, why founders should ask what happens if they succeed, and what Stripe's own data says about the best time to start a company.
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301
Jeff Dean: The 1% Rule for Building in AI
In 2001, Jeff Dean and Sanjay Ghemawat did the math and realized Google’s entire search index would fit in RAM — then shipped it in a few days, and search got fast. In 2013, another napkin calculation showed that three minutes of daily speech recognition per user would require doubling Google’s server fleet. That one became the TPU. At Startup School 2026, Google’s Chief Scientist talks with YC’s Diana Hu through the thought experiments behind both, why inference hardware is the next specialization, and where two or three people in a room can still win.Transcript: https://www.ycrootaccess.com/p/jeff-dean-the-1-rule-for-building
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300
Alexandr Wang: “This is a Once-in-a-Civilization Opportunity”
Alexandr Wang's advice to his 18-year-old self: develop your own internal compass for how the future will unfold, and hold conviction in it against the noise. At Startup School 2026, the Scale AI (YC S16) founder — now leading Meta's Superintelligence Labs — talks with Garry Tan about rebuilding a frontier lab from scratch, why talent density compounds, and how to spot the exponential worth betting your twenties on.
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299
Blake Scholl: Breaking the Supersonic Ban
In 1969, we landed on the moon and flew Concorde. Half a century later, we could do neither.Blake Scholl founded Boom Supersonic (YC W16), the startup building America’s first supersonic airliner, to change that. At Startup School 2026, he shares how a cardboard mockup with Office Depot seats became XB-1, the first independently developed jet to break the sound barrier, and why founders have to build for both the worst day and the best day.He also answers founder questions about teaching yourself hard things, breaking into hardware without the right resume, and finding work-life harmony while building something ambitious.
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298
Sam Altman: "Never a Better Time to Do a Startup"
In 2005, Sam Altman was a Stanford sophomore in YC’s first batch, building a startup in a little Cambridge office while Paul Graham cooked the founders dinner. Twenty years later, as co-founder & CEO of OpenAI, he closed Startup School 2026 in conversation with YC's Garry Tan — on agents, ambition, and why the ceiling for what a startup can take on has never been higher.
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297
Boris Cherny: Building Claude Code
Fresh off the launch of Opus 5, Claude Code creator Boris Cherny joins Diana Hu at Startup School 2026 to talk about what the newest models can do, how Claude Code came to be, and what it means to build products when the underlying capabilities keep accelerating.
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296
Jensen Huang: The Mindset That Built NVIDIA
NVIDIA started with the wrong technology, learned the right one from three textbooks bought at Fry’s, and went on to invent most of the major breakthroughs in modern computing.At Startup School 2026 at Chase Center, Garry Tan sits down with Founder and CEO Jensen Huang to talk about confronting reality, learning your way into new domains, and why resilience — getting through one day at a time — matters more than anything else.
