All Episodes
MIB Agents OsteoBites and osTEAo — 223 episodes
Dissecting and Targeting Metastatic Drivers in Osteosarcoma
Validation of MCL1 inhibition and combinatorial therapy for elimination of osteosarcoma lung metastasis
Combinatorial immunotherapy to overcome cellular therapy resistance in osteosarcoma
Epigenetic Regulation of the Type I Interferon Pathway in Osteosarcoma: Implications for Immune Checkpoint Blockade
osTEAo: Live from FACTOR '26!
osTEAo: Advocacy Doesn't End at Discharge
Your Story, Your Tissue, Your Impact: Changing the Future of Osteosarcoma
A Guide to FACTOR 2026 Scientific Panels
osTEAo - More Than Physical: The Mental Toll of Cancer
A Phase 1/2, Study to Evaluate LNTH-2403, a LRRC15-targeted radiopharmaceutical, in Patients with Relapsed/Refractory Osteosarcoma
Defining tumor-specific vulnerabilities by mapping oncogenic structural variation in osteosarcoma
osTEAo: The Sound of Strength
Zanzalintinib in Osteosarcoma: Balancing Disease Control and Quality of Life
Extracellular Matrix Degradation to Overcome Osteosarcoma Chemoresistance
Targeting EPHA2 with dual-armored CAR T cells for immunotherapy in pediatric osteosarcoma
Identifying mechanisms of chemoresistance in metastatic osteosarcoma using molecular barcoding
New insights into shared molecular and genomic features between humans and dogs with OS
Implementing personalized, adaptive therapies in osteosarcoma
osTEAo: The Sibling Side of Cancer
High-throughput characterization of pathobiological responses in osteosarcoma tumors treated with LRRC15-targeted radiotherapy to uncover curative co-treatment approaches
osTEAo: New Year, Same Cancer
Next generation dual-CAR gamma delta T cells for the treatment of pediatric osteosarcoma
Insights from the Musculoskeletal Tumor Society (MSTS) December 2025 Annual Meeting
Results of a phase II trial of olaparib in combination with ceralasertib in patients with recurrent and unresectable osteosarcoma
Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution
osTEAo: Navigating Loss in the AYA Community
Synergy of ATM and PARP Inhibitors in Pediatric Osteosarcoma
Comparative extracellular vesicle (EV) biomarkers for osteosarcoma risk and prognosis
osTEAo - Spooky Sarcoma Stories
Insights from the AACR Special Conference in Cancer Research: Discovery and Innovation in Pediatric Cancer
Phase 1/2 clinical trial to evaluate the safety and efficacy of domatinostat in combination with sirolimus in adolescents and adults with relapsed, refractory sarcoma
osTEAo - Turning Pain Into Purpose
Distinct patterns of chromosomal instability fuel osteosarcoma progression and influence patient outcomes
Deciphering the impact of STING agonists on the tumor microenvironment in osteosarcoma
osTEAo: The Fault in Our Scars - Dating & Cancer
Clinical biomarkers for osteosarcoma stratification (cBOSS): Insights from a working group
Simultaneous targeting of CDK4/6 and BETs is independent of RB status in osteosarcoma
osTEAo: When Positivity Silences Pain
Old drugs, new tricks? A novel immunomodulatory approach to relapsed osteosarcoma therapy
Molecular subtyping of osteosarcoma, ecDNA and more
osTEAo: What to Expect When You're Not Expecting
A Guide to the FACTOR 2025 Scientific Panels with Matteo Trucco, MD
Autologous Cancer Vaccine with Checkpoint Inhibitor for Treatment of Canine Osteosarcoma
Stuck on the Sidelines: AYA Cancer & FOMO
Surgical Options and Advances in Osteosarcoma (La Cirugía de Salvamento de Extremidades)
Advocating for Cures: How You Can Support the Give Kids a Chance Act and Advance Pediatric Cancer Research
Tumor cGAS-STING repression drives immune evasion in osteosarcoma and is therapeutically targetable via host STING activation
osTEAo: Accessibility Wins, Fails & WTF Moments
Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: Consensus Recommendations from the Children’s Oncology Group Bone Tumour Committee
Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis
Multi-modal omics analysis identifies targetable sensory neuron circuitry that promotes sarcoma disease progression
osTEAo: Paws and Reflect: How Pets Help Us Heal
An Organoid-based Functional Precision Medicine Trial in Osteosarcoma (PREMOST)
Minimally Invasive Metastasectomy in Canines (MIMIC)
Live-cell whole tissue models reveal sources of dynamic signaling heterogeneity and single cell drug response variation in the metastatic niche
osTEAo: Cancer Fatigue: How to Escape the Cancerverse
COG Blueprint for Research on Bone Tumors
Understanding Tumor Evolution in Osteosarcoma
Macrophage engineered vesicles to treat pediatric Osteosarcoma.
