The Wellness Zone Podcast

In this episode of The Wellness Zone, Dr. Sears takes a closer look at what ultra-processed really means—and why the definition itself may be deeply flawed.

This week on the Wellness Zone Podcast: We hear a lot about the gut microbiome and how our diet affects it—but what’s really happening when we eat food?

Body fat—not BMI—is the true predictor of your risk for heart disease and early death. In this episode, Dr. Barry Sears explains why BMI often gets it wrong and introduces a better at-home solution: the Body Fat Calculator at ZoneLiving.com.

Dr. Barry Sears and Mary Perry discuss Supercritical Fluid Technology, one of the most advanced and innovative manufacturing techniques in the omega-3 industry.

It’s been 30 years since The Zone changed the way we think about food, health, and inflammation. In this special Wellness Zone podcast, Dr. Barry Sears looks back on the origins of The Zone—from its unlikely start inspired by the 1982 Nobel Prize in Medicine to its rise as one of the first diet books to bring hard science into the mainstream. Plus, discover why The Zone is more relevant today than ever before, as chronic disease, metabolic disorders, and inflammation continue to rise.

Type 2 diabetes affects nearly 38 million Americans, and nearly 100 million adults are prediabetic. In this episode of the Wellness Zone podcast, Dr. Barry Sears breaks down the growing diabetes epidemic and the staggering toll it’s taking on our healthcare system—and how the Zone diet can help.

In this episode of The Wellness Zone, Dr. Barry Sears takes you on a fascinating journey through the history of fish oil—from 18th-century transatlantic cod trade to the Norwegian innovations that transformed the industry. You’ll even hear why kids in the early 1900s were force-fed spoonfuls of cod liver oil before leaving the house—and how that tablespoon delivered 25 times more omega-3s than the average American gets today.

When you’re awake, your body faces constant wear and tear. Sleep, however, is your body’s prime time for repair, resetting your metabolic processes and preparing you for the challenges of the day. Join Dr. Barry Sears and Mary Perry as they explore the critical connection between sleep quality and metabolic health. 

Polyphenols do more than just give fruits and vegetables their vibrant colors—they have the potential to influence your genes. That’s right, the food you eat can literally turn certain genes on or off. But how does this work? It all comes down to AMPK, the master regulator of metabolism.

The Metabolic Way to Improve Athletic Performance | Dr. Barry Sears What’s the secret to peak athletic performance? It all comes down to two key factors: energy production and focus. Join Dr. Barry Sears as he explains how Metabolic Engineering can give athletes the edge they need to perform at their

GLP-1 drugs are now being used to treat addiction. But while GLP-1 drugs can be powerful, they come with serious side effects. The good news? You can achieve similar benefits naturally through Metabolic Engineering®, which is also based on calorie restriction—but designed for long-term health.

From the water you drink to the food you eat, these tiny plastic particles are nearly impossible to avoid. Tune in to learn what you can do to minimize your exposure and protect your health—plus how all this relates back to your metabolism.

Have you ever wondered why centenarians—those remarkable individuals who live to 100 or beyond—are almost never obese? It’s not just a coincidence. Obesity is far more than a number on the scale; it’s a chronic inflammatory condition that speeds up aging and steals away your healthspan—the precious years you spend vibrant, active, and free from disease

There’s no approved drug to treat Alzheimer’s. But your diet can play a crucial role in prevention. Reducing insulin resistance may be one of the most powerful ways to protect your brain. That’s where Metabolic Engineering® comes in. In this episode, join Mary Perry and me to learn how this groundbreaking dietary approach can help lower your risk of cognitive decline and keep your brain healthier for years to come.

Ultra-processed foods often get a bad rap—and for good reason. But what if we could re-engineer foods we love—like pasta, bread, and pastries—to not only keep their nutrients intact but also activate natural pathways that reduce hunger and inflammation caused by obesity? Well, we can. It’s called Zone Foods, and it’s not science fiction—it’s science.

GLP-1 drugs are often hailed as ‘miracle treatments’. But what makes them effective isn’t magic; it’s the activation of AMPK. This same metabolic pathway can be naturally activated through diet. Dr. Barry Sears and Maruy Perry dive into how this works and why AMPK might be the key to unlocking better health with less of a need for medication.

How old are you, really? While your chronological age is just a number, your biological age reveals the true state of your body’s health. In this episode of the Wellness Zone, Dr. Barry Sears and Mary Perry explore the intriguing science of epigenetics—what switches our genes on or off—and how it impacts aging.

In this episode of The Wellness Zone podcast, Dr. Barry Sears and Mary Perry break down how your metabolism plays a key role in not just living longer, but living better. Tune in to discover the science behind improving your quality of life, and how small changes today can set you up for a healthier future.

In this episode of the Wellness Zone Podcast, Dr. Barry Sears and Mary Perry, Director of Clinical Trials, explain the three stages of Metabolic Engineering, using a rocket analogy to break it down. Stage one is a calorie-restricted diet, like the Zone diet, to activate AMPK. Stage two involves omega-3s to reduce inflammation, and stage three introduces polyphenols to ensure a smooth transition to the Zone. Together, these stages set you on the path to a longer, healthier life.