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295
World Models, Explained
Why do even our best AI models need tens of thousands of examples to learn skills that a human picks up in a handful of tries?Solving this problem is one of the great open challenges in modern AI. World models, which give AI an internal simulation of its environment, are one of the most promising paths forward.In this episode of Decoded, YC's Ankit Gupta and Francois Chaubard discuss the intuition and math behind world models, new research, and current applications in self-driving, robotics, and more.Full Transcript: https://ycrootaccess.substack.com/p/world-models-an-intuitive-introduction
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294
How To Better Understand Your Users
Most founders obsess over dashboards and aggregate metrics, but some of the best product insights come from understanding how individual users actually use their product.In this episode of Startup School, YC's David Lieb walks through one of his favorite tools for better understanding your users, the dot plot. It's a simple two-dimensional grid that reveals usage patterns no aggregate chart can show you.He’ll cover why it gives founders a better sense of product health, what patterns to look for, and real-world exam
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293
Why Domain Experts Are Winning In The Age Of AI
Bryant Chou co-founded Webflow, which today powers around 1% of all websites on the internet. Now he's back in the current YC batch with Ploy, an AI-powered website and marketing platform that doesn't just build your site — it connects to your analytics, CRM, and search console to optimize your marketing while you sleep. In this episode of the Lightcone he explains how he built Ploy to be “anti slop,” how building today compares to his first startup, and why founders with domain expertise are making a comeback.Chapters:00:00 — What Experience Gives You in the Age of AI00:38 — Meet Bryant Chou, Co-Founder of Webflow01:22 — His New Startup Ploy02:47 — Rebuilding the Posterous website From 200803:27 — Rebuilding the Scribd website From 200705:04 — Rebuilding the Auctomatic website From 200706:19 — Rebuilding the Escher Reality website From 201707:11 — 12% of the YC Batch Uses Ploy08:26 — The D&D Theory of Founder Skills10:05 — Democratizing Marketing and Growth10:50 — Live Demo: The Design Slurper13:21 — Your Website Should Work for You While You Sleep14:26 — Integrations, Analytics, and the Marketing Brain17:27 — Ploy's Anti-Slop Engine: 3,500 Curated Design Prompts20:05 — The Andy Warhol Theory of AI22:35 — Webflow Origin Story24:26 — Building in a Competitive Market Then vs. Now26:01 — First Three Months: Webflow 2013 vs. Ploy 202527:17 — What Experience Teaches You That Models Can't28:51 — Will Better Models Kill Products Like Ploy?30:32 — The Competitive Moat of Purpose-Built AI33:01 — Agents as Customers: CLI, MCP, and AEO35:02 — Young Founders vs. Experienced Founders36:36 — The Idea Maze and Cloning Yourself With AI42:37 — The Magnifying Glass MomentApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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292
How To Pick A Startup Idea
Many founders get stuck trying to find the perfect startup idea before they commit. But the perfect idea doesn't exist in the abstract. The only way to find what works is to pick one, go deep, and get feedback from real customers.In this episode of Startup School, YC's Jon Xu breaks down how to choose what to build, "burn the other boats," and go deep enough to practically run your customer's business— and why that depth is what surfaces the better idea underneath.
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291
"The CEO Must Be the Chief AI Officer"
Brex co-founder and CEO Pedro Franceschi believes most people still underestimate how much AI will change the way companies are built. AI isn't just another tool, it's a new foundation for building products, teams, and companies.In this episode of Lightcone, Pedro shares why he thinks we're only months into a platform shift as significant as the invention of electricity, how AI has changed the way he works, and why every founder should be "token maxing" to understand the limits of the technology firsthand.He explains why the CEO needs to be the chief AI officer, how Brex is rebuilding itself around AI, and why founders should rethink what's possible when intelligence is available on demand.
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290
How to Build an AI-Native Services Company