osTEAo: Hospital Holidays
Repurposing Virus Specific T cells as Immune Therapy for Osteosarcoma
Repurposing Drugs for Osteosarcoma
The ablative and immunomodulatory effects of histotripsy treatment in osteosarcoma
osTEAo: Spooky Sarcoma Stories
Molecular and cellular deconstruction of metastatic osteosarcoma
osTEAo: Back to School: Cancer + Curriculum
Fit for Filing Academic Clinical Trials: An Industry Perspective
Magnetic Resonance Guided (MRg) High Intensity Focused Ultrasound (HIFU) For Palliation of Canine Appendicular Osteosarcoma
osTEAo - Clear Scans…So Now What?
Clinical Utility of Functional Precision Medicine to Guide Treatments for Osteosarcoma Patients
Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy
A Multi-Institution Study in Combination with Relapsed or Refractory Pediatric Bone and Soft Tissue
osTEAo: The Sibling Situation
Genomes, Avatars and AI: The Future of Personalized Medicine
Exploring Novel Immunotherapies for Canine Osteosarcoma
A Guide to the FACTOR 2024 Scientific Panels with Matteo Trucco, MD
osTEAo: Long Term Side Effects from Treatment For Osteosarcoma and AYA Cancer
Creating a translational genomic framework for canine osteosarcoma: updates on the NCI DOG2 project
Positioning Poly-(ADP)-ribose polymerase inhibitors (PARPi) for the treatment of Osteosarcoma
TGF-beta inhibition as a novel therapeutic option in Osteosarcoma
Out on a Limb - Travel Tips for AYA Cancer Patients
Phase 1 Study of Cabozantinib in Combination with Topotecan-Cyclophosphamide for Patients with Relapsed or Refractory Ewing Sarcoma or Osteosarcoma
Targeting Urea Cycle Dysfunction to Prevent and Treat Osteosarcoma Metastasis
osTEAo: Patient Experiences with Lung Surgery for Osteosarcoma
Osteosarcoma Explorer: A Data Commons With Clinical, Genomic, Protein, and Tissue Imaging Data for Osteosarcoma Research
Patient perspectives on participating in research and clinical trials
Tissue Engineering Strategies for Elucidating Osteosarcoma Biology and Drug Discovery
Liquid biopsy in Ewing sarcoma and osteosarcoma as a prognostic and response diagnostic: The LEOPARD Study
Managing Stress in AYA Cancer Patients
Prevention of Cisplatin-induced Hearing Loss: Implications for Young People Treated for Osteosarcoma
TACOS: A Phase 2 Trial of Atezolizumab and Cabozantinib in OsteoSarcoma
osTEAo: Making friends after a cancer diagnosis
Interventions to promote physical function during and after treatment for osteosarcoma
The Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan (CAUSAL) study
Developing a Multiscale Transcriptional Atlas of Sarcoma
Immunological Mechanisms of Cancer Defense
osTEAo: Long Term Osteosarcoma Survivors: Where They Were and Where They Are Now
Cabozantinib as a Maintenance Therapy to Prevent Recurrence of High-Risk Pediatric Solid Tumors
osTEAo - Coping with Cancer through Music
OsteoBites Preguntas & Respuestas con Nino Rainusso, MD
TCF-001 TRACK (Target Rare Cancer Knowledge): A Clinical Trial Studying Precision Medicine in Rare Cancers
Repurposing Disulfiram to Overcome Chemotherapy Resistance in Relapsed Sarcomas
osTEAo Tea Spill: AYA Cancer Gab Sesh
Addressing the Unmet Scientific Challenges in Osteosarcoma Treatment through Innovative Engineering Techniques
Implementing Multi-Targeted Tyrosine Kinase Inhibitors in Combination with Chemotherapy for Osteosarcoma