From ancient willow bark to modern aspirin, all the way to today’s GLP-1, we'll explore how these mighty remedies have evolved. And guess what? They all share a secret superpower: activating AMPK!

When you think of menopause, diet might not be the first thing that comes to mind—but it should be. The symptoms of menopause are deeply intertwined with the metabolic shifts occurring in your body.

Today, we’re diving into a groundbreaking topic—Managing ADHD with Metabolic Engineering. While Metabolic Engineering isn’t a cure for ADHD, it can significantly enhance the effectiveness of ADHD medications. How? Both Metabolic Engineering and these medications activate a key enzyme called AMPK. When AMPK is activated, your brain’s neurotransmitters can perform at their best, leading to better focus and control. Tune in to learn how you can optimize your brain health and improve your ADHD management.

AGEs are Advanced Glycated Endproducts. AGEs are bad for your health because they contribute to oxidative stress and inflammation, both key factors in the aging process and the development of various chronic diseases.

Welcome to another episode of the Wellness Zone Podcast with Dr. Barry Sears and Mary Perry. This week we delve into a groundbreaking study that reveals how GLP-1 drugs—those new weight loss and diabetes injectables—may have the potential to turn off cancer cells. But your diet may provide the same results.

Recent studies have asked, "What's the best way to lose weight?" Is it through weight loss drugs like Ozempic? A low-calorie, high-protein diet? Or is it a combination of both? The answer may surprise you.

A recent study looked at the effect of a long-term ketogenic diet on inflammation and senescent cells (zombie cells). Here's what they found.

Dr. Barry Sears and Mary Perry discuss how your metabolism is far more important than a multivitamin pill.

Are new weight loss drugs like Ozempic and Wegovy helping America's Obesity crisis? Or are they causing more harm? Dr. Barry Sears and Mary Perry discuss the issue on this week's Wellness Zone podcast

Welcome to the latest episode of the Wellness Zone Podcast! Join Dr. Barry Sears and Mary Perry as they delve into the recent studies casting doubt on the link between Omega-3 fish oil and stroke or heart disease. Get ready to separate fact from fiction – is there a genuine risk, or is it all rubbish? Tune in to find out!

Welcome to The Wellness Zone Podcast with Dr. Barry Sears and Mary Perry. This week's topic: Intermittent Fasting.    

Welcome to The Wellness Zone Podcast with Dr. Barry Sears and Mary Perry. This week's topic: Is a Ketogenic Diet better for you than following the Zone Diet?

Welcome to The Wellness Zone Podcast with Dr. Barry Sears and Mary Perry. This week's topic: The Outbreak of Ozempic.

Welcome to The Wellness Zone Podcast with Dr. Barry Sears and Mary Perry. This week's topic: The Future of Weight Loss Drugs and Obesity.

Treating Depression is extremely complex, especially with patients with chronic inflammation, who may experience more severe symptoms. Addressing inflammation through an anti-inflammatory diet could enhance the effectiveness of depression medication.

This week on the Wellness Zone Podcast with Dr. Barry Sears and Mary Perry: Most prescription drugs we use today only treat the symptoms and not the underlying cause. A proper diet and an efficient metabolism are better at dealing with the root of chronic disease—and can help make prescription drugs work better.

This week in the Wellness Zone Podcast with Dr. Barry Sears and Mary Perry, we're examining what's true when it comes to drug and pharmaceutical advertising. How well do these drugs ACTUALLY work? And how to factor in "Number Needed To Treat".

Welcome to the Wellness Zone Podcast, featuring Dr. Barry Sears and Mary Perry. This week they discuss obesity in America, and how it affects our healthcare system.

This week on The Wellness Zone Podcast, Dr. Barry Sears and Mary Perry look at the metabolic pros and cons of fruit and vegetables. What's healthier for you?

The key to growing old successfully is aging at a biological rate slower than your chronological age. To do that, your metabolism has to be working at peak efficiency.  How do I make my metabolism as efficient as possible? What drug do I use? There's no drug, but there is one proven technology. It's called calorie restriction. “Well, that means I'm not eating anything.” No, calorie restriction is defined as restricting calories without restricting nutrition. It means you're eating fewer calories, but you're maintaining high levels of nutrient intake. Learn more and join our community at DrSears.com

This week on The Wellness Zone Podcast, Dr. Barry Sears and Mary Perry discuss how you can measure your levels of Insulin Resistance to determine how well you are.

Episode 7 of The Wellness Zone podcast with Dr. Barry Sears and Mary Perry. This week's topic: Understanding Metabolic Engineering

Hosts Dr. Barry Sears and Mary Perry discuss senescent Cells, otherwise known as Zombie cells.    Learn more and join our community at DrSears.com

Dr. Barry Sears and Mary Perry explain Satiety and how to restrict your caloric intake without always feeling hungry, tired, and irritable—the natural way.

Dr. Barry Sears and Mary Perry define what Wellness is, and how to maintain wellness for a lifetime.