Some of the biggest companies of the next decade won't be software businesses, they'll be services companies like insurance carriers, law firms, and tax practices rebuilt from scratch with AI doing most of the work. In this episode of Startup School, YC Visiting Partner Charlie Warren walks through the playbook for building AI native services companies, covering how to pick a market with the right traits, why variance kills these businesses faster than anything else, and the P&L math that’ll transform your business model.Chapters:00:00 — Intro to AI Services Companies01:01 — Picking the Right Market02:55 — Markets YC Likes Right Now03:43 — The Sam Altman Test04:35 — The Right Founding Team05:28 — Building the Product06:19 — Variance Is the Existential Problem07:08 — The Early Demand Trap07:53 — How to Price AI Services08:41 — The P&L Walkthrough09:33 — AI Operating Leverage10:27 — Don't Buy Your Way InApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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289
How To Build Superintelligence Inside Your Company
Building superintelligence inside a company isn't about adding AI as a feature. It's about making it the operating system the whole organization runs on. In this episode of the Lightcone, we sat down with YC's Pete Koomen to talk for the first time about how he led the effort to build YC's internal agent infrastructure from the ground up. We cover how giving agents unrestricted access to one database changed everything, the self-improving skill loops that get smarter overnight and why he thinks we've arrived at the personal computer moment for AI.Chapters:00:00 — Intro00:39 — YC's AI Stack02:15 — The Finance Team Problem That Started It All05:07 — SQL Access Changes Everything07:20 — One Database to Rule Them All09:14 — Jevons Paradox 10:07 — Denormalizing for Agents (G-Brain)12:15 — The Single-Player Era of Agents14:16 — 350 Tools and a Shared Registry16:24 — Skillify, DRY, and MECE Resolvers18:23 — The Self-Improving Dream Cycle20:26 — The Two-Sentence Pitch Skill23:06 — How Super Intelligence Compounds25:10 — Recording Everything as a Building Layer27:10 — The Shared Organizational Brain29:18 — Trust-Default Culture as a Requirement30:44 — Raising the Floor for New Employees32:35 — Horseless Carriages Essay Explained34:24 — Why Chat Is the Best Interface for Agents36:10 — Garry's List → G-Brain Rewrite38:50 — Just-in-Time Software40:49 — Centralizing vs. Decentralizing AI43:32 — The Personal AI RevolutionApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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288
How The Best Companies Defend Against Mediocrity And Rot
In this episode of the Main Function Garry sits down with Eric Ries, author of "The Lean Startup", about his new book, "Incorruptible: Why Good Companies Go Bad And How Great Companies Stay Great". Ries breaks down why shareholder primacy often leads to company and product degradation, how founders can lose control of the companies they build, and what legal structures and governance models can protect a company's core mission from outside threats.
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287
Paul Graham: Should you move to Silicon Valley?
Paul Graham is a co-founder of Y Combinator. He's funded and mentored companies like Dropbox, Airbnb, DoorDash, and thousands of others through YC, and is one of the most influential voices in the startup world.In this talk at our YC | Stockholm event last month, Paul walks through why ambitious founders should move to Silicon Valley at least briefly, what makes it uniquely valuable — from serendipitous meetings and faster investor decisions to a deeply embedded pay-it-forward culture — and why returning home afterward may be one of the most powerful things a founder can do to help their local ecosystem, using Stockholm as a case study for what it would take to become the Silicon Valley of Europe.
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286
Tokenmaxxing: How Top Builders Use AI To Do The Work Of 400 Engineers
We're entering a new era of software where a single person, working with AI agents, can build products that previously required entire teams.In this episode of Lightcone, the hosts break down the rise of AI coding agents, "tokenmaxxing", and the emerging workflows behind tools like Claude Code and OpenClaw. They discuss why AI systems today feel less like productivity tools and more like collaborators, why the future of AI should be personal and user-controlled, and how founders are starting to build software in completely new ways.
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285
Beyond Bigger Models: Recursion As The Next Scaling Law In AI
A 7-million parameter model outperforming models a thousand times its size on tasks like ARC Prize. That's what recursive reasoning unlocks.In this episode of Decoded, YC's Ankit Gupta and Francois Chaubard break down two recent papers on recursive AI models, HRMs and TRMs, that are achieving state-of-the-art results with a fraction of the parameters of today's largest models.They explain why standard LLMs hit a fundamental ceiling on certain reasoning tasks, how recursion at inference time gives small models the compute depth to break through it, and what happens when you combine these ideas with the power of large-scale foundation models.