Immune Therapies in EGFR-Expressing Cancers
OsTEAo - An Honest Q&A with Osteosarcoma AYA Patients, Survivors, and Siblings
Treatment of Osteosarcoma Using Smart Targeted Drug Delivery Nanoplatforms
MIB Agents and SARC: A Case Study in Collaboration
OSI Funded Work
OsTEAo - Survivor's Guilt and Grief with grief coach Lori Krause
Pretargeted Approach to Delivery of Radiopharmaceutical Therapy for Bone Cancer - a Click Chemistry Study in Canines with Osteosarcoma
osTEAo - Coping with Humor: A Review of Cancer Memes
The Importance of Patient-Powered Osteosarcoma Research: Count Me In
Osteosarcoma Organoid Models: The Potential and Limitations of Personalized Avatars
Reprogramming NK Cells Within the Tumor Microenvironment of Osteosarcoma Lung Metastases
osTEAo- Returning to Yourself: Confidence and Identity as an AYA Cancer Patient
OSI Connect: Osteosarcoma Answers and Assistance
Open Clinical Trial: GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2
SCF-Skp2 Protein Complex as a Therapy for Osteosarcoma by Blocking the Mutational Effects of Rb and p53
osTEAo - Navigating Scanxiety
Cold Atmospheric Plasma: A New Therapeutical Option for Osteosarcoma?
UHRF1 Overexpression Promotes Osteosarcoma Metastasis through Altered Exosome Production and AMPK/SEMA3E Suppression
Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiosurgery (SRS) for Sarcoma
osTEAo - Navigating Campus: Limb-Salvage and Amputation Patient Perspectives
Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks
SarcoSIGHT- A Randomised Controlled Trial of Fluorescence Guided Sarcoma Surgery versus Standard Care
Virtual Surgical Planning and 3D Printing in Pediatric Musculoskeletal Oncological Resections
Two Epigenetically Distinct Cellular States in Osteo are Regulated by a State-Specific Set of Transcription Factors Driving Differential Drug Response
Clinical Trial: Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors
Cell Based Therapies for Osteosarcoma
osTEAo Q&A with Dr. Kurt Weiss - What questions do you have about Osteosarcoma but are afraid to ask?
Interventional Radiology/HIFU Perspectives for Osteosarcoma
Focal Adhesion Kinase (FAK) Inhibition to Improve Losartan-Sunitinib Immunotherapy in Metastatic Osteosarcoma
Updates from Clinical Sequencing of 2,138 Bone and Soft Tissue Sarcomas
osTEAo Presents Halloween Spooky Stories
How Osteosarcoma Evolves from Diagnosis to Relapse
Transforming the Way Researchers Share Data: Lessons from the Pediatric Cancer Data Commons
osTEAo - Dating & Intimacy with Lauren Broschak, MSW, LCSW, OSW-C
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma
Report on the Phase I/II Study of Single-Agent Lenvatinib in Children and Adolescents with Refractory or Relapsed Solid Malignancies and Young Adults with Osteosarcoma
Inhaled Recombinant Human IL-15 in Dogs with Naturally Occurring Pulmonary Metastases from Osteosarcoma or Melanoma: a Phase 1 Study
Outsmarting OS 2021 Funded Research Update: Exploring Aldehyde Dehydrogenase and Androgen Receptor Actions to OutSmart Osteosarcoma Metastases
Back to School: OsteoWarrior and OsteoSibling Perspectives
Combination Therapies to Improve Immune-Mediated Approaches for Osteosarcoma
Using RNA-Nanoparticle Vaccines to Overcome the Immunosuppressive Tumor Microenvironment of Canine Osteosarcoma
COG Project: Every Child - Episode Sponsored by Osteosarcoma Institute