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284
How to Build the Future: Demis Hassabis
Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistry. Today he leads Google DeepMind, pushing toward the same goal he set as a teenager: AGI. On this special live episode of How to Build the Future, he sat down with YC's Garry Tan to talk about what still needs to happen to get us to AGI, his advice for founders on how to stay ahead of the curve and what the next big scientific breakthroughs might be. Chapters:00:00 — Intro00:46 — Demis Hassabis: From Chess Prodigy to DeepMind01:48 — What’s Missing Before We Get To AGI?03:36 — Why Memory Is Still Unsolved06:14 — How AlphaGo Shaped Gemini08:06 — Why Smaller Models Are Getting So Powerful10:46 — The 1000x Engineer12:40 — Continual Learning and the Future of Agents13:32 — Why AI Still Fails at Basic Reasoning15:33 — Are Agents Overhyped or Just Getting Started?18:31 — Can AI Become Truly Creative?20:26 — Open Models, Gemma, and Local AI22:26 — Why Gemini Was Built Multimodal24:08 — What Happens When Inference Gets Cheap?25:24 — From AlphaFold to the Virtual Cells28:24 — AI as the Ultimate Tool for Science30:43 — Advice for Founders33:30 — The AlphaFold Breakthrough Pattern35:20 — Can AI Make Real Scientific Discoveries?37:59 — What to Build Before AGI ArrivesApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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283
The $9B Startup That Wants to Create a Billion New Developers
Replit is the leading no-code app builder for consumers and enterprise, letting anyone with an idea build real, deployed software using natural language. The company just raised a $400 million Series D at a $9 billion valuation.In this episode of Founder Firesides, co-founder and CEO Amjad Masad sat down with YC's Andrew Miklas to talk about Replit's 10-year journey from browser IDE to vibe coding platform, why the people getting the most value aren't traditional developers but founders and domain experts closest to the problem, and what Agent 4 unlocks with parallel agents, built-in design, and the ability to run your entire company on Replit.
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282
The Playbook For Building An AI Native Company
AI isn't just making teams more productive. It's changing how companies should be built.In this episode of Startup School, YC Partner Diana Hu explains what it means to build an AI-native company, where AI isn't just a tool but the operating system your company runs on.She breaks down how to make your company queryable so agents can improve across every function, why management hierarchies break down when an intelligence layer replaces human middleware, and why early-stage founders have a massive edge in building this way from day one.
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281
Stripe Head of Design Katie Dill Breaks Down Their New Website
Even the most successful websites eventually need a redesign. Take Stripe for example. After six years with the same homepage, they recently unveiled a brand new site that reflects how the fintech giant has evolved over the past few years. So when is the time right for a new landing page? And what should you prioritize in the redesign? In this episode of Design Review YC’s Aaron Epstein sat down Stripe’s Head of Design Katie Dill to pull the curtain back on their high profile redesign and to discuss how their team is evolving in a world dominated by new AI design tools.
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280
The GPT Moment for Robotics Is Here
Physical Intelligence is building a foundation model that can control any robot to do any task — what the team describes as the GPT-1 moment for robotics.The company's cross-embodiment approach trains across many different robot platforms, and recent results show tasks being performed zero-shot that last year required hundreds of hours of data collection.In this episode of The Lightcone, co-founder Quan Vuong sat down with Garry, Jared, Diana, and Harj to talk about why robotics is finally ready for its scaling moment, how PI runs its models in the cloud rather than on-device, and the playbook for what Quan sees as a Cambrian explosion of vertical robotics companies.
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279
This Startup Wants To Catch Cancer Before It Spreads
1 in 11 babies born in America this year will be screened by a genetic test that didn't exist a decade ago.Biotech startup BillionToOne turned a simple but radical idea—detecting rare fragments of fetal DNA in a mother's blood—into one of the most widely used prenatal tests in the U.S. And they're not stopping there. The same approach could unlock something even bigger: early-stage cancer detection from a blood test, a breakthrough that could one day save millions of lives.In this episode of Hard Tech, YC's Jared Friedman sits down with David Tsao and Oguzhan Atay to hear how they went from half a lab bench to a $4B biotech company—and why they believe this is just the beginning of what their technology can do.
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278
This Startup Secretly Detects Fraud For Fortune 500s
In this episode of Founder Firesides, YC Managing Partner Jared Friedman talks to Karine Mellata, co-founder of Variance (W23), who is coming out of stealth and announcing their $21 million Series A. Variance builds purpose-built AI agents for risk and compliance — automating fraud detection, content review, and identity verification for Fortune 500 companies and platforms like GoFundMe. They discuss why Variance built in the shadows for three years, detecting state-sponsored fraud rings, and the accident that nearly ended the company.
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277
How François Chollet Is Building A New Path To AGI
François Chollet has spent years asking a different question than most of the AI world. Instead of scaling what already works, he’s trying to understand what intelligence actually is—and how to build it from first principles. In this episode of Lightcone, he traces that path from his early work on deep learning to the creation of the ARC prize, and the launch of ARC V3, a new benchmark designed to measure something deeper than performance: the ability to learn, adapt, and reason efficiently in entirely new environments. He explains why today’s systems may be hitting limits, what recent breakthroughs really mean, and why reaching true general intelligence may require a fundamentally different approach.00:00 - AGI by 2030?00:31 - Introducing Ndea: A New Path Beyond Deep Learning01:08 - A New ML Paradigm 01:30 - Replacing neural nets with compact symbolic programs03:04 - Why Ndea Isn’t Competing With Coding Agents05:20 - Why Everyone Might Be Wrong About Scaling LLMs07:22 - Why Coding Agents Suddenly Work So Well08:50 - The Limits of LLMs in Non-Verifiable Domains10:48 - What AGI Actually Means (And Why Most Definitions Are Wrong)13:30 - Why Deep Learning Hits a Wall 14:00 - ARC’s Origin Story18:20 - ARC Benchmarks Explained: From V1 to V322:49 - The RL Loop Powering Coding Agents Today27:03 - ARC-AGI V3: Measuring “Agentic Intelligence”31:14 - Inside the ARC Game Studio35:31 - Could AGI Fit in 10,000 Lines of Code?44:01 - Building Ndea: From Idea to Compounding Research Stack46:46 - The Future of ARC: Benchmarks That Evolve With AI47:21 - Why There’s Still Huge Opportunity for New AI Paradigms53:37 - How to Build a Breakout Open Source Project - Lessons From Kera56:39 - Advice For How To Think About AIApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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276
Inside The Startup Reinventing America’s Trillion Dollar Chemical Industry
Solugen is reinventing the trillion-dollar chemical manufacturing industry by combining biology and chemistry in a new way. In this episode of Hard Tech, YC's Jared Friedman visits co-founders Gaurab Chakrabarti and Sean Hunt at their Houston HQ to see how they went from a $7,000 PVC reactor to a billion-dollar company competing with industry giants. They cover the breakthrough behind their enzymatic + catalytic production, how they found their first customers, and why starting small and staying close to customers let them win in a capital-intensive industry.Chapters:00:00 - A New Kind of Chemical Plant01:02 - Fusing Biology + Chemistry In a New Way02:23 - The Eureka Moment: From Pancreatic Cancer to Hydrogen Peroxide03:30 - Using A Sugar Feedstock Over Oil and Gas 04:22 - Proving Enzymes Work at Scale In Chemical Manufacturing05:16 - The $7K PVC Reactor06:44 - Finding First Customers at YC08:12 - What The Co-founders Got Out of YC09:33 - Seed Round to Bio Forge10:32 - Scaling to a Full-Size Plant (Bioforge)11:57 - The Future of American Manufacturing12:29 - The Next Decade of SolugenApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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275
Building A Global AI Startup From India
In this episode of The Lightcone, we talk with Mukund and Madhav Jha, the founders of Emergent - an AI platform that lets anyone build and ship production-ready software. In just eight months, users have created more than 7 million apps on Emergent, with the number doubling in just the last 45 days. We discuss how they built one of the most powerful AI coding agents, why they focused on non-technical users and what it's like building in India for a global audience.Apply to Y Combinator: https://www.ycombinator.com/applyChapters:00:00 - Intro01:06 - What Is Emergent?01:18 - Founder Backstory02:09 - From AI Testing to General Coding Agents02:52 - Getting Ahead of the Market04:18 - The Pivot to Non-Technical Users05:22 - Why Second Movers Can Win in AI09:04 - Building for Production, Not Just Prototypes18:21 - Live Demo: Building Apps with Emergent24:40 - How Emergent Hires and Runs a Lean Team29:04 - Is SaaS Dead? The Rise of Personalized Software34:04 - The Future: Niche Apps, Solo Builders and AI Agency
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274
The Future Of Brain-Computer Interfaces with Science's Max Hodak
YC alum Max Hodak is the co-founder of Neuralink and founder of Science, a company building brain-computer interfaces that can restore sight.Science has developed a tiny retinal implant that stimulates cells in the eye to help blind patients see again. More than 40 patients have already received the treatment in clinical trials, including one who recently read a full novel for the first time in over a decade.In this episode of How to Build the Future, Max joined Garry to discuss how BCIs work, what it takes to engineer the brain, and why brain-computer interfaces may become one of the most important technologies of the next decade.