Body Image for AYAs with Cancer with Dr. Lori Weiner
Unanswered Clinical Questions in Sarcoma: Opportunities to Move from Bedside to Bench - Episode Sponsored by Osteosarcoma Institute
Molecular Profiling Identifies Targeted Therapy Opportunities in Pediatric Solid Cancer - Episode Sponsored by Osteosarcoma Institute
Navigating Pediatric Cancer Clinical Trials
Update on OSI funded phase 2 Trial of Olaparib + Ceralasertib in Recurrent Osteosarcoma
Limb Salvage Surgery for OS: Patient & Surgeon Perspectives sponsored by the Osteosarcoma Institute
"Armored" CAR T cells for Osteosarcoma sponsored by BTG Specialty Pharmaceuticals
Immunotherapy for Osteosarcoma - Where Do We Go From Here? Sponsored by BTG Specialty Pharmaceuticals
The Osteosarcoma Project sponsored by BTG Specialty Pharmaceuticals
osTEAo Debut
Update on Clinical Trial Development Targeting Tumor Microenvironment in Refractory and Metastatic Osteosarcoma
Exploring the Use of a Predictive Tool for Methotrexate Clearance sponsored by BTG Specialty Pharmaceuticals
A Phase 1/2 Study of ZN-c3 Plus Gemcitabine in Relapsed or Refractory Osteosarcoma
MYC Amplification as a Prognostic Biomarker in Osteosarcoma Sponsored by BTG Speciality Pharmaceuticals
Compassionate Use of Investigational Drugs: A Strategy to Access Unapproved Therapies for Pediatric Oncology Patients Presented by BTG Speciality Pharmaceuticals
The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) International Randomized Controlled Trial Sponsored by BTG Specialty Pharmaceuticals
Osteosarcoma Q&A with OsteoWarriors sponsored by BTG Specialty Pharmaceuticals
Truths & Myths of Nutrition in Cancer sponsored by BTG Specialty Pharmaceuticals
Amputation for OS; Patient & Surgeon Perspectives sponsored by BTG Speciality Pharmaceuticals
Surgical Management of Pulmonary Metastases in People with Osteosarcoma - COG Trial
Human Trial for OST-HER2
Osteosarcoma Q&A with Dr. Peter Anderson and OsteoWarriors
Osteobites: Back to Activity, Rotationplasty
OsteoBites: Clinical Trials for Relapsed or Refractory Osteosarcoma - The OLIE Study and Beyond!
Encore, Testing & Research Directory
Real Talk: What it's really like and how WE feel about Osteosarcoma.
Planning for Dignity and What Matters Most to You
Let's Talk Fertility and Osteosarcoma
How "Hydroxychloroquine and "self-eating" works with Osteosarcoma.
Osteosarcoma Update from Dr. Huang - 2019 OutSmarting Osteosarcoma recipient
OsteoBites Welcomes Junior Board Members to discuss "Four OsteoWarriors' Perspectives".
OsteoBites welcomes Dr. Moyez Jiwa to discuss "The Art of Doctoring"
Osteosarcoma OsteoBites S2 Ep 18: Richard Gorlick, MD & Yifei Wang, MD “Antibody Drug Conjugates for Osteosarcoma”
Osteosarcoma OsteoBites S2 Ep 17: Lara Davis, MD, OHSU Knight Cancer Institute “New Osteosarcoma Clinical Trials”
Osteosarcoma OsteoBites S2 Ep 16: Julie Lanford, MPH, RD, CSO, LDN on “Nutrition & Cancer; Truths & Myths”
Osteosarcoma OsteoBites S2 Ep 15: Katie Greenzang, MD, EdM Dana-Farber CI & Harvard Med School “What’s Next? Survivorship"
Osteosarcoma OsteoBites S2 Ep 14: Lillian Guenther, MD Dana-Farber CI & Harvard Med School “CRISPR Screening to Identify Novel Genomic Targets"
Osteosarcoma OsteoBites S2 E13: Scott Sauer, PhD on “Preventing Osteosarcoma Lethal Recurrence by Targeting Disseminated Tumor Cells”
Osteosarcoma OsteoBites S2 Ep12: Dan Prince, MD, MPH on “Regenerative Surgery for Bone Sarcomas”
Osteosarcoma OsteoBites S2 Ep 11: Ines Lohse, PhD on “Drug Sensitivity Testing for the Treatment Stratification of Cancer Patients”
Osteosarcoma OsteoBites S2 Ep 10: Sumit Gupta, MD, PhD, FRCPC “Long Term Mental Health Outcomes in Adolescents and Young Adults with Cancer”
MIB Agents OsteoBites S2 Ep 9: Jane Yanagawa, MD, “Osteosarcoma Lung Metastases”
OsteoBites S2 Ep 8: Chand Khanna DVM, PhD, “A Comparative Approach To Metastasis: Biology and Therapy”
OsteoBites S2 Ep7: Corrie Painter, PhD “The Osteosarcoma Project, Patient-Partnered Research Update”
OsteoBites S2 Ep6: Brian Van Tine, MD, PhD on “Osteosarcoma Tumor Metabolism”
OsteoBites S2 Ep5: Robbie Majzner, MD on “Unleashing the Pediatric Immune System Against Osteosarcoma and Other Solid Tumors”
OsteoBites S3 Ep4: Lor Randall, MD, "Sarcomatology: A Trans-Disciplinary Approach"
OsteoBites S2 Ep3: Pete Anderson, MD, PhD "Understanding Lab, Path and Scan Reports and Other Questions Answered"
OsteoBites S2 Ep2: Alejandro Sweet Cordero, MD "Genome-Informed Targeted Therapies for Osteosarcoma"
OsteoBites S2 Ep1: Erin Murphy, Associate Professor, Radiation Oncology at Cleveland Clinic: Radiosurgery and SBRT for Sarcoma”
OsteoBites S1 Ep28: Ryan Roberts, MD, PhD. “Dear Lungs, Stop enabling this cancer: Targeting interactions that facilitate osteosarcoma metastasis.”
OsteoBites S1 Ep27: Brian Crompton, MD, “New Genomic Approaches to Understanding Osteosarcoma”
OsteoBites S1 Ep25: Sulagna Banerjee, PhD, “Modeling Osteosarcoma in Mice”
OsteoBites S1 Ep24: Andy Woods & Charles Keller, MD: "Legacy Autopsy”
Lauren: Osteosarcoma Survivor, Sibling of OsteoAngel and MIB Jr. Board Member
OsteoBites S1 Ep23: Brian Flesner, DVM, MS, DACVIM: "Adjuvant Chemotherapy for Canine Osteosarcoma ”
OsteoBites S1 Ep22: Reed: "Moffitt Osteosarcoma Research Approach”
OsteoBites S1 Ep21: Kurt Weiss, MD, A Day In the Life of a Musculoskeletal Oncologist
OsteoBites S1 Ep20: Correlative Science Leading to Active and Emerging Clinical Trials for #Osteosarcoma
OsteoBites S1 Ep19: Modeling & Targeting MYC-Driven Osteosarcoma
OsteoBites S1 Ep18: Coping Through Cancer: Tips for Parents & Caregivers
OsteoBites S1 Ep17: The #Osteosarcoma Patient Decision Aid for Surgical Options in the Lower Extremity
OsteoBites S1 Ep16: Peter Anderson, MD, PhD on Making It Better for OS Patients
OsteoBites S1 Ep15: Survivorship Care Planning with David Poplack, MD and Ellen Shohet, RN
OsteoBites S1 Ep14 Katie Janeway, MD, NEW Osteosarcoma Clinical Trial
OsteoBites S1 Ep12: John Healey, MD, Precision Surgery for Osteosarcoma
OsteoBites S1 Ep11: Alanna Church, MD and Christina Ip-Toma, MIB Testing & Research Directory
OsteoBites S1 Ep10: Simon Holland and Elly App
OsteoBites S1 Ep9: Amputee Coalition
OsteoBites S1 Ep8: Osteosarcoma Research, Joshua Schiffman, MD
OsteoBites S1 Ep7: Osteosarcoma Research, Matteo Trucco, MD
OsteoBites S1 Ep6: Osteosarcoma Research, J. Andrew Livingston, MD
OsteoBites S1 Ep5: Osteosarcoma Research, Alex Huang, MD, PhD of UH Rainbow Babies & Children's & CWRU
OsteoBites S1 EP2: Osteosarcoma Q&A with Matteo Trucco, MD of Cleveland Clinic
OsteoBites S1 Ep4: Upfront Surgery for Osteosarcoma, David Loeb, MD, PhD & Matteo Trucco, MD
OsteoBites: S1, EP3 Osteosarcoma Institute with Lee Helman, MD & Joyce Schaffer, RN