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273
How To Avoid AI Design Slop
As no-code design tools become more common, so do the pitfalls. You know what they look like - the purple gradients, annoying hover effects, sections that fade as you scroll. So how do you avoid a site that feels vibe coded while still taking advantage of these new tools? In this episode of Design Review, YC’s Aaron Epstein is joined by Visiting Partner Raphael Schaad, the founder and designer of Cron (now Notion Calendar). Together they’ll review user submitted sites with an eye for how to leverage these tools and avoid the common vibe coding mistakes.
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272
The Fastest Path To Super Intelligence
Poetiq is a new startup founded by former DeepMind researchers that recently achieved a major jump on the ARC-AGI and Humanity's Last Exam benchmark by layering a recursive self-improvement system on top of existing models. In this episode of Lightcone, Poetiq's Founder & CEO Ian Fischer joined us to discuss how small teams can build “reasoning harnesses” that outperform base models, what that means for startups and why automating prompt engineering may be one of the most powerful levers in AI today.Chapters:00:00 – Intro00:40 – What Is Poetiq?01:07 – Recursive Self-Improvement Explained02:07 – The Fine-Tuning Trap02:59 – “Stilts” for LLMs03:14 – Recursive Self-Improvement vs. Fine-Tuning05:05 – Taking the Top Spot on ARC-AGI06:37 – Beating Claude on Humanity’s Last Exam08:40 – How the Meta-System Works10:26 – Beyond RL: A New S-Curve11:32 – Automating Prompt Engineering13:37 – From 5% to 95% Performance14:50 – Early Access & Putting Your Agent on Stilts16:17 – From YC Founder to DeepMind Researcher18:29 – Advice for Engineers in the AI EraApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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271
The AI Agent Economy Is Here
With the takeoff of OpenClaw and MoltBook, a new agent-driven economy is taking shape.In this episode of the Lightcone, we took a look at the explosive growth of AI dev tools and whether the time has come for builders to make something agents want.
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270
Inside Claude Code With Its Creator Boris Cherny
A very special guest on this episode of the Lightcone! Boris Cherny, the creator of Claude Code, sits down to share the incredible journey of developing one of the most transformative coding tools of the AI era.
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269
The New Way To Build A Startup
In the AI era, startups aren't winning by hiring faster — they're winning by automating as many internal functions as possible. In this episode of Main Function, Garry breaks down how tiny teams are beating companies 20x their size by building automations into every workflow, from engineering to ops to customer support.
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268
OpenClaw And The Future Of Personal AI Agents
You’ve probably already heard all about OpenClaw (formerly Clawdbot/Moltbot). The viral sensation is an open-source AI assistant that runs on your own device, connects with messaging apps you already use, and goes beyond chat to actually execute tasks like managing your email, calendars, files, workflows, and more. Now meet the man behind it. YC’s Raphael Schaad sat down with Peter Steinberger, the creator of OpenClaw, to discuss the “aha” moment behind the viral personal AI agent, why local-first agents could replace many of today’s apps, and how personal agents will reshape the future of software.Chapters:00:00 – OpenClaw takes over the internet00:44 – Life after going viral01:28 – Why OpenClaw took off, what sets it apart02:56 – Bots talking to bots (and hiring humans)04:11 – From “God AI” to swarm intelligence05:07 – Peter’s original “aha” moment06:38 – Rebuilding the agent as a conversation07:38 – The moment it exceeded expectations10:21 – Are apps going to disappear?12:31 – Memory, data silos, and ownership14:39 – The privacy reality of personal agents15:05 – Letting the bot loose in public Discord16:55 – Giving an agent a personality18:19 – Contrarian building philosophy20:09 – CLIs vs MCPs21:28 – Building for humans first21:46 – The road aheadApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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267
We're All Addicted To Claude Code
Wondering why your maker-turned-manager suddenly seems distracted in meetings? Maybe they're addicted to coding agents! In this episode of Lightcone, Calvin French-Owen — a co-founder of Segment and former engineer on OpenAI's Codex team — joins us to talk about why coding agents suddenly feel so powerful, the differences between Codex, Claude Code, and Cursor, and what the future of work will look like.
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266
How To Get Your First Customers
When you're starting out, it isn’t enough to just build a minimum viable product. You also need a minimum evolvable product - one that can adapt to the needs of those critical early customers. In this episode of Main Function, YC General Partner Ankit Gupta offers an update to the classic MVP playbook. He’ll outline strategies for getting your first customers, the power of adaptability and how feedback from early users will ultimately shape the future of your product and your company.Apply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobsChapters:00:00 – The Minimum Evolvable Product00:46 – Finding the First Believers01:29 – Counterintuitive Rules To Get Early Users02:10 – Learn Fast, Don’t Fear Churn02:52 – How Early Users Shape the Market You Enter04:22 – Tesla Case Study05:14 – How To Build To Evolve
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265
Inside The Startup Building Reusable Rockets
Stoke Space is racing to build the world's first fully reusable rockets that can launch, survive reentry, and fly again and again. In this episode of Hard Tech, YC’s Aaron Epstein sits down with Stoke Space co-founders Andy Lapsa and Tom Feldman to find out why they chose to take on one of the hardest problems in rocket science, how an obsession with efficiency gives them an edge, and what full reusability could unlock for the future of spaceflight.Apply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
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264
What Surprised Us Most In 2025
2025 was the year AI stopped feeling chaotic and started feeling buildable. In this Lightcone episode, the YC partners break down the surprises of the year, from shifting model dominance to why the real opportunity is moving back to the application layer, and why the next wave of AI startups may be just getting started.
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263
How Intelligent Is AI, Really?
ARC-AGI is redefining how to measure progress on the path to AGI - focusing on reasoning, generalization, and adaptability instead of memorization or scale.During this month's NeurIPS 2025 conference, YC's Diana Hu sat down with ARC Prize Foundation President Greg Kamradt to find out why most AI benchmarks fail, how ARC-AGI reveals the limits of today’s models, and why measuring intelligence may be harder than building it.
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262
The End of the Designer–Engineer Divide
Head of Design Ryo Lu helped transform Cursor from a feature-layer on top of VS Code into one of the world's leading AI code editors.He joins YC's Aaron Epstein on Design Review to talk about the path that brought him to Cursor, how rapid prototyping reshaped the core product and how he's breaking down the barriers that once separated designers and coders.
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261
From Pivot Hell To $1.4 Billion Unicorn
In just a few years, James Hawkins took PostHog from an idea hacked together right before YC's W20 deadline to a unicorn powering product analytics for thousands of teams.He joins YC's Brad Flora to talk about surviving six months of "pivot hell," why open-source analytics was the breakthrough, and how PostHog grew from fighting for its first users to launching full product lines—plus what he's learned about momentum, staying close to customers, and using transparency and humor to build a company that stands out.
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260
The Best Consumer Startup Ideas Were "Impossible" Until Now
Every major shift in consumer tech has a moment when it suddenly becomes accessible to millions. Michael Mignano helped spark one of those moments with Anchor, making podcast creation something anyone could do with a tap. Now at Lightspeed, he sees AI bringing a similar leap to music, media, and everyday apps.In this conversation, he and Garry trace the arc from the early days of social audio to today's consumer AI boom—and dig into what founders should focus on as the next generation of creative tools takes shape.
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ABOUT THIS SHOW
We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.